Free for academic non-profit institutions. Other users need a Commercial license

Aliases for THAP5 Gene

Aliases for THAP5 Gene

  • THAP Domain Containing 5 2 3 5

External Ids for THAP5 Gene

Previous GeneCards Identifiers for THAP5 Gene

  • GC07M107718
  • GC07M107763
  • GC07M107796
  • GC07M107990
  • GC07M108194
  • GC07M102571

Summaries for THAP5 Gene

GeneCards Summary for THAP5 Gene

THAP5 (THAP Domain Containing 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protease binding. An important paralog of this gene is THAP4.

UniProtKB/Swiss-Prot for THAP5 Gene

  • Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560).

Additional gene information for THAP5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP5 Gene

Genomics for THAP5 Gene

GeneHancer (GH) Regulatory Elements for THAP5 Gene

Promoters and enhancers for THAP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I108567 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 576.5 -0.1 -69 4.5 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC THAP5 PNPLA8 DNAJB9 ENSG00000272854 CBLL1 LOC105375448
GH07I108523 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 34.8 +43.9 43856 5.4 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 PNPLA8 THAP5 ENSG00000272854 DNAJB9 ENSG00000273055 RPL7P32 GC07M108510 GC07P108537
GH07I108453 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.5 +114.3 114272 3.2 SIN3A FEZF1 ZNF2 GLIS2 ZNF548 KLF13 SP3 REST ZNF610 GLIS1 NRCAM THAP5 ENSG00000273055 LAMB1 RPL7P32 GC07M108348
GH07I107890 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 +678.2 678205 2.8 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 DLD CBLL1 THAP5 ENSG00000273055 GC07M107805
GH07I108550 Enhancer 0.6 dbSUPER 36.3 +16.7 16713 5.1 NFRKB EBF1 DPF2 IRF4 IKZF1 NBN ZNF24 IKZF2 SPI1 THAP5 PNPLA8 GC07P108537 DNAJB9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THAP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THAP5 gene promoter:

Genomic Locations for THAP5 Gene

Genomic Locations for THAP5 Gene
chr7:108,554,543-108,569,768
(GRCh38/hg38)
Size:
15,226 bases
Orientation:
Minus strand
chr7:108,194,987-108,210,194
(GRCh37/hg19)

Genomic View for THAP5 Gene

Genes around THAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP5 Gene

Proteins for THAP5 Gene

  • Protein details for THAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6K1-THAP5_HUMAN
    Recommended name:
    THAP domain-containing protein 5
    Protein Accession:
    Q7Z6K1

    Protein attributes for THAP5 Gene

    Size:
    395 amino acids
    Molecular mass:
    45416 Da
    Quaternary structure:
    • Interacts with HTRA2; under apoptotic conditions (PubMed:19502560). Interacts with ABRAXAS2 (PubMed:21195082).
    SequenceCaution:
    • Sequence=AAH53634.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL24383.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for THAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THAP5 Gene

Post-translational modifications for THAP5 Gene

Other Protein References for THAP5 Gene

No data available for DME Specific Peptides for THAP5 Gene

Domains & Families for THAP5 Gene

Gene Families for THAP5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for THAP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THAP5: view

No data available for UniProtKB/Swiss-Prot for THAP5 Gene

Function for THAP5 Gene

Molecular function for THAP5 Gene

UniProtKB/Swiss-Prot Function:
Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560).
UniProtKB/Swiss-Prot Induction:
Up-regulated both in response to UV light treatment and cisplatin, agents that cause DNA damage (at protein level).

Gene Ontology (GO) - Molecular Function for THAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 19502560
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP5: view

Phenotypes for THAP5 Gene

genes like me logo Genes that share phenotypes with THAP5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP5 Gene

Localization for THAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THAP5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP5 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for THAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 19502560
genes like me logo Genes that share ontologies with THAP5: view

Pathways & Interactions for THAP5 Gene

SuperPathways for THAP5 Gene

No Data Available

Interacting Proteins for THAP5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000400500%0d%0a9606.ENSP00000298492%0d%0a
Selected Interacting proteins: Q7Z6K1-THAP5_HUMAN ENSP00000400500 for THAP5 Gene via IID STRING MINT

Gene Ontology (GO) - Biological Process for THAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0045786 negative regulation of cell cycle IMP 19502560
genes like me logo Genes that share ontologies with THAP5: view

No data available for Pathways by source and SIGNOR curated interactions for THAP5 Gene

Drugs & Compounds for THAP5 Gene

No Compound Related Data Available

Transcripts for THAP5 Gene

Unigene Clusters for THAP5 Gene

THAP domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for THAP5 Gene

GeneLoc Exon Structure for
THAP5
ECgene alternative splicing isoforms for
THAP5

Expression for THAP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THAP5 Gene

Protein differential expression in normal tissues from HIPED for THAP5 Gene

This gene is overexpressed in Ovary (36.5), NK cells (17.5), and Pancreas (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THAP5 Gene



Protein tissue co-expression partners for THAP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of THAP5 Gene:

THAP5

SOURCE GeneReport for Unigene cluster for THAP5 Gene:

Hs.707689

mRNA Expression by UniProt/SwissProt for THAP5 Gene:

Q7Z6K1-THAP5_HUMAN
Tissue specificity: Detected in heart (PubMed:19502560, PubMed:21195082). Detected in brain and muscle (at protein level) (PubMed:19502560). Highly expressed in the heart. Also found in brain and skeletal muscle (PubMed:19502560, PubMed:21195082).

Evidence on tissue expression from TISSUES for THAP5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with THAP5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP5 Gene

Orthologs for THAP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP5 33 34
  • 99.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THAP5 34
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THAP5 33 34
  • 89.17 (n)
cow
(Bos Taurus)
Mammalia THAP5 33 34
  • 87.41 (n)
oppossum
(Monodelphis domestica)
Mammalia THAP5 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves THAP5 33 34
  • 62.52 (n)
lizard
(Anolis carolinensis)
Reptilia THAP5 34
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thap5 33
  • 51.83 (n)
Species where no ortholog for THAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THAP5 Gene

ENSEMBL:
Gene Tree for THAP5 (if available)
TreeFam:
Gene Tree for THAP5 (if available)

Paralogs for THAP5 Gene

Paralogs for THAP5 Gene

(3) SIMAP similar genes for THAP5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for THAP5 Gene

genes like me logo Genes that share paralogs with THAP5: view

Variants for THAP5 Gene

Sequence variations from dbSNP and Humsavar for THAP5 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000153138 -- 108,566,102(-) A/G intron_variant
rs1000484289 -- 108,565,858(-) G/T coding_sequence_variant, intron_variant, missense_variant
rs1001085553 -- 108,567,434(-) G/C intron_variant
rs1001283581 -- 108,568,753(-) G/T intron_variant
rs1001374272 -- 108,571,118(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for THAP5 Gene

Variant ID Type Subtype PubMed ID
nsv970570 CNV duplication 23825009
esv3572052 CNV loss 25503493

Variation tolerance for THAP5 Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THAP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP5 Gene

Disorders for THAP5 Gene

Additional Disease Information for THAP5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for THAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP5 Gene

Publications for THAP5 Gene

  1. THAP5 is a DNA-binding transcriptional repressor that is regulated in melanoma cells during DNA damage-induced cell death. (PMID: 21110952) Balakrishnan MP … Zervos AS (Biochemical and biophysical research communications 2011) 3 4 58
  2. Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination. (PMID: 21195082) Cilenti L … Zervos AS (Journal of molecular and cellular cardiology 2011) 3 4 58
  3. THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death. (PMID: 19502560) Balakrishnan MP … Zervos AS (American journal of physiology. Heart and circulatory physiology 2009) 3 4 58
  4. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M … Girard JP (Trends in biochemical sciences 2003) 2 3 58
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58

Products for THAP5 Gene

Sources for THAP5 Gene

Content
Loading form....