Aliases for THAP6 Gene

Aliases for THAP6 Gene

  • THAP Domain Containing 6 2 3 5
  • THAP Domain-Containing Protein 6 3 4

External Ids for THAP6 Gene

Previous GeneCards Identifiers for THAP6 Gene

  • GC04P076832
  • GC04P076898
  • GC04P076796
  • GC04P076658
  • GC04P076439
  • GC04P072186

Summaries for THAP6 Gene

GeneCards Summary for THAP6 Gene

THAP6 (THAP Domain Containing 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is THAP2.

Gene Wiki entry for THAP6 Gene

Additional gene information for THAP6 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THAP6 Gene

Genomics for THAP6 Gene

GeneHancer (GH) Regulatory Elements for THAP6 Gene

Promoters and enhancers for THAP6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J075511 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 512.8 +4.0 3961 4.9 FOXK2 ZBTB40 ZNF217 EP300 SIN3A NRF1 USF1 POLR2G SP1 PHF8 RCHY1 THAP6 lnc-RCHY1-5 NUP54 SDAD1
GH04J075512 Promoter 0.4 Ensembl 500.7 +1.2 1241 0.2 FOS THAP6 RCHY1 lnc-RCHY1-5
GH04J075722 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.5 +215.2 215231 5.8 ZBTB40 EP300 CTCF NRF1 MYC POLR2G USF1 SP1 NCOR1 GTF2E2 USO1 G3BP2 RF00017-4332 lnc-G3BP2-1 NUP54 THAP6 SDAD1 CDKL2 PARM1-AS1 ODAPH
GH04J076146 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 12.5 +638.0 638041 4.2 RXRA EP300 ZBTB40 ZNF217 SIN3A NRF1 TCF12 POLR2G SP1 GTF2E2 NUP54 ENSG00000286074 lnc-SCARB2-2 ART3 THAP6 RPL7P17 SCARB2 lnc-SCARB2-4
GH04J075847 Enhancer 0.5 ENCODE 21.2 +337.8 337763 0.2 ZNF426 ZNF781 ZNF433 ZNF518A ZBTB8A ZNF101 ZNF394 THAP6 SDAD1 NUP54 ENSG00000229717 PPEF2 RCHY1 piR-37097-076 RF00004-088 RNU2-16P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around THAP6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for THAP6

Top Transcription factor binding sites by QIAGEN in the THAP6 gene promoter:
  • LCR-F1
  • NF-1
  • NF-1/L

Genomic Locations for THAP6 Gene

Genomic Locations for THAP6 Gene
chr4:75,509,860-75,550,473
(GRCh38/hg38)
Size:
40,614 bases
Orientation:
Plus strand
chr4:76,439,156-76,475,683
(GRCh37/hg19)
Size:
36,528 bases
Orientation:
Plus strand

Genomic View for THAP6 Gene

Genes around THAP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP6 Gene

Proteins for THAP6 Gene

  • Protein details for THAP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBB0-THAP6_HUMAN
    Recommended name:
    THAP domain-containing protein 6
    Protein Accession:
    Q8TBB0
    Secondary Accessions:
    • B4E146
    • Q5HYJ7
    • Q5JPC6

    Protein attributes for THAP6 Gene

    Size:
    222 amino acids
    Molecular mass:
    25691 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for THAP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THAP6 Gene

Post-translational modifications for THAP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for THAP6 Gene

Domains & Families for THAP6 Gene

Gene Families for THAP6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for THAP6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP6 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52043, highly similar to THAP domain-containing protein 6 (B4E146_HUMAN)
  • THAP domain-containing protein 6 (THAP6_HUMAN)
genes like me logo Genes that share domains with THAP6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for THAP6 Gene

Function for THAP6 Gene

Phenotypes From GWAS Catalog for THAP6 Gene

Gene Ontology (GO) - Molecular Function for THAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP6: view
genes like me logo Genes that share phenotypes with THAP6: view

Animal Model Products

CRISPR Products

miRNA for THAP6 Gene

miRTarBase miRNAs that target THAP6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP6 Gene

Localization for THAP6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP6 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with THAP6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THAP6 Gene

Pathways & Interactions for THAP6 Gene

PathCards logo

SuperPathways for THAP6 Gene

No Data Available

Interacting Proteins for THAP6 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q8TBB0-THAP6_HUMAN ENSP00000309007 for THAP6 Gene via UniProtKB STRING IID

;

Gene Ontology (GO) - Biological Process for THAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with THAP6: view

No data available for Pathways by source and SIGNOR curated interactions for THAP6 Gene

Drugs & Compounds for THAP6 Gene

No Compound Related Data Available

Transcripts for THAP6 Gene

mRNA/cDNA for THAP6 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: -
SP3: - - -
SP4:
SP5: - - - -
SP6: - -

Relevant External Links for THAP6 Gene

GeneLoc Exon Structure for
THAP6

Expression for THAP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THAP6 Gene

Protein differential expression in normal tissues from HIPED for THAP6 Gene

This gene is overexpressed in Heart (57.5) and Monocytes (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for THAP6 Gene



Protein tissue co-expression partners for THAP6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for THAP6

SOURCE GeneReport for Unigene cluster for THAP6 Gene:

Hs.479971

Evidence on tissue expression from TISSUES for THAP6 Gene

  • Heart(4.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with THAP6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP6 Gene

Orthologs for THAP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP6 31 30
  • 99.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia THAP6 31 30
  • 92.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia THAP6 31 30
  • 92.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thap6 30
  • 89.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THAP6 31
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii THAP6 (2 of 2) 31
  • 23 (a)
OneToMany
CU655961.1 31
  • 19 (a)
OneToMany
Species where no ortholog for THAP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP6 Gene

ENSEMBL:
Gene Tree for THAP6 (if available)
TreeFam:
Gene Tree for THAP6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for THAP6: view image

Paralogs for THAP6 Gene

(2) SIMAP similar genes for THAP6 Gene using alignment to 9 proteins:

  • THAP6_HUMAN
  • B4E146_HUMAN
  • D6RBC3_HUMAN
  • D6RC19_HUMAN
  • D6REL7_HUMAN
  • D6REQ5_HUMAN
  • D6RF27_HUMAN
  • D6RFK7_HUMAN
  • D6RJG2_HUMAN
genes like me logo Genes that share paralogs with THAP6: view

Variants for THAP6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for THAP6 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
775069 Benign: not provided 75,514,275(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for THAP6 Gene

Structural Variations from Database of Genomic Variants (DGV) for THAP6 Gene

Variant ID Type Subtype PubMed ID
esv3601031 CNV loss 21293372
nsv594687 CNV loss 21841781
nsv7363 OTHER inversion 18451855

Variation tolerance for THAP6 Gene

Residual Variation Intolerance Score: 86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THAP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP6 Gene

Disorders for THAP6 Gene

Additional Disease Information for THAP6

No disorders were found for THAP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP6 Gene

Publications for THAP6 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M … Girard JP (Trends in biochemical sciences 2003) 2 3 54
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 54

Products for THAP6 Gene

Sources for THAP6 Gene