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THOC5 (THO Complex 5) is a Protein Coding gene. Among its related pathways are Cleavage of Growing Transcript in the Termination Region and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include mRNA binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA | -- |
GO:0003729 | mRNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 19059247 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000346 | transcription export complex | IDA | 15833825 |
GO:0000347 | THO complex | IDA | 15998806 |
GO:0000445 | THO complex part of transcription export complex | IBA,IDA | 15998806 |
GO:0000784 | colocalizes_with nuclear chromosome, telomeric region | IDA | 24270157 |
GO:0005634 | nucleus | IEA,IDA | 19059247 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cleavage of Growing Transcript in the Termination Region | ||
2 | Transport of Mature Transcript to Cytoplasm | ||
3 | RNA transport | ||
4 | Gene Expression |
.48
|
|
5 | mRNA Splicing - Major Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006397 | mRNA processing | IEA | -- |
GO:0006405 | RNA export from nucleus | TAS | -- |
GO:0006406 | mRNA export from nucleus | IBA,TAS | -- |
GO:0008380 | RNA splicing | IEA | -- |
GO:0030154 | cell differentiation | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: |
ExUns: | 24b |
---|---|
SP1: | |
SP2: | |
SP3: | |
SP4: | |
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | THOC5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | THOC5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | THOC5 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Thoc5 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Thoc5 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | THOC5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | THOC5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | THOC5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | thoc5 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | fmip-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | thoc5 30 31 |
|
OneToOne | |
Dr.2250 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004746 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | thoc5 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | Y32H12A.2 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
782635 | Benign: not provided | 29,517,289(-) | C/T | MISSENSE_VARIANT | |
790774 | Benign: not provided | 29,512,036(-) | G/A | SYNONYMOUS_VARIANT | |
rs1264823745 | A breast cancer sample | p.Thr380Lys | |||
rs1280359906 | A breast cancer sample | p.Gly499Ser | |||
rs1049534 | - | p.Val579Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2724126 | CNV | deletion | 23290073 |
esv3568351 | CNV | loss | 25503493 |
esv3647536 | CNV | gain | 21293372 |
esv3647538 | CNV | gain | 21293372 |
esv3647539 | CNV | gain | 21293372 |
esv3893473 | CNV | loss | 25118596 |
nsv1110864 | OTHER | inversion | 24896259 |
nsv510513 | OTHER | sequence alteration | 20534489 |
nsv834172 | CNV | loss | 17160897 |
No disorders were found for THOC5 Gene.