Aliases for THAP7 Gene

Aliases for THAP7 Gene

  • THAP Domain Containing 7 2 3 5
  • THAP Domain-Containing Protein 7 3 4

External Ids for THAP7 Gene

Previous GeneCards Identifiers for THAP7 Gene

  • GC22M019678
  • GC22M021353
  • GC22M004622

Summaries for THAP7 Gene

GeneCards Summary for THAP7 Gene

THAP7 (THAP Domain Containing 7) is a Protein Coding gene. Diseases associated with THAP7 include Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex and Exstrophy Of Bladder. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and C2H2 zinc finger domain binding. An important paralog of this gene is THAP2.

UniProtKB/Swiss-Prot Summary for THAP7 Gene

  • Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.

Gene Wiki entry for THAP7 Gene

Additional gene information for THAP7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THAP7 Gene

Genomics for THAP7 Gene

GeneHancer (GH) Regulatory Elements for THAP7 Gene

Promoters and enhancers for THAP7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around THAP7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for THAP7

Top Transcription factor binding sites by QIAGEN in the THAP7 gene promoter:
  • c-Ets-1
  • CUTL1
  • Lmo2
  • MIF-1
  • MyoD
  • Olf-1
  • p53
  • Pax-2
  • Pax-2a
  • Pax-2b

Genomic Locations for THAP7 Gene

Genomic Locations for THAP7 Gene
chr22:20,999,104-21,002,196
(GRCh38/hg38)
Size:
3,093 bases
Orientation:
Minus strand
chr22:21,353,393-21,356,485
(GRCh37/hg19)
Size:
3,093 bases
Orientation:
Minus strand

Genomic View for THAP7 Gene

Genes around THAP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP7 Gene

Proteins for THAP7 Gene

  • Protein details for THAP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT49-THAP7_HUMAN
    Recommended name:
    THAP domain-containing protein 7
    Protein Accession:
    Q9BT49
    Secondary Accessions:
    • B2RD97
    • D3DX40

    Protein attributes for THAP7 Gene

    Size:
    309 amino acids
    Molecular mass:
    34414 Da
    Quaternary structure:
    • Interacts with HDAC3 and nuclear hormone receptor corepressors.

neXtProt entry for THAP7 Gene

Post-translational modifications for THAP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP7 Gene

Domains & Families for THAP7 Gene

Gene Families for THAP7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for THAP7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP7 Gene

GenScript: Design optimal peptide antigens:
  • THAP domain-containing protein 7 (THAP7_HUMAN)
genes like me logo Genes that share domains with THAP7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for THAP7 Gene

Function for THAP7 Gene

Molecular function for THAP7 Gene

UniProtKB/Swiss-Prot Function:
Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.

Phenotypes From GWAS Catalog for THAP7 Gene

Gene Ontology (GO) - Molecular Function for THAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with THAP7: view
genes like me logo Genes that share phenotypes with THAP7: view

Animal Model Products

CRISPR Products

miRNA for THAP7 Gene

miRTarBase miRNAs that target THAP7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THAP7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP7 Gene

Localization for THAP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THAP7 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP7 gene
Compartment Confidence
nucleus 5
extracellular 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0016607 nuclear speck IDA 17577209
genes like me logo Genes that share ontologies with THAP7: view

Pathways & Interactions for THAP7 Gene

PathCards logo

SuperPathways for THAP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 17577209
genes like me logo Genes that share ontologies with THAP7: view

No data available for Pathways by source and SIGNOR curated interactions for THAP7 Gene

Drugs & Compounds for THAP7 Gene

No Compound Related Data Available

Transcripts for THAP7 Gene

mRNA/cDNA for THAP7 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THAP7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: -
SP8: - -
SP9: - - - - - - -
SP10:

Relevant External Links for THAP7 Gene

GeneLoc Exon Structure for
THAP7

Expression for THAP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THAP7 Gene

Protein differential expression in normal tissues from HIPED for THAP7 Gene

This gene is overexpressed in Adipocyte (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for THAP7 Gene



Protein tissue co-expression partners for THAP7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for THAP7

SOURCE GeneReport for Unigene cluster for THAP7 Gene:

Hs.512756

Evidence on tissue expression from TISSUES for THAP7 Gene

  • Liver(4.1)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with THAP7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP7 Gene

Orthologs for THAP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP7 31 30
  • 99.35 (n)
OneToOne
dog
(Canis familiaris)
Mammalia THAP7 31 30
  • 91.05 (n)
OneToOne
cow
(Bos Taurus)
Mammalia THAP7 31 30
  • 90.26 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Thap7 17 31 30
  • 89 (n)
rat
(Rattus norvegicus)
Mammalia Thap7 30
  • 87.92 (n)
chicken
(Gallus gallus)
Aves THAP7 31 30
  • 64.82 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THAP7 31
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thap7 30
  • 56.66 (n)
Str.10237 30
zebrafish
(Danio rerio)
Actinopterygii thap7 31 30
  • 48.91 (n)
OneToOne
Species where no ortholog for THAP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP7 Gene

ENSEMBL:
Gene Tree for THAP7 (if available)
TreeFam:
Gene Tree for THAP7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for THAP7: view image

Paralogs for THAP7 Gene

genes like me logo Genes that share paralogs with THAP7: view

Variants for THAP7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for THAP7 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs426938 - p.Ala115Pro

Additional dbSNP identifiers (rs#s) for THAP7 Gene

Structural Variations from Database of Genomic Variants (DGV) for THAP7 Gene

Variant ID Type Subtype PubMed ID
dgv4483n100 CNV gain 25217958
dgv7993n54 CNV gain 21841781
dgv7994n54 CNV gain 21841781
esv2678175 CNV deletion 23128226
esv2763693 CNV gain 21179565
esv3647304 CNV loss 21293372
esv3647305 CNV gain 21293372
esv3893441 CNV gain+loss 25118596
nsv1056614 CNV loss 25217958
nsv1062280 CNV gain 25217958
nsv1065617 CNV gain 25217958
nsv436864 CNV insertion 17901297
nsv471185 CNV loss 18288195
nsv482071 CNV gain 20164927
nsv523162 CNV loss 19592680
nsv588305 CNV loss 21841781
nsv588306 CNV gain 21841781
nsv828960 CNV loss 20364138
nsv828961 CNV gain 20364138
nsv834141 CNV loss 17160897
nsv834142 CNV gain 17160897

Variation tolerance for THAP7 Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THAP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP7 Gene

Disorders for THAP7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for THAP7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bladder exstrophy-epispadias-cloacal exstrophy complex
  • eec
exstrophy of bladder
  • bladder exstrophy
brunner syndrome
  • brnrs
spasmodic dystonia
  • laryngeal dystonia
- elite association - COSMIC cancer census association via MalaCards
Search THAP7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for THAP7

genes like me logo Genes that share disorders with THAP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THAP7 Gene

Publications for THAP7 Gene

  1. Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription. (PMID: 16195249) Macfarlan T … Chakravarti D (Molecular endocrinology (Baltimore, Md.) 2006) 3 23 54
  2. Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor. (PMID: 15561719) Macfarlan T … Chakravarti D (The Journal of biological chemistry 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 54
  5. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M … Girard JP (Trends in biochemical sciences 2003) 2 3 54

Products for THAP7 Gene

Sources for THAP7 Gene