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The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
THBS2 (Thrombospondin 2) is a Protein Coding gene. Diseases associated with THBS2 include Intervertebral Disc Disease and Back Pain. Among its related pathways are Signaling by GPCR and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005201 | extracellular matrix structural constituent | RCA | 28327460 |
GO:0005509 | calcium ion binding | IEA | -- |
GO:0005515 | protein binding | IPI | 19818485 |
GO:0008201 | heparin binding | TAS,IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA,TAS | -- |
GO:0005604 | basement membrane | IEA | -- |
GO:0031012 | extracellular matrix | IEA | -- |
GO:0031091 | platelet alpha granule | IDA | 1737102 |
GO:0062023 | collagen-containing extracellular matrix | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Focal Adhesion |
.61
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.61
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2 | PI3K-Akt signaling pathway | ||
3 | O-glycosylation of TSR domain-containing proteins | ||
4 | Diseases of glycosylation | ||
5 | Metabolism of proteins |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | IEA | -- |
GO:0016525 | negative regulation of angiogenesis | IDA | 20714802 |
GO:0051965 | positive regulation of synapse assembly | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
ExUns: | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||
SP2: | |||||||||||||||
SP3: | |||||||||||||||
SP4: | |||||||||||||||
SP5: | |||||||||||||||
SP6: | |||||||||||||||
SP7: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | THBS2 30 |
|
||
Dog (Canis familiaris) |
Mammalia | THBS2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | THBS2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | THBS2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | THBS2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Thbs2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Thbs2 30 |
|
||
Chicken (Gallus gallus) |
Aves | THBS2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | THBS2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | thbs2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | thbs2a 31 31 |
|
OneToMany | |
LOC100535241 30 |
|
||||
thbs2b 31 |
|
OneToMany | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6394 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Tsp 31 32 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709115 | Likely Benign: not provided | 169,237,628(-) | G/A | MISSENSE_VARIANT | |
711867 | Benign: not provided | 169,221,447(-) | G/C | SYNONYMOUS_VARIANT | |
711868 | Benign: not provided | 169,222,230(-) | G/A | SYNONYMOUS_VARIANT | |
712641 | Benign: not provided | 169,248,628(-) | G/C | MISSENSE_VARIANT | |
721973 | Benign: not provided | 169,225,212(-) | G/A | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
intervertebral disc disease |
|
|
back pain |
|
|
posterior uveal melanoma |
|
|
spinal stenosis |
|
|
myxoid liposarcoma |
|
|