Aliases for TGM5 Gene
External Ids for TGM5 Gene
Previous GeneCards Identifiers for TGM5 Gene
This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009]
GeneCards Summary for TGM5 Gene
TGM5 (Transglutaminase 5) is a Protein Coding gene. Diseases associated with TGM5 include Peeling Skin Syndrome 2 and Peeling Skin Syndrome 1. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is TGM7.
UniProtKB/Swiss-Prot Summary for TGM5 Gene
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.