Aliases for THEM5 Gene
External Ids for THEM5 Gene
Previous GeneCards Identifiers for THEM5 Gene
GeneCards Summary for THEM5 Gene
THEM5 (Thioesterase Superfamily Member 5) is a Protein Coding gene. Diseases associated with THEM5 include Gynatresia and Median Rhomboid Glossitis. Among its related pathways are alpha-linolenic (omega3) and linoleic (omega6) acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include palmitoyl-CoA hydrolase activity. An important paralog of this gene is THEM4.
UniProtKB/Swiss-Prot Summary for THEM5 Gene
Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (PubMed:22586271). Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271). Required for normal mitochondrial function (PubMed:22586271).