Free for academic non-profit institutions. Other users need a Commercial license

Aliases for THEG Gene

Aliases for THEG Gene

  • Theg Spermatid Protein 2 3 5
  • Cancer/Testis Antigen 56 2 3 4
  • CT56 3 4
  • Testicular Haploid Expressed Gene Protein 3
  • Theg Homolog (Mouse) 2
  • Testis-Specific 3
  • Theg Homolog 3
  • THEG1 3

External Ids for THEG Gene

Previous GeneCards Identifiers for THEG Gene

  • GC19M000302
  • GC19M000313
  • GC19M000131

Summaries for THEG Gene

Entrez Gene Summary for THEG Gene

  • This gene is specifically expressed in the nucleus of haploid male germ cells. The orthologous gene in mice encodes a protein that may play a role in protein assembly through interactions with T-complex protein 1 subunit epsilon. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for THEG Gene

THEG (Theg Spermatid Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for THEG Gene

  • May be involved (but not essential) in spermatogenesis.

Additional gene information for THEG Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEG Gene

Genomics for THEG Gene

GeneHancer (GH) Regulatory Elements for THEG Gene

Promoters and enhancers for THEG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I000376 Promoter 0.5 EPDnew 550.8 +0.7 657 0.1 THEG GC19M000365 GC19P000369
GH19I000377 Promoter 0.5 EPDnew 550.8 +0.0 37 0.1 GC19M000365 THEG GC19P000369
GH19I000341 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 11.5 +33.0 33019 3.5 IRF4 ZNF48 RUNX3 SP5 NFYC ZNF592 KAT8 MBD2 GMEB1 KDM1A MIER2 THEG GC19M000319
GH19I000412 Enhancer 0.6 ENCODE 11.6 -35.7 -35717 0.7 CTCF KLF1 MAZ SP2 ZIC2 ZFP69B ZNF692 POLR2A GLIS1 PATZ1 PIR44542 THEG PIR54633
GH19I000282 Enhancer 0.5 dbSUPER 11.4 +94.4 94438 0.5 CTCF ADNP ZMYM3 KDM1A PLPP2 THEG C2CD4C VN2R11P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THEG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THEG gene promoter:

Genomic Locations for THEG Gene

Genomic Locations for THEG Gene
14,957 bases
Minus strand

Genomic View for THEG Gene

Genes around THEG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEG Gene

Proteins for THEG Gene

  • Protein details for THEG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testicular haploid expressed gene protein
    Protein Accession:
    Secondary Accessions:
    • A6NMJ8

    Protein attributes for THEG Gene

    379 amino acids
    Molecular mass:
    43444 Da
    Quaternary structure:
    • Interacts with CCT5.

    Alternative splice isoforms for THEG Gene


neXtProt entry for THEG Gene

Post-translational modifications for THEG Gene

No Post-translational modifications

Other Protein References for THEG Gene

No data available for DME Specific Peptides for THEG Gene

Domains & Families for THEG Gene

Gene Families for THEG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for THEG Gene


Suggested Antigen Peptide Sequences for THEG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THEG: view

No data available for UniProtKB/Swiss-Prot for THEG Gene

Function for THEG Gene

Molecular function for THEG Gene

UniProtKB/Swiss-Prot Function:
May be involved (but not essential) in spermatogenesis.

Phenotypes From GWAS Catalog for THEG Gene

Gene Ontology (GO) - Molecular Function for THEG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with THEG: view
genes like me logo Genes that share phenotypes with THEG: view

Animal Models for THEG Gene

MGI Knock Outs for THEG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for THEG Gene

Localization for THEG Gene

Subcellular locations from UniProtKB/Swiss-Prot for THEG Gene

Nucleus. Note=Localized predominantly in the nucleus of haploid round spermatid. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THEG gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for THEG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with THEG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for THEG Gene

Pathways & Interactions for THEG Gene

No Data Available

Interacting Proteins for THEG Gene

Gene Ontology (GO) - Biological Process for THEG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis TAS,IEA --
GO:0030154 cell differentiation IEA --
GO:0051131 chaperone-mediated protein complex assembly TAS 10747865
genes like me logo Genes that share ontologies with THEG: view

No data available for Pathways by source and SIGNOR curated interactions for THEG Gene

Drugs & Compounds for THEG Gene

No Compound Related Data Available

Transcripts for THEG Gene

mRNA/cDNA for THEG Gene

Unigene Clusters for THEG Gene

Theg spermatid protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for THEG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP3: - - - - -

Relevant External Links for THEG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THEG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THEG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THEG Gene

This gene is overexpressed in Testis (x46.5).

Protein differential expression in normal tissues from HIPED for THEG Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THEG Gene

Protein tissue co-expression partners for THEG Gene

NURSA nuclear receptor signaling pathways regulating expression of THEG Gene:


SOURCE GeneReport for Unigene cluster for THEG Gene:


mRNA Expression by UniProt/SwissProt for THEG Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with THEG: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for THEG Gene

Orthologs for THEG Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia THEG 33 34
  • 99.21 (n)
(Bos Taurus)
Mammalia THEG 33 34
  • 77.4 (n)
(Canis familiaris)
Mammalia THEG 33 34
  • 76.54 (n)
(Mus musculus)
Mammalia Theg 33 16 34
  • 76.46 (n)
(Rattus norvegicus)
Mammalia Theg 33
  • 69.7 (n)
(Monodelphis domestica)
Mammalia THEG 34
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia THEG 34
  • 34 (a)
(Danio rerio)
Actinopterygii THEG 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
Species where no ortholog for THEG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEG Gene

Gene Tree for THEG (if available)
Gene Tree for THEG (if available)

Paralogs for THEG Gene

No data available for Paralogs for THEG Gene

Variants for THEG Gene

Sequence variations from dbSNP and Humsavar for THEG Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000184247 -- 367,533(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000368630 -- 371,419(-) T/C 3_prime_UTR_variant, intron_variant
rs1000417116 -- 373,271(-) C/T intron_variant
rs1000702549 -- 370,669(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000760372 -- 366,357(-) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for THEG Gene

Variant ID Type Subtype PubMed ID
nsv9660 CNV loss 18304495
nsv953938 CNV deletion 24416366
nsv833702 CNV loss 17160897
nsv577980 CNV gain 21841781
nsv577978 CNV gain 21841781
nsv522660 CNV loss 19592680
nsv509711 CNV insertion 20534489
nsv428360 CNV gain 18775914
nsv1146930 CNV deletion 26484159
nsv1134737 CNV deletion 24896259
nsv1127641 CNV deletion 24896259
nsv1065558 CNV gain 25217958
esv3643348 CNV loss 21293372
esv3583200 CNV loss 25503493
esv2758742 CNV gain 17122850
esv2669963 CNV deletion 23128226
esv2422333 CNV duplication 17116639
esv1010364 CNV insertion 20482838
dgv3420n100 CNV gain 25217958

Variation tolerance for THEG Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THEG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEG Gene

Disorders for THEG Gene

Additional Disease Information for THEG

No disorders were found for THEG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THEG Gene

Publications for THEG Gene

  1. Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG). (PMID: 11173852) Mannan A … Burfeind P (Cytogenetics and cell genetics 2000) 2 3 4 58
  2. Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. (PMID: 10747865) Yanaka N … Mori C (The Journal of biological chemistry 2000) 3 4 58
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58
  4. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K … Vidal M (Nature methods 2009) 3 58
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual JF … Vidal M (Nature 2005) 3 58

Products for THEG Gene

Sources for THEG Gene

Loading form....