The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chr... See more...

Aliases for TGIF2 Gene

Aliases for TGIF2 Gene

  • TGFB Induced Factor Homeobox 2 2 3 5
  • TGFB-Induced Factor 2 (TALE Family Homeobox) 2 3
  • Homeobox Protein TGIF2 3 4
  • Transcription Growth Factor-Beta-Induced Factor 2 3
  • TGF(Beta)-Induced Transcription Factor 2 3
  • TGF-Beta-Induced Transcription Factor 2 4
  • TGFB-Induced Factor Homeobox 2 2
  • 5'-TG-3' Interacting Factor 2 3
  • 5'-TG-3'-Interacting Factor 2 4
  • TGFB-Induced Factor 2 4
  • TGIF2 5

External Ids for TGIF2 Gene

Previous GeneCards Identifiers for TGIF2 Gene

  • GC20P034930
  • GC20P035840
  • GC20P035887
  • GC20P034635
  • GC20P035201
  • GC20P031911

Summaries for TGIF2 Gene

Entrez Gene Summary for TGIF2 Gene

  • The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for TGIF2 Gene

TGIF2 (TGFB Induced Factor Homeobox 2) is a Protein Coding gene. Diseases associated with TGIF2 include Holoprosencephaly 4 and Holoprosencephaly. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is TGIF1.

UniProtKB/Swiss-Prot Summary for TGIF2 Gene

  • Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.

Gene Wiki entry for TGIF2 Gene

Additional gene information for TGIF2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TGIF2 Gene

Genomics for TGIF2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TGIF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TGIF2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TGIF2

Top Transcription factor binding sites by QIAGEN in the TGIF2 gene promoter:
  • E47
  • GATA-6
  • Sox9
  • Tal-1beta
  • USF-1
  • USF-1:USF-2
  • USF1
  • Zic3

Genomic Locations for TGIF2 Gene

Genomic Locations for TGIF2 Gene
chr20:36,573,473-36,593,952
(GRCh38/hg38)
Size:
20,480 bases
Orientation:
Plus strand
chr20:35,201,876-35,222,355
(GRCh37/hg19)
Size:
20,480 bases
Orientation:
Plus strand

Genomic View for TGIF2 Gene

Genes around TGIF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGIF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGIF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGIF2 Gene

Proteins for TGIF2 Gene

  • Protein details for TGIF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZN2-TGIF2_HUMAN
    Recommended name:
    Homeobox protein TGIF2
    Protein Accession:
    Q9GZN2
    Secondary Accessions:
    • B2R9U3
    • E1P5T9
    • H0YNI0

    Protein attributes for TGIF2 Gene

    Size:
    237 amino acids
    Molecular mass:
    25878 Da
    Quaternary structure:
    • Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.
    SequenceCaution:
    • Sequence=BX377269; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • TGIF2 is amplified and overexpressed in several ovarian cancer cell lines.

    Alternative splice isoforms for TGIF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TGIF2 Gene

Post-translational modifications for TGIF2 Gene

  • The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TGIF2 Gene

Domains & Families for TGIF2 Gene

Gene Families for TGIF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TGIF2 Gene

Suggested Antigen Peptide Sequences for TGIF2 Gene

GenScript: Design optimal peptide antigens:
  • TGF-beta-induced transcription factor 2 (TGIF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZN2

UniProtKB/Swiss-Prot:

TGIF2_HUMAN :
  • Belongs to the TALE/TGIF homeobox family.
Family:
  • Belongs to the TALE/TGIF homeobox family.
genes like me logo Genes that share domains with TGIF2: view

Function for TGIF2 Gene

Molecular function for TGIF2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.

Phenotypes From GWAS Catalog for TGIF2 Gene

Gene Ontology (GO) - Molecular Function for TGIF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS 11006116
genes like me logo Genes that share ontologies with TGIF2: view
genes like me logo Genes that share phenotypes with TGIF2: view

Animal Models for TGIF2 Gene

MGI Knock Outs for TGIF2:
  • Tgif2 Tgif2<tm1Dwot>
  • Tgif2 Tgif2<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Targeted motifs for TGIF2 Gene
HOMER Transcription Factor Regulatory Elements motif TGIF2
  • Consensus sequence: TGTCANYT Submotif: canonical Cell Type: mES GEO ID: GSE55404

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGIF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TGIF2 Gene

Localization for TGIF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGIF2 Gene

Nucleus. Note=Excluded from nucleoli.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TGIF2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
extracellular 2
cytosol 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Centrosome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TGIF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus TAS 11006116
GO:0005654 nucleoplasm TAS --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with TGIF2: view

Pathways & Interactions for TGIF2 Gene

genes like me logo Genes that share pathways with TGIF2: view

Gene Ontology (GO) - Biological Process for TGIF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS --
GO:0006355 regulation of transcription, DNA-templated NAS 11006116
GO:0010470 regulation of gastrulation IEA --
GO:0038092 nodal signaling pathway IEA --
GO:0045666 positive regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with TGIF2: view

No data available for SIGNOR curated interactions for TGIF2 Gene

Drugs & Compounds for TGIF2 Gene

No Compound Related Data Available

Transcripts for TGIF2 Gene

mRNA/cDNA for TGIF2 Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGIF2

Alternative Splicing Database (ASD) splice patterns (SP) for TGIF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6: - - - - -
SP7: - - - - - -

Relevant External Links for TGIF2 Gene

GeneLoc Exon Structure for
TGIF2

Expression for TGIF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TGIF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TGIF2 Gene

This gene is overexpressed in Platelet (52.3) and Heart (16.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TGIF2 Gene



Protein tissue co-expression partners for TGIF2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TGIF2

SOURCE GeneReport for Unigene cluster for TGIF2 Gene:

Hs.632264

mRNA Expression by UniProt/SwissProt for TGIF2 Gene:

Q9GZN2-TGIF2_HUMAN
Tissue specificity: Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.

Evidence on tissue expression from TISSUES for TGIF2 Gene

  • Muscle(4.4)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with TGIF2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TGIF2 Gene

Orthologs for TGIF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TGIF2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TGIF2 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm7148 31
  • 93 (a)
OneToMany
Tgif2 30 17 31
  • 88.65 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia TGIF2 30 31
  • 91.56 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TGIF2 30 31
  • 89.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tgif2 30
  • 89.65 (n)
Oppossum
(Monodelphis domestica)
Mammalia TGIF2 31
  • 70 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TGIF2 31
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TGIF2 31
  • 57 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TGIF2 31
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tgif2 30
  • 58.77 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100535338 30
  • 59.49 (n)
TGIF2 31
  • 42 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta vis 31 32
  • 16 (a)
ManyToMany
achi 31 32
  • 15 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOS8 31
  • 15 (a)
ManyToMany
CUP9 31
  • 14 (a)
ManyToMany
Species where no ortholog for TGIF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TGIF2 Gene

ENSEMBL:
Gene Tree for TGIF2 (if available)
TreeFam:
Gene Tree for TGIF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TGIF2: view image

Paralogs for TGIF2 Gene

(12) SIMAP similar genes for TGIF2 Gene using alignment to 5 proteins:

  • TGIF2_HUMAN
  • H0YKN5_HUMAN
  • U3KQ25_HUMAN
  • U3KQB5_HUMAN
  • U3KQS0_HUMAN

Pseudogenes.org Pseudogenes for TGIF2 Gene

genes like me logo Genes that share paralogs with TGIF2: view

Variants for TGIF2 Gene

Additional dbSNP identifiers (rs#s) for TGIF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TGIF2 Gene

Variant ID Type Subtype PubMed ID
nsv1057192 CNV loss 25217958
nsv833967 CNV loss 17160897

Variation tolerance for TGIF2 Gene

Residual Variation Intolerance Score: 30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TGIF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TGIF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TGIF2 Gene

Disorders for TGIF2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TGIF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
holoprosencephaly 4
  • hpe4
holoprosencephaly
  • holoprosencephaly sequence
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TGIF2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TGIF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TGIF2 Gene

Publications for TGIF2 Gene

  1. TGIF2 interacts with histone deacetylase 1 and represses transcription. (PMID: 11427533) Melhuish TA … Wotton D (The Journal of biological chemistry 2001) 3 4 23
  2. Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines. (PMID: 11006116) Imoto I … Inazawa J (Biochemical and biophysical research communications 2000) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4

Products for TGIF2 Gene

Sources for TGIF2 Gene