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Aliases for THAP4 Gene

Aliases for THAP4 Gene

  • THAP Domain Containing 4 2 3 5
  • THAP Domain-Containing Protein 4 3
  • CGI-36 3
  • PP238 3

External Ids for THAP4 Gene

Previous GeneCards Identifiers for THAP4 Gene

  • GC02M242543
  • GC02M242844
  • GC02M242243
  • GC02M234277

Summaries for THAP4 Gene

GeneCards Summary for THAP4 Gene

THAP4 (THAP Domain Containing 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is THAP5.

Gene Wiki entry for THAP4 Gene

Additional gene information for THAP4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP4 Gene

Genomics for THAP4 Gene

GeneHancer (GH) Regulatory Elements for THAP4 Gene

Promoters and enhancers for THAP4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I241616 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 560.7 +18.5 18518 4.1 HDGF PKNOX1 ARNT GLI4 YY1 ETS1 ZNF143 FOS KLF13 SP3 THAP4 ING5 ENSG00000223374 SNED1 ENSG00000235351 MTERF4 FARP2 BOK D2HGDH DTYMK
GH02I241635 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.5 -0.1 -77 4 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 ZNF766 E2F8 ZNF207 ZNF143 ATG4B THAP4 BOK RNA5SP122 ING5 GC02M241661
GH02I241759 Enhancer 0.6 FANTOM5 1.3 -121.7 -121715 0.2 PKNOX1 GATA3 CREB1 CUX1 MAFK EMSY D2HGDH PDCD1 ATG4B THAP4 PIR37451 ENSG00000234793 GC02P241747
GH02I241641 Enhancer 0.9 Ensembl ENCODE 0.8 -4.5 -4476 0.8 SOX13 MXI1 SAP130 ARID4B KMT2B RAD21 THRB RARA NR2F6 GATAD2A D2HGDH ENSG00000234793 ING5 RNA5SP122 ENSG00000235351 THAP4 ATG4B GC02M241661
GH02I241609 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +27.3 27278 2.1 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 ZNF207 BOK ENSG00000223374 BOK-AS1 D2HGDH SNED1 ANO7 ENSG00000235351 RNA5SP122 ATG4B THAP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THAP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THAP4 gene promoter:

Genomic Locations for THAP4 Gene

Genomic Locations for THAP4 Gene
53,121 bases
Minus strand

Genomic View for THAP4 Gene

Genes around THAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP4 Gene

Proteins for THAP4 Gene

  • Protein details for THAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    THAP domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q53NU7
    • Q6GRN0
    • Q6IPJ3
    • Q9NW26
    • Q9Y325

    Protein attributes for THAP4 Gene

    577 amino acids
    Molecular mass:
    62890 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=AAH00247.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH09439.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91560.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for THAP4 Gene

    Alternative splice isoforms for THAP4 Gene


neXtProt entry for THAP4 Gene

Post-translational modifications for THAP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP4 Gene

No data available for DME Specific Peptides for THAP4 Gene

Domains & Families for THAP4 Gene

Gene Families for THAP4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for THAP4 Gene


Suggested Antigen Peptide Sequences for THAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THAP4: view

No data available for UniProtKB/Swiss-Prot for THAP4 Gene

Function for THAP4 Gene

Phenotypes From GWAS Catalog for THAP4 Gene

Gene Ontology (GO) - Molecular Function for THAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0020037 heme binding IMP 21387410
GO:0042803 protein homodimerization activity IMP 21387410
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP4: view
genes like me logo Genes that share phenotypes with THAP4: view

miRNA for THAP4 Gene

miRTarBase miRNAs that target THAP4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP4 Gene

Localization for THAP4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP4 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with THAP4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THAP4 Gene

Pathways & Interactions for THAP4 Gene

SuperPathways for THAP4 Gene

No Data Available

Interacting Proteins for THAP4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8WY91-THAP4_HUMAN ENSP00000385006 for THAP4 Gene via IID MINT STRING

Gene Ontology (GO) - Biological Process for THAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with THAP4: view

No data available for Pathways by source and SIGNOR curated interactions for THAP4 Gene

Drugs & Compounds for THAP4 Gene

No Compound Related Data Available

Transcripts for THAP4 Gene

Unigene Clusters for THAP4 Gene

THAP domain containing 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP4 Gene

No ASD Table

Relevant External Links for THAP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THAP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THAP4 Gene

Protein differential expression in normal tissues from HIPED for THAP4 Gene

This gene is overexpressed in Tonsil (17.8), Skin (11.7), Heart (11.4), Salivary gland (7.2), and Oral epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THAP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of THAP4 Gene:


SOURCE GeneReport for Unigene cluster for THAP4 Gene:


Evidence on tissue expression from TISSUES for THAP4 Gene

  • Nervous system(4.6)
  • Eye(4.2)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with THAP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP4 Gene

Orthologs for THAP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for THAP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia THAP4 33 34
  • 99.13 (n)
(Canis familiaris)
Mammalia THAP4 34
  • 86 (a)
(Mus musculus)
Mammalia Thap4 33 16 34
  • 84.39 (n)
(Rattus norvegicus)
Mammalia Thap4 33
  • 83.95 (n)
(Monodelphis domestica)
Mammalia THAP4 34
  • 83 (a)
(Bos Taurus)
Mammalia THAP4 33 34
  • 82.37 (n)
(Ornithorhynchus anatinus)
Mammalia THAP4 34
  • 71 (a)
(Gallus gallus)
Aves THAP4 34 33
  • 80.12 (n)
(Anolis carolinensis)
Reptilia THAP4 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia thap4 33
  • 60.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33974 33
(Danio rerio)
Actinopterygii thap4 34 33
  • 64.63 (n)
wufb76g01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6292 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003313 33
  • 55.84 (n)
(Caenorhabditis elegans)
Secernentea C52G5.2 34
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79260 33
  • 49.17 (n)
(Oryza sativa)
Liliopsida Os01g0679600 33
  • 52.81 (n)
Species where no ortholog for THAP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THAP4 Gene

Gene Tree for THAP4 (if available)
Gene Tree for THAP4 (if available)

Paralogs for THAP4 Gene

Paralogs for THAP4 Gene

genes like me logo Genes that share paralogs with THAP4: view

Variants for THAP4 Gene

Sequence variations from dbSNP and Humsavar for THAP4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000003762 -- 241,638,313(-) A/G upstream_transcript_variant
rs1000016200 -- 241,595,918(-) G/T intron_variant
rs1000061220 -- 241,595,663(-) A/G intron_variant
rs1000071605 -- 241,584,367(-) C/T downstream_transcript_variant
rs1000113830 -- 241,638,565(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for THAP4 Gene

Variant ID Type Subtype PubMed ID
dgv165e55 CNV loss 17911159
dgv2379e59 CNV duplication 20981092
esv1008655 CNV deletion 20482838
esv1033771 CNV insertion 17803354
esv21920 CNV gain 19812545
esv2662519 CNV deletion 23128226
esv2676442 CNV deletion 23128226
esv2722011 CNV deletion 23290073
esv2722012 CNV deletion 23290073
esv2722013 CNV deletion 23290073
esv3561312 CNV deletion 23714750
nsv1116839 CNV deletion 24896259
nsv1118902 CNV deletion 24896259
nsv1133496 CNV deletion 24896259
nsv508901 CNV insertion 20534489
nsv584970 CNV loss 21841781
nsv584974 CNV gain 21841781
nsv834588 CNV loss 17160897
nsv956705 CNV deletion 24416366

Variation tolerance for THAP4 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THAP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP4 Gene

Disorders for THAP4 Gene

Additional Disease Information for THAP4

No disorders were found for THAP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP4 Gene

Publications for THAP4 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. Structure of the C-terminal heme-binding domain of THAP domain containing protein 4 from Homo sapiens. (PMID: 21387410) Bianchetti CM … Phillips GN (Proteins 2011) 3 4 58
  3. Voxelwise genome-wide association study (vGWAS). (PMID: 20171287) Stein JL … Alzheimer's Disease Neuroimaging Initiative (NeuroImage 2010) 3 44 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for THAP4 Gene

Sources for THAP4 Gene

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