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Aliases for THADA Gene

Aliases for THADA Gene

  • THADA, Armadillo Repeat Containing 2 3 5
  • Gene Inducing Thyroid Adenomas Protein 3 4
  • GITA 3 4
  • Death Receptor-Interacting Protein 3
  • Thyroid Adenoma-Associated Protein 3
  • Thyroid Adenoma Associated 2
  • KIAA1767 4
  • ARMC13 3

External Ids for THADA Gene

Previous GeneCards Identifiers for THADA Gene

  • GC02M043432
  • GC02M043369
  • GC02M043311
  • GC02M043393

Summaries for THADA Gene

Entrez Gene Summary for THADA Gene

  • This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and apoptosis. [provided by RefSeq, Sep 2016]

GeneCards Summary for THADA Gene

THADA (THADA, Armadillo Repeat Containing) is a Protein Coding gene. Diseases associated with THADA include Adenoma. Gene Ontology (GO) annotations related to this gene include binding.

Additional gene information for THADA Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THADA Gene

Genomics for THADA Gene

GeneHancer (GH) Regulatory Elements for THADA Gene

Promoters and enhancers for THADA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I043595 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 563.5 -0.1 -59 2.2 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 THADA PLEKHH2 GC02M043593
GH02I043592 Promoter 0.5 EPDnew 550.8 +3.6 3645 0.1 THADA PLEKHH2 GC02M043477
GH02I043216 Promoter/Enhancer 3.2 VISTA UCNEbase EPDnew Ensembl ENCODE dbSUPER 34.8 +372.8 372771 13 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ZFP36L2 THADA RNU6-1048P PLEKHH2 ENSG00000234936 LINC01126 LINC02580 GC02P042660
GH02I042808 Enhancer 1.5 Ensembl ENCODE dbSUPER 42.3 +785.6 785636 3.4 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 LOC105374567 TRI-TAT2-1 GC02P042811 THADA EML4 OXER1 PLEKHH2 HAAO GC02P042660
GH02I043994 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 25.7 -399.7 -399736 2.6 PKNOX1 CLOCK ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 POLR2B LRPPRC GC02P043995 THADA RNU6-1048P RN7SL455P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THADA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THADA gene promoter:

Genomic Locations for THADA Gene

Genomic Locations for THADA Gene
365,221 bases
Minus strand

Genomic View for THADA Gene

Genes around THADA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THADA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THADA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THADA Gene

Proteins for THADA Gene

  • Protein details for THADA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thyroid adenoma-associated protein
    Protein Accession:
    Secondary Accessions:
    • A8K1V8
    • B7WNS6
    • Q3KR04
    • Q53RC6
    • Q53TB2
    • Q6YHU2
    • Q6ZU38
    • Q8IY32
    • Q8TAU8
    • Q96I88
    • Q9BZF7
    • Q9C096
    • Q9H6U0
    • Q9H6W7

    Protein attributes for THADA Gene

    1953 amino acids
    Molecular mass:
    219607 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15133.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15162.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21858.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for THADA Gene

    Alternative splice isoforms for THADA Gene

neXtProt entry for THADA Gene

Post-translational modifications for THADA Gene

  • Ubiquitination at isoforms=2, 3, 5, 6702 and isoforms=2, 31008
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for THADA Gene

Domains & Families for THADA Gene

Gene Families for THADA Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for THADA Gene

Suggested Antigen Peptide Sequences for THADA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the THADA family.
  • Belongs to the THADA family.
genes like me logo Genes that share domains with THADA: view

Function for THADA Gene

Phenotypes From GWAS Catalog for THADA Gene

Gene Ontology (GO) - Molecular Function for THADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with THADA: view
genes like me logo Genes that share phenotypes with THADA: view

Animal Model Products

miRNA for THADA Gene

miRTarBase miRNAs that target THADA

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THADA Gene

Localization for THADA Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THADA gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for THADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0098554 cytoplasmic side of endoplasmic reticulum membrane ISS --
genes like me logo Genes that share ontologies with THADA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THADA Gene

Pathways & Interactions for THADA Gene

SuperPathways for THADA Gene

No Data Available

Gene Ontology (GO) - Biological Process for THADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IMP 28399403
GO:0055088 lipid homeostasis IGI 28399403
GO:1901895 negative regulation of calcium-transporting ATPase activity ISS --
GO:1990845 adaptive thermogenesis ISS --
genes like me logo Genes that share ontologies with THADA: view

No data available for Pathways by source and SIGNOR curated interactions for THADA Gene

Drugs & Compounds for THADA Gene

No Compound Related Data Available

Transcripts for THADA Gene

Unigene Clusters for THADA Gene

Thyroid adenoma associated:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THADA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - -
SP7: - - -
SP8: -
SP9: -

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - -
SP6: - - - - - -
SP7: - - - -
SP10: - -

Relevant External Links for THADA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THADA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THADA Gene

Protein differential expression in normal tissues from HIPED for THADA Gene

This gene is overexpressed in Bone (34.4) and Esophagus (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THADA Gene

Protein tissue co-expression partners for THADA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THADA Gene:


SOURCE GeneReport for Unigene cluster for THADA Gene:


mRNA Expression by UniProt/SwissProt for THADA Gene:

Tissue specificity: Expressed in pancreas, adrenal medulla, thyroid, adrenal cortex, testis, thymus, small intestine and stomach.

Evidence on tissue expression from TISSUES for THADA Gene

  • Nervous system(4.5)
  • Pancreas(4.4)
  • Skin(4.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with THADA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for THADA Gene

Orthologs for THADA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for THADA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia THADA 33 34
  • 99.51 (n)
(Canis familiaris)
Mammalia THADA 33 34
  • 87.45 (n)
(Bos Taurus)
Mammalia THADA 33 34
  • 87.37 (n)
(Rattus norvegicus)
Mammalia Thada 33
  • 83.03 (n)
(Mus musculus)
Mammalia Thada 33 16 34
  • 81.85 (n)
(Monodelphis domestica)
Mammalia THADA 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
-- 34
  • 49 (a)
(Gallus gallus)
Aves THADA 33 34
  • 65.23 (n)
(Anolis carolinensis)
Reptilia THADA 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia thada 33
  • 60.73 (n)
(Danio rerio)
Actinopterygii thada 34
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15618 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea Y92H12A.5 34
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for THADA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THADA Gene

Gene Tree for THADA (if available)
Gene Tree for THADA (if available)

Paralogs for THADA Gene

No data available for Paralogs for THADA Gene

Variants for THADA Gene

Sequence variations from dbSNP and Humsavar for THADA Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs201555818 benign, Abnormality of neuronal migration 43,556,551(-) G/A coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs769958179 benign, Abnormality of neuronal migration 43,586,943(-) C/T 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000001782 -- 43,283,912(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000019946 -- 43,427,738(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000023158 -- 43,463,429(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for THADA Gene

Variant ID Type Subtype PubMed ID
dgv148e55 CNV loss 17911159
dgv3797n100 CNV loss 25217958
dgv6829n54 CNV loss 21841781
dgv6830n54 CNV loss 21841781
esv1449377 CNV insertion 17803354
esv23574 CNV loss 19812545
esv2658999 CNV deletion 23128226
esv2660992 CNV deletion 23128226
esv2662742 CNV deletion 23128226
esv2663547 CNV deletion 23128226
esv2678286 CNV deletion 23128226
esv2719991 CNV deletion 23290073
esv2719992 CNV deletion 23290073
esv2719993 CNV deletion 23290073
esv2763651 CNV loss 21179565
esv3303215 CNV mobile element insertion 20981092
esv3383365 CNV insertion 20981092
esv34046 CNV loss 18971310
esv34086 CNV loss 18971310
esv3439008 CNV insertion 20981092
esv3555733 CNV deletion 23714750
esv3555744 CNV deletion 23714750
esv3555755 CNV deletion 23714750
esv3583764 CNV loss 25503493
esv3583765 CNV loss 25503493
esv3590524 CNV loss 21293372
esv3590525 CNV loss 21293372
esv3590527 CNV loss 21293372
esv3590529 CNV gain 21293372
esv3590531 CNV loss 21293372
esv3590534 CNV loss 21293372
esv3891993 CNV gain 25118596
esv8546 CNV gain 19470904
nsv1000464 CNV loss 25217958
nsv1001365 CNV gain 25217958
nsv1002186 CNV gain 25217958
nsv1007740 CNV gain 25217958
nsv1015137 CNV loss 25217958
nsv1071590 CNV deletion 25765185
nsv1123322 CNV deletion 24896259
nsv1142255 CNV deletion 24896259
nsv2707 CNV insertion 18451855
nsv2708 CNV deletion 18451855
nsv457163 CNV loss 19166990
nsv511782 CNV loss 21212237
nsv520247 CNV loss 19592680
nsv525157 CNV loss 19592680
nsv581659 CNV loss 21841781
nsv581660 CNV gain 21841781
nsv953774 CNV duplication 24416366

Variation tolerance for THADA Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.23; 96.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THADA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THADA Gene

Disorders for THADA Gene

MalaCards: The human disease database

(1) MalaCards diseases for THADA Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • acinar cell adenoma
- elite association - COSMIC cancer census association via MalaCards
Search THADA in MalaCards View complete list of genes associated with diseases


  • Note=Chromosomal aberrations involving THADA have been observed in benign thyroid adenomas. Translocation t(2;3)(p21;p25) and translocation t(2;7)(p21;p15); the sequences derived from chromosomes 3p25 and 7p15 do not appear to include a coding region and the fusion events probably result in truncated THADA proteins.

Additional Disease Information for THADA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with THADA: view

No data available for Genatlas for THADA Gene

Publications for THADA Gene

  1. Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas. (PMID: 12955091) Rippe V … Bullerdiek J (Oncogene 2003) 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  3. Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer. (PMID: 20878950) Sun J … Xu J (The Prostate 2011) 3 44 58
  4. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. (PMID: 21151128) Chen ZJ … Zhao Y (Nature genetics 2011) 3 44 58
  5. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C … Soranzo N (Nature 2011) 3 44 58

Products for THADA Gene

Sources for THADA Gene

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