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Aliases for TGM7 Gene

Aliases for TGM7 Gene

  • Transglutaminase 7 2 3 5
  • Transglutaminase Z 2 3 4
  • EC 4 56
  • TGase Z 3 4
  • TGase-7 3 4
  • TG(Z) 3 4
  • TGZ 3 4
  • Protein-Glutamine Gamma-Glutamyltransferase Z 3
  • Transglutaminase-7 4
  • TGMZ 3

External Ids for TGM7 Gene

Previous GeneCards Identifiers for TGM7 Gene

  • GC15M038936
  • GC15M036464
  • GC15M041147
  • GC15M041284
  • GC15M041355
  • GC15M043568
  • GC15M020417

Summaries for TGM7 Gene

Entrez Gene Summary for TGM7 Gene

  • Transglutaminases (TGM; EC are a family of structurally and functionally related enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background information on transglutaminases, see TGM1 (MIM 190195).[supplied by OMIM, Jul 2002]

GeneCards Summary for TGM7 Gene

TGM7 (Transglutaminase 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is TGM5.

UniProtKB/Swiss-Prot for TGM7 Gene

  • Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Additional gene information for TGM7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGM7 Gene

Genomics for TGM7 Gene

GeneHancer (GH) Regulatory Elements for TGM7 Gene

Promoters and enhancers for TGM7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I043302 Promoter 0.6 EPDnew 550.8 -0.1 -51 0.1 CEBPB TGM7 ENSG00000260406 ADAL
GH15I043370 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 27.4 -68.8 -68835 2.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B E2F8 ZSCAN29 TUBGCP4 ADAL TGM7 RN7SL487P
GH15I043491 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 23.7 -191.0 -190978 3.2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 POLR2B TP53BP1 ZSCAN29 ADAL TGM7 CTDSPL2 MFAP1 UBR1 TUBGCP4 CDAN1 GC15M043494
GH15I043440 Enhancer 1.2 Ensembl ENCODE 26.3 -138.8 -138837 2 HDGF FOXA2 ATF1 ARNT ARID4B SIN3A ZNF2 YY1 E2F8 ARID2 ADAL TGM7 MAP1A TP53BP1 PIR42778 PIR48108
GH15I043469 Enhancer 0.8 ENCODE 26.5 -167.5 -167547 0.7 MEIS2 LEF1 ATF1 TEAD4 TAL1 JUN CEBPG FOSL1 TCF12 NCOR1 ADAL TGM7 PIR42778 GC15M043494 TP53BP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TGM7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TGM7 gene promoter:

Genomic Locations for TGM7 Gene

Genomic Locations for TGM7 Gene
25,976 bases
Minus strand

Genomic View for TGM7 Gene

Genes around TGM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGM7 Gene

Proteins for TGM7 Gene

  • Protein details for TGM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase Z
    Protein Accession:

    Protein attributes for TGM7 Gene

    710 amino acids
    Molecular mass:
    79941 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for TGM7 Gene

Selected DME Specific Peptides for TGM7 Gene


Post-translational modifications for TGM7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TGM7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TGM7 Gene

Gene Families for TGM7 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TGM7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the transglutaminase superfamily. Transglutaminase family.
  • Belongs to the transglutaminase superfamily. Transglutaminase family.
genes like me logo Genes that share domains with TGM7: view

Function for TGM7 Gene

Molecular function for TGM7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)-(gamma-glutamyl)-L-lysine cross-link + NH(3).
UniProtKB/Swiss-Prot Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Enzyme Numbers (IUBMB) for TGM7 Gene

Phenotypes From GWAS Catalog for TGM7 Gene

Gene Ontology (GO) - Molecular Function for TGM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003810 protein-glutamine gamma-glutamyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TGM7: view
genes like me logo Genes that share phenotypes with TGM7: view

miRNA for TGM7 Gene

miRTarBase miRNAs that target TGM7

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TGM7 Gene

Localization for TGM7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TGM7 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TGM7 Gene

Pathways & Interactions for TGM7 Gene

No Data Available

Interacting Proteins for TGM7 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q96PF1-TGM7_HUMAN ENSP00000389466 for TGM7 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TGM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018149 peptide cross-linking IEA --
genes like me logo Genes that share ontologies with TGM7: view

No data available for Pathways by source and SIGNOR curated interactions for TGM7 Gene

Drugs & Compounds for TGM7 Gene

(3) Drugs for TGM7 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Enzyme, substrate 0
Ammonia Approved Pharma 0
calcium Approved Nutra 0
genes like me logo Genes that share compounds with TGM7: view

Transcripts for TGM7 Gene

mRNA/cDNA for TGM7 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TGM7 Gene

Transglutaminase 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TGM7 Gene

No ASD Table

Relevant External Links for TGM7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TGM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TGM7 Gene

mRNA differential expression in normal tissues according to GTEx for TGM7 Gene

This gene is overexpressed in Testis (x19.6), Muscle - Skeletal (x9.8), and Esophagus - Mucosa (x6.2).

NURSA nuclear receptor signaling pathways regulating expression of TGM7 Gene:


SOURCE GeneReport for Unigene cluster for TGM7 Gene:


mRNA Expression by UniProt/SwissProt for TGM7 Gene:

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with TGM7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TGM7 Gene

Orthologs for TGM7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TGM7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TGM7 33 34
  • 99.23 (n)
(Canis familiaris)
Mammalia TGM7 33 34
  • 85.34 (n)
(Bos Taurus)
Mammalia TGM7 33 34
  • 85.26 (n)
(Mus musculus)
Mammalia Tgm7 33 16 34
  • 82.23 (n)
(Rattus norvegicus)
Mammalia LOC102552199 33
  • 82.11 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
-- 34
  • 43 (a)
(Gallus gallus)
Aves -- 34
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 35 (a)
-- 34
  • 34 (a)
-- 34
  • 33 (a)
(Danio rerio)
Actinopterygii tgm8 34
  • 37 (a)
Species where no ortholog for TGM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGM7 Gene

Gene Tree for TGM7 (if available)
Gene Tree for TGM7 (if available)

Paralogs for TGM7 Gene

Paralogs for TGM7 Gene

(8) SIMAP similar genes for TGM7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TGM7: view

Variants for TGM7 Gene

Sequence variations from dbSNP and Humsavar for TGM7 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000048500 -- 43,291,517(-) T/C intron_variant
rs1000199967 -- 43,303,853(-) A/G upstream_transcript_variant
rs1000223377 -- 43,297,683(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000273599 -- 43,304,090(-) G/A upstream_transcript_variant
rs1000526789 -- 43,298,944(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TGM7 Gene

Variant ID Type Subtype PubMed ID
nsv1138361 CNV deletion 24896259

Variation tolerance for TGM7 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TGM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGM7 Gene

Disorders for TGM7 Gene

Additional Disease Information for TGM7

No disorders were found for TGM7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TGM7 Gene

Publications for TGM7 Gene

  1. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. (PMID: 11390390) Grenard P … Aeschlimann D (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. Phage-displayed peptide library screening for preferred human substrate peptide sequences for transglutaminase 7. (PMID: 23876241) Kuramoto K … Hitomi K (Archives of biochemistry and biophysics 2013) 3 58
  3. Expression of breast cancer specific gene-1 (BCSG-1/gamma-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. (PMID: 16786148) Martin TA … Jiang WG (Oncology reports 2006) 22 58
  4. A plasminogen-like protein, present in the apical extracellular environment of thyroid epithelial cells, degrades thyroglobulin in vitro. (PMID: 16259961) Giraud A … Mallet B (Biochemical and biophysical research communications 2005) 22 58
  5. HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A. (PMID: 7906657) Amendola A … Piacentini M (FEBS letters 1994) 3 58

Products for TGM7 Gene

Sources for TGM7 Gene

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