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Aliases for THAP10 Gene

Aliases for THAP10 Gene

  • THAP Domain Containing 10 2 3 5

External Ids for THAP10 Gene

Previous GeneCards Identifiers for THAP10 Gene

  • GC15M068749
  • GC15M068889
  • GC15M068960
  • GC15M071173
  • GC15M048009

Summaries for THAP10 Gene

Entrez Gene Summary for THAP10 Gene

  • This gene encodes a member of a family of proteins sharing an N-terminal Thanatos-associated domain. The Thanatos-associated domain contains a zinc finger signature similar to DNA-binding domains. This gene is part of a bidirectional gene pair on the long arm of chromosome 15 that is regulated by estrogen and may play a role in breast cancer. [provided by RefSeq, Nov 2010]

GeneCards Summary for THAP10 Gene

THAP10 (THAP Domain Containing 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

Additional gene information for THAP10 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP10 Gene

Genomics for THAP10 Gene

GeneHancer (GH) Regulatory Elements for THAP10 Gene

Promoters and enhancers for THAP10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I070890 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 464 2.7 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 E2F8 ZNF143 THAP10 LRRC49 RPL17P39 LARP6 TLE3 KRT8P9
GH15I070088 Promoter/Enhancer 3.1 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.3 +797.2 797194 13.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 TLE3 THAP10 LRRC49 GC15P070099 LOC105370877
GH15I070526 Enhancer 1.4 Ensembl ENCODE dbSUPER 31.7 +366.0 366039 1.1 FEZF1 ZNF2 ZNF213 ZNF302 FOS KLF13 SP3 JUNB REST ZNF610 PIR55212 THAP10 RPL17P39 LRRC49 LINC02205 GC15M070491
GH15I071082 Enhancer 1.1 ENCODE dbSUPER 31.6 -190.5 -190517 2.1 ZNF493 ZFP64 ZNF121 ZNF213 KLF7 ZNF548 ZNF202 SP3 JUNB REST RPL17P39 LRRC49 THAP10 CT62 LARP6 ENSG00000259744 TLE3 LOC105370886 RPL5P3
GH15I070491 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.3 +398.9 398935 5.6 HDGF PKNOX1 NEUROD1 SIN3A FEZF1 ZNF2 ZNF766 ZNF213 ZNF416 FOS LRRC49 TLE3 THAP10 RPL17P39 MIR629 LINC02205 PIR51135 GC15M070491
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THAP10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THAP10 gene promoter:

Genomic Locations for THAP10 Gene

Genomic Locations for THAP10 Gene
11,444 bases
Minus strand

Genomic View for THAP10 Gene

Genes around THAP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP10 Gene

Proteins for THAP10 Gene

  • Protein details for THAP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    THAP domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • B2R8R0

    Protein attributes for THAP10 Gene

    257 amino acids
    Molecular mass:
    28351 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THAP10 Gene

Post-translational modifications for THAP10 Gene

No Post-translational modifications

Other Protein References for THAP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP10 Gene

Domains & Families for THAP10 Gene

Gene Families for THAP10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for THAP10 Gene


Suggested Antigen Peptide Sequences for THAP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THAP10: view

No data available for UniProtKB/Swiss-Prot for THAP10 Gene

Function for THAP10 Gene

Phenotypes From GWAS Catalog for THAP10 Gene

Gene Ontology (GO) - Molecular Function for THAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP10: view

Phenotypes for THAP10 Gene

genes like me logo Genes that share phenotypes with THAP10: view

miRNA for THAP10 Gene

miRTarBase miRNAs that target THAP10

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP10 Gene

Localization for THAP10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP10 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THAP10 Gene

Pathways & Interactions for THAP10 Gene

SuperPathways for THAP10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THAP10 Gene


No data available for Pathways by source and SIGNOR curated interactions for THAP10 Gene

Drugs & Compounds for THAP10 Gene

No Compound Related Data Available

Transcripts for THAP10 Gene

mRNA/cDNA for THAP10 Gene

Unigene Clusters for THAP10 Gene

THAP domain containing 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP10 Gene

No ASD Table

Relevant External Links for THAP10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THAP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THAP10 Gene

Protein differential expression in normal tissues from HIPED for THAP10 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THAP10 Gene

Protein tissue co-expression partners for THAP10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THAP10 Gene:


SOURCE GeneReport for Unigene cluster for THAP10 Gene:


Evidence on tissue expression from TISSUES for THAP10 Gene

  • Nervous system(4.5)
  • Pancreas(4.1)
  • Skin(4)
genes like me logo Genes that share expression patterns with THAP10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP10 Gene

Orthologs for THAP10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for THAP10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia THAP10 33 34
  • 99.09 (n)
(Canis familiaris)
Mammalia THAP10 33 34
  • 79.5 (n)
(Monodelphis domestica)
Mammalia THAP10 34
  • 70 (a)
(Bos Taurus)
Mammalia THAP10 34
  • 42 (a)
Species where no ortholog for THAP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THAP10 Gene

Gene Tree for THAP10 (if available)
Gene Tree for THAP10 (if available)

Paralogs for THAP10 Gene

No data available for Paralogs for THAP10 Gene

Variants for THAP10 Gene

Sequence variations from dbSNP and Humsavar for THAP10 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000137025 -- 70,882,124(-) T/C 3_prime_UTR_variant
rs1000235905 -- 70,885,706(-) C/A/T intron_variant
rs1000247061 -- 70,885,999(-) T/C intron_variant
rs1000288174 -- 70,888,908(-) C/T intron_variant
rs1000406181 -- 70,889,346(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for THAP10 Gene

Variant ID Type Subtype PubMed ID
nsv827381 CNV loss 20364138
dgv153n21 CNV loss 19592680

Variation tolerance for THAP10 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THAP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP10 Gene

Disorders for THAP10 Gene

Additional Disease Information for THAP10

No disorders were found for THAP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP10 Gene

Publications for THAP10 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M … Girard JP (Trends in biochemical sciences 2003) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for THAP10 Gene

Sources for THAP10 Gene

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