Aliases for TGM2 Gene
External Ids for TGM2 Gene
Previous GeneCards Identifiers for TGM2 Gene
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TGM2 Gene
TGM2 (Transglutaminase 2) is a Protein Coding gene. Diseases associated with TGM2 include Dermatitis Herpetiformis and Balanitis Xerotica Obliterans. Among its related pathways are Phospholipase-C Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include GTP binding and protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is TGM5.
UniProtKB/Swiss-Prot Summary for TGM2 Gene
Catalyzes the cross-linking of proteins, such as WDR54, and the conjugation of polyamines to proteins.