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The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and... See more...
Aliases for THBS1 Gene
Aliases for THBS1 Gene
External Ids for THBS1 Gene
- HGNC: 11785
- NCBI Entrez Gene: 7057
- Ensembl: ENSG00000137801
- OMIM®: 188060
- UniProtKB/Swiss-Prot: P07996
Previous GeneCards Identifiers for THBS1 Gene
- GC15P035240
- GC15P032769
- GC15P037452
- GC15P037589
- GC15P037660
- GC15P039873
- GC15P016716
Summaries for THBS1 Gene
-
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for THBS1 Gene
THBS1 (Thrombospondin 1) is a Protein Coding gene. Diseases associated with THBS1 include Thrombotic Thrombocytopenic Purpura and Peters-Plus Syndrome. Among its related pathways are MET promotes cell motility and Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS2.
UniProtKB/Swiss-Prot Summary for THBS1 Gene
-
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).
Additional gene information for THBS1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THBS1 Gene
Genomics for THBS1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for THBS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around THBS1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for THBS1
- Top Transcription factor binding sites by QIAGEN in the THBS1 gene promoter:
-
- CREB
- deltaCREB
- GR-alpha
- MyoD
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for THBS1 Gene
Latest Assembly
- chr15:39,581,079-39,599,466
- (GRCh38/hg38)
- Size:
- 18,388 bases
- Orientation:
- Plus strand
Previous Assembly
- chr15:39,873,280-39,891,667
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 18,388 bases
- Orientation:
- Plus strand
Genomic View for THBS1 Gene
Genes around THBS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q14 by HGNC
- 15q14 by Entrez Gene
- 15q14 by Ensembl
THBS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for THBS1 Gene
Proteins for THBS1 Gene
-
Protein details for THBS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07996-TSP1_HUMAN
- Recommended name:
- Thrombospondin-1
- Protein Accession:
- P07996
- A8K6H4
- B4E3J7
- B9EGH6
- Q15667
- Q59E99
Protein attributes for THBS1 Gene
- Size:
- 1170 amino acids
- Molecular mass:
- 129383 Da
- Quaternary structure:
-
- Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts with ATF6 (via lumenal domain) (By similarity).
- SequenceCaution:
-
- Sequence=BAD93149.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for THBS1 Gene
Protein Expression for THBS1 Gene
Post-translational modifications for THBS1 Gene
Other Protein References for THBS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences THBS1 / Thrombospondin-1 Monoclonal Antibody and THBS1 / Thrombospondin-1 Antibody
- G Biosciences Immunotag™ THBS1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for THBS1
- Novus Biologicals Antibodies for THBS1
-
Abcam antibodies for THBS1
- Invitrogen Antibodies for THBS1 (AFLGC-THBS1)
- antibodies-online: Show 366 available Thrombospondin 1 Antibodies ranked by validation data
- Compare Top Thrombospondin 1 Antibodies
-
Recommended
- 121 WB Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IEP Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 52 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 49 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for THBS1
-
Santa Cruz Biotechnology (SCBT) Antibodies for THBS1
- Sino Biological Antibodies for THBS1
Protein products for research
- G Biosciences Human Thrombospondin-1/THBS1, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for THBS1
- Origene Custom Protein Services for THBS1
- ProSpec Recombinant Proteins for THBS1
-
Abcam proteins for THBS1
Assay products for research
- G Biosciences Immunotag™ Thrombospondin-1 ELISA Kit
- RayBiotech Human Thrombospondin 1 ELISA
- Novus Biologicals ELISA Kits for THBS1
- antibodies-online: Show 101 available Thrombospondin 1 Elisa Kits ranked by validation data
- Compare Top Thrombospondin 1 Elisa Kits
-
Quality Products:
- ABIN366828
- ABIN1117433
- ABIN414489
- ABIN1672826
- ABIN5676208
- ABIN924891
- ABIN2703490
- ABIN3198482
- ABIN5521701
- ABIN2708388
- ABIN6574175
- ABIN6720537
- ABIN1117401
- ABIN1117419
- ABIN415440
- ABIN4948064
- ABIN4948063
- ABIN1081886
- ABIN5521702
- ABIN367912
- ABIN6574176
- ABIN1117432
- ABIN416163
- ABIN1572700
- ABIN368110
- ABIN5521703
- ABIN5670566
- ABIN627385
- ABIN5659183
- ABIN6254459
- ABIN414031
- ABIN456872
- ABIN1572697
- ABIN5659179
- ABIN996197
- ABIN2539531
- ABIN6208131
- ABIN1161703
No data available for DME Specific Peptides for THBS1 Gene
Domains & Families for THBS1 Gene
Gene Families for THBS1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for THBS1 Gene
- InterPro:
- Blocks:
-
- Type I EGF
- EGF-like calcium-binding
- Thrombospondin, type I
- Thrombospondin, N-terminal
- Thrombospondin type 1 repeat signature
- Thrombospondin, C-terminal
- von Willebrand factor, type C
Suggested Antigen Peptide Sequences for THBS1 Gene
- GenScript: Design optimal peptide antigens:
-
- THBS1 protein (A0PJG0_HUMAN)
- cDNA FLJ52119 (B4DDK8_HUMAN)
- Thrombospondin-1 (TSP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P07996- Family:
-
- Belongs to the thrombospondin family.
Function for THBS1 Gene
Molecular function for THBS1 Gene
- UniProtKB/Swiss-Prot Function:
- Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).
- GENATLAS Biochemistry:
- thrombospondin I (140kDa),glycoprotein expressed in extracellular matrix protein involved in platelet aggregation,embryogenesis,morphogenesis,cell adhesion molecule,major activator of TGFB1
Phenotypes From GWAS Catalog for THBS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001786 | phosphatidylserine binding | IDA | 18940719 |
| GO:0001968 | fibronectin binding | IDA | 6693501 |
| GO:0005178 | integrin binding | IMP | 17413041 |
| GO:0005201 | extracellular matrix structural constituent | RCA | 20551380 |
| GO:0005509 | calcium ion binding | NAS | 9304800 |
Phenotypes for THBS1 Gene
- MGI mutant phenotypes for THBS1:
-
inferred from 2 alleles
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- renal/urinary system phenotype
- liver/biliary system phenotype
- hematopoietic system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- integument phenotype
- GenomeRNAi human phenotypes for THBS1:
-
- Increased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- no effect
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased epidermal growth factor (EGF) endocytosis
Animal Models for THBS1 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for THBS1 - Starting at $85 >
- * THBS1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for THBS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THBS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for THBS1
miRNA for THBS1 Gene
- miRTarBase miRNAs that target THBS1
-
- hsa-miR-1-3p (MIRT001328)
- hsa-let-7b-5p (MIRT001586)
- hsa-miR-30a-3p (MIRT001763)
- hsa-miR-98-5p (MIRT004943)
- hsa-let-7a-5p (MIRT004958)
- hsa-miR-17-5p (MIRT005626)
- hsa-miR-20a-5p (MIRT005627)
- hsa-miR-92a-3p (MIRT005628)
- mmu-let-7b-5p (MIRT012299)
- hsa-miR-155-5p (MIRT020932)
- hsa-miR-132-3p (MIRT021834)
- hsa-miR-30a-5p (MIRT028645)
- hsa-miR-19a-3p (MIRT031304)
- hsa-let-7d-5p (MIRT032122)
- bta-miR-17-5p (MIRT053860)
- bta-miR-21-5p (MIRT053887)
- bta-miR-221 (MIRT053997)
- hsa-let-7g-5p (MIRT054662)
- hsa-miR-27b-3p (MIRT438199)
- hsa-miR-182-5p (MIRT438374)
- hsa-miR-4276 (MIRT466331)
- hsa-miR-190a-3p (MIRT466333)
- hsa-miR-4528 (MIRT466334)
- hsa-miR-4302 (MIRT466335)
- hsa-miR-6733-3p (MIRT466336)
- hsa-miR-410-3p (MIRT466337)
- hsa-miR-648 (MIRT466338)
- hsa-miR-5680 (MIRT466339)
- hsa-miR-4637 (MIRT466340)
- hsa-miR-8084 (MIRT466341)
- hsa-miR-3121-3p (MIRT466342)
- hsa-miR-19b-3p (MIRT466343)
- hsa-miR-3609 (MIRT466344)
- hsa-miR-6857-5p (MIRT466345)
- hsa-miR-491-5p (MIRT466346)
- hsa-miR-198 (MIRT466347)
- hsa-miR-92a-2-5p (MIRT466348)
- hsa-miR-6766-5p (MIRT466349)
- hsa-miR-6756-5p (MIRT466350)
- hsa-miR-4450 (MIRT466351)
- hsa-miR-766-5p (MIRT466352)
- hsa-miR-657 (MIRT466353)
- hsa-miR-3665 (MIRT466354)
- hsa-miR-1205 (MIRT466355)
- hsa-miR-1273g-3p (MIRT466356)
- hsa-miR-125a-3p (MIRT466357)
- hsa-miR-6754-5p (MIRT466358)
- hsa-miR-4441 (MIRT466359)
- hsa-miR-4270 (MIRT466360)
- hsa-miR-211-3p (MIRT466361)
- hsa-miR-4756-5p (MIRT466362)
- hsa-miR-4739 (MIRT466363)
- hsa-miR-1321 (MIRT466364)
- hsa-miR-509-5p (MIRT466365)
- hsa-miR-509-3-5p (MIRT466366)
- hsa-miR-4418 (MIRT466367)
- hsa-miR-3163 (MIRT485052)
- hsa-miR-548c-3p (MIRT485053)
- hsa-miR-5096 (MIRT500799)
- hsa-miR-3149 (MIRT500801)
- hsa-miR-297 (MIRT500802)
- hsa-miR-675-3p (MIRT500803)
- hsa-miR-567 (MIRT500804)
- hsa-miR-202-3p (MIRT500805)
- hsa-miR-5003-5p (MIRT500806)
- hsa-miR-380-3p (MIRT500807)
- hsa-miR-3065-5p (MIRT500808)
- hsa-miR-411-3p (MIRT500809)
- hsa-miR-379-3p (MIRT500810)
- hsa-miR-3529-3p (MIRT500811)
- hsa-miR-4495 (MIRT500812)
- hsa-miR-7-2-3p (MIRT500813)
- hsa-miR-7-1-3p (MIRT500814)
- hsa-miR-1252-3p (MIRT500815)
- hsa-let-7f-5p (MIRT500816)
- hsa-let-7c-5p (MIRT500817)
- hsa-miR-4458 (MIRT500818)
- hsa-let-7e-5p (MIRT500819)
- hsa-let-7i-5p (MIRT500820)
- hsa-miR-4500 (MIRT500821)
- hsa-miR-6516-5p (MIRT682114)
- hsa-miR-455-3p (MIRT682115)
- hsa-miR-6825-5p (MIRT682116)
- hsa-miR-650 (MIRT682117)
- hsa-miR-3612 (MIRT682118)
- hsa-miR-6499-3p (MIRT682119)
- hsa-miR-2467-3p (MIRT682120)
- hsa-miR-6086 (MIRT682121)
- hsa-miR-377-5p (MIRT682122)
- hsa-miR-1827 (MIRT682123)
- hsa-miR-4537 (MIRT682124)
- hsa-miR-6889-5p (MIRT682125)
- hsa-miR-6777-5p (MIRT682126)
- hsa-miR-4257 (MIRT682127)
- hsa-miR-6511a-5p (MIRT682128)
- hsa-miR-1910-3p (MIRT682129)
- hsa-miR-4655-5p (MIRT682130)
- mmu-let-7e-5p (MIRT732900)
- hsa-miR-320c (MIRT733526)
- hsa-miR-487b-3p (MIRT734942)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THBS1
- Browse OriGene Inhibitory RNA Products For THBS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THBS1
Clone products for research
- Applied Biological Materials (abm): Clones for THBS1 - Starting at $45 >
- * THBS1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for THBS1
- Addgene plasmids for THBS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THBS1
Cell Lines for research
-
Horizon Cell Lines for THBS1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THBS1 Gene
Localization for THBS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for THBS1 Gene
- Secreted. Cell surface. Secreted, extracellular space, extracellular matrix. Endoplasmic reticulum. Sarcoplasmic reticulum. Note=Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity). {ECO:0000250 UniProtKB:P35441, ECO:0000269 PubMed:6341993, ECO:0000269 PubMed:6777381}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| peroxisome | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | HDA,TAS | -- |
| GO:0005577 | fibrinogen complex | IDA | 3997886 |
| GO:0005615 | extracellular space | IDA | 6777381 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005783 | endoplasmic reticulum | ISS | -- |
Pathways & Interactions for THBS1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 2 | Bladder cancer |
.66
|
.66
|
| 3 | ECM-receptor interaction | ||
| 4 | Focal Adhesion |
.61
|
.61
|
| 5 | PI3K-Akt signaling pathway | ||
Pathways by source for THBS1 Gene
9 BioSystems pathways for THBS1 Gene
18 Reactome pathways for THBS1 Gene
12 KEGG pathways for THBS1 Gene
2 Qiagen pathways for THBS1 Gene
- Inhibition of Angiogenesis by TSP1
- p53 Signaling
1 Cell Signaling Technology pathway for THBS1 Gene
1 GeneTex pathway for THBS1 Gene
Interacting Proteins for THBS1 Gene
Selected Interacting proteins:
P07996-TSP1_HUMAN
ENSP00000260356
for THBS1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for THBS1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IMP | 17413041 |
| GO:0001666 | response to hypoxia | NAS | 9304800 |
| GO:0001937 | negative regulation of endothelial cell proliferation | IMP | 17413041 |
| GO:0001953 | negative regulation of cell-matrix adhesion | IDA | 16150726 |
| GO:0002040 | sprouting angiogenesis | IMP | 17879962 |
Drugs & Compounds for THBS1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| CVX-045 | Pharma | Antibody | Others | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human Thrombospondin-1/THBS1, Lyophilized
Transcripts for THBS1 Gene
mRNA/cDNA for THBS1 Gene
- 1 REFSEQ mRNAs :
- 27 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000260356 7789 nts (view in UCSC)
- ENST00000397591 582 nts (view in UCSC)
- ENST00000466755 500 nts (view in UCSC)
- ENST00000484734 1291 nts (view in UCSC)
- ENST00000490247 431 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for THBS1 - Starting at $85 >
- * THBS1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for THBS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THBS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for THBS1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THBS1
- Browse OriGene Inhibitory RNA Products For THBS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THBS1
Clone products for research
- Applied Biological Materials (abm): Clones for THBS1 - Starting at $45 >
- * THBS1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for THBS1
- Addgene plasmids for THBS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THBS1
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: |
Relevant External Links for THBS1 Gene
- GeneLoc Exon Structure for
- THBS1
Expression for THBS1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Tendon & Ligament (Muscoskeletal System)
This gene is overexpressed in Platelet (25.4), Bone marrow mesenchymal stem cell (18.2), Amniocyte (9.7), and Peripheral blood mononuclear cells (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THBS1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for THBS1
SOURCE GeneReport for Unigene cluster for THBS1 Gene:
Hs.164226Evidence on tissue expression from TISSUES for THBS1 Gene
- Liver(4.8)
- Heart(4.8)
- Blood(4.6)
- Bone marrow(4.6)
- Lung(4.5)
- Saliva(4.2)
- Kidney(4.2)
- Skin(4.1)
- Nervous system(4.1)
- Bone(4)
- Intestine(3.8)
- Spleen(3.4)
- Muscle(3.1)
- Pancreas(3)
- Lymph node(3)
- Gall bladder(2.6)
- Stomach(2.5)
- Adrenal gland(2.5)
- Eye(2.4)
- Thyroid gland(2.1)
Primer products for research
-
OriGene qPCR primer pairs for THBS1
-
OriGene qPCR primer pairs and template standards for THBS1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THBS1 Gene
Orthologs for THBS1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | THBS1 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | THBS1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | THBS1 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | THBS1 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Thbs1 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Thbs1 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | THBS1 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | THBS1 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | THBS1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | thbs1 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | THBS1 (2 of 2) 30 |
|
OneToMany | |
| thbs1b 30 |
|
OneToMany | |||
| thbs1 29 |
|
||||
| -- 29 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Tsp 30 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany |
- Species where no ortholog for THBS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for THBS1 Gene
- ENSEMBL:
- Gene Tree for THBS1 (if available)
- TreeFam:
- Gene Tree for THBS1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for THBS1: view image
- Alliance of Genome Resources:
- Additional Orthologs for THBS1
Paralogs for THBS1 Gene
Variants for THBS1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for THBS1 Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 929776 | Likely Pathogenic: Premature ovarian failure | 39,585,503(+) |
C/T NM_003246.4(THBS1):c.1060C>T (p.Pro354Ser) |
MISSENSE | |
| 996688 | Association: Autism spectrum disorder | 39,593,107(+) |
C/T NM_003246.4(THBS1):c.2875C>T (p.Arg959Ter) |
NONSENSE | |
| rs112165137 | Benign: not provided | 39,594,182(+) |
G/A NM_003246.4(THBS1):c.3351G>A (p.Lys1117=) |
SYNONYMOUS | |
| rs112670485 | Likely Benign: not provided | 39,593,635(+) |
C/T NM_003246.4(THBS1):c.3234C>T (p.Asn1078=) |
SYNONYMOUS | |
| rs112782285 | Benign: not provided | 39,583,664(+) |
C/T NM_003246.4(THBS1):c.675C>T (p.Asp225=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3569465 | CNV | gain | 25503493 |
| nsv1048628 | CNV | gain | 25217958 |
| nsv1502 | CNV | deletion | 18451855 |
| nsv832977 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.94;
89.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for THBS1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THBS1 Gene
Disorders for THBS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| thrombotic thrombocytopenic purpura |
|
|
| peters-plus syndrome |
|
|
| malaria |
|
|
| stiff skin syndrome |
|
|
| pseudoachondroplasia |
|
|
Search THBS1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for THBS1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for THBS1 Gene
Publications for THBS1 Gene
- Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence. (PMID: 18178577) Koch W … Kastrati A (Human molecular genetics 2008) 3 22 40
- The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size. (PMID: 16684956) Zwicker JI … Mannucci P (Blood 2006) 3 22 40
- Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. (PMID: 12391027) Tan K … Wang JH (The Journal of cell biology 2002) 3 4 22
- Biophysical characterization, including disulfide bond assignments, of the anti-angiogenic type 1 domains of human thrombospondin-1. (PMID: 12450399) Huwiler KG … Mosher DF (Biochemistry 2002) 3 4 22
- Structure and chromosomal localization of the human thrombospondin gene. (PMID: 2341158) Wolf FW … Dixit VM (Genomics 1990) 2 3 22
ExternalLinks
Products for THBS1 Gene
- View all 15 R&D Systems THBS1 (Thrombospondin-1) Products
- View all R&D Systems THBS1 (Thrombospondin-1) Proteins and Enzymes
- View all 5 R&D Systems THBS1 (Thrombospondin-1) Primary Antibodies
- View all 3 R&D Systems THBS1 (Thrombospondin-1) ELISAs
- View all R&D Systems THBS1 (Thrombospondin-1) Simple Plex Assays
- View all 5 R&D Systems THBS1 (Thrombospondin-1) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom THBS1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for THBS1
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for THBS1
- Origene Custom Protein Services for THBS1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THBS1
- Browse OriGene Inhibitory RNA Products For THBS1
- OriGene qPCR primer pairs for THBS1
- OriGene qPCR primer pairs and template standards for THBS1
- OriGene CRISPR knockouts for THBS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For THBS1
- Sino Biological Human cDNA Clone for THBS1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for THBS1
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for THBS1
- Novus Biologicals proteins and lysates for THBS1
- Novus Biologicals ELISA Kits for THBS1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for THBS1
- Abcam proteins for THBS1
- Find your target
- Browse Primary Antibodies
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- Browse Proteins and Peptides
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- VectorBuilder Custom and pre-made DNA vectors for THBS1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for THBS1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for THBS1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for THBS1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for THBS1
- Addgene plasmids for THBS1
- antibodies-online: Show 366 available Thrombospondin 1 Antibodies ranked by validation data
- Compare Top Thrombospondin 1 Antibodies
- Recommended
- 121 WB Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IEP Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 52 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 49 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 101 available Thrombospondin 1 Elisa Kits ranked by validation data
- Compare Top Thrombospondin 1 Elisa Kits
- Quality Products:
- ABIN366828
- ABIN1117433
- ABIN414489
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- antibodies-online: Show 44 available Thrombospondin 1 Proteins ranked by validation data
- Compare Top Thrombospondin 1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for THBS1
- Search Santa Cruz Biotechnology (SCBT) for THBS1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for THBS1
- Horizon Cell Lines for THBS1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THBS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THBS1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for THBS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THBS1
Sources for THBS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources