Aliases for THAP11 Gene
Aliases for THAP11 Gene
External Ids for THAP11 Gene
- HGNC: 23194
- Entrez Gene: 57215
- Ensembl: ENSG00000168286
- OMIM: 609119
- UniProtKB: Q96EK4
Previous GeneCards Identifiers for THAP11 Gene
- GC16U900023
- GC16P067652
- GC16P066433
- GC16P067876
- GC16P053749
Summaries for THAP11 Gene
-
The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]
GeneCards Summary for THAP11 Gene
THAP11 (THAP Domain Containing 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.
UniProtKB/Swiss-Prot for THAP11 Gene
-
Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).
Additional gene information for THAP11 Gene
- Monarch Initiative
- Search for THAP11 at DataMed
- Search for THAP11 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP11 Gene
Genomics for THAP11 Gene
GeneHancer (GH) Regulatory Elements for THAP11 Gene
Promoters and enhancers for THAP11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around THAP11 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the THAP11 gene promoter:
-
- GATA-2
- MyoD
- ATF-2
- CRE-BP1
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- Egr-4
Regulatory Element Products
Genomic Locations for THAP11 Gene
Genomic Locations for THAP11 Gene
- chr16:67,842,082-67,844,195
- (GRCh38/hg38)
- Size:
- 2,114 bases
- Orientation:
- Plus strand
- chr16:67,876,213-67,878,098
- (GRCh37/hg19)
- Size:
- 1,886 bases
- Orientation:
- Plus strand
Genomic View for THAP11 Gene
Genes around THAP11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.1 by Entrez Gene
- 16q22.1 by HGNC
- 16q22.1 by Ensembl
THAP11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for THAP11 Gene
Proteins for THAP11 Gene
-
Protein details for THAP11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96EK4-THA11_HUMAN
- Recommended name:
- THAP domain-containing protein 11
- Protein Accession:
- Q96EK4
- A4UCT5
- A8K002
- O94795
Protein attributes for THAP11 Gene
- Size:
- 314 amino acids
- Molecular mass:
- 34455 Da
- Quaternary structure:
-
- Interacts (via coiled coil domain) with HCFC1.
Protein Expression for THAP11 Gene
Post-translational modifications for THAP11 Gene
Other Protein References for THAP11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for THAP11 (THAP11)
-
Custom Antibody ServicesOriGene Antibodies for THAP11
- Novus Biologicals Antibodies for THAP11
-
Abcam antibodies for THAP11
- Invitrogen Antibodies for THAP11 (AFLGC-THAP11)
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-
Custom Antibody ServicesProSci Antibodies for THAP11
-
Santa Cruz Biotechnology (SCBT) Antibodies for THAP11
Protein Products
-
OriGene Purified Proteins for THAP11
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- ProSpec Recombinant Proteins for THAP11
- Search GeneTex for Proteins for THAP11
-
Abcam proteins for THAP11
Assay Products
No data available for DME Specific Peptides for THAP11 Gene
Domains & Families for THAP11 Gene
Gene Families for THAP11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for THAP11 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for THAP11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96EK4- Family:
-
- Belongs to the THAP11 family.
Function for THAP11 Gene
Molecular function for THAP11 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).
Phenotypes From GWAS Catalog for THAP11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 19008924 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISM | 19274049 |
| GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 19008924 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA,IDA | 23306615 |
Phenotypes for THAP11 Gene
- MGI mutant phenotypes for THAP11:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for THAP11:
Animal Models for THAP11 Gene
- MGI Knock Outs for THAP11:
-
- Thap11 Thap11<tm1.1Tpz>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for THAP11
-
CRISPR Products
-
OriGene CRISPR knockouts for THAP11
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- Overview of 108 available THAP11 gene related products
- Applied Biological Materials CRISPR for THAP11
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for THAP11
- GenScript: Design CRISPR guide RNA sequences for THAP11
Targeted motifs for THAP11 Gene
HOMER Transcription Factor Regulatory Elements motif THAP11
- Consensus sequence: RACTACAACTCCCAGVAKGC Submotif: canonical Cell Type: ES GEO ID: GSE51522
miRNA Products
Inhibitory RNA Products
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- Overview of 108 available THAP11 gene related products
Clone Products
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- Applied Biological Materials Clones for THAP11
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for THAP11
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA and Transcription Factor Targets for THAP11 Gene
Localization for THAP11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for THAP11 Gene
- Nucleus. Cytoplasm. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 3 |
- Cytokinetic bridge (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0045171 | intercellular bridge | IDA | -- |
Pathways & Interactions for THAP11 Gene
No Data Available
Interacting Proteins for THAP11 Gene
Selected Interacting proteins:
Q96EK4-THA11_HUMAN
ENSP00000304689
for THAP11 Gene via
UniProtKB
STRING
IID
MINT
GPS-Prot Interaction Network for THAP11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 19008924 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for THAP11 Gene
Transcripts for THAP11 Gene
mRNA/cDNA for THAP11 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (146) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000303596 2114 bps (uc002euo.4)
Unigene Clusters for THAP11 Gene
- THAP domain containing 11:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for THAP11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THAP11
- genomics-online: gRNA clones - Search results for 108 available THAP11 gene related products
- Overview of 108 available THAP11 gene related products
- Applied Biological Materials CRISPR for THAP11
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for THAP11
- GenScript: Design CRISPR guide RNA sequences for THAP11
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THAP11
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Clone Products
- GenScript: Custom all cDNA clones Services for THAP11
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- Applied Biological Materials Clones for THAP11
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for THAP11 Gene
This gene is overexpressed in Lung (49.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THAP11 Gene
NURSA nuclear receptor signaling pathways regulating expression of THAP11 Gene:
THAP11SOURCE GeneReport for Unigene cluster for THAP11 Gene:
Hs.632200Evidence on tissue expression from TISSUES for THAP11 Gene
- Nervous system(4.5)
- Lung(2.4)
Primer Products
-
OriGene qPCR primer pairs for THAP11
-
OriGene qPCR primer pairs and template standards for THAP11
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP11 Gene
Orthologs for THAP11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | THAP11 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Thap11 33 |
|
||
| cow (Bos Taurus) |
Mammalia | THAP11 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | THAP11 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Thap11 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | THAP11 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | THAP11 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | THAP11 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | thap11 34 33 |
|
OneToOne | |
| wufa14e04 33 |
|
- Species where no ortholog for THAP11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for THAP11 Gene
- ENSEMBL:
- Gene Tree for THAP11 (if available)
- TreeFam:
- Gene Tree for THAP11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for THAP11: view image
Paralogs for THAP11 Gene
No data available for Paralogs for THAP11 Gene
Variants for THAP11 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for THAP11 Gene
- THA11_HUMAN-Q96EK4
- The length of the poly-Gln region is variable in the population.
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs188675529 | likely-pathogenic, Mental retardation 3, X-linked | 67,842,794(+) | C/G/T | coding_sequence_variant, missense_variant, synonymous_variant | |
| rs1000978795 | -- | 67,842,871(+) | A/G | coding_sequence_variant, missense_variant | |
| rs1001019773 | -- | 67,842,406(+) | G/A | 5_prime_UTR_variant | |
| rs1002196565 | -- | 67,843,147(+) | C/T | coding_sequence_variant, missense_variant | |
| rs1002994345 | -- | 67,840,621(+) | G/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.30;
6.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for THAP11 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for THAP11 Gene
Additional Disease Information for THAP11
No disorders were found for THAP11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP11 Gene
Publications for THAP11 Gene
- NMR studies of a new family of DNA binding proteins: the THAP proteins. (PMID: 23306615) Gervais V … Milon A (Journal of biomolecular NMR 2013) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M … Girard JP (Trends in biochemical sciences 2003) 2 3 58
- Selection system for genes encoding nuclear-targeted proteins. (PMID: 9853615) Ueki N … Muramatsu M (Nature biotechnology 1998) 3 4 58
- Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. (PMID: 8325628) Li SH … Ross CA (Genomics 1993) 2 3 58
Products for THAP11 Gene
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Sources for THAP11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt