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THEGL Gene(Protein Coding)

Theg Spermatid Protein Like

GCID:
GC04P056530
GIFtS:
30
Genes Participants
UDN Logo

Aliases for THEGL Gene

Aliases for THEGL Gene

  • Theg Spermatid Protein Like 2 3 5
  • Theg Spermatid-Like Protein 4

External Ids for THEGL Gene

Previous GeneCards Identifiers for THEGL Gene

  • GC04P057398

Summaries for THEGL Gene

GeneCards Summary for THEGL Gene

THEGL (Theg Spermatid Protein Like) is a Protein Coding gene.

Additional gene information for THEGL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEGL Gene

Genomics for THEGL Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for THEGL Gene

Promoters and enhancers for THEGL Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I056530 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 567.6 +0.1 105 1.4 TAF9B MZF1 SIN3A BMI1 ZNF335 POLR2B EGR1 SCRT2 ZHX1 SP3 THEGL LOC105377665 SRP72 ARL9 ENSG00000251799 SPINK2 GLDCP1
GH04I056531 Enhancer 0.4 ENCODE 550.8 +1.0 1015 0.2 TEAD4 MGA LOC105377665 THEGL ARL9 SRP72 ENSG00000251799 SPINK2 GLDCP1
GH04I056544 Enhancer 1.2 Ensembl ENCODE 0.4 +14.2 14220 1.2 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 SP3 MXD4 REST SMARCB1 SPINK2 ENSG00000251799 AASDH ARL9 THEGL GLDCP1
GH04I056540 Enhancer 0.4 Ensembl 0.4 +10.3 10326 0.2 ZNF512 ATF2 ARL9 SRP72 PAICS PPAT SPINK2 ENSG00000251799 HOPX AASDH THEGL GLDCP1
GH04I056592 Promoter 0.5 Ensembl 0.2 +62.0 62026 0.4 GLDCP1 HOPX ENSG00000251799 SPINK2 GC04P056642 THEGL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THEGL on UCSC Golden Path with GeneCards custom track

Genomic Locations for THEGL Gene

Genomic Locations for THEGL Gene
chr4:56,530,575-56,641,550
(GRCh38/hg38)
Size:
110,976 bases
Orientation:
Plus strand
chr4:57,396,775-57,469,673
(GRCh37/hg19)

Genomic View for THEGL Gene

Genes around THEGL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEGL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEGL Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for THEGL Gene

Proteins for THEGL Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for THEGL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DJG4-THEGL_HUMAN
    Recommended name:
    Testicular haploid expressed gene protein-like
    Protein Accession:
    P0DJG4

    Protein attributes for THEGL Gene

    Size:
    465 amino acids
    Molecular mass:
    53028 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THEGL Gene

Protein Expression for THEGL Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for THEGL Gene

No Post-translational modifications

Other Protein References for THEGL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THEGL Gene

Domains & Families for THEGL Gene

Gene Families for THEGL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for THEGL Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THEGL: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for THEGL Gene

Function for THEGL Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes for THEGL Gene

MGI mutant phenotypes for THEGL:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with THEGL: view

Animal Models for THEGL Gene

MGI Knock Outs for THEGL:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for THEGL Gene

Localization for THEGL Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for THEGL Gene

Pathways & Interactions for THEGL Gene

SuperPathways for THEGL Gene

PathCards logo More details on SuperPathways for THEGL
No Data Available

Interacting Proteins for THEGL Gene

Selected Interacting proteins: P0DJG4-THEGL_HUMAN for THEGL Gene via IID

Symbol External ID(s) Details
MAPK3

Gene Ontology (GO) - Biological Process for THEGL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for THEGL Gene

Drugs & Compounds for THEGL Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for THEGL Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for THEGL Gene

(6) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THEGL Gene

Theg spermatid protein-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THEGL Gene

No ASD Table

Relevant External Links for THEGL Gene

GeneLoc Exon Structure for
THEGL
ECgene alternative splicing isoforms for
THEGL

Expression for THEGL Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THEGL Gene

mRNA expression in normal human tissues for THEGL Gene
mRNA expression by GTEx for THEGL Gene

mRNA differential expression in normal tissues according to GTEx for THEGL Gene

This gene is overexpressed in Testis (x29.2).

Protein differential expression in normal tissues from HIPED for THEGL Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (48.6) and Cerebrospinal fluid (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for THEGL Gene



Protein tissue co-expression partners for THEGL Gene

NURSA nuclear receptor signaling pathways regulating expression of THEGL Gene:

THEGL

SOURCE GeneReport for Unigene cluster for THEGL Gene:

Hs.573073
genes like me logo Genes that share expression patterns with THEGL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for THEGL Gene

Orthologs for THEGL Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEGL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia THEGL 33
  • 98.91 (n)
cow
(Bos Taurus)
 Mammalia THEGL 33
  • 78.54 (n)
dog
(Canis familiaris)
 Mammalia THEGL 33 34
  • 77.88 (n)
mouse
(Mus musculus)
 Mammalia 1700023E05Rik 33 34
  • 71.51 (n)
Thegl 16
rat
(Rattus norvegicus)
 Mammalia LOC498350 33
  • 70.4 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia THEGL 34
  • 39 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia THEGL 34
  • 37 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 36 (a)
 OneToOne
Species where no ortholog for THEGL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THEGL Gene

ENSEMBL:
Gene Tree for THEGL (if available)
TreeFam:
Gene Tree for THEGL (if available)

Paralogs for THEGL Gene

No data available for Paralogs for THEGL Gene

Variants for THEGL Gene

Sequence variations from dbSNP and Humsavar for THEGL Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10000144 -- 56,543,897(+) T/A intron_variant
rs1000021130 -- 56,606,028(+) A/G genic_downstream_transcript_variant, intron_variant
rs10000346 -- 56,583,157(+) C/T intron_variant
rs1000053741 -- 56,555,869(+) A/G intron_variant
rs1000054544 -- 56,563,617(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for THEGL Gene

Variant ID Type Subtype PubMed ID
nsv964047 CNV duplication 23825009
nsv829942 CNV gain 17160897
nsv829941 CNV loss 17160897
esv3600579 CNV loss 21293372
esv3600578 CNV loss 21293372
dgv5213n100 CNV gain 25217958

Variation tolerance for THEGL Gene

Gene Damage Index Score: 6.67; 78.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THEGL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THEGL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEGL Gene

Disorders for THEGL Gene

Additional Disease Information for THEGL

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for THEGL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THEGL Gene

Publications for THEGL Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  3. CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly. (PMID: 26831064) Ertych N … Bastians H (Proceedings of the National Academy of Sciences of the United States of America 2016) 3

Products for THEGL Gene

Sources for THEGL Gene

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