Aliases for TGM2 Gene
Aliases for TGM2 Gene
External Ids for TGM2 Gene
- HGNC: 11778
- Entrez Gene: 7052
- Ensembl: ENSG00000198959
- OMIM: 190196
- UniProtKB: P21980
Previous GeneCards Identifiers for TGM2 Gene
- GC20M036486
- GC20M037395
- GC20M037442
- GC20M036190
- GC20M036756
- GC20M033493
Summaries for TGM2 Gene
-
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TGM2 Gene
TGM2 (Transglutaminase 2) is a Protein Coding gene. Diseases associated with TGM2 include Balanitis Xerotica Obliterans and Balanitis. Among its related pathways are Ca, cAMP and Lipid Signaling and Thromboxane A2 receptor signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is TGM5.
UniProtKB/Swiss-Prot for TGM2 Gene
-
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Additional gene information for TGM2 Gene
- Monarch Initiative
- Search for TGM2 at DataMed
- Search for TGM2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGM2 Gene
Genomics for TGM2 Gene
GeneHancer (GH) Regulatory Elements for TGM2 Gene
Promoters and enhancers for TGM2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around TGM2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TGM2 gene promoter:
-
- STAT1
- COUP-TF
- COUP
- COUP-TF1
- HNF-4alpha1
Regulatory Element Products
Genomic Locations for TGM2 Gene
Genomic Locations for TGM2 Gene
- chr20:38,127,387-38,166,578
- (GRCh38/hg38)
- Size:
- 39,192 bases
- Orientation:
- Minus strand
- chr20:36,756,863-36,794,980
- (GRCh37/hg19)
- Size:
- 38,118 bases
- Orientation:
- Minus strand
Genomic View for TGM2 Gene
Genes around TGM2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.23 by Entrez Gene
- 20q11.23 by HGNC
- 20q11.23 by Ensembl
TGM2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TGM2 Gene
Proteins for TGM2 Gene
-
Protein details for TGM2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P21980-TGM2_HUMAN
- Recommended name:
- Protein-glutamine gamma-glutamyltransferase 2
- Protein Accession:
- P21980
- E1P5V9
- Q16436
- Q6B838
- Q9BTN7
- Q9H035
- Q9UH35
Protein attributes for TGM2 Gene
- Size:
- 687 amino acids
- Molecular mass:
- 77329 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
-
- Monomer.
Three dimensional structures from OCA and Proteopedia for TGM2 Gene
Protein Expression for TGM2 Gene
Post-translational modifications for TGM2 Gene
Other Protein References for TGM2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TGM2 (Transglutaminase 2/TGM2)
-
Custom Antibody ServicesOriGene Antibodies for TGM2
- Novus Biologicals Antibodies for TGM2
-
Abcam antibodies for TGM2
- Invitrogen Antibodies for TGM2
- antibodies-online: Search results for 299 available Transglutaminase 2 Antibodies ranked by validation data
- Compare Top Transglutaminase 2 Antibodies
-
Recommended
- 184 WB Antibodies (anti-human)
- 57 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 51 IHC (p) Antibodies (anti-rat)
- 46 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 4 FACS Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
- 56 WB Antibodies (anti-mouse)
- 51 IHC (p) Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- GeneTex TGM2 Antibody for TGM2
-
Custom Antibody ServicesProSci Antibodies for TGM2
-
Santa Cruz Biotechnology (SCBT) Antibodies for TGM2
- Sino Biological Antibodies for TGM2
Protein Products
- R&D Systems Proteins and Enzymes for TGM2 (Transglutaminase 2/TGM2)
- Search Origene for MassSpec and Protein Over-expression Lysates for TGM2
- Origene Custom Protein Services for TGM2
- Sino Biological Recombinant Proteins for TGM2
- Sino Biological Cell Lysates for TGM2
- ProSpec Recombinant Proteins for TGM2
- Search GeneTex for Proteins for TGM2
-
ProSci Proteins for TGM2
-
Abcam proteins for TGM2
Assay Products
No data available for DME Specific Peptides for TGM2 Gene
Domains & Families for TGM2 Gene
Gene Families for TGM2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for TGM2 Gene
Suggested Antigen Peptide Sequences for TGM2 Gene
Graphical View of Domain Structure for InterPro Entry
P21980UniProtKB/Swiss-Prot:
TGM2_HUMAN :- Belongs to the transglutaminase superfamily. Transglutaminase family.
- Family:
-
- Belongs to the transglutaminase superfamily. Transglutaminase family.
Function for TGM2 Gene
Molecular function for TGM2 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
- UniProtKB/Swiss-Prot CatalyticActivity:
- A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)-(gamma-glutamyl)-L-lysine cross-link + NH(3).
- UniProtKB/Swiss-Prot Induction:
- By retinoic acid.
- GENATLAS Biochemistry:
- transglutaminase,C polypeptide,tissue,type II (80kDa),cytoplasmic,ubiquitous,interacting with huntingtin
Enzyme Numbers (IUBMB) for TGM2 Gene
Phenotypes From GWAS Catalog for TGM2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003810 | protein-glutamine gamma-glutamyltransferase activity | ISS | -- |
| GO:0005515 | protein binding | IPI | 9442029 |
| GO:0005525 | GTP binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016746 | transferase activity, transferring acyl groups | IEA | -- |
Phenotypes for TGM2 Gene
- MGI mutant phenotypes for TGM2:
-
inferred from 5 alleles
- cardiovascular system phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for TGM2:
Animal Models for TGM2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TGM2
-
CRISPR Products
-
OriGene CRISPR knockouts for TGM2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TGM2
- Applied Biological Materials CRISPR for TGM2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGM2
- GenScript: Design CRISPR guide RNA sequences for TGM2
miRNA for TGM2 Gene
- miRTarBase miRNAs that target TGM2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TGM2
- Browse OriGene Inhibitory RNA Products For TGM2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGM2
Clone Products
- Sino Biological Human cDNA Clone for TGM2
- VectorBuilder custom plasmid, inducible vectors for TGM2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TGM2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TGM2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TGM2
- genomics-online: cdna clones - Search results for 142 available Transglutaminase 2 gene related products
- Overview of 142 available Transglutaminase 2 gene related products
- orf clones - Search results for 142 available Transglutaminase 2 gene related products
- Overview of 142 available Transglutaminase 2 gene related products
- Applied Biological Materials Clones for TGM2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TGM2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TGM2 Gene
Localization for TGM2 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| mitochondrion | 5 |
| cytosol | 5 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| cytoskeleton | 2 |
| lysosome | 1 |
- Cytosol (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IDA,IEA | 24349085 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005829 | cytosol | IDA | 24349085 |
| GO:0005886 | plasma membrane | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for TGM2 Gene
Pathways & Interactions for TGM2 Gene
Pathways by source for TGM2 Gene
1 GeneTex pathway for TGM2 Gene
1 BioSystems pathway for TGM2 Gene
1 KEGG pathway for TGM2 Gene
1 GeneGo (Thomson Reuters) pathway for TGM2 Gene
1 R&D Systems pathway for TGM2 Gene
2 Qiagen pathways for TGM2 Gene
1 Cell Signaling Technology pathway for TGM2 Gene
Interacting Proteins for TGM2 Gene
Selected Interacting proteins:
P21980-TGM2_HUMAN
ENSP00000355330
for TGM2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TGM2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001974 | blood vessel remodeling | IEA | -- |
| GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway | IEA | -- |
| GO:0018149 | peptide cross-linking | IEA | -- |
| GO:0018153 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine | IEA | -- |
| GO:0032471 | negative regulation of endoplasmic reticulum calcium ion concentration | IMP | 24349085 |
Drugs & Compounds for TGM2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| L-Glutamine | Approved, Investigational | Nutra | Full agonist, Agonist, Enzyme, substrate | 0 | ||
| calcium | Approved | Nutra | 0 | |||
| Hexylresorcinol | Approved | Pharma | Target, inhibitor | 0 | ||
| Ammonia | Approved | Pharma | 0 | |||
| Guanosine diphosphate | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for TGM2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cystamine dihydrochloride | 56-17-7 |
Transcripts for TGM2 Gene
mRNA/cDNA for TGM2 Gene
- (6) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (999) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000361475 5070 bps (uc002xhr.5)
- ENST00000469269 3467 bps (uc002xhq.5)
- ENST00000468262 1862 bps (uc031rtj.2)
- ENST00000474777 2287 bps (uc061wxc.1)
- ENST00000373403 1018 bps (uc061wxd.1)
Unigene Clusters for TGM2 Gene
- Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TGM2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TGM2
- Applied Biological Materials CRISPR for TGM2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGM2
- GenScript: Design CRISPR guide RNA sequences for TGM2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TGM2
- Browse OriGene Inhibitory RNA Products For TGM2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGM2
Clone Products
- Sino Biological Human cDNA Clone for TGM2
- VectorBuilder custom plasmid, inducible vectors for TGM2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TGM2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TGM2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TGM2
- genomics-online: cdna clones - Search results for 142 available Transglutaminase 2 gene related products
- Overview of 142 available Transglutaminase 2 gene related products
- orf clones - Search results for 142 available Transglutaminase 2 gene related products
- Overview of 142 available Transglutaminase 2 gene related products
- Applied Biological Materials Clones for TGM2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - |
| ExUns: | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18a | · | 18b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | |||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||
| SP19: |
Expression for TGM2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Mesenchymal Condensate Cells Zeugopod
- Membranous Facial Bones
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Mesenchymal Condensate Cells Zeugopod
- Meckels Cartilage
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- Primary Hair Placode Cells Hair Follicle
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Primary Hair Placode Cells Hair Follicle
- Basal Keratinocytes Embryonic Epidermis
- Skeletal Muscle (Muscoskeletal System)
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
- Spleen (Hematopoietic System)
- Blood (Cardiovascular System)
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Kidney (Urinary System)
- Heart (Cardiovascular System)
-
Umbilical Cord (Extraembryonic Tissues)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for TGM2 Gene
This gene is overexpressed in Artery - Coronary (x8.6) and Artery - Tibial (x6.7).
This gene is overexpressed in Urinary Bladder (9.5), Gallbladder (9.1), and Placenta (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TGM2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TGM2 Gene:
TGM2SOURCE GeneReport for Unigene cluster for TGM2 Gene:
Hs.517033Evidence on tissue expression from TISSUES for TGM2 Gene
- Kidney(4.9)
- Liver(4.9)
- Lung(4.9)
- Nervous system(4.9)
- Heart(4.6)
- Lymph node(4.4)
- Pancreas(3.9)
- Intestine(3.6)
- Eye(3.5)
- Muscle(2.9)
- Blood(2.6)
- Skin(2.4)
- Thyroid gland(2.4)
- Gall bladder(2.1)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for TGM2
-
OriGene qPCR primer pairs for TGM2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TGM2 Gene
Orthologs for TGM2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TGM2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TGM2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TGM2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Tgm2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tgm2 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TGM2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TGM2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TGM2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tgm2 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | tgm2-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tgm2b 34 33 |
|
OneToMany | |
| tgm2a 34 |
|
OneToMany | |||
| Dr.16524 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8978 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7356 35 |
|
|
|
| Tg 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | Cin.2702 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2702 33 |
|
- Species where no ortholog for TGM2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for TGM2 Gene
- ENSEMBL:
- Gene Tree for TGM2 (if available)
- TreeFam:
- Gene Tree for TGM2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TGM2: view image
Paralogs for TGM2 Gene
(10) SIMAP similar genes for TGM2 Gene using alignment to 7 proteins:
- TGM2_HUMAN
- A2A299_HUMAN
- A2A2A0_HUMAN
- B4DIT7_HUMAN
- F5H6P0_HUMAN
- Q6DKH2_HUMAN
- Q9BXQ0_HUMAN
Variants for TGM2 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036554 | A colorectal cancer sample | p.Gly660Val | |||
| rs1000074361 | -- | 38,137,273(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000081758 | -- | 38,137,473(-) | CAAACAAACAAACAAAC/CAAACAAACAAAC | downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1000181313 | -- | 38,165,411(-) | G/C/T | 5_prime_UTR_variant, intron_variant | |
| rs1000259380 | -- | 38,157,280(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4308n100 | CNV | gain | 25217958 |
| esv2763659 | CNV | gain | 21179565 |
| esv29167 | CNV | gain | 19812545 |
| esv3893333 | CNV | loss | 25118596 |
| nsv1057334 | CNV | loss | 25217958 |
| nsv585963 | CNV | gain | 21841781 |
| nsv833972 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.35;
53.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TGM2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGM2 Gene
Disorders for TGM2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| balanitis xerotica obliterans |
|
|
| balanitis |
|
|
| autoimmune disease of gastrointestinal tract |
|
|
| dermatitis herpetiformis |
|
|
| gluten allergy |
|
|
Search TGM2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TGM2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TGM2 Gene
Publications for TGM2 Gene
- Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online. (PMID: 17939176) Porzio O … Barbetti F (Human mutation 2007) 3 4 22 44 58
- The TGM2 gene is associated with schizophrenia in a British population. (PMID: 18561261) Bradford M … Wei J (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 22 44 58
- Transglutaminase 2 undergoes a large conformational change upon activation. (PMID: 18092889) Pinkas DM … Khosla C (PLoS biology 2007) 3 4 22 58
- Germline mutations in TGM2 do not contribute to coeliac disease susceptibility in the Swedish population. (PMID: 11742196) Popat S … Houlston RS (European journal of gastroenterology & hepatology 2001) 3 22 44 58
- Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes. (PMID: 20052409) Hallstrand TS … Henderson WR (PloS one 2010) 3 22 58
Products for TGM2 Gene
- R&D Systems Antibodies for TGM2 (Transglutaminase 2/TGM2)
- R&D Systems Proteins and Enzymes for TGM2 (Transglutaminase 2/TGM2)
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for TGM2
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- Search Origene for MassSpec and Protein Over-expression Lysates for TGM2
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- OriGene qPCR primer pairs and template standards for TGM2
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- OriGene CRISPR knockouts for TGM2
- OriGene ORF clones in human for TGM2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TGM2
- GenScript: Next-day shipping of latest version cDNA ORF clones for TGM2 in any vector
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- GenScript: Design CRISPR guide RNA sequences for TGM2
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Browse ELISA Kits
- Abcam antibodies for TGM2
- Abcam proteins for TGM2
- Find your target
- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- ProSpec Recombinant Proteins for TGM2
- Cyagen custom Knockout/knockin (KOKI) mouse models for TGM2
- VectorBuilder custom plasmid, inducible vectors for TGM2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TGM2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TGM2
- antibodies-online: Search results for 299 available Transglutaminase 2 Antibodies ranked by validation data
- Compare Top Transglutaminase 2 Antibodies
- Recommended
- 184 WB Antibodies (anti-human)
- 57 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 51 IHC (p) Antibodies (anti-rat)
- 46 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 4 FACS Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
- 56 WB Antibodies (anti-mouse)
- 51 IHC (p) Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- antibodies-online: Search results for 40 available Transglutaminase 2 Elisa Kits ranked by validation data
- Compare Top Transglutaminase 2 Elisa Kits
- antibodies-online: Search results for 31 available Transglutaminase 2 Proteins ranked by validation data
- Compare Top Transglutaminase 2 Proteins
- GeneTex TGM2 Antibody for TGM2
- Search GeneTex for Proteins for TGM2
- Santa Cruz Biotechnology (SCBT) Antibodies for TGM2
- Search Santa Cruz Biotechnology (SCBT) for TGM2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TGM2
- Custom Antibody ServicesProSci Antibodies for TGM2
- ProSci Proteins for TGM2
- Horizon Cell Lines for TGM2
- genomics-online: cdna clones - Search results for 142 available Transglutaminase 2 gene related products
- Overview of 142 available Transglutaminase 2 gene related products
- orf clones - Search results for 142 available Transglutaminase 2 gene related products
- Overview of 142 available Transglutaminase 2 gene related products
- genomics-online: gRNA clones - Search results for 142 available Transglutaminase 2 gene related products
- Overview of 142 available Transglutaminase 2 gene related products
- genomics-online: primer clones - Search results for 142 available Transglutaminase 2 gene related products
- Overview of 142 available Transglutaminase 2 gene related products
- genomics-online: shRNA clones - Search results for 142 available Transglutaminase 2 gene related products
- Overview of 142 available Transglutaminase 2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TGM2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TGM2
- GeneCopoeia miRNA 3'UTR Target clone products for TGM2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGM2
Sources for TGM2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88)