Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
THBS1 (Thrombospondin 1) is a Protein Coding gene. Diseases associated with THBS1 include Thrombotic Thrombocytopenic Purpura and Peters-Plus Syndrome. Among its related pathways are Signaling by GPCR and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001786 | phosphatidylserine binding | IDA | 18940719 |
GO:0001968 | fibronectin binding | IDA | 6693501 |
GO:0005178 | integrin binding | IMP | 17413041 |
GO:0005201 | extracellular matrix structural constituent | RCA | 20551380 |
GO:0005509 | calcium ion binding | NAS | 9304800 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA,TAS | -- |
GO:0005577 | fibrinogen complex | IDA | 3997886 |
GO:0005615 | extracellular space | IDA | 6777381 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005783 | endoplasmic reticulum | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
2 | Bladder cancer |
.66
|
.66
|
3 | ECM-receptor interaction | ||
4 | Focal Adhesion |
.61
|
.61
|
5 | PI3K-Akt signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000187 | activation of MAPK activity | IMP | 17413041 |
GO:0001666 | response to hypoxia | NAS | 9304800 |
GO:0001937 | negative regulation of endothelial cell proliferation | IMP | 17413041 |
GO:0001953 | negative regulation of cell-matrix adhesion | IDA | 16150726 |
GO:0002040 | sprouting angiogenesis | IMP | 17879962 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
CVX-045 | Pharma | Antibody | Others | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: |
ExUns: | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||
SP2: | |||||||||||
SP3: | |||||||||||
SP4: | |||||||||||
SP5: | |||||||||||
SP6: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | THBS1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | THBS1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | THBS1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | THBS1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Thbs1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Thbs1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | THBS1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | THBS1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | THBS1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | thbs1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | THBS1 (2 of 2) 31 |
|
OneToMany | |
thbs1b 31 |
|
OneToMany | |||
thbs1 30 |
|
||||
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Tsp 31 32 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
712840 | Benign: not provided | 39,593,425(+) | C/T | SYNONYMOUS_VARIANT | |
717028 | Likely Benign: not provided | 39,593,678(+) | A/G | INTRON_VARIANT | |
725158 | Likely Benign: not provided | 39,591,226(+) | T/C | SYNONYMOUS_VARIANT | |
729190 | Benign: not provided | 39,594,182(+) | G/A | SYNONYMOUS_VARIANT | |
733360 | Likely Benign: not provided | 39,593,231(+) | A/T | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3569465 | CNV | gain | 25503493 |
nsv1048628 | CNV | gain | 25217958 |
nsv1502 | CNV | deletion | 18451855 |
nsv832977 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
thrombotic thrombocytopenic purpura |
|
|
peters-plus syndrome |
|
|
malaria |
|
|
pseudoachondroplasia |
|
|
stiff skin syndrome |
|
|