The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role ... See more...

Aliases for TGIF1 Gene

Aliases for TGIF1 Gene

  • TGFB Induced Factor Homeobox 1 2 3 5
  • 5'-TG-3'-Interacting Factor 1 3 4
  • Homeobox Protein TGIF1 3 4
  • TGIF 3 4
  • Transforming Growth Factor-Beta-Induced Factor 3
  • TGFB-Induced Factor (TALE Family Homeobox) 2
  • TALE Homeobox TG-Interacting Factor 3
  • TGFB-Induced Factor Homeobox 1 2
  • HPE4 3

External Ids for TGIF1 Gene

Previous HGNC Symbols for TGIF1 Gene

  • HPE4
  • TGIF

Previous GeneCards Identifiers for TGIF1 Gene

  • GC18P003404
  • GC18P003376
  • GC18P003412

Summaries for TGIF1 Gene

Entrez Gene Summary for TGIF1 Gene

  • The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]

GeneCards Summary for TGIF1 Gene

TGIF1 (TGFB Induced Factor Homeobox 1) is a Protein Coding gene. Diseases associated with TGIF1 include Holoprosencephaly 4 and Semilobar Holoprosencephaly. Among its related pathways are Gene Expression and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is TGIF2.

UniProtKB/Swiss-Prot Summary for TGIF1 Gene

  • Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.

Gene Wiki entry for TGIF1 Gene

Additional gene information for TGIF1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TGIF1 Gene

Genomics for TGIF1 Gene

GeneHancer (GH) Regulatory Elements for TGIF1 Gene

Promoters and enhancers for TGIF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TGIF1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TGIF1

Top Transcription factor binding sites by QIAGEN in the TGIF1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for TGIF1 Gene

Genomic Locations for TGIF1 Gene
chr18:3,411,608-3,459,978
(GRCh38/hg38)
Size:
48,371 bases
Orientation:
Plus strand
chr18:3,411,606-3,458,409
(GRCh37/hg19)
Size:
46,804 bases
Orientation:
Plus strand

Genomic View for TGIF1 Gene

Genes around TGIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGIF1 Gene

Proteins for TGIF1 Gene

  • Protein details for TGIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15583-TGIF1_HUMAN
    Recommended name:
    Homeobox protein TGIF1
    Protein Accession:
    Q15583
    Secondary Accessions:
    • A6NE42
    • A6NLU7
    • F8VZB6
    • Q6ICR0
    • Q8N5X9
    • Q9NRS0

    Protein attributes for TGIF1 Gene

    Size:
    401 amino acids
    Molecular mass:
    43013 Da
    Quaternary structure:
    • Interacts with CTBP, SMAD2, SMAD3 and HDAC1.

    Three dimensional structures from OCA and Proteopedia for TGIF1 Gene

    Alternative splice isoforms for TGIF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TGIF1 Gene

Post-translational modifications for TGIF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TGIF1 Gene

Domains & Families for TGIF1 Gene

Gene Families for TGIF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TGIF1 Gene

Suggested Antigen Peptide Sequences for TGIF1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76181, highly similar to Homo sapiens TGFB-induced factor (TALE family homeobox) (TGIF), transcript variant 2, mRNA (F8VZB6_HUMAN)
  • 5'-TG-3'-interacting factor 1 (TGIF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15583

UniProtKB/Swiss-Prot:

TGIF1_HUMAN :
  • Belongs to the TALE/TGIF homeobox family.
Family:
  • Belongs to the TALE/TGIF homeobox family.
genes like me logo Genes that share domains with TGIF1: view

Function for TGIF1 Gene

Molecular function for TGIF1 Gene

UniProtKB/Swiss-Prot Function:
Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.

Phenotypes From GWAS Catalog for TGIF1 Gene

Gene Ontology (GO) - Molecular Function for TGIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10764806
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IMP 10764806
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS 8537382
genes like me logo Genes that share ontologies with TGIF1: view
genes like me logo Genes that share phenotypes with TGIF1: view

Human Phenotype Ontology for TGIF1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TGIF1 Gene

MGI Knock Outs for TGIF1:

Animal Model Products

CRISPR Products

miRNA for TGIF1 Gene

miRTarBase miRNAs that target TGIF1

Transcription Factor Targets for TGIF1 Gene

Selected GeneGlobe predicted Target genes for TGIF1
Targeted motifs for TGIF1 Gene
HOMER Transcription Factor Regulatory Elements motif TGIF1
  • Consensus sequence: YTGWCADY Submotif: canonical Cell Type: mES GEO ID: GSE55404

Clone Products

  • Addgene plasmids for TGIF1

No data available for Enzyme Numbers (IUBMB) for TGIF1 Gene

Localization for TGIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGIF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TGIF1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TGIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with TGIF1: view

Pathways & Interactions for TGIF1 Gene

genes like me logo Genes that share pathways with TGIF1: view

SIGNOR curated interactions for TGIF1 Gene

Activates:

Gene Ontology (GO) - Biological Process for TGIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS 8537382
GO:0010629 negative regulation of gene expression IEA --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with TGIF1: view

Drugs & Compounds for TGIF1 Gene

(34) Drugs for TGIF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(21) Additional Compounds for TGIF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TGIF1: view

Transcripts for TGIF1 Gene

mRNA/cDNA for TGIF1 Gene

13 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for TGIF1

Alternative Splicing Database (ASD) splice patterns (SP) for TGIF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g
SP1: - - - - - - - -
SP2: -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -
SP8:
SP9: - - - -
SP10: - -

Relevant External Links for TGIF1 Gene

GeneLoc Exon Structure for
TGIF1

Expression for TGIF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TGIF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TGIF1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TGIF1

SOURCE GeneReport for Unigene cluster for TGIF1 Gene:

Hs.373550

Evidence on tissue expression from TISSUES for TGIF1 Gene

  • Liver(4.3)
  • Nervous system(4.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TGIF1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • pharynx
  • pituitary gland
  • skull
  • tooth
General:
  • skin
genes like me logo Genes that share expression patterns with TGIF1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TGIF1 Gene

Orthologs for TGIF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TGIF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TGIF1 31 30
  • 99 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 31
  • 93 (a)
OneToMany
TGIF1 30
  • 90.93 (n)
-- 31
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TGIF1 31 30
  • 89.29 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tgif1 17 31 30
  • 86.64 (n)
rat
(Rattus norvegicus)
Mammalia Tgif1 30
  • 85.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TGIF1 31
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TGIF1 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves TGIF1 31 30
  • 76.46 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TGIF1 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tgif1 30
  • 72.55 (n)
MGC75852 30
African clawed frog
(Xenopus laevis)
Amphibia tgif-prov 30
zebrafish
(Danio rerio)
Actinopterygii tgif1 31 30
  • 61.63 (n)
OneToOne
wufb33g11 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13280 30
fruit fly
(Drosophila melanogaster)
Insecta achi 31
  • 18 (a)
ManyToMany
vis 31
  • 18 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOS8 31
  • 19 (a)
ManyToMany
CUP9 33 33 31
  • 18 (a)
Species where no ortholog for TGIF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGIF1 Gene

ENSEMBL:
Gene Tree for TGIF1 (if available)
TreeFam:
Gene Tree for TGIF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TGIF1: view image

Paralogs for TGIF1 Gene