Aliases for THNSL1 Gene

Aliases for THNSL1 Gene

  • Threonine Synthase Like 1 2 3 5
  • Threonine Synthase-Like 1 2 3 4
  • TSH1 3 4
  • Threonine Synthase-Like 1 (S. Cerevisiae) 2
  • Threonine Synthase-Like 1 (Bacterial) 2

External Ids for THNSL1 Gene

Previous GeneCards Identifiers for THNSL1 Gene

  • GC10P025310
  • GC10P025345
  • GC10P024966

Summaries for THNSL1 Gene

GeneCards Summary for THNSL1 Gene

THNSL1 (Threonine Synthase Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding and threonine synthase activity. An important paralog of this gene is THNSL2.

Additional gene information for THNSL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THNSL1 Gene

Genomics for THNSL1 Gene

GeneHancer (GH) Regulatory Elements for THNSL1 Gene

Promoters and enhancers for THNSL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J025015 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 511.2 -0.3 -255 3.8 ZBTB40 EP300 SIN3A NRF1 TCF12 MYC POLR2G USF1 RBAK GTF2E2 THNSL1 ENKUR lnc-ENKUR-2 ARHGAP21 ENSG00000285859 RF00017-617
GH10J024988 Enhancer 0.9 Ensembl ENCODE 16.2 -27.4 -27422 0.9 CTBP1 LEF1 NCOR1 ZNF316 ZBTB17 CEBPG MAX ZNF592 PBX2 TAL1 THNSL1 ENKUR ARHGAP21 piR-59136-005 lnc-ENKUR-2 ENSG00000285859 PRTFDC1 RF00017-617
GH10J025067 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +51.7 51656 2.3 ZSCAN5C ZNF639 TRIM28 ATF2 ZNF263 ZNF184 FOS STAT3 HIC1 ZNF664 THNSL1 ENKUR piR-38351-036 RF00017-617 ENSG00000285859
GH10J024974 Enhancer 0.8 Ensembl ENCODE dbSUPER 16.4 -41.4 -41393 1.2 CTCF RAD21 ZBTB33 HNF4A CEBPB CHAMP1 SP1 CC2D1A THNSL1 PRTFDC1 ENKUR ENSG00000285859 piR-59136-005
GH10J024962 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.2 -53.2 -53233 2.1 SKI FOXA2 ZNF316 MAFF CREB3L1 FOS FOSL2 CEBPB ZBTB33 JUN THNSL1 ENKUR PRTFDC1 ENSG00000285859 piR-59136-005
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around THNSL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for THNSL1

Top Transcription factor binding sites by QIAGEN in the THNSL1 gene promoter:
  • C/EBPalpha
  • CUTL1
  • En-1
  • GATA-1
  • GATA-2
  • GATA-3
  • Pbx1a
  • POU2F1
  • POU2F1a

Genomic Locations for THNSL1 Gene

Genomic Locations for THNSL1 Gene
chr10:25,016,579-25,026,664
(GRCh38/hg38)
Size:
10,086 bases
Orientation:
Plus strand
chr10:25,305,508-25,315,593
(GRCh37/hg19)
Size:
10,086 bases
Orientation:
Plus strand

Genomic View for THNSL1 Gene

Genes around THNSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THNSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THNSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THNSL1 Gene

Proteins for THNSL1 Gene

  • Protein details for THNSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYQ7-THNS1_HUMAN
    Recommended name:
    Threonine synthase-like 1
    Protein Accession:
    Q8IYQ7
    Secondary Accessions:
    • B3KWL1
    • D3DRV3
    • Q5VV21

    Protein attributes for THNSL1 Gene

    Size:
    743 amino acids
    Molecular mass:
    83070 Da
    Cofactor:
    Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    No Data Available

neXtProt entry for THNSL1 Gene

Post-translational modifications for THNSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THNSL1 Gene

No data available for DME Specific Peptides for THNSL1 Gene

Domains & Families for THNSL1 Gene

Gene Families for THNSL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for THNSL1 Gene

Blocks:
  • Pyridoxal-5'-phosphate-dependent enzyme, beta family
  • Shikimate kinase family signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THNSL1 Gene

GenScript: Design optimal peptide antigens:
  • Threonine synthase-like 1 (THNS1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IYQ7

UniProtKB/Swiss-Prot:

THNS1_HUMAN :
  • Belongs to the threonine synthase family.
Family:
  • Belongs to the threonine synthase family.
genes like me logo Genes that share domains with THNSL1: view

Function for THNSL1 Gene

Phenotypes From GWAS Catalog for THNSL1 Gene

Gene Ontology (GO) - Molecular Function for THNSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with THNSL1: view
genes like me logo Genes that share phenotypes with THNSL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THNSL1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THNSL1 Gene

Localization for THNSL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THNSL1 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THNSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with THNSL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THNSL1 Gene

Pathways & Interactions for THNSL1 Gene

PathCards logo

SuperPathways for THNSL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THNSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with THNSL1: view

No data available for Pathways by source and SIGNOR curated interactions for THNSL1 Gene

Drugs & Compounds for THNSL1 Gene

(2) Drugs for THNSL1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyridoxal Phosphate Approved, Investigational Nutra Target, cofactor 20
Threonine Approved Nutra Target 34
genes like me logo Genes that share compounds with THNSL1: view

Transcripts for THNSL1 Gene

mRNA/cDNA for THNSL1 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THNSL1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THNSL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for THNSL1 Gene

GeneLoc Exon Structure for
THNSL1

Expression for THNSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THNSL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THNSL1 Gene

This gene is overexpressed in Lymph node (7.3) and Liver (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THNSL1 Gene



Protein tissue co-expression partners for THNSL1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for THNSL1

SOURCE GeneReport for Unigene cluster for THNSL1 Gene:

Hs.645274
genes like me logo Genes that share expression patterns with THNSL1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for THNSL1 Gene

Orthologs for THNSL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for THNSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THNSL1 31 30
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia THNSL1 31 30
  • 91.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia THNSL1 31 30
  • 90.4 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Thnsl1 17 31 30
  • 84.39 (n)
rat
(Rattus norvegicus)
Mammalia Thnsl1 30
  • 82.93 (n)
oppossum
(Monodelphis domestica)
Mammalia THNSL1 31
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THNSL1 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves THNSL1 31 30
  • 73.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THNSL1 31
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thnsl1 30
  • 69.62 (n)
Str.13522 30
zebrafish
(Danio rerio)
Actinopterygii LOC101883988 30
  • 60.38 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THR4 31
  • 32 (a)
OneToMany
Species where no ortholog for THNSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THNSL1 Gene

ENSEMBL:
Gene Tree for THNSL1 (if available)
TreeFam:
Gene Tree for THNSL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for THNSL1: view image

Paralogs for THNSL1 Gene

Paralogs for THNSL1 Gene

(1) SIMAP similar genes for THNSL1 Gene using alignment to 1 proteins:

  • THNS1_HUMAN
genes like me logo Genes that share paralogs with THNSL1: view

Variants for THNSL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for THNSL1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
758211 Benign: not provided 24,990,617(+) G/T INTRON_VARIANT
800559 Uncertain Significance: not provided 24,995,869(+) TC/T SPLICE_ACCEPTOR_VARIANT
rs34929144 - p.Ala248Glu
rs35827877 - p.Leu154Pro
rs41279890 - p.Pro239Arg

Additional dbSNP identifiers (rs#s) for THNSL1 Gene

Variation tolerance for THNSL1 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.06; 75.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THNSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THNSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for THNSL1 Gene

Disorders for THNSL1 Gene

Additional Disease Information for THNSL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for THNSL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THNSL1 Gene

Publications for THNSL1 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41 54
  2. A threonine synthase homolog from a mammalian genome. (PMID: 17034760) Donini S … Peracchi A (Biochemical and biophysical research communications 2006) 2 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54

Products for THNSL1 Gene

Sources for THNSL1 Gene