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Aliases for TGIF2LY Gene

Aliases for TGIF2LY Gene

  • TGFB Induced Factor Homeobox 2 Like Y-Linked 2 3
  • TGF-Beta-Induced Transcription Factor 2-Like Protein 3 4
  • TGFB-Induced Factor 2-Like Protein, Y-Linked 3 4
  • TGFB-Induced Factor 2-Like, Y-Linked 2 3
  • TGIF-Like On The Y 3 4
  • TGIFLY 3 4
  • TGFB Induced Factor Homeobox 2 Like, Y-Linked 5
  • TGFB-Induced Factor Homeobox 2-Like, Y-Linked 2
  • Homeobox Protein TGIF2LY 3

External Ids for TGIF2LY Gene

Previous GeneCards Identifiers for TGIF2LY Gene

  • GC0YP003412
  • GC0YP003150
  • GC0YP003490
  • GC0YP003447

Summaries for TGIF2LY Gene

Entrez Gene Summary for TGIF2LY Gene

  • This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. This gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. The C-terminus of this protein is divergent from that of its chromosome X homolog (TGIF2LX), suggesting that this protein may act as a regulator of TGIF2LX. [provided by RefSeq, Jul 2008]

GeneCards Summary for TGIF2LY Gene

TGIF2LY (TGFB Induced Factor Homeobox 2 Like Y-Linked) is a Protein Coding gene. An important paralog of this gene is TGIF2LX.

UniProtKB/Swiss-Prot for TGIF2LY Gene

  • May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.

Additional gene information for TGIF2LY Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGIF2LY Gene

Genomics for TGIF2LY Gene

GeneHancer (GH) Regulatory Elements for TGIF2LY Gene

Top Transcription factor binding sites by QIAGEN in the TGIF2LY gene promoter:
  • CREB
  • POU2F2C
  • POU2F2B
  • POU2F2 (Oct-2.1)
  • POU2F2
  • POU2F1a
  • POU2F1
  • oct-B3
  • oct-B2
  • Oct-B1

Genomic Locations for TGIF2LY Gene

Genomic Locations for TGIF2LY Gene
1,001 bases
Plus strand
1,001 bases
Plus strand

Genomic View for TGIF2LY Gene

Genes around TGIF2LY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGIF2LY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGIF2LY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGIF2LY Gene

Proteins for TGIF2LY Gene

  • Protein details for TGIF2LY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein TGIF2LY
    Protein Accession:
    Secondary Accessions:
    • A2VCU1

    Protein attributes for TGIF2LY Gene

    185 amino acids
    Molecular mass:
    20814 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TGIF2LY Gene

Post-translational modifications for TGIF2LY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TGIF2LY Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TGIF2LY Gene

Domains & Families for TGIF2LY Gene

Gene Families for TGIF2LY Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TGIF2LY Gene

Suggested Antigen Peptide Sequences for TGIF2LY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TALE/TGIF homeobox family.
  • Belongs to the TALE/TGIF homeobox family.
genes like me logo Genes that share domains with TGIF2LY: view

Function for TGIF2LY Gene

Molecular function for TGIF2LY Gene

UniProtKB/Swiss-Prot Function:
May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.

Gene Ontology (GO) - Molecular Function for TGIF2LY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TGIF2LY: view
genes like me logo Genes that share phenotypes with TGIF2LY: view

Animal Model Products

miRNA for TGIF2LY Gene

miRTarBase miRNAs that target TGIF2LY

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TGIF2LY Gene

Localization for TGIF2LY Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGIF2LY Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TGIF2LY gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TGIF2LY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TGIF2LY: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TGIF2LY Gene

Pathways & Interactions for TGIF2LY Gene

SuperPathways for TGIF2LY Gene

No Data Available

Gene Ontology (GO) - Biological Process for TGIF2LY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with TGIF2LY: view

No data available for Pathways by source and SIGNOR curated interactions for TGIF2LY Gene

Drugs & Compounds for TGIF2LY Gene

No Compound Related Data Available

Transcripts for TGIF2LY Gene

mRNA/cDNA for TGIF2LY Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TGIF2LY Gene

TGFB-induced factor homeobox 2-like, Y-linked:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TGIF2LY Gene

No ASD Table

Relevant External Links for TGIF2LY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TGIF2LY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TGIF2LY Gene

mRNA differential expression in normal tissues according to GTEx for TGIF2LY Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for TGIF2LY Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TGIF2LY Gene

Protein tissue co-expression partners for TGIF2LY Gene

NURSA nuclear receptor signaling pathways regulating expression of TGIF2LY Gene:


SOURCE GeneReport for Unigene cluster for TGIF2LY Gene:


mRNA Expression by UniProt/SwissProt for TGIF2LY Gene:

Tissue specificity: Specifically expressed in adult testis.

Evidence on tissue expression from TISSUES for TGIF2LY Gene

  • Adrenal gland(2.4)
genes like me logo Genes that share expression patterns with TGIF2LY: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TGIF2LY Gene

Orthologs for TGIF2LY Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TGIF2LY Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TGIF2LX 34
  • 64 (a)
(Canis familiaris)
Mammalia -- 34
  • 37 (a)
(Mus musculus)
Mammalia Tgif2lx2 34
  • 23 (a)
Tgif2lx1 34
  • 23 (a)
fruit fly
(Drosophila melanogaster)
Insecta vis 34
  • 9 (a)
achi 34
  • 9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CUP9 34
  • 12 (a)
TOS8 34
  • 11 (a)
Species where no ortholog for TGIF2LY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TGIF2LY Gene

Gene Tree for TGIF2LY (if available)
Gene Tree for TGIF2LY (if available)

Paralogs for TGIF2LY Gene

Paralogs for TGIF2LY Gene

(10) SIMAP similar genes for TGIF2LY Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TGIF2LY: view

Variants for TGIF2LY Gene

Sequence variations from dbSNP and Humsavar for TGIF2LY Gene

SNP ID Clin Chr 0Y pos Variation AA Info Type
rs1053786 -- 3,579,810(+) A/G 3_prime_UTR_variant
rs1053787 -- 3,579,826(+) A/G 3_prime_UTR_variant
rs1053788 -- 3,579,837(+) T/A 3_prime_UTR_variant
rs1053790 -- 3,579,874(+) T/C 3_prime_UTR_variant
rs1053791 -- 3,579,923(+) C/G 3_prime_UTR_variant

Additional Variant Information for TGIF2LY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TGIF2LY Gene

Disorders for TGIF2LY Gene

Additional Disease Information for TGIF2LY

No disorders were found for TGIF2LY Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TGIF2LY Gene

Publications for TGIF2LY Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 3 4 58
  2. The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon. (PMID: 12226713) Blanco-Arias P … Affara NA (Mammalian genome : official journal of the International Mammalian Genome Society 2002) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T … Hayashizaki Y (Cell 2010) 3 58

Products for TGIF2LY Gene

Sources for TGIF2LY Gene

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