Aliases for THEM4 Gene
External Ids for THEM4 Gene
Previous GeneCards Identifiers for THEM4 Gene
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]
GeneCards Summary for THEM4 Gene
THEM4 (Thioesterase Superfamily Member 4) is a Protein Coding gene. Diseases associated with THEM4 include Palmoplantar Keratoderma, Bothnian Type and Wolf-Hirschhorn Syndrome. Among its related pathways are RET signaling and alpha-linolenic (omega3) and linoleic (omega6) acid metabolism. Gene Ontology (GO) annotations related to this gene include palmitoyl-CoA hydrolase activity. An important paralog of this gene is THEM5.
UniProtKB/Swiss-Prot Summary for THEM4 Gene
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.