Aliases for THAP9 Gene

Aliases for THAP9 Gene

  • THAP Domain Containing 9 2 3 5
  • THAP Domain-Containing Protein 9 3 4
  • DNA Transposase THAP9 3 4
  • HTh9 3 4
  • EC 2.7.7.- 4
  • FLJ34093 2
  • THAP9 5

External Ids for THAP9 Gene

Previous GeneCards Identifiers for THAP9 Gene

  • GC04P084214
  • GC04P084280
  • GC04P084179
  • GC04P084040
  • GC04P083821
  • GC04P079563

Summaries for THAP9 Gene

GeneCards Summary for THAP9 Gene

THAP9 (THAP Domain Containing 9) is a Protein Coding gene. Diseases associated with THAP9 include Central Nervous System Tuberculosis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transferase activity.

UniProtKB/Swiss-Prot Summary for THAP9 Gene

  • Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition.

Additional gene information for THAP9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THAP9 Gene

Genomics for THAP9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for THAP9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around THAP9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for THAP9

Top Transcription factor binding sites by QIAGEN in the THAP9 gene promoter:
  • AREB6
  • c-Myc
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • Max
  • MZF-1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for THAP9 Gene

Genomic Locations for THAP9 Gene
chr4:82,900,650-82,920,283
(GRCh38/hg38)
Size:
19,634 bases
Orientation:
Plus strand
chr4:83,821,837-83,841,284
(GRCh37/hg19)
Size:
19,448 bases
Orientation:
Plus strand

Genomic View for THAP9 Gene

Genes around THAP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP9 Gene

Proteins for THAP9 Gene

  • Protein details for THAP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5L6-THAP9_HUMAN
    Recommended name:
    DNA transposase THAP9
    Protein Accession:
    Q9H5L6
    Secondary Accessions:
    • B3KRE2
    • Q59AC9

    Protein attributes for THAP9 Gene

    Size:
    903 amino acids
    Molecular mass:
    103411 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Able to mediate mobilization of P-elements when transfected in Drosophila.

neXtProt entry for THAP9 Gene

Post-translational modifications for THAP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for THAP9 Gene

Domains & Families for THAP9 Gene

Gene Families for THAP9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for THAP9 Gene

Suggested Antigen Peptide Sequences for THAP9 Gene

GenScript: Design optimal peptide antigens:
  • THAP domain-containing protein 9 (THAP9_HUMAN)
genes like me logo Genes that share domains with THAP9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for THAP9 Gene

Function for THAP9 Gene

Molecular function for THAP9 Gene

UniProtKB/Swiss-Prot Function:
Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition.

Enzyme Numbers (IUBMB) for THAP9 Gene

Phenotypes From GWAS Catalog for THAP9 Gene

Gene Ontology (GO) - Molecular Function for THAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0004803 transposase activity IDA 23349291
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with THAP9: view

Phenotypes for THAP9 Gene

genes like me logo Genes that share phenotypes with THAP9: view

Animal Model Products

CRISPR Products

miRNA for THAP9 Gene

miRTarBase miRNAs that target THAP9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THAP9

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP9 Gene

Localization for THAP9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP9 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for THAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
genes like me logo Genes that share ontologies with THAP9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THAP9 Gene

Pathways & Interactions for THAP9 Gene

PathCards logo

SuperPathways for THAP9 Gene

No Data Available

Interacting Proteins for THAP9 Gene

Gene Ontology (GO) - Biological Process for THAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination IEA,IDA 23349291
GO:0006313 transposition, DNA-mediated IDA 23349291
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0015074 DNA integration IEA,IDA 23349291
genes like me logo Genes that share ontologies with THAP9: view

No data available for Pathways by source and SIGNOR curated interactions for THAP9 Gene

Drugs & Compounds for THAP9 Gene

No Compound Related Data Available

Transcripts for THAP9 Gene

mRNA/cDNA for THAP9 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THAP9

Alternative Splicing Database (ASD) splice patterns (SP) for THAP9 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2:
SP3: - -
SP4: - - -
SP5:
SP6: - - -

Relevant External Links for THAP9 Gene

GeneLoc Exon Structure for
THAP9

Expression for THAP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THAP9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for THAP9

SOURCE GeneReport for Unigene cluster for THAP9 Gene:

Hs.582050

Evidence on tissue expression from TISSUES for THAP9 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with THAP9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP9 Gene

Orthologs for THAP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia THAP9 30 31
  • 99.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia THAP9 30 31
  • 90.47 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia THAP9 30 31
  • 88.03 (n)
OneToOne
Chicken
(Gallus gallus)
Aves THAP9 30 31
  • 54.22 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia THAP9 31
  • 34 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100493283 30
  • 40.92 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101883007 30
  • 45.57 (n)
THAP9 (1 of 3) 31
  • 28 (a)
OneToMany
THAP9 (2 of 3) 31
  • 28 (a)
OneToMany
THAP9 (3 of 3) 31
  • 27 (a)
OneToMany
Species where no ortholog for THAP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for THAP9 Gene

ENSEMBL:
Gene Tree for THAP9 (if available)
TreeFam:
Gene Tree for THAP9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for THAP9: view image

Paralogs for THAP9 Gene

(2) SIMAP similar genes for THAP9 Gene using alignment to 6 proteins:

  • THAP9_HUMAN
  • D6R957_HUMAN
  • D6RCT5_HUMAN
  • D6REM3_HUMAN
  • F2Z371_HUMAN
  • H0Y9F3_HUMAN
genes like me logo Genes that share paralogs with THAP9: view

No data available for Paralogs for THAP9 Gene

Variants for THAP9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for THAP9 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs1031639 - p.Met284Ile
rs35532215 - p.Val833Ile
rs6535411 - p.Asn812Asp
rs897945 - p.Leu299Phe

Additional dbSNP identifiers (rs#s) for THAP9 Gene

Structural Variations from Database of Genomic Variants (DGV) for THAP9 Gene

Variant ID Type Subtype PubMed ID
esv3425333 CNV duplication 20981092

Variation tolerance for THAP9 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.20; 84.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THAP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP9 Gene

Disorders for THAP9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for THAP9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
central nervous system tuberculosis
  • intracranial tuberculoma
- elite association - COSMIC cancer census association via MalaCards
Search THAP9 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with THAP9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THAP9 Gene

Publications for THAP9 Gene

  1. The human THAP9 gene encodes an active P-element DNA transposase. (PMID: 23349291) Majumdar S … Rio DC (Science (New York, N.Y.) 2013) 3 4
  2. THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves. (PMID: 20010837) Sabogal A … Rio DC (Nature structural & molecular biology 2010) 3 4
  3. Homologs of Drosophila P transposons were mobile in zebrafish but have been domesticated in a common ancestor of chicken and human. (PMID: 15616143) Hammer SE … Hagemann S (Molecular biology and evolution 2005) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M … Girard JP (Trends in biochemical sciences 2003) 2 3

Products for THAP9 Gene

Sources for THAP9 Gene