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Aliases for THOC5 Gene
Aliases for THOC5 Gene
External Ids for THOC5 Gene
- HGNC: 19074
- Entrez Gene: 8563
- Ensembl: ENSG00000100296
- OMIM: 612733
- UniProtKB: Q13769
Previous HGNC Symbols for THOC5 Gene
- C22orf19
Previous GeneCards Identifiers for THOC5 Gene
- GC00U902870
- GC22M028231
- GC22M029901
- GC22M012867
Summaries for THOC5 Gene
GeneCards Summary for THOC5 Gene
THOC5 (THO Complex 5) is a Protein Coding gene. Among its related pathways are Cleavage of Growing Transcript in the Termination Region and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include mRNA binding.
UniProtKB/Swiss-Prot Summary for THOC5 Gene
-
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.
-
Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.
Additional gene information for THOC5 Gene
- HGNC(19074)
- Entrez Gene(8563)
- Ensembl(ENSG00000100296)
- OMIM(612733)
- UniProtKB(Q13769)
- Open Targets Platform(ENSG00000100296)
- Search for THOC5 at DataMed
- Search for THOC5 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THOC5 Gene
Genomics for THOC5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for THOC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around THOC5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for THOC5
- Top Transcription factor binding sites by QIAGEN in the THOC5 gene promoter:
-
- E47
- p53
- Tal-1beta
- ZID
Genomic Locations for THOC5 Gene
Genomic Locations for THOC5 Gene
- chr22:29,505,879-29,555,216
- (GRCh38/hg38)
- Size:
- 49,338 bases
- Orientation:
- Minus strand
- chr22:29,901,868-29,951,205
- (GRCh37/hg19)
- Size:
- 49,338 bases
- Orientation:
- Minus strand
Genomic View for THOC5 Gene
Genes around THOC5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.2 by HGNC
- 22q12.2 by Entrez Gene
- 22q12.2 by Ensembl
THOC5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for THOC5 Gene
Proteins for THOC5 Gene
-
Protein details for THOC5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13769-THOC5_HUMAN
- Recommended name:
- THO complex subunit 5 homolog
- Protein Accession:
- Q13769
- O60839
- Q9UPZ5
Protein attributes for THOC5 Gene
- Size:
- 683 amino acids
- Molecular mass:
- 78508 Da
- Quaternary structure:
-
- Interacts with phosphorylated CSF1R (By similarity). Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with ALYREF/THOC4, and THOC7. Interacts (via N-terminus) with the NTF2 domain of NXF1. Forms a complex with CEBPB. Interacts with CPSF6; indicative for an association with the cleavage factor Im (CFIm) complex. Interacts with THOC1 (By similarity). Interacts with LUZP4. Interacts with NCBP3 (PubMed:26382858).
- SequenceCaution:
-
- Sequence=BAA76827.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for THOC5 Gene
Post-translational modifications for THOC5 Gene
- Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes (By similarity). Phosphorylation at Tyr-225 modulates mRNA binding.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for THOC5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ THOC5 Antibody
- BioLegend Purified anti-FMIP
- Novus Biologicals Antibodies for THOC5
-
Abcam antibodies for THOC5
- Invitrogen Antibodies for THOC5 (AFLGC-THOC5)
-
Biorbyt antibodies for THOC5
-
Santa Cruz Biotechnology (SCBT) Antibodies for THOC5
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for THOC5
- Origene Custom Protein Services for THOC5
- antibodies-online: Show 3 available THOC5 Proteins ranked by validation data
- Compare Top THOC5 Proteins
-
Quality Products:
No data available for DME Specific Peptides for THOC5 Gene
Domains & Families for THOC5 Gene
Gene Families for THOC5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for THOC5 Gene
- GenScript: Design optimal peptide antigens:
-
- hTREX90 (THOC5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13769- Family:
-
- Belongs to the THOC5 family.
Function for THOC5 Gene
Molecular function for THOC5 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.
- UniProtKB/Swiss-Prot Function:
- Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.
Phenotypes From GWAS Catalog for THOC5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0003729 | mRNA binding | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 19059247 |
Phenotypes for THOC5 Gene
- MGI mutant phenotypes for THOC5:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for THOC5:
Animal Models for THOC5 Gene
- MGI Knock Outs for THOC5:
-
- Thoc5 Thoc5<tm1.1Tate>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for THOC5 - Select products 50% OFF >
- * THOC5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for THOC5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THOC5
-
Santa Cruz Biotechnology (SCBT) CRISPR for THOC5
miRNA for THOC5 Gene
- miRTarBase miRNAs that target THOC5
-
- hsa-miR-98-5p (MIRT027661)
- hsa-miR-615-3p (MIRT039858)
- hsa-miR-186-5p (MIRT044988)
- hsa-miR-30a-3p (MIRT049915)
- hsa-let-7f-5p (MIRT051410)
- hsa-let-7b-5p (MIRT052279)
- hsa-miR-5089-5p (MIRT514867)
- hsa-miR-6842-3p (MIRT514868)
- hsa-miR-7151-3p (MIRT514869)
- hsa-miR-5095 (MIRT514870)
- hsa-miR-5787 (MIRT514871)
- hsa-miR-4505 (MIRT514872)
- hsa-miR-4430 (MIRT514873)
- hsa-miR-3652 (MIRT514874)
- hsa-miR-6778-3p (MIRT514875)
- hsa-miR-6506-5p (MIRT514876)
- hsa-miR-619-5p (MIRT514877)
- hsa-miR-4740-3p (MIRT514878)
- hsa-miR-6504-3p (MIRT514879)
- hsa-miR-7703 (MIRT716129)
- hsa-miR-6807-5p (MIRT716130)
- hsa-miR-4252 (MIRT716131)
- hsa-miR-4793-3p (MIRT716132)
- hsa-miR-1273g-3p (MIRT716133)
- hsa-miR-4650-5p (MIRT716134)
- hsa-miR-1972 (MIRT716135)
- hsa-miR-6863 (MIRT716136)
- hsa-miR-510-5p (MIRT716137)
- hsa-miR-1227-3p (MIRT761416)
- hsa-miR-1254 (MIRT761645)
- hsa-miR-3116 (MIRT764761)
- hsa-miR-3690 (MIRT767118)
- hsa-miR-4638-3p (MIRT770516)
- hsa-miR-508-5p (MIRT773202)
- hsa-miR-517a-3p (MIRT773474)
- hsa-miR-517b-3p (MIRT773475)
- hsa-miR-517c-3p (MIRT773476)
- hsa-miR-6501-3p (MIRT776512)
- hsa-miR-6512-3p (MIRT776956)
- hsa-miR-6720-5p (MIRT777802)
- hsa-miR-6849-3p (MIRT780355)
- hsa-miR-766-3p (MIRT781911)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THOC5
- Browse OriGene Inhibitory RNA Products For THOC5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THOC5
Clone Products
- Applied Biological Materials (abm): Clones for THOC5 - Select products 50% OFF >
- * THOC5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223275
- MR223275
- MR223275L3
- MR223275L4
- RC200382
- RC200382L3
- RC200382L4
- RC213773
- RC213773L3
- RC213773L4
- RC219611
- RC219611L3
- RC219611L4
- RC223375
- RC223375L3
- RC223375L4
- RG200382
- RG213773
- RG219611
- RG223375
- RR201699
- RR201699L3
- RR201699L4
- MR223275L3V
- MR223275L4V
- RC200382L3V
- RC200382L4V
- RC213773L3V
- RC213773L4V
- RC219611L3V
- RC219611L4V
- RC223375L3V
- RC223375L4V
- RR201699L3V
- RR201699L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for THOC5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THOC5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THOC5 Gene
Localization for THOC5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for THOC5 Gene
- Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm. {ECO:0000269 PubMed:19059247}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000346 | transcription export complex | IDA | 15833825 |
| GO:0000347 | THO complex | IDA | 15998806 |
| GO:0000445 | THO complex part of transcription export complex | IBA,IDA | 15998806 |
| GO:0000784 | colocalizes_with nuclear chromosome, telomeric region | IDA | 24270157 |
| GO:0005634 | nucleus | IEA,IDA | 19059247 |
Pathways & Interactions for THOC5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cleavage of Growing Transcript in the Termination Region | ||
| 2 | Transport of Mature Transcript to Cytoplasm | ||
| 3 | RNA transport | ||
| 4 | Gene Expression |
.48
|
|
| 5 | mRNA Splicing - Major Pathway | ||
Pathways by source for THOC5 Gene
1 KEGG pathway for THOC5 Gene
Interacting Proteins for THOC5 Gene
Selected Interacting proteins:
Q13769-THOC5_HUMAN
ENSP00000420306
for THOC5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for THOC5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0006405 | RNA export from nucleus | TAS | -- |
| GO:0006406 | mRNA export from nucleus | IBA,TAS | -- |
| GO:0008380 | RNA splicing | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
Transcripts for THOC5 Gene
mRNA/cDNA for THOC5 Gene
- 4 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000358079 2427 nts (view in UCSC)
- ENST00000397871 2560 nts (view in UCSC)
- ENST00000397872 2676 nts (view in UCSC)
- ENST00000397873 2374 nts (view in UCSC)
- ENST00000414902 484 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for THOC5 - Select products 50% OFF >
- * THOC5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for THOC5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THOC5
-
Santa Cruz Biotechnology (SCBT) CRISPR for THOC5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THOC5
- Browse OriGene Inhibitory RNA Products For THOC5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THOC5
Clone Products
- Applied Biological Materials (abm): Clones for THOC5 - Select products 50% OFF >
- * THOC5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223275
- MR223275
- MR223275L3
- MR223275L4
- RC200382
- RC200382L3
- RC200382L4
- RC213773
- RC213773L3
- RC213773L4
- RC219611
- RC219611L3
- RC219611L4
- RC223375
- RC223375L3
- RC223375L4
- RG200382
- RG213773
- RG219611
- RG223375
- RR201699
- RR201699L3
- RR201699L4
- MR223275L3V
- MR223275L4V
- RC200382L3V
- RC200382L4V
- RC213773L3V
- RC213773L4V
- RC219611L3V
- RC219611L4V
- RC223375L3V
- RC223375L4V
- RR201699L3V
- RR201699L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for THOC5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THOC5
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
| ExUns: | 24b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: |
Relevant External Links for THOC5 Gene
- GeneLoc Exon Structure for
- THOC5
Expression for THOC5 Gene
mRNA differential expression in normal tissues according to GTEx for THOC5 Gene
This gene is overexpressed in Whole Blood (x4.7).
This gene is overexpressed in Peripheral blood mononuclear cells (21.1) and Lymph node (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THOC5 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for THOC5
SOURCE GeneReport for Unigene cluster for THOC5 Gene:
Hs.75361mRNA Expression by UniProt/SwissProt for THOC5 Gene:
Q13769-THOC5_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for THOC5 Gene
- Nervous system(4.8)
- Liver(4.3)
- Intestine(4.3)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for THOC5
-
OriGene qPCR primer pairs and template standards for THOC5
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for THOC5 Gene
Orthologs for THOC5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | THOC5 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | THOC5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | THOC5 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Thoc5 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Thoc5 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | THOC5 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | THOC5 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | THOC5 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | thoc5 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | fmip-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | thoc5 30 31 |
|
OneToOne | |
| Dr.2250 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004746 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | thoc5 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | Y32H12A.2 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for THOC5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for THOC5 Gene
- ENSEMBL:
- Gene Tree for THOC5 (if available)
- TreeFam:
- Gene Tree for THOC5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for THOC5: view image
Paralogs for THOC5 Gene
No data available for Paralogs for THOC5 Gene
Variants for THOC5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for THOC5 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 782635 | Benign: not provided | 29,517,289(-) | C/T | MISSENSE_VARIANT | |
| 790774 | Benign: not provided | 29,512,036(-) | G/A | SYNONYMOUS_VARIANT | |
| rs1264823745 | A breast cancer sample | p.Thr380Lys | |||
| rs1280359906 | A breast cancer sample | p.Gly499Ser | |||
| rs1049534 | - | p.Val579Ile |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2724126 | CNV | deletion | 23290073 |
| esv3568351 | CNV | loss | 25503493 |
| esv3647536 | CNV | gain | 21293372 |
| esv3647538 | CNV | gain | 21293372 |
| esv3647539 | CNV | gain | 21293372 |
| esv3893473 | CNV | loss | 25118596 |
| nsv1110864 | OTHER | inversion | 24896259 |
| nsv510513 | OTHER | sequence alteration | 20534489 |
| nsv834172 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.24;
88.08% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for THOC5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- THOC5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THOC5 Gene
Disorders for THOC5 Gene
Additional Disease Information for THOC5
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for THOC5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THOC5 Gene
Publications for THOC5 Gene
- Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). (PMID: 19059247) El Bounkari O … Tamura T (FEBS letters 2009) 3 4 23
- THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover. (PMID: 18373705) Pierce A … Whetton AD (British journal of haematology 2008) 2 3 4
- Recruitment of the human TREX complex to mRNA during splicing. (PMID: 15998806) Masuda S … Reed R (Genes & development 2005) 2 3 4
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
- Cloning of a novel, anonymous gene from a megabase-range YAC and cosmid contig in the neurofibromatosis type 2/meningioma region on human chromosome 22q12. (PMID: 8242058) Xie YG … Dumanski JP (Human molecular genetics 1993) 2 3 4
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Sources for THOC5 Gene
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