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THOC5 (THO Complex 5) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and RNA Polymerase II Transcription Termination. Gene Ontology (GO) annotations related to this gene include mRNA binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA | -- |
GO:0003729 | mRNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 19059247 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000346 | transcription export complex | IDA | 15833825 |
GO:0000347 | THO complex | IDA | 15998806 |
GO:0000445 | THO complex part of transcription export complex | IBA,IDA | 15998806 |
GO:0000781 | colocalizes_with chromosome, telomeric region | IDA | 24270157 |
GO:0005634 | nucleus | IEA,IDA | 19059247 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RNA Polymerase II Transcription Termination | ||
2 | Transport of Mature Transcript to Cytoplasm | ||
3 | RNA transport | ||
4 | Gene Expression |
.48
|
|
5 | mRNA Splicing - Major Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006397 | mRNA processing | IEA | -- |
GO:0006405 | RNA export from nucleus | TAS | -- |
GO:0006406 | mRNA export from nucleus | IBA,TAS | -- |
GO:0008380 | RNA splicing | IEA | -- |
GO:0030154 | cell differentiation | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: |
ExUns: | 24b |
---|---|
SP1: | |
SP2: | |
SP3: | |
SP4: | |
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | THOC5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | THOC5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | THOC5 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Thoc5 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Thoc5 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | THOC5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | THOC5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | THOC5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | thoc5 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | fmip-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | thoc5 30 31 |
|
OneToOne | |
Dr.2250 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004746 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | thoc5 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | Y32H12A.2 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1264823745 | A breast cancer sample |
p.Thr380Lys |
|||
rs1280359906 | A breast cancer sample |
p.Gly499Ser |
|||
rs16987733 | Benign: not provided | 29,512,036(-) |
G/A NM_001002877.2(THOC5):c.1782C>T (p.Asn594=) |
SYNONYMOUS | |
rs35832657 | Benign: not provided | 29,517,289(-) |
C/T NM_003678.5(THOC5):c.1567G>A (p.Val523Met) |
MISSENSE | |
rs1049534 | - |
p.Val579Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2724126 | CNV | deletion | 23290073 |
esv3568351 | CNV | loss | 25503493 |
esv3647536 | CNV | gain | 21293372 |
esv3647538 | CNV | gain | 21293372 |
esv3647539 | CNV | gain | 21293372 |
esv3893473 | CNV | loss | 25118596 |
nsv1110864 | OTHER | inversion | 24896259 |
nsv510513 | OTHER | sequence alteration | 20534489 |
nsv834172 | CNV | loss | 17160897 |
No disorders were found for THOC5 Gene.