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The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and... See more...
Aliases for THBS1 Gene
Aliases for THBS1 Gene
External Ids for THBS1 Gene
- HGNC: 11785
- Entrez Gene: 7057
- Ensembl: ENSG00000137801
- OMIM: 188060
- UniProtKB: P07996
Previous GeneCards Identifiers for THBS1 Gene
- GC15P035240
- GC15P032769
- GC15P037452
- GC15P037589
- GC15P037660
- GC15P039873
- GC15P016716
Summaries for THBS1 Gene
-
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for THBS1 Gene
THBS1 (Thrombospondin 1) is a Protein Coding gene. Diseases associated with THBS1 include Thrombotic Thrombocytopenic Purpura and Posterior Uveal Melanoma. Among its related pathways are Phagosome and Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS2.
UniProtKB/Swiss-Prot Summary for THBS1 Gene
-
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).
Additional gene information for THBS1 Gene
- Monarch Initiative
- Search for THBS1 at DataMed
- Search for THBS1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THBS1 Gene
Genomics for THBS1 Gene
GeneHancer (GH) Regulatory Elements for THBS1 Gene
Promoters and enhancers for THBS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around THBS1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the THBS1 gene promoter:
-
- CREB
- deltaCREB
- GR-alpha
- MyoD
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for THBS1 Gene
Genomic Locations for THBS1 Gene
- chr15:39,581,079-39,599,466
- (GRCh38/hg38)
- Size:
- 18,388 bases
- Orientation:
- Plus strand
- chr15:39,873,280-39,891,667
- (GRCh37/hg19)
- Size:
- 18,388 bases
- Orientation:
- Plus strand
Genomic View for THBS1 Gene
Genes around THBS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q14 by HGNC
- 15q14 by Entrez Gene
- 15q14 by Ensembl
THBS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for THBS1 Gene
Proteins for THBS1 Gene
-
Protein details for THBS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07996-TSP1_HUMAN
- Recommended name:
- Thrombospondin-1
- Protein Accession:
- P07996
- A8K6H4
- B4E3J7
- B9EGH6
- Q15667
- Q59E99
Protein attributes for THBS1 Gene
- Size:
- 1170 amino acids
- Molecular mass:
- 129383 Da
- Quaternary structure:
-
- Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts with ATF6 (via lumenal domain) (By similarity).
- SequenceCaution:
-
- Sequence=BAD93149.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for THBS1 Gene
Protein Expression for THBS1 Gene
Post-translational modifications for THBS1 Gene
Other Protein References for THBS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ THBS1 Antibody
- Atlas Antibodies Anti-THBS1 Antibody
-
Creative Diagnostics
- Rabbit Anti-Human THBS1 Polyclonal antibody
- Anti-THBS1 monoclonal antibody, clone B7.2 [Biotin]
- Anti-THBS1 monoclonal antibody, clone D7.8
- Anti-THBS1 monoclonal antibody, clone TQN432
- Anti-THBS1 monoclonal antibody, clone B5.2
- Anti-THBS1 monoclonal antibody, clone 629DU29.23.9
- Anti-THBS1 (N-terminal) polyclonal antibody
- Anti-THBS1 polyclonal antibody [Biotin]
- Anti-THBS1 monoclonal antibody, clone 402332
- Anti-THBS1 monoclonal antibody, clone 244
-
Custom Antibody ServicesOriGene Antibodies for THBS1
- Novus Biologicals Antibodies for THBS1
-
Abcam antibodies for THBS1
- Invitrogen Antibodies for THBS1 (AFLGC-THBS1)
- antibodies-online: Show 366 available Thrombospondin 1 Antibodies ranked by validation data
- Compare Top Thrombospondin 1 Antibodies
-
Recommended
- 121 WB Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IEP Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 52 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 49 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Biorbyt antibodies for THBS1
-
Santa Cruz Biotechnology (SCBT) Antibodies for THBS1
Protein Products
- G Biosciences Human Thrombospondin-1/THBS1, Lyophilized
-
Creative Biomart
- Recombinant Human Thrombospondin 1
- Native Human THBS1 (THBS1-31514TH)
- Recombinant Human THBS1 protein, glycosylated
- Recombinant Human THBS1
- Native Human THBS1 (THBS1-31515TH)
- Recombinant Human THBS1 293 Cell Lysate
- Natve Human Thrombospondin
- Recombinant Human THBS1 protein, His-tagged
- Recombinant Human THBS1 Protein, MYC/DDK-tagged
-
OriGene Purified Proteins for THBS1
- Search Origene for MassSpec and Protein Over-expression Lysates for THBS1
- Origene Custom Protein Services for THBS1
- ProSpec Recombinant Proteins for THBS1
-
Abcam proteins for THBS1
Assay Products
- G Biosciences Immunotag™ Thrombospondin-1 ELISA Kit
- RayBiotech Human Thrombospondin 1 ELISA
- Aviva Systems Biology THBS1 ELISA Kit (Human) : 96 Wells (OKEH02928) and THBS1 ELISA Kit (Human) (OKCD06581)
-
Custom Assay ServicesOriGene ELISA Kits for THBS1
- Novus Biologicals ELISA Kits for THBS1
- antibodies-online: Show 101 available Thrombospondin 1 Elisa Kits ranked by validation data
- Compare Top Thrombospondin 1 Elisa Kits
-
Quality Products:
- ABIN366828
- ABIN1117433
- ABIN414489
- ABIN1672826
- ABIN5676208
- ABIN924891
- ABIN2703490
- ABIN3198482
- ABIN5521701
- ABIN2708388
- ABIN6574175
- ABIN6720537
- ABIN1117401
- ABIN1117419
- ABIN415440
- ABIN4948064
- ABIN4948063
- ABIN1081886
- ABIN5521702
- ABIN367912
- ABIN6574176
- ABIN1117432
- ABIN416163
- ABIN1572700
- ABIN368110
- ABIN5521703
- ABIN5670566
- ABIN627385
- ABIN5659183
- ABIN6254459
- ABIN414031
- ABIN456872
- ABIN1572697
- ABIN5659179
- ABIN996197
- ABIN2539531
- ABIN6208131
- ABIN1161703
No data available for DME Specific Peptides for THBS1 Gene
Domains & Families for THBS1 Gene
Gene Families for THBS1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for THBS1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for THBS1 Gene
- GenScript: Design optimal peptide antigens:
-
- THBS1 protein (A0PJG0_HUMAN)
- cDNA FLJ52119 (B4DDK8_HUMAN)
- Thrombospondin-1 (TSP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P07996- Family:
-
- Belongs to the thrombospondin family.
Function for THBS1 Gene
Molecular function for THBS1 Gene
- UniProtKB/Swiss-Prot Function:
- Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).
- GENATLAS Biochemistry:
- thrombospondin I (140kDa),glycoprotein expressed in extracellular matrix protein involved in platelet aggregation,embryogenesis,morphogenesis,cell adhesion molecule,major activator of TGFB1
Phenotypes From GWAS Catalog for THBS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001786 | phosphatidylserine binding | IDA | 18940719 |
| GO:0001968 | fibronectin binding | IDA | 6693501 |
| GO:0005178 | integrin binding | IMP | 17413041 |
| GO:0005201 | extracellular matrix structural constituent | RCA | 20551380 |
| GO:0005509 | calcium ion binding | NAS | 9304800 |
Phenotypes for THBS1 Gene
- MGI mutant phenotypes for THBS1:
-
inferred from 2 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for THBS1:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
Animal Models for THBS1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for THBS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THBS1
- genomics-online: gRNA clones - Search for available Thrombospondin 1 gRNA products
- Overview of 123 available Thrombospondin 1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for THBS1 - Select products 50% OFF >
- * THBS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * THBS1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for THBS1
miRNA for THBS1 Gene
- miRTarBase miRNAs that target THBS1
-
- hsa-mir-1-3p (MIRT001328)
- hsa-let-7b-5p (MIRT001586)
- hsa-mir-30a-3p (MIRT001763)
- hsa-mir-98-5p (MIRT004943)
- hsa-let-7a-5p (MIRT004958)
- hsa-mir-17-5p (MIRT005626)
- hsa-mir-20a-5p (MIRT005627)
- hsa-mir-92a-3p (MIRT005628)
- hsa-mir-155-5p (MIRT020932)
- hsa-mir-132-3p (MIRT021834)
- hsa-mir-30a-5p (MIRT028645)
- hsa-mir-19a-3p (MIRT031304)
- hsa-let-7d-5p (MIRT032122)
- bta-mir-17-5p (MIRT053860)
- bta-mir-21-5p (MIRT053887)
- bta-mir-221 (MIRT053997)
- hsa-let-7g-5p (MIRT054662)
- hsa-mir-27b-3p (MIRT438199)
- hsa-mir-182-5p (MIRT438374)
- hsa-mir-4276 (MIRT466331)
- hsa-mir-190a-3p (MIRT466333)
- hsa-mir-4528 (MIRT466334)
- hsa-mir-4302 (MIRT466335)
- hsa-mir-6733-3p (MIRT466336)
- hsa-mir-410-3p (MIRT466337)
- hsa-mir-648 (MIRT466338)
- hsa-mir-5680 (MIRT466339)
- hsa-mir-4637 (MIRT466340)
- hsa-mir-8084 (MIRT466341)
- hsa-mir-3121-3p (MIRT466342)
- hsa-mir-19b-3p (MIRT466343)
- hsa-mir-3609 (MIRT466344)
- hsa-mir-6857-5p (MIRT466345)
- hsa-mir-491-5p (MIRT466346)
- hsa-mir-198 (MIRT466347)
- hsa-mir-92a-2-5p (MIRT466348)
- hsa-mir-6766-5p (MIRT466349)
- hsa-mir-6756-5p (MIRT466350)
- hsa-mir-4450 (MIRT466351)
- hsa-mir-766-5p (MIRT466352)
- hsa-mir-657 (MIRT466353)
- hsa-mir-3665 (MIRT466354)
- hsa-mir-1205 (MIRT466355)
- hsa-mir-1273g-3p (MIRT466356)
- hsa-mir-125a-3p (MIRT466357)
- hsa-mir-6754-5p (MIRT466358)
- hsa-mir-4441 (MIRT466359)
- hsa-mir-4270 (MIRT466360)
- hsa-mir-211-3p (MIRT466361)
- hsa-mir-4756-5p (MIRT466362)
- hsa-mir-4739 (MIRT466363)
- hsa-mir-1321 (MIRT466364)
- hsa-mir-509-5p (MIRT466365)
- hsa-mir-509-3-5p (MIRT466366)
- hsa-mir-4418 (MIRT466367)
- hsa-mir-3163 (MIRT485052)
- hsa-mir-548c-3p (MIRT485053)
- hsa-mir-5096 (MIRT500799)
- hsa-mir-3149 (MIRT500801)
- hsa-mir-297 (MIRT500802)
- hsa-mir-675-3p (MIRT500803)
- hsa-mir-567 (MIRT500804)
- hsa-mir-202-3p (MIRT500805)
- hsa-mir-5003-5p (MIRT500806)
- hsa-mir-380-3p (MIRT500807)
- hsa-mir-3065-5p (MIRT500808)
- hsa-mir-411-3p (MIRT500809)
- hsa-mir-379-3p (MIRT500810)
- hsa-mir-3529-3p (MIRT500811)
- hsa-mir-4495 (MIRT500812)
- hsa-mir-7-2-3p (MIRT500813)
- hsa-mir-7-1-3p (MIRT500814)
- hsa-mir-1252-3p (MIRT500815)
- hsa-let-7f-5p (MIRT500816)
- hsa-let-7c-5p (MIRT500817)
- hsa-mir-4458 (MIRT500818)
- hsa-let-7e-5p (MIRT500819)
- hsa-let-7i-5p (MIRT500820)
- hsa-mir-4500 (MIRT500821)
- hsa-mir-6516-5p (MIRT682114)
- hsa-mir-455-3p (MIRT682115)
- hsa-mir-6825-5p (MIRT682116)
- hsa-mir-650 (MIRT682117)
- hsa-mir-3612 (MIRT682118)
- hsa-mir-6499-3p (MIRT682119)
- hsa-mir-2467-3p (MIRT682120)
- hsa-mir-6086 (MIRT682121)
- hsa-mir-377-5p (MIRT682122)
- hsa-mir-1827 (MIRT682123)
- hsa-mir-4537 (MIRT682124)
- hsa-mir-6889-5p (MIRT682125)
- hsa-mir-6777-5p (MIRT682126)
- hsa-mir-4257 (MIRT682127)
- hsa-mir-6511a-5p (MIRT682128)
- hsa-mir-1910-3p (MIRT682129)
- hsa-mir-4655-5p (MIRT682130)
- hsa-mir-320c (MIRT733526)
- hsa-mir-487b-3p (MIRT734942)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for THBS1
- Browse OriGene Inhibitory RNA Products For THBS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THBS1
- genomics-online: shRNA clones - Search for available Thrombospondin 1 shRNA products
- Overview of 123 available Thrombospondin 1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for THBS1
- Addgene plasmids for THBS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THBS1
- Applied Biological Materials (abm): Clones for THBS1 - Select products 50% OFF >
- * THBS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * THBS1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for THBS1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THBS1 Gene
Localization for THBS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for THBS1 Gene
- Secreted. Cell surface. Secreted, extracellular space, extracellular matrix. Endoplasmic reticulum. Sarcoplasmic reticulum. Note=Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity). {ECO:0000250 UniProtKB:P35441, ECO:0000269 PubMed:6341993, ECO:0000269 PubMed:6777381}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| endoplasmic reticulum | 4 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| peroxisome | 0 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | HDA,TAS | -- |
| GO:0005577 | fibrinogen complex | IDA | 3997886 |
| GO:0005615 | extracellular space | IDA | 6777381 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005783 | endoplasmic reticulum | ISS | -- |
Pathways & Interactions for THBS1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 2 | Bladder cancer |
.66
|
.66
|
| 3 | ECM-receptor interaction | ||
| 4 | Focal Adhesion |
.62
|
.62
|
| 5 | PI3K-Akt signaling pathway | ||
Pathways by source for THBS1 Gene
9 BioSystems pathways for THBS1 Gene
18 Reactome pathways for THBS1 Gene
12 KEGG pathways for THBS1 Gene
2 Qiagen pathways for THBS1 Gene
- Inhibition of Angiogenesis by TSP1
- p53 Signaling
1 Cell Signaling Technology pathway for THBS1 Gene
1 GeneTex pathway for THBS1 Gene
Interacting Proteins for THBS1 Gene
Selected Interacting proteins:
P07996-TSP1_HUMAN
ENSP00000260356
for THBS1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for THBS1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IMP | 17413041 |
| GO:0001666 | response to hypoxia | NAS | 9304800 |
| GO:0001937 | negative regulation of endothelial cell proliferation | IMP | 17413041 |
| GO:0001953 | negative regulation of cell-matrix adhesion | IDA | 16150726 |
| GO:0002040 | sprouting angiogenesis | IMP | 17879962 |
Drugs & Compounds for THBS1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| CVX-045 | Pharma | Antibody | Others | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human Thrombospondin-1/THBS1, Lyophilized
-
Creative Biomart
- Recombinant Human Thrombospondin 1
- Native Human THBS1 (THBS1-31514TH)
- Recombinant Human THBS1 protein, glycosylated
- Recombinant Human THBS1
- Native Human THBS1 (THBS1-31515TH)
- Recombinant Human THBS1 293 Cell Lysate
- Natve Human Thrombospondin
- Recombinant Human THBS1 protein, His-tagged
- Recombinant Human THBS1 Protein, MYC/DDK-tagged
Transcripts for THBS1 Gene
mRNA/cDNA for THBS1 Gene
- (1) REFSEQ mRNAs :
- (27) Additional mRNA sequences :
- (563) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000260356 7775 bps (ENST00000260356.5)
- ENST00000397591 582 bps (ENST00000397591.2)
- ENST00000466755 500 bps (ENST00000466755.1)
- ENST00000484734 1291 bps (ENST00000484734.1)
- ENST00000490247 431 bps (ENST00000490247.1)
CRISPR Products
-
OriGene CRISPR knockouts for THBS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THBS1
- genomics-online: gRNA clones - Search for available Thrombospondin 1 gRNA products
- Overview of 123 available Thrombospondin 1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for THBS1 - Select products 50% OFF >
- * THBS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * THBS1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for THBS1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for THBS1
- Browse OriGene Inhibitory RNA Products For THBS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THBS1
- genomics-online: shRNA clones - Search for available Thrombospondin 1 shRNA products
- Overview of 123 available Thrombospondin 1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for THBS1
- Addgene plasmids for THBS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THBS1
- Applied Biological Materials (abm): Clones for THBS1 - Select products 50% OFF >
- * THBS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * THBS1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: |
Expression for THBS1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Tendon & Ligament (Muscoskeletal System)
This gene is overexpressed in Platelet (25.4), Bone marrow mesenchymal stem cell (18.2), Amniocyte (9.7), and Peripheral blood mononuclear cells (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THBS1 Gene
NURSA nuclear receptor signaling pathways regulating expression of THBS1 Gene:
THBS1SOURCE GeneReport for Unigene cluster for THBS1 Gene:
Hs.164226Evidence on tissue expression from TISSUES for THBS1 Gene
- Heart(4.8)
- Liver(4.8)
- Blood(4.6)
- Bone marrow(4.5)
- Lung(4.4)
- Kidney(4.1)
- Saliva(4)
- Skin(4)
- Nervous system(3.9)
- Bone(3.7)
- Intestine(3.5)
- Spleen(2.9)
- Muscle(2.8)
- Lymph node(2.6)
- Pancreas(2.6)
- Gall bladder(2.4)
- Eye(2.2)
Primer Products
-
OriGene qPCR primer pairs for THBS1
-
OriGene qPCR primer pairs and template standards for THBS1
- genomics-online: primer clones - Search for available Thrombospondin 1 Primer products
- Overview of 123 available Thrombospondin 1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THBS1 Gene
Orthologs for THBS1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | THBS1 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | THBS1 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | THBS1 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | THBS1 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Thbs1 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Thbs1 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | THBS1 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | THBS1 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | THBS1 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | thbs1 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | THBS1 (2 of 2) 33 |
|
OneToMany | |
| thbs1b 33 |
|
OneToMany | |||
| thbs1 32 |
|
||||
| -- 32 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Tsp 33 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for THBS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for THBS1 Gene
- ENSEMBL:
- Gene Tree for THBS1 (if available)
- TreeFam:
- Gene Tree for THBS1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for THBS1: view image
Paralogs for THBS1 Gene
Variants for THBS1 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2292305 | benign, not specified, - | 39,588,621(+) | A/C/G | coding_sequence_variant, intron_variant, missense_variant | |
| rs770788788 | uncertain-significance, not provided | 39,588,108(+) | G/A/C | coding_sequence_variant, missense_variant | |
| rs2228261 | benign, not specified | 39,588,157(+) | C/T | coding_sequence_variant, synonymous_variant | |
| rs2228263 | benign, not specified | 39,593,100(+) | T/C | coding_sequence_variant, synonymous_variant | |
| rs2229364 | benign, not specified | 39,587,516(+) | G/A | coding_sequence_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3569465 | CNV | gain | 25503493 |
| nsv1048628 | CNV | gain | 25217958 |
| nsv1502 | CNV | deletion | 18451855 |
| nsv832977 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.94;
89.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for THBS1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THBS1 Gene
Disorders for THBS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| thrombotic thrombocytopenic purpura |
|
|
| posterior uveal melanoma |
|
|
| peters-plus syndrome |
|
|
| babesiosis |
|
|
| corneal neovascularization |
|
Search THBS1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for THBS1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for THBS1 Gene
Publications for THBS1 Gene
- Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. (PMID: 12391027) Tan K … Wang JH (The Journal of cell biology 2002) 3 4 23 56
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
- A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 43 56
- A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 43 56
- Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 43 56
ExternalLinks
Products for THBS1 Gene
- View all 15 R&D Systems THBS1 (Thrombospondin-1) Products
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- Browse Primary Antibodies
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- antibodies-online: Show 366 available Thrombospondin 1 Antibodies ranked by validation data
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- 121 WB Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IEP Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IP Antibody (anti-human)
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- 52 WB Antibodies (anti-mouse)
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- 49 WB Antibodies (anti-rat)
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- antibodies-online: Show 44 available Thrombospondin 1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for THBS1
- Search Santa Cruz Biotechnology (SCBT) for THBS1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for THBS1
- Horizon Cell Lines for THBS1
- genomics-online: cdna clones - Search for available Thrombospondin 1 CDNA products
- Overview of 123 available Thrombospondin 1 gene related products
- orf clones - Search for available Thrombospondin 1 ORF products
- Overview of 123 available Thrombospondin 1 gene related products
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- Overview of 123 available Thrombospondin 1 gene related products
- genomics-online: primer clones - Search for available Thrombospondin 1 Primer products
- Overview of 123 available Thrombospondin 1 gene related products
- genomics-online: shRNA clones - Search for available Thrombospondin 1 shRNA products
- Overview of 123 available Thrombospondin 1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THBS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THBS1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for THBS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THBS1
- Biorbyt antibodies for THBS1
Sources for THBS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA