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The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of... See more...
Aliases for THBS2 Gene
External Ids for THBS2 Gene
- HGNC: 11786
- NCBI Entrez Gene: 7058
- Ensembl: ENSG00000186340
- OMIM®: 188061
- UniProtKB/Swiss-Prot: P35442
Previous GeneCards Identifiers for THBS2 Gene
- GC06U990123
- GC06M9S0210
- GC06M169433
- GC06M169615
- GC06M167041
Summaries for THBS2 Gene
-
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
GeneCards Summary for THBS2 Gene
THBS2 (Thrombospondin 2) is a Protein Coding gene. Diseases associated with THBS2 include Intervertebral Disc Disease and Back Pain. Among its related pathways are O-glycosylation of TSR domain-containing proteins and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS1.
UniProtKB/Swiss-Prot Summary for THBS2 Gene
-
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
Additional gene information for THBS2 Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THBS2 Gene
Genomics for THBS2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for THBS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around THBS2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for THBS2
- Top Transcription factor binding sites by QIAGEN in the THBS2 gene promoter:
-
- MyoD
- Nkx2-5
Genomic Locations for THBS2 Gene
Latest Assembly
- chr6:169,215,780-169,254,050
- (GRCh38/hg38)
- Size:
- 38,271 bases
- Orientation:
- Minus strand
Previous Assembly
- chr6:169,615,880-169,653,941
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 38,062 bases
- Orientation:
- Minus strand
Genomic View for THBS2 Gene
Genes around THBS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q27 by HGNC
- 6q27 by Entrez Gene
- 6q27 by Ensembl
THBS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for THBS2 Gene
Proteins for THBS2 Gene
-
Protein details for THBS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35442-TSP2_HUMAN
- Recommended name:
- Thrombospondin-2
- Protein Accession:
- P35442
- A6H8N1
- A7E232
- Q5RI52
Protein attributes for THBS2 Gene
- Size:
- 1172 amino acids
- Molecular mass:
- 129991 Da
- Quaternary structure:
-
- Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V collagen.
Protein Expression for THBS2 Gene
Post-translational modifications for THBS2 Gene
Other Protein References for THBS2 Gene
Antibodies for research
- NSJ Bioreagents Thrombospondin 2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for THBS2
- Novus Biologicals Antibodies for THBS2
-
Abcam antibodies for THBS2
- Invitrogen Antibodies for THBS2 (AFLGC-THBS2)
-
Custom Antibody ServicesProSci Antibodies for THBS2
-
Santa Cruz Biotechnology (SCBT) Antibodies for THBS2
Protein products for research
-
OriGene Purified Proteins for THBS2
- Search Origene for MassSpec and Protein Over-expression Lysates for THBS2
- Origene Custom Protein Services for THBS2
-
Abcam proteins for THBS2
Assay products for research
- RayBiotech Human Thrombospondin-2 ELISA and Custom Rabbit Thrombospondin-2 ELISA
-
Custom Assay ServicesOriGene ELISA Kits for THBS2
-
Boster Bio ELISA Kits for THBS2
No data available for DME Specific Peptides for THBS2 Gene
Domains & Families for THBS2 Gene
Gene Families for THBS2 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for THBS2 Gene
- InterPro:
- Blocks:
-
- Type I EGF
- EGF-like calcium-binding
- Thrombospondin, type I
- Thrombospondin type 1 repeat signature
- Thrombospondin, C-terminal
- von Willebrand factor, type C
Suggested Antigen Peptide Sequences for THBS2 Gene
- GenScript: Design optimal peptide antigens:
-
- Thrombospondin-2 (TSP2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P35442- Family:
-
- Belongs to the thrombospondin family.
Function for THBS2 Gene
Molecular function for THBS2 Gene
- UniProtKB/Swiss-Prot Function:
- Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
- GENATLAS Biochemistry:
- thrombospondin II,extracellular,glycoprotein expressed in smooth muscle,fibroblast in cell adhesion molecule
Phenotypes From GWAS Catalog for THBS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005201 | extracellular matrix structural constituent | RCA | 28327460 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 19818485 |
| GO:0008201 | heparin binding | IEA | -- |
Phenotypes for THBS2 Gene
- MGI mutant phenotypes for THBS2:
-
inferred from 1 alleles
- muscle phenotype
- homeostasis/metabolism phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- hematopoietic system phenotype
- neoplasm
- limbs/digits/tail phenotype
- skeleton phenotype
- integument phenotype
- GenomeRNAi human phenotypes for THBS2:
Animal Models for THBS2 Gene
- MGI Knock Outs for THBS2:
-
- Thbs2 Thbs2<tm1Bst>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for THBS2 - Starting at $85 >
- * THBS2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for THBS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THBS2
-
Santa Cruz Biotechnology (SCBT) CRISPR for THBS2
miRNA for THBS2 Gene
- miRTarBase miRNAs that target THBS2
-
- hsa-miR-27b-3p (MIRT438198)
- hsa-miR-133a-3p (MIRT528904)
- hsa-miR-4281 (MIRT528905)
- hsa-miR-6793-3p (MIRT528906)
- hsa-miR-662 (MIRT528907)
- hsa-miR-6814-5p (MIRT528908)
- hsa-miR-4719 (MIRT528909)
- hsa-miR-7853-5p (MIRT528910)
- hsa-miR-105-5p (MIRT528911)
- hsa-miR-365b-3p (MIRT528912)
- hsa-miR-365a-3p (MIRT528913)
- hsa-miR-5572 (MIRT614036)
- hsa-miR-6855-5p (MIRT614037)
- hsa-miR-3170 (MIRT614038)
- hsa-miR-6819-5p (MIRT614039)
- hsa-miR-6812-5p (MIRT614040)
- hsa-miR-6737-5p (MIRT614041)
- hsa-miR-4536-5p (MIRT614042)
- hsa-miR-193b-5p (MIRT614043)
- hsa-miR-938 (MIRT614044)
- hsa-miR-299-3p (MIRT614045)
- hsa-miR-4657 (MIRT614046)
- hsa-miR-4491 (MIRT614047)
- hsa-miR-129-2-3p (MIRT614048)
- hsa-miR-129-1-3p (MIRT614049)
- hsa-miR-5706 (MIRT652697)
- hsa-miR-4782-5p (MIRT652698)
- hsa-miR-3191-5p (MIRT652699)
- hsa-miR-6826-3p (MIRT652700)
- hsa-miR-1236-3p (MIRT652701)
- hsa-miR-6515-3p (MIRT652702)
- hsa-miR-6824-3p (MIRT652703)
- hsa-miR-6764-3p (MIRT652704)
- hsa-miR-518c-5p (MIRT652705)
- hsa-miR-4469 (MIRT652706)
- hsa-miR-6769b-3p (MIRT652707)
- hsa-miR-4723-3p (MIRT652708)
- hsa-miR-3183 (MIRT652709)
- hsa-miR-4667-3p (MIRT652710)
- hsa-miR-1470 (MIRT652711)
- hsa-miR-6756-3p (MIRT652712)
- hsa-miR-3127-3p (MIRT652713)
- hsa-miR-361-3p (MIRT652714)
- hsa-miR-6839-5p (MIRT652715)
- hsa-miR-378j (MIRT652716)
- hsa-miR-6787-5p (MIRT717650)
- hsa-miR-663a (MIRT717651)
- hsa-miR-1908-5p (MIRT717652)
- hsa-miR-744-5p (MIRT717653)
- hsa-miR-3615 (MIRT717654)
- hsa-miR-1307-3p (MIRT717655)
- hsa-miR-6741-3p (MIRT717656)
- hsa-miR-6809-3p (MIRT717657)
- hsa-miR-6833-3p (MIRT717658)
- hsa-miR-4768-5p (MIRT717659)
- hsa-miR-6818-3p (MIRT717660)
- hsa-miR-6844 (MIRT717661)
- hsa-miR-4753-3p (MIRT717662)
- hsa-miR-6873-3p (MIRT717663)
- hsa-miR-593-3p (MIRT717664)
- hsa-miR-6895-3p (MIRT717665)
- hsa-miR-130b-5p (MIRT717666)
- hsa-miR-6817-3p (MIRT717667)
- hsa-miR-6845-3p (MIRT717668)
- hsa-miR-6845-5p (MIRT722581)
- hsa-miR-6762-5p (MIRT722582)
- hsa-miR-939-5p (MIRT722583)
- hsa-miR-1343-5p (MIRT722584)
- hsa-miR-4771 (MIRT722585)
- hsa-miR-4518 (MIRT722586)
- hsa-miR-1266-5p (MIRT722587)
- hsa-miR-6767-5p (MIRT722588)
- hsa-miR-6798-5p (MIRT722589)
- hsa-miR-510-5p (MIRT722590)
- hsa-miR-670-3p (MIRT722591)
- hsa-miR-4326 (MIRT722592)
- hsa-miR-3193 (MIRT722593)
- hsa-miR-1228-3p (MIRT722594)
- hsa-miR-3922-5p (MIRT722595)
- hsa-miR-29b-3p (MIRT734217)
- hsa-miR-135b-5p (MIRT734929)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THBS2
- Browse OriGene Inhibitory RNA Products For THBS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THBS2
Clone products for research
- Applied Biological Materials (abm): Clones for THBS2 - Starting at $45 >
- * THBS2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for THBS2
- Addgene plasmids for THBS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THBS2
Cell Lines for research
- ESI BIO PureStem 4D20.8, NCr-fac Progenitor for THBS2
-
Horizon Cell Lines for THBS2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THBS2 Gene
Localization for THBS2 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nuclear speckles (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005604 | basement membrane | IEA | -- |
| GO:0031012 | extracellular matrix | IEA | -- |
| GO:0031091 | platelet alpha granule | IDA | 1737102 |
| GO:0062023 | collagen-containing extracellular matrix | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for THBS2 Gene
Pathways & Interactions for THBS2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Focal Adhesion |
.61
|
.61
|
| 2 | PI3K-Akt signaling pathway | ||
| 3 | O-glycosylation of TSR domain-containing proteins | ||
| 4 | Diseases of glycosylation | ||
| 5 | Metabolism of proteins | ||
Pathways by source for THBS2 Gene
2 BioSystems pathways for THBS2 Gene
10 Reactome pathways for THBS2 Gene
6 KEGG pathways for THBS2 Gene
1 R&D Systems pathway for THBS2 Gene
1 Qiagen pathway for THBS2 Gene
- Inhibition of Matrix Metalloproteinases
Interacting Proteins for THBS2 Gene
Selected Interacting proteins:
P35442-TSP2_HUMAN
ENSP00000355751
for THBS2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for THBS2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0016525 | negative regulation of angiogenesis | IEA,IDA | 20714802 |
| GO:0051965 | positive regulation of synapse assembly | IEA | -- |
Transcripts for THBS2 Gene
mRNA/cDNA for THBS2 Gene
- 5 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000366787 5811 nts (view in UCSC)
- ENST00000435791 437 nts (view in UCSC)
- ENST00000461848 641 nts (view in UCSC)
- ENST00000472733 481 nts (view in UCSC)
- ENST00000488355 875 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for THBS2 - Starting at $85 >
- * THBS2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for THBS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THBS2
-
Santa Cruz Biotechnology (SCBT) CRISPR for THBS2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THBS2
- Browse OriGene Inhibitory RNA Products For THBS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THBS2
Clone products for research
- Applied Biological Materials (abm): Clones for THBS2 - Starting at $45 >
- * THBS2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for THBS2
- Addgene plasmids for THBS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THBS2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||
| SP2: | |||||||||||||||
| SP3: | |||||||||||||||
| SP4: | |||||||||||||||
| SP5: | |||||||||||||||
| SP6: | |||||||||||||||
| SP7: |
Relevant External Links for THBS2 Gene
- GeneLoc Exon Structure for
- THBS2
Expression for THBS2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Prechondrocytes Stylopod Epiphyseal End
- Prechondrocytes Zeugopod Epiphyseal End
- Prechondrocytes Autopod Epiphyseal End
- Mesenchymal Condensate Cells Stylopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Prechondrocytes Stylopod Epiphyseal End
- Prechondrocytes Zeugopod Epiphyseal End
- Prechondrocytes Autopod Epiphyseal End
- Mesenchymal Condensate Cells Stylopod
- Inner Cell Mass (Early Embryonic Tissues)
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Mesenchymal Condensate Cells Stylopod
- Mesenchymal Condensate Cells Zeugopod
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
-
Hair
- Basal Keratinocytes Embryonic Epidermis
- Lower Urinary Tract (Urinary System)
- Neural Crest (Gastrulation Derivatives)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
-
Smooth Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for THBS2 Gene
This gene is overexpressed in Artery - Aorta (x9.9) and Artery - Coronary (x7.9).
This gene is overexpressed in Amniocyte (22.7), Breast (17.5), Pancreas (9.1), Cerebrospinal fluid (6.9), and Bone marrow mesenchymal stem cell (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THBS2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for THBS2
SOURCE GeneReport for Unigene cluster for THBS2 Gene:
Hs.371147mRNA Expression by UniProt/SwissProt for THBS2 Gene:
P35442-TSP2_HUMAN
Tissue specificity:
High expression in invertebral disk tissue.
Evidence on tissue expression from TISSUES for THBS2 Gene
- Nervous system(4)
- Bone(3.3)
- Heart(2.9)
- Skin(2.9)
- Pancreas(2.8)
- Muscle(2.6)
- Blood(2.4)
- Intestine(2.2)
- Liver(2.2)
- Eye(2.1)
- Lung(2)
Primer products for research
-
OriGene qPCR primer pairs for THBS2
-
OriGene qPCR primer pairs and template standards for THBS2
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for THBS2 Gene
Orthologs for THBS2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | THBS2 29 |
|
||
| Dog (Canis familiaris) |
Mammalia | THBS2 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | THBS2 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | THBS2 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | THBS2 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Thbs2 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Thbs2 29 |
|
||
| Chicken (Gallus gallus) |
Aves | THBS2 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | THBS2 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | thbs2 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | thbs2a 30 30 |
|
OneToMany | |
| LOC100535241 29 |
|
||||
| thbs2b 30 |
|
OneToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6394 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Tsp 30 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany |
- Species where no ortholog for THBS2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for THBS2 Gene
- ENSEMBL:
- Gene Tree for THBS2 (if available)
- TreeFam:
- Gene Tree for THBS2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for THBS2: view image
- Alliance of Genome Resources:
- Additional Orthologs for THBS2
Paralogs for THBS2 Gene
Variants for THBS2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for THBS2 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs117760328 | Benign: not provided | 169,248,507(-) |
G/A NM_003247.4(THBS2):c.519C>T (p.Phe173=) |
SYNONYMOUS | |
| rs140852957 | Benign: not provided | 169,221,505(-) |
G/A NM_003247.4(THBS2):c.3296C>T (p.Pro1099Leu) |
MISSENSE | |
| rs142051087 | Benign: not provided | 169,222,254(-) |
C/T NM_003247.4(THBS2):c.3216G>A (p.Thr1072=) |
SYNONYMOUS | |
| rs143976396 | Benign: not provided | 169,232,122(-) |
T/A NM_003247.4(THBS2):c.2009A>T (p.His670Leu) |
MISSENSE | |
| rs144067288 | Likely Benign: not provided | 169,248,551(-) |
C/T NM_003247.4(THBS2):c.475G>A (p.Glu159Lys) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.10;
61.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for THBS2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THBS2 Gene
Disorders for THBS2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| intervertebral disc disease |
|
|
| back pain |
|
|
| posterior uveal melanoma |
|
|
| spinal stenosis |
|
|
| myxoid liposarcoma |
|
|
Search THBS2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TSP2_HUMAN- Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269 PubMed:18455130}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
Additional Disease Information for THBS2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for THBS2 Gene
Publications for THBS2 Gene
- A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. (PMID: 18455130) Hirose Y … Ikegawa S (American journal of human genetics 2008) 2 3 4 40 72
- Decreased frequency of the 3'UTR T>G single nucleotide polymorphism of thrombospondin-2 gene in sudden death due to plaque erosion. (PMID: 19631562) Burke A … Fowler D (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2010) 3 22 40
- Assessment of genetic risk factors for thoracic aortic aneurysm in hypertensive patients. (PMID: 18600213) Kato K … Yamada Y (American journal of hypertension 2008) 3 22 40
- Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence. (PMID: 18178577) Koch W … Kastrati A (Human molecular genetics 2008) 3 22 40
- Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance. (PMID: 17202846) Park BL … Shin HD (Experimental & molecular medicine 2006) 3 22 40
ExternalLinks
Products for THBS2 Gene
- View all 11 R&D Systems THBS2 (Thrombospondin-2) Products
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Sources for THBS2 Gene
- (1) GeneCards
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- (4) UniProtKB/Swiss-Prot
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