Aliases for THAP11 Gene
External Ids for THAP11 Gene
Previous GeneCards Identifiers for THAP11 Gene
The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]
GeneCards Summary for THAP11 Gene
THAP11 (THAP Domain Containing 11) is a Protein Coding gene. Diseases associated with THAP11 include Disorders Of Intracellular Cobalamin Metabolism and Methylmalonic Acidemia And Homocysteinemia, Cblx Type. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.
UniProtKB/Swiss-Prot Summary for THAP11 Gene
Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).