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Aliases for THAP9 Gene

Aliases for THAP9 Gene

  • THAP Domain Containing 9 2 3 5
  • THAP Domain-Containing Protein 9 3 4
  • HTh9 3 4
  • DNA Transposase THAP9 3
  • EC 2.7.7.- 4

External Ids for THAP9 Gene

Previous GeneCards Identifiers for THAP9 Gene

  • GC04P084214
  • GC04P084280
  • GC04P084179
  • GC04P084040
  • GC04P083821
  • GC04P079563

Summaries for THAP9 Gene

GeneCards Summary for THAP9 Gene

THAP9 (THAP Domain Containing 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transferase activity. An important paralog of this gene is THAP6.

UniProtKB/Swiss-Prot for THAP9 Gene

  • Active transposase that specifically recognizes the bipartite 5-TXXGGGX(A/T)-3 consensus motif and mediates transposition.

Additional gene information for THAP9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP9 Gene

Genomics for THAP9 Gene

GeneHancer (GH) Regulatory Elements for THAP9 Gene

Promoters and enhancers for THAP9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I082898 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.3 -271 4.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 THAP9-AS1 GC04P082899 SEC31A THAP9 HNRNPD HELQ ABRAXAS1
GH04I083152 Enhancer 1.1 FANTOM5 Ensembl ENCODE 18.7 +252.4 252439 1.5 CEBPB ZNF384 CEBPG MAFF ZNF316 CEBPA EMSY MAFK TRIM28 PLAC8 THAP9 HPSE COQ2 LIN54 GC04M083225
GH04I083149 Enhancer 1 FANTOM5 Ensembl ENCODE 18.8 +249.7 249731 2.5 JUN FOS NR2F2 MIXL1 PLAC8 THAP9 HPSE COQ2 LIN54 GC04M083225
GH04I083315 Enhancer 0.8 FANTOM5 Ensembl ENCODE 21.4 +416.1 416146 1.8 PRDM10 HPSE THAP9 PLAC8 COQ2 HELQ LIN54 LOC105377313
GH04I083180 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +279.9 279936 0.9 NR2F1 TRIM22 EBF1 DPF2 ATF2 RELA IKZF1 ATF7 ZSCAN29 ZNF24 PLAC8 THAP9 HPSE COQ2 LIN54 GC04M083225
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THAP9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THAP9 gene promoter:

Genomic Locations for THAP9 Gene

Genomic Locations for THAP9 Gene
chr4:82,900,684-82,920,283
(GRCh38/hg38)
Size:
19,600 bases
Orientation:
Plus strand
chr4:83,821,837-83,841,284
(GRCh37/hg19)

Genomic View for THAP9 Gene

Genes around THAP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP9 Gene

Proteins for THAP9 Gene

  • Protein details for THAP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5L6-THAP9_HUMAN
    Recommended name:
    DNA transposase THAP9
    Protein Accession:
    Q9H5L6
    Secondary Accessions:
    • B3KRE2
    • Q59AC9

    Protein attributes for THAP9 Gene

    Size:
    903 amino acids
    Molecular mass:
    103411 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Able to mediate mobilization of P-elements when transfected in Drosophila.

neXtProt entry for THAP9 Gene

Post-translational modifications for THAP9 Gene

No Post-translational modifications

No data available for DME Specific Peptides for THAP9 Gene

Domains & Families for THAP9 Gene

Gene Families for THAP9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for THAP9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THAP9: view

No data available for UniProtKB/Swiss-Prot for THAP9 Gene

Function for THAP9 Gene

Molecular function for THAP9 Gene

UniProtKB/Swiss-Prot Function:
Active transposase that specifically recognizes the bipartite 5-TXXGGGX(A/T)-3 consensus motif and mediates transposition.

Enzyme Numbers (IUBMB) for THAP9 Gene

Phenotypes From GWAS Catalog for THAP9 Gene

Gene Ontology (GO) - Molecular Function for THAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004803 transposase activity IDA 23349291
GO:0016740 transferase activity IEA --
GO:0043565 sequence-specific DNA binding IDA 20010837
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP9: view

Phenotypes for THAP9 Gene

genes like me logo Genes that share phenotypes with THAP9: view

Animal Model Products

CRISPR Products

miRNA for THAP9 Gene

miRTarBase miRNAs that target THAP9

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP9 Gene

Localization for THAP9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP9 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THAP9 Gene

Pathways & Interactions for THAP9 Gene

SuperPathways for THAP9 Gene

No Data Available

Interacting Proteins for THAP9 Gene

Gene Ontology (GO) - Biological Process for THAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination IEA,IDA 23349291
GO:0006313 transposition, DNA-mediated IDA 23349291
GO:0015074 DNA integration IDA,IEA 23349291
genes like me logo Genes that share ontologies with THAP9: view

No data available for Pathways by source and SIGNOR curated interactions for THAP9 Gene

Drugs & Compounds for THAP9 Gene

No Compound Related Data Available

Transcripts for THAP9 Gene

Unigene Clusters for THAP9 Gene

THAP domain containing 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP9 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2:
SP3: - -
SP4: - - -
SP5:
SP6: - - -

Relevant External Links for THAP9 Gene

GeneLoc Exon Structure for
THAP9
ECgene alternative splicing isoforms for
THAP9

Expression for THAP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THAP9 Gene

NURSA nuclear receptor signaling pathways regulating expression of THAP9 Gene:

THAP9

SOURCE GeneReport for Unigene cluster for THAP9 Gene:

Hs.582050

Evidence on tissue expression from TISSUES for THAP9 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with THAP9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP9 Gene

Orthologs for THAP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP9 33 34
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia THAP9 33 34
  • 90.47 (n)
cow
(Bos Taurus)
Mammalia THAP9 33 34
  • 88.03 (n)
chicken
(Gallus gallus)
Aves THAP9 33 34
  • 54.22 (n)
lizard
(Anolis carolinensis)
Reptilia THAP9 34
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493283 33
  • 40.92 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101883007 33
  • 45.57 (n)
THAP9 (1 of 3) 34
  • 28 (a)
OneToMany
THAP9 (2 of 3) 34
  • 28 (a)
OneToMany
THAP9 (3 of 3) 34
  • 27 (a)
OneToMany
Species where no ortholog for THAP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP9 Gene

ENSEMBL:
Gene Tree for THAP9 (if available)
TreeFam:
Gene Tree for THAP9 (if available)

Paralogs for THAP9 Gene

Paralogs for THAP9 Gene

(2) SIMAP similar genes for THAP9 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with THAP9: view

Variants for THAP9 Gene

Sequence variations from dbSNP and Humsavar for THAP9 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000019032 -- 82,900,290(+) T/C upstream_transcript_variant
rs1000154176 -- 82,899,867(+) A/C upstream_transcript_variant
rs1000224887 -- 82,919,785(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000554053 -- 82,912,486(+) A/G intron_variant, non_coding_transcript_variant
rs1000859753 -- 82,908,996(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for THAP9 Gene

Variant ID Type Subtype PubMed ID
esv3425333 CNV duplication 20981092

Variation tolerance for THAP9 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.20; 84.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THAP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP9 Gene

Disorders for THAP9 Gene

Additional Disease Information for THAP9

No disorders were found for THAP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP9 Gene

Publications for THAP9 Gene

  1. The human THAP9 gene encodes an active P-element DNA transposase. (PMID: 23349291) Majumdar S … Rio DC (Science (New York, N.Y.) 2013) 3 4 58
  2. THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves. (PMID: 20010837) Sabogal A … Rio DC (Nature structural & molecular biology 2010) 3 4 58
  3. Homologs of Drosophila P transposons were mobile in zebrafish but have been domesticated in a common ancestor of chicken and human. (PMID: 15616143) Hammer SE … Hagemann S (Molecular biology and evolution 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M … Girard JP (Trends in biochemical sciences 2003) 2 3 58

Products for THAP9 Gene

Sources for THAP9 Gene

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