Aliases for THBS2 Gene
External Ids for THBS2 Gene
- HGNC: 11786
- Entrez Gene: 7058
- Ensembl: ENSG00000186340
- OMIM: 188061
- UniProtKB: P35442
Previous GeneCards Identifiers for THBS2 Gene
- GC06U990123
- GC06M9S0210
- GC06M169433
- GC06M169615
- GC06M167041
Summaries for THBS2 Gene
-
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
GeneCards Summary for THBS2 Gene
THBS2 (Thrombospondin 2) is a Protein Coding gene. Diseases associated with THBS2 include Intervertebral Disc Disease and Posterior Uveal Melanoma. Among its related pathways are Metabolism of proteins and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS1.
UniProtKB/Swiss-Prot for THBS2 Gene
-
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
Additional gene information for THBS2 Gene
- Monarch Initiative
- Search for THBS2 at DataMed
- Search for THBS2 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THBS2 Gene
Genomics for THBS2 Gene
GeneHancer (GH) Regulatory Elements for THBS2 Gene
Promoters and enhancers for THBS2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06I169250 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE dbSUPER | 550.8 | +1.7 | 1682 | 4.3 | MXI1 PKNOX1 USF1 MAX ATF2 POLR2A POU5F1 FOS ATF7 EZH2 | THBS2 LINC02544 LOC101929523 | |
| GH06I169069 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 12 | +181.2 | 181167 | 7.8 | MAX HIC1 FOSL1 ZNF335 POLR2A CBFA2T2 FOSL2 FOS MAFK RFX1 | THBS2 LOC102724357 PIR53465 GC06P169164 | |
| GH06I169212 | Promoter/Enhancer | 1.5 | Ensembl ENCODE dbSUPER | 4.9 | +39.8 | 39777 | 3.8 | ELF3 PKNOX1 RB1 ZBTB40 RAD21 YY1 ZNF766 CBX5 ATF7 FOS | LOC101929523 LINC01615 THBS2 | |
| GH06I169095 | Enhancer | 1 | FANTOM5 ENCODE dbSUPER | 6.6 | +154.8 | 154791 | 6.7 | CTCF BACH1 RFX5 SP1 ZNF316 JUND POLR2A ZNF157 NFE2 FOS | THBS2 LOC102724357 PIR53465 GC06P169164 | |
| GH06I169228 | Enhancer | 0.5 | dbSUPER | 13.2 | +23.6 | 23557 | 3.6 | ZNF316 MAFG MAFK EMSY | THBS2 ENSG00000266896 LOC101929523 LINC02544 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around THBS2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the THBS2 gene promoter:
Regulatory Element Products
Genomic Locations for THBS2 Gene
Genomic Locations for THBS2 Gene
- chr6:169,215,780-169,254,114
- (GRCh38/hg38)
- Size:
- 38,335 bases
- Orientation:
- Minus strand
- chr6:169,615,875-169,654,139
- (GRCh37/hg19)
Genomic View for THBS2 Gene
Genes around THBS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q27 by Ensembl
- 6q27 by Entrez Gene
- 6q27 by HGNC
THBS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for THBS2 Gene
Proteins for THBS2 Gene
-
Protein details for THBS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35442-TSP2_HUMAN
- Recommended name:
- Thrombospondin-2
- Protein Accession:
- P35442
- A6H8N1
- A7E232
- Q5RI52
Protein attributes for THBS2 Gene
- Size:
- 1172 amino acids
- Molecular mass:
- 129991 Da
- Quaternary structure:
-
- Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V collagen.
Protein Expression for THBS2 Gene
Post-translational modifications for THBS2 Gene
Other Protein References for THBS2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for THBS2 (Thrombospondin-2)
-
Custom Antibody ServicesOriGene Antibodies for THBS2
- Novus Biologicals Antibodies for THBS2
-
Abcam antibodies for THBS2
-
Cloud-Clone Corp. Antibodies for THBS2
- Invitrogen Antibodies for THBS2
- GeneTex THBS2 antibody for THBS2
-
Santa Cruz Biotechnology (SCBT) Antibodies for THBS2
Protein Products
- R&D Systems Proteins and Enzymes for THBS2 (Thrombospondin-2)
-
OriGene Purified Proteins for THBS2
- Search Origene for MassSpec and Protein Over-expression Lysates for THBS2
- Origene Custom Protein Services for THBS2
-
Cloud-Clone Corp. Proteins for THBS2
- Search GeneTex for Proteins for THBS2
-
Abcam proteins for THBS2
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for THBS2
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for THBS2 (Thrombospondin-2)
- Novus Biologicals ELISA Kits for THBS2
-
Cloud-Clone Corp. Assay Kits for THBS2
No data available for DME Specific Peptides for THBS2 Gene
Domains & Families for THBS2 Gene
Gene Families for THBS2 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for THBS2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for THBS2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35442- Family:
-
- Belongs to the thrombospondin family.
Function for THBS2 Gene
Molecular function for THBS2 Gene
- GENATLAS Biochemistry:
- thrombospondin II,extracellular,glycoprotein expressed in smooth muscle,fibroblast in cell adhesion molecule
- UniProtKB/Swiss-Prot Function:
- Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
Phenotypes From GWAS Catalog for THBS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 19818485 |
| GO:0008201 | heparin binding | IEA,TAS | -- |
Phenotypes for THBS2 Gene
- MGI mutant phenotypes for THBS2:
-
inferred from 1 alleles
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- neoplasm
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for THBS2:
Animal Models for THBS2 Gene
- MGI Knock Outs for THBS2:
-
- Thbs2 tm1Bst
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for THBS2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for THBS2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for THBS2 gene
- Search ViGene Biosciences for THBS2
CRISPR Products
-
OriGene CRISPR knockouts for THBS2
- Applied Biological Materials CRISPR for THBS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for THBS2
- GenScript: Design CRISPR guide RNA sequences for THBS2
miRNA for THBS2 Gene
- miRTarBase miRNAs that target THBS2
-
- hsa-mir-27b-3p (MIRT438198)
- hsa-mir-133a-3p (MIRT528904)
- hsa-mir-4281 (MIRT528905)
- hsa-mir-6793-3p (MIRT528906)
- hsa-mir-662 (MIRT528907)
- hsa-mir-6814-5p (MIRT528908)
- hsa-mir-4719 (MIRT528909)
- hsa-mir-7853-5p (MIRT528910)
- hsa-mir-105-5p (MIRT528911)
- hsa-mir-365b-3p (MIRT528912)
- hsa-mir-365a-3p (MIRT528913)
- hsa-mir-5572 (MIRT614036)
- hsa-mir-6855-5p (MIRT614037)
- hsa-mir-3170 (MIRT614038)
- hsa-mir-6819-5p (MIRT614039)
- hsa-mir-6812-5p (MIRT614040)
- hsa-mir-6737-5p (MIRT614041)
- hsa-mir-4536-5p (MIRT614042)
- hsa-mir-193b-5p (MIRT614043)
- hsa-mir-938 (MIRT614044)
- hsa-mir-299-3p (MIRT614045)
- hsa-mir-4657 (MIRT614046)
- hsa-mir-4491 (MIRT614047)
- hsa-mir-129-2-3p (MIRT614048)
- hsa-mir-129-1-3p (MIRT614049)
- hsa-mir-5706 (MIRT652697)
- hsa-mir-4782-5p (MIRT652698)
- hsa-mir-3191-5p (MIRT652699)
- hsa-mir-6826-3p (MIRT652700)
- hsa-mir-1236-3p (MIRT652701)
- hsa-mir-6515-3p (MIRT652702)
- hsa-mir-6824-3p (MIRT652703)
- hsa-mir-6764-3p (MIRT652704)
- hsa-mir-518c-5p (MIRT652705)
- hsa-mir-4469 (MIRT652706)
- hsa-mir-6769b-3p (MIRT652707)
- hsa-mir-4723-3p (MIRT652708)
- hsa-mir-3183 (MIRT652709)
- hsa-mir-4667-3p (MIRT652710)
- hsa-mir-1470 (MIRT652711)
- hsa-mir-6756-3p (MIRT652712)
- hsa-mir-3127-3p (MIRT652713)
- hsa-mir-361-3p (MIRT652714)
- hsa-mir-6839-5p (MIRT652715)
- hsa-mir-378j (MIRT652716)
- hsa-mir-6787-5p (MIRT717650)
- hsa-mir-663a (MIRT717651)
- hsa-mir-1908-5p (MIRT717652)
- hsa-mir-744-5p (MIRT717653)
- hsa-mir-3615 (MIRT717654)
- hsa-mir-1307-3p (MIRT717655)
- hsa-mir-6741-3p (MIRT717656)
- hsa-mir-6809-3p (MIRT717657)
- hsa-mir-6833-3p (MIRT717658)
- hsa-mir-4768-5p (MIRT717659)
- hsa-mir-6818-3p (MIRT717660)
- hsa-mir-6844 (MIRT717661)
- hsa-mir-4753-3p (MIRT717662)
- hsa-mir-6873-3p (MIRT717663)
- hsa-mir-593-3p (MIRT717664)
- hsa-mir-6895-3p (MIRT717665)
- hsa-mir-130b-5p (MIRT717666)
- hsa-mir-6817-3p (MIRT717667)
- hsa-mir-6845-3p (MIRT717668)
- hsa-mir-6845-5p (MIRT722581)
- hsa-mir-6762-5p (MIRT722582)
- hsa-mir-939-5p (MIRT722583)
- hsa-mir-1343-5p (MIRT722584)
- hsa-mir-4771 (MIRT722585)
- hsa-mir-4518 (MIRT722586)
- hsa-mir-1266-5p (MIRT722587)
- hsa-mir-6767-5p (MIRT722588)
- hsa-mir-6798-5p (MIRT722589)
- hsa-mir-510-5p (MIRT722590)
- hsa-mir-670-3p (MIRT722591)
- hsa-mir-4326 (MIRT722592)
- hsa-mir-3193 (MIRT722593)
- hsa-mir-1228-3p (MIRT722594)
- hsa-mir-3922-5p (MIRT722595)
- hsa-mir-29b-3p (MIRT734217)
- hsa-mir-135b-5p (MIRT734929)
miRNA Products
- Search ViGene Biosciences for THBS2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for THBS2
- Browse OriGene Inhibitory RNA Products For THBS2
-
ViGene Biosciences ready-to-package AAV shRNAs for THBS2 gene
Clone Products
- Sino Biological Human cDNA Clone for THBS2
- VectorBuilder custom plasmid, inducible vectors for THBS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for THBS2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for THBS2
- genomics-online: cdna clones - Search results for 90 available Thrombospondin 2 gene related products
- Overview of 90 available Thrombospondin 2 gene related products
- orf clones - Search results for 90 available Thrombospondin 2 gene related products
- Overview of 90 available Thrombospondin 2 gene related products
- Applied Biological Materials Clones for THBS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem 4D20.8, NCr-fac Progenitor for THBS2
-
Horizon Cell Lines for THBS2
-
ViGene Biosciences adenoviral particle packaged cDNA for THBS2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for THBS2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for THBS2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THBS2 Gene
Localization for THBS2 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| nucleus | 2 |
| cytosol | 2 |
- Cytosol (2)
- Nuclear speckles (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA,TAS | -- |
| GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
| GO:0005604 | basement membrane | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0031012 | extracellular matrix | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for THBS2 Gene
Pathways & Interactions for THBS2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Focal Adhesion |
.62
|
.62
|
| 2 | PI3K-Akt signaling pathway | ||
| 3 | O-glycosylation of TSR domain-containing proteins | ||
| 4 | Diseases of glycosylation | ||
| 5 | Metabolism of proteins | ||
Pathways by source for THBS2 Gene
2 BioSystems pathways for THBS2 Gene
10 Reactome pathways for THBS2 Gene
6 KEGG pathways for THBS2 Gene
1 R&D Systems pathway for THBS2 Gene
1 Qiagen pathway for THBS2 Gene
Interacting Proteins for THBS2 Gene
Selected Interacting proteins:
P35442-TSP2_HUMAN
ENSP00000355751
for THBS2 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0016525 | negative regulation of angiogenesis | IDA | 20714802 |
| GO:0030198 | extracellular matrix organization | IEA | -- |
| GO:0051965 | positive regulation of synapse assembly | IEA | -- |
Transcripts for THBS2 Gene
mRNA/cDNA for THBS2 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (320) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for THBS2
- Applied Biological Materials CRISPR for THBS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for THBS2
- GenScript: Design CRISPR guide RNA sequences for THBS2
miRNA Products
- Search ViGene Biosciences for THBS2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for THBS2
- Browse OriGene Inhibitory RNA Products For THBS2
-
ViGene Biosciences ready-to-package AAV shRNAs for THBS2 gene
Clone Products
- Sino Biological Human cDNA Clone for THBS2
- VectorBuilder custom plasmid, inducible vectors for THBS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for THBS2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for THBS2
- genomics-online: cdna clones - Search results for 90 available Thrombospondin 2 gene related products
- Overview of 90 available Thrombospondin 2 gene related products
- orf clones - Search results for 90 available Thrombospondin 2 gene related products
- Overview of 90 available Thrombospondin 2 gene related products
- Applied Biological Materials Clones for THBS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||
| SP2: | |||||||||||||||
| SP3: | |||||||||||||||
| SP4: | |||||||||||||||
| SP5: | |||||||||||||||
| SP6: | |||||||||||||||
| SP7: |
Expression for THBS2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Prechondrocytes Stylopod Epiphyseal End
- Prechondrocytes Zeugopod Epiphyseal End
- Prechondrocytes Autopod Epiphyseal End
- Mesenchymal Condensate Cells Stylopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Prechondrocytes Stylopod Epiphyseal End
- Prechondrocytes Zeugopod Epiphyseal End
- Prechondrocytes Autopod Epiphyseal End
- Mesenchymal Condensate Cells Stylopod
- Inner Cell Mass (Early Embryonic Tissues)
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Mesenchymal Condensate Cells Stylopod
- Mesenchymal Condensate Cells Zeugopod
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
-
Hair
- Basal Keratinocytes Embryonic Epidermis
- Lower Urinary Tract (Urinary System)
- Neural Crest (Gastrulation Derivatives)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
-
Smooth Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for THBS2 Gene
This gene is overexpressed in Artery - Aorta (x9.9) and Artery - Coronary (x7.9).
This gene is overexpressed in Amniocyte (22.7), Breast (17.5), Pancreas (9.1), Cerebrospinal fluid (6.9), and Bone marrow mesenchymal stem cell (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THBS2 Gene
NURSA nuclear receptor signaling pathways regulating expression of THBS2 Gene:
THBS2SOURCE GeneReport for Unigene cluster for THBS2 Gene:
Hs.371147mRNA Expression by UniProt/SwissProt for THBS2 Gene:
P35442-TSP2_HUMAN
Tissue specificity:
High expression in invertebral disk tissue.
Evidence on tissue expression from TISSUES for THBS2 Gene
- Nervous system(3.7)
- Bone(3)
- Heart(2.6)
- Skin(2.6)
- Pancreas(2.1)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for THBS2
- genomics-online: primer clones - Search results for 90 available Thrombospondin 2 gene related products
- Overview of 90 available Thrombospondin 2 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for THBS2 Gene
Orthologs for THBS2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | THBS2 33 |
|
||
| dog (Canis familiaris) |
Mammalia | THBS2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | THBS2 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | THBS2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | THBS2 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Thbs2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Thbs2 33 |
|
||
| chicken (Gallus gallus) |
Aves | THBS2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | THBS2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | thbs2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | thbs2a 34 34 |
|
OneToMany | |
| LOC100535241 33 |
|
||||
| thbs2b 34 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6394 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Tsp 35 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for THBS2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for THBS2 Gene
Variants for THBS2 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs9406328 | risk-factor, Lumbar disc herniation, susceptibility to | 169,234,915(-) | G/A | intron_variant | |
| rs1000097373 | -- | 169,233,850(-) | C/T | intron_variant | |
| rs1000163392 | -- | 169,235,143(-) | A/C | intron_variant | |
| rs1000178974 | -- | 169,250,253(-) | T/C | intron_variant | |
| rs1000196319 | -- | 169,239,069(-) | G/A | intron_variant |
Residual Variation Intolerance Score:
46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.10;
61.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for THBS2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THBS2 Gene
Disorders for THBS2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| intervertebral disc disease |
|
|
| posterior uveal melanoma |
|
|
| back pain |
|
|
| intestinal schistosomiasis |
|
|
| spinal stenosis |
|
|
Search THBS2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TSP2_HUMAN- Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269 PubMed:18455130}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for THBS2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for THBS2 Gene
Publications for THBS2 Gene
- A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. (PMID: 18455130) Hirose Y … Ikegawa S (American journal of human genetics 2008) 2 3 4 44 58
- Decreased frequency of the 3'UTR T>G single nucleotide polymorphism of thrombospondin-2 gene in sudden death due to plaque erosion. (PMID: 19631562) Burke A … Fowler D (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2010) 3 22 44 58
- Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence. (PMID: 18178577) Koch W … Kastrati A (Human molecular genetics 2008) 3 22 44 58
- Assessment of genetic risk factors for thoracic aortic aneurysm in hypertensive patients. (PMID: 18600213) Kato K … Yamada Y (American journal of hypertension 2008) 3 22 44 58
- Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance. (PMID: 17202846) Park BL … Shin HD (Experimental & molecular medicine 2006) 3 22 44 58
Products for THBS2 Gene
- R&D Systems Antibodies for THBS2 (Thrombospondin-2)
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- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for THBS2 (Thrombospondin-2)
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- Custom Antibody ServicesOriGene Antibodies for THBS2
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- Novus Biologicals Antibodies for THBS2
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- Browse Antibodies
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- Abcam antibodies for THBS2
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- Cloud-Clone Corp. Antibodies for THBS2
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- Browse Knockouts at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for THBS2
- VectorBuilder custom plasmid, inducible vectors for THBS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for THBS2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for THBS2
- antibodies-online: Search results for 74 available Thrombospondin 2 Antibodies ranked by validation data
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- Quality Products:
- antibodies-online: Search results for 41 available Thrombospondin 2 Elisa Kits ranked by validation data
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- Quality Products:
- GeneTex THBS2 antibody for THBS2
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- ViGene Biosciences adenoviral particle packaged cDNA for THBS2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for THBS2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for THBS2 gene
- Search ViGene Biosciences for THBS2
- Santa Cruz Biotechnology (SCBT) Antibodies for THBS2
- Search Santa Cruz Biotechnology (SCBT) for THBS2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for THBS2
- Horizon Cell Lines for THBS2
- genomics-online: cdna clones - Search results for 90 available Thrombospondin 2 gene related products
- Overview of 90 available Thrombospondin 2 gene related products
- orf clones - Search results for 90 available Thrombospondin 2 gene related products
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Sources for THBS2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
