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The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chr... See more...
Aliases for TGIF2 Gene
Aliases for TGIF2 Gene
External Ids for TGIF2 Gene
- HGNC: 15764
- Entrez Gene: 60436
- Ensembl: ENSG00000118707
- OMIM: 607294
- UniProtKB: Q9GZN2
Previous GeneCards Identifiers for TGIF2 Gene
- GC20P034930
- GC20P035840
- GC20P035887
- GC20P034635
- GC20P035201
- GC20P031911
Summaries for TGIF2 Gene
-
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for TGIF2 Gene
TGIF2 (TGFB Induced Factor Homeobox 2) is a Protein Coding gene. Diseases associated with TGIF2 include Holoprosencephaly 4 and Holoprosencephaly. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is TGIF1.
UniProtKB/Swiss-Prot Summary for TGIF2 Gene
-
Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
Additional gene information for TGIF2 Gene
- HGNC(15764)
- Entrez Gene(60436)
- Ensembl(ENSG00000118707)
- OMIM(607294)
- UniProtKB(Q9GZN2)
- Open Targets Platform(ENSG00000118707)
- Search for TGIF2 at DataMed
- Search for TGIF2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TGIF2 Gene
Genomics for TGIF2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TGIF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TGIF2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TGIF2
- Top Transcription factor binding sites by QIAGEN in the TGIF2 gene promoter:
-
- E47
- GATA-6
- Sox9
- Tal-1beta
- USF-1
- USF-1:USF-2
- USF1
- Zic3
Genomic Locations for TGIF2 Gene
Genomic Locations for TGIF2 Gene
- chr20:36,573,473-36,593,952
- (GRCh38/hg38)
- Size:
- 20,480 bases
- Orientation:
- Plus strand
- chr20:35,201,876-35,222,355
- (GRCh37/hg19)
- Size:
- 20,480 bases
- Orientation:
- Plus strand
Genomic View for TGIF2 Gene
Genes around TGIF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.23 by HGNC
- 20q11.23 by Entrez Gene
- 20q11.23 by Ensembl
TGIF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TGIF2 Gene
Proteins for TGIF2 Gene
-
Protein details for TGIF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9GZN2-TGIF2_HUMAN
- Recommended name:
- Homeobox protein TGIF2
- Protein Accession:
- Q9GZN2
- B2R9U3
- E1P5T9
- H0YNI0
Protein attributes for TGIF2 Gene
- Size:
- 237 amino acids
- Molecular mass:
- 25878 Da
- Quaternary structure:
-
- Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.
- SequenceCaution:
-
- Sequence=BX377269; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- TGIF2 is amplified and overexpressed in several ovarian cancer cell lines.
Protein Expression for TGIF2 Gene
Post-translational modifications for TGIF2 Gene
- The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TGIF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences TGIF2 Antibody (LS-B9414) and TGIF2 Antibody (LS-B11170)
- Novus Biologicals Antibodies for TGIF2
- Invitrogen Antibodies for TGIF2 (AFLGC-TGIF2)
-
Boster Bio Antibodies for TGIF2
-
Santa Cruz Biotechnology (SCBT) Antibodies for TGIF2
Protein Products
-
OriGene Purified Proteins for TGIF2
- Search Origene for MassSpec and Protein Over-expression Lysates for TGIF2
- Origene Custom Protein Services for TGIF2
- antibodies-online: Show 6 available TGIF2 Proteins ranked by validation data
- Compare Top TGIF2 Proteins
-
Quality Products:
-
Abcam proteins for TGIF2
No data available for DME Specific Peptides for TGIF2 Gene
Domains & Families for TGIF2 Gene
Gene Families for TGIF2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for TGIF2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TGIF2 Gene
- GenScript: Design optimal peptide antigens:
-
- TGF-beta-induced transcription factor 2 (TGIF2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9GZN2- Family:
-
- Belongs to the TALE/TGIF homeobox family.
Function for TGIF2 Gene
Molecular function for TGIF2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
Phenotypes From GWAS Catalog for TGIF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | NAS | 11006116 |
Phenotypes for TGIF2 Gene
- MGI mutant phenotypes for TGIF2:
-
inferred from 2 alleles
- nervous system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- reproductive system phenotype
- vision/eye phenotype
- embryo phenotype
- craniofacial phenotype
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for TGIF2:
Animal Models for TGIF2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TGIF2 - Select products 50% OFF >
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for TGIF2
miRNA for TGIF2 Gene
- miRTarBase miRNAs that target TGIF2
-
- hsa-miR-148a-3p (MIRT000298)
- hsa-miR-30c-5p (MIRT007108)
- hsa-miR-181a-5p (MIRT025109)
- hsa-miR-101-3p (MIRT027288)
- hsa-miR-149-3p (MIRT038620)
- hsa-miR-1260b (MIRT052726)
- hsa-miR-29b-3p (MIRT053746)
- hsa-miR-34a-5p (MIRT201842)
- hsa-miR-29c-3p (MIRT253487)
- mmu-miR-34a-5p (MIRT438529)
- hsa-miR-3120-5p (MIRT496752)
- hsa-miR-6894-3p (MIRT496753)
- hsa-miR-6820-5p (MIRT496754)
- hsa-miR-4763-5p (MIRT496755)
- hsa-miR-3166 (MIRT496756)
- hsa-miR-4446-5p (MIRT630790)
- hsa-miR-5006-3p (MIRT630791)
- hsa-miR-4755-5p (MIRT630792)
- hsa-miR-670-5p (MIRT630793)
- hsa-miR-6747-3p (MIRT630794)
- hsa-miR-6752-3p (MIRT630795)
- hsa-miR-7641 (MIRT665881)
- hsa-miR-548t-3p (MIRT665882)
- hsa-miR-548ap-3p (MIRT665883)
- hsa-miR-548aa (MIRT665884)
- hsa-miR-548z (MIRT665885)
- hsa-miR-548h-3p (MIRT665886)
- hsa-miR-548d-3p (MIRT665887)
- hsa-miR-548bb-3p (MIRT665888)
- hsa-miR-548ac (MIRT665889)
- hsa-miR-148a-5p (MIRT733044)
- hsa-miR-34c-5p (MIRT733424)
- hsa-miR-34a-3p (MIRT733806)
- hsa-miR-541-3p (MIRT735457)
- hsa-miR-1224-3p (MIRT736084)
- hsa-miR-6758-5p (MIRT754892)
- hsa-miR-6856-5p (MIRT757738)
Targeted motifs for TGIF2 Gene
HOMER Transcription Factor Regulatory Elements motif TGIF2
- Consensus sequence: TGTCANYT Submotif: canonical Cell Type: mES GEO ID: GSE55404
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for TGIF2 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for TGIF2
- Addgene plasmids for TGIF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TGIF2
Cell Line Products
-
Horizon Cell Lines for TGIF2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TGIF2 Gene
Localization for TGIF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TGIF2 Gene
- Nucleus. Note=Excluded from nucleoli.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 4 |
| extracellular | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
- Nucleoplasm (4)
- Centrosome (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | TAS | 11006116 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005813 | centrosome | IDA | -- |
Pathways & Interactions for TGIF2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
| 2 | Gene Expression |
.48
|
|
| 3 | TGF-beta signaling pathway (KEGG) | ||
| 4 | Signaling by GPCR | ||
| 5 | Regulation of nuclear SMAD2/3 signaling | ||
Pathways by source for TGIF2 Gene
2 BioSystems pathways for TGIF2 Gene
1 KEGG pathway for TGIF2 Gene
Interacting Proteins for TGIF2 Gene
GPS-Prot Interaction Network for TGIF2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | -- |
| GO:0006355 | regulation of transcription, DNA-templated | NAS | 11006116 |
| GO:0010470 | regulation of gastrulation | IEA | -- |
| GO:0038092 | nodal signaling pathway | IEA | -- |
| GO:0045666 | positive regulation of neuron differentiation | IEA | -- |
No data available for SIGNOR curated interactions for TGIF2 Gene
Transcripts for TGIF2 Gene
mRNA/cDNA for TGIF2 Gene
- 4 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000373872 3406 nts (view in UCSC)
- ENST00000373874 3432 nts (view in UCSC)
- ENST00000557885 659 nts (view in UCSC)
- ENST00000558028 638 nts (view in UCSC)
- ENST00000558465 785 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TGIF2 - Select products 50% OFF >
- * TGIF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TGIF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TGIF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGIF2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TGIF2
- Browse OriGene Inhibitory RNA Products For TGIF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGIF2
Clone Products
- Applied Biological Materials (abm): Clones for TGIF2 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TGIF2
- Addgene plasmids for TGIF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TGIF2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - |
Relevant External Links for TGIF2 Gene
- GeneLoc Exon Structure for
- TGIF2
Expression for TGIF2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Eye (Sensory Organs)
- Blood (Hematopoietic System)
This gene is overexpressed in Platelet (52.3) and Heart (16.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TGIF2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TGIF2
SOURCE GeneReport for Unigene cluster for TGIF2 Gene:
Hs.632264mRNA Expression by UniProt/SwissProt for TGIF2 Gene:
Q9GZN2-TGIF2_HUMAN
Tissue specificity:
Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.
Evidence on tissue expression from TISSUES for TGIF2 Gene
- Muscle(4.4)
- Lymph node(2.1)
Primer Products
-
OriGene qPCR primer pairs for TGIF2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TGIF2 Gene
Orthologs for TGIF2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TGIF2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gm7148 31 |
|
OneToMany | |
| Tgif2 30 17 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | TGIF2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TGIF2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tgif2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | TGIF2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TGIF2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TGIF2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TGIF2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tgif2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100535338 30 |
|
||
| TGIF2 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | vis 31 32 |
|
ManyToMany | |
| achi 31 32 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TOS8 31 |
|
ManyToMany | |
| CUP9 31 |
|
ManyToMany |
- Species where no ortholog for TGIF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TGIF2 Gene
- ENSEMBL:
- Gene Tree for TGIF2 (if available)
- TreeFam:
- Gene Tree for TGIF2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TGIF2: view image
Paralogs for TGIF2 Gene
Paralogs for TGIF2 Gene
(12) SIMAP similar genes for TGIF2 Gene using alignment to 5 proteins:
- TGIF2_HUMAN
- H0YKN5_HUMAN
- U3KQ25_HUMAN
- U3KQB5_HUMAN
- U3KQS0_HUMAN
Pseudogenes.org Pseudogenes for TGIF2 Gene
Variants for TGIF2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1057192 | CNV | loss | 25217958 |
| nsv833967 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.09;
2.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TGIF2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TGIF2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TGIF2 Gene
Disorders for TGIF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| holoprosencephaly 4 |
|
|
| holoprosencephaly |
|
|
| ovarian cancer |
|
|
Search TGIF2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TGIF2
No data available for UniProtKB/Swiss-Prot and Genatlas for TGIF2 Gene
Publications for TGIF2 Gene
- TGIF2 interacts with histone deacetylase 1 and represses transcription. (PMID: 11427533) Melhuish TA … Wotton D (The Journal of biological chemistry 2001) 3 4 23
- Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines. (PMID: 11006116) Imoto I … Inazawa J (Biochemical and biophysical research communications 2000) 2 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
ExternalLinks
Products for TGIF2 Gene
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- antibodies-online: Show 22 available TGIF2 Antibodies ranked by validation data
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- antibodies-online: Show 6 available TGIF2 Proteins ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for TGIF2
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- Boster Bio Antibodies for TGIF2
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Sources for TGIF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
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