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Aliases for THAP7 Gene

Aliases for THAP7 Gene

  • THAP Domain Containing 7 2 3 5

External Ids for THAP7 Gene

Previous GeneCards Identifiers for THAP7 Gene

  • GC22M019678
  • GC22M021353
  • GC22M004622

Summaries for THAP7 Gene

GeneCards Summary for THAP7 Gene

THAP7 (THAP Domain Containing 7) is a Protein Coding gene. Diseases associated with THAP7 include Exstrophy Of Bladder. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and C2H2 zinc finger domain binding.

UniProtKB/Swiss-Prot for THAP7 Gene

  • Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.

Gene Wiki entry for THAP7 Gene

Additional gene information for THAP7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP7 Gene

Genomics for THAP7 Gene

GeneHancer (GH) Regulatory Elements for THAP7 Gene

Promoters and enhancers for THAP7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I021000 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 113 4.5 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 THAP7-AS1 THAP7 PIR35374 GC22M021007 GC22M021006 LZTR1 RANBP1 ABHD17AP4 P2RX6 PIR41411
GH22I020494 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 42 +506.4 506353 2.7 CLOCK FEZF1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 MED15 KLHL22 LOC101928824 LZTR1 DGCR8 RPL7AP70 TRMT2A RPL8P5 LOC100420177 THAP7
GH22I020978 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 26.9 +20.6 20632 5.3 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 LZTR1 ENSG00000272829 THAP7-AS1 LOC100420177 PI4KAP2 THAP7 TRMT2A ZDHHC8 ABHD17AP4 ENSG00000273342
GH22I021936 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.3 -942.6 -942551 17.5 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 PPM1F ENSG00000224086 TOP3BP1 TOP3B LZTR1 IGLV5-52 PPIL2 ENSG00000234630 ENSG00000272779 THAP7
GH22I020961 Enhancer 1.2 Ensembl ENCODE 43.1 +40.2 40209 0.9 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A YBX1 ZNF280A ZNF213 E2F8 DGCR8 LZTR1 THAP7 PPIL2 TRMT2A THAP7-AS1 ZDHHC8 CCDC116 LOC100420177 PI4KAP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THAP7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THAP7 gene promoter:

Genomic Locations for THAP7 Gene

Genomic Locations for THAP7 Gene
3,093 bases
Minus strand

Genomic View for THAP7 Gene

Genes around THAP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP7 Gene

Proteins for THAP7 Gene

  • Protein details for THAP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    THAP domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • B2RD97
    • D3DX40

    Protein attributes for THAP7 Gene

    309 amino acids
    Molecular mass:
    34414 Da
    Quaternary structure:
    • Interacts with HDAC3 and nuclear hormone receptor corepressors.

neXtProt entry for THAP7 Gene

Post-translational modifications for THAP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP7 Gene

Domains & Families for THAP7 Gene

Gene Families for THAP7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for THAP7 Gene


Suggested Antigen Peptide Sequences for THAP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THAP7: view

No data available for UniProtKB/Swiss-Prot for THAP7 Gene

Function for THAP7 Gene

Molecular function for THAP7 Gene

UniProtKB/Swiss-Prot Function:
Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.

Phenotypes From GWAS Catalog for THAP7 Gene

Gene Ontology (GO) - Molecular Function for THAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
GO:0047485 protein N-terminus binding IPI 17577209
genes like me logo Genes that share ontologies with THAP7: view
genes like me logo Genes that share phenotypes with THAP7: view

Animal Model Products

CRISPR Products

miRNA for THAP7 Gene

miRTarBase miRNAs that target THAP7

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP7 Gene

Localization for THAP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THAP7 Gene

Nucleus. Chromosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP7 gene
Compartment Confidence
nucleus 5
extracellular 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005694 chromosome IEA --
GO:0016607 nuclear speck IDA 17577209
GO:0031965 nuclear membrane IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with THAP7: view

Pathways & Interactions for THAP7 Gene

SuperPathways for THAP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 17577209
genes like me logo Genes that share ontologies with THAP7: view

No data available for Pathways by source and SIGNOR curated interactions for THAP7 Gene

Drugs & Compounds for THAP7 Gene

No Compound Related Data Available

Transcripts for THAP7 Gene

Unigene Clusters for THAP7 Gene

THAP domain containing 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: -
SP8: - -
SP9: - - - - - - -

Relevant External Links for THAP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THAP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THAP7 Gene

Protein differential expression in normal tissues from HIPED for THAP7 Gene

This gene is overexpressed in Adipocyte (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THAP7 Gene

Protein tissue co-expression partners for THAP7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THAP7 Gene:


SOURCE GeneReport for Unigene cluster for THAP7 Gene:


Evidence on tissue expression from TISSUES for THAP7 Gene

  • Liver(4.1)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with THAP7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP7 Gene

Orthologs for THAP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia THAP7 33 34
  • 99.35 (n)
(Canis familiaris)
Mammalia THAP7 33 34
  • 91.05 (n)
(Bos Taurus)
Mammalia THAP7 33 34
  • 90.26 (n)
(Mus musculus)
Mammalia Thap7 33 16 34
  • 89 (n)
(Rattus norvegicus)
Mammalia Thap7 33
  • 87.92 (n)
(Gallus gallus)
Aves THAP7 33 34
  • 64.82 (n)
(Anolis carolinensis)
Reptilia THAP7 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia thap7 33
  • 56.66 (n)
Str.10237 33
(Danio rerio)
Actinopterygii thap7 33 34
  • 48.91 (n)
Species where no ortholog for THAP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP7 Gene

Gene Tree for THAP7 (if available)
Gene Tree for THAP7 (if available)

Paralogs for THAP7 Gene

No data available for Paralogs for THAP7 Gene

Variants for THAP7 Gene

Sequence variations from dbSNP and Humsavar for THAP7 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000361993 -- 21,001,756(-) C/T intron_variant
rs1000682653 -- 21,000,487(-) C/A intron_variant
rs1001657904 -- 21,002,246(-) C/G upstream_transcript_variant
rs1002270665 -- 21,003,831(-) G/T upstream_transcript_variant
rs1002352034 -- 20,999,389(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for THAP7 Gene

Variant ID Type Subtype PubMed ID
dgv4483n100 CNV gain 25217958
dgv7993n54 CNV gain 21841781
dgv7994n54 CNV gain 21841781
esv2678175 CNV deletion 23128226
esv2763693 CNV gain 21179565
esv3647304 CNV loss 21293372
esv3647305 CNV gain 21293372
esv3893441 CNV gain+loss 25118596
nsv1056614 CNV loss 25217958
nsv1062280 CNV gain 25217958
nsv1065617 CNV gain 25217958
nsv436864 CNV insertion 17901297
nsv471185 CNV loss 18288195
nsv482071 CNV gain 20164927
nsv523162 CNV loss 19592680
nsv588305 CNV loss 21841781
nsv588306 CNV gain 21841781
nsv828960 CNV loss 20364138
nsv828961 CNV gain 20364138
nsv834141 CNV loss 17160897
nsv834142 CNV gain 17160897

Variation tolerance for THAP7 Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THAP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP7 Gene

Disorders for THAP7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for THAP7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
exstrophy of bladder
  • bladder exstrophy
- elite association - COSMIC cancer census association via MalaCards
Search THAP7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for THAP7

genes like me logo Genes that share disorders with THAP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THAP7 Gene

Publications for THAP7 Gene

  1. Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription. (PMID: 16195249) Macfarlan T … Chakravarti D (Molecular endocrinology (Baltimore, Md.) 2006) 3 22 58
  2. Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor. (PMID: 15561719) Macfarlan T … Chakravarti D (The Journal of biological chemistry 2005) 3 4 58
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M … Girard JP (Trends in biochemical sciences 2003) 2 3 58

Products for THAP7 Gene

Sources for THAP7 Gene

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