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The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role ... See more...
Aliases for TGIF1 Gene
Aliases for TGIF1 Gene
External Ids for TGIF1 Gene
- HGNC: 11776
- Entrez Gene: 7050
- Ensembl: ENSG00000177426
- OMIM: 602630
- UniProtKB: Q15583
Previous HGNC Symbols for TGIF1 Gene
- HPE4
- TGIF
Previous GeneCards Identifiers for TGIF1 Gene
- GC18P003404
- GC18P003376
- GC18P003412
Summaries for TGIF1 Gene
-
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
GeneCards Summary for TGIF1 Gene
TGIF1 (TGFB Induced Factor Homeobox 1) is a Protein Coding gene. Diseases associated with TGIF1 include Holoprosencephaly 4 and Semilobar Holoprosencephaly. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is TGIF2.
UniProtKB/Swiss-Prot Summary for TGIF1 Gene
-
Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Additional gene information for TGIF1 Gene
- HGNC(11776)
- Entrez Gene(7050)
- Ensembl(ENSG00000177426)
- OMIM(602630)
- UniProtKB(Q15583)
- Open Targets Platform(ENSG00000177426)
- Monarch Initiative
- Search for TGIF1 at DataMed
- Search for TGIF1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TGIF1 Gene
Genomics for TGIF1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TGIF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TGIF1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TGIF1
- Top Transcription factor binding sites by QIAGEN in the TGIF1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
Genomic Locations for TGIF1 Gene
Genomic Locations for TGIF1 Gene
- chr18:3,411,608-3,459,978
- (GRCh38/hg38)
- Size:
- 48,371 bases
- Orientation:
- Plus strand
- chr18:3,411,606-3,458,409
- (GRCh37/hg19)
- Size:
- 46,804 bases
- Orientation:
- Plus strand
Genomic View for TGIF1 Gene
Genes around TGIF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18p11.31 by HGNC
- 18p11.31 by Entrez Gene
- 18p11.31 by Ensembl
TGIF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TGIF1 Gene
Proteins for TGIF1 Gene
-
Protein details for TGIF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15583-TGIF1_HUMAN
- Recommended name:
- Homeobox protein TGIF1
- Protein Accession:
- Q15583
- A6NE42
- A6NLU7
- F8VZB6
- Q6ICR0
- Q8N5X9
- Q9NRS0
Protein attributes for TGIF1 Gene
- Size:
- 401 amino acids
- Molecular mass:
- 43013 Da
- Quaternary structure:
-
- Interacts with CTBP, SMAD2, SMAD3 and HDAC1.
Protein Expression for TGIF1 Gene
Post-translational modifications for TGIF1 Gene
Other Protein References for TGIF1 Gene
- ENSEMBL proteins:
-
- ENSP00000449287
- ENSP00000449531
- ENSP00000483499
- ENSP00000448121
- ENSP00000449973
- ENSP00000339631
- ENSP00000384133
- ENSP00000448934
- ENSP00000446944
- ENSP00000462285
- ENSP00000450025
- ENSP00000343969
- ENSP00000327959
- ENSP00000449580
- ENSP00000449722
- ENSP00000446838
- ENSP00000449501
- ENSP00000385206
- ENSP00000447747
- ENSP00000383031
- ENSP00000384970
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ TGIF1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for TGIF1
- Novus Biologicals Antibodies for TGIF1
-
Abcam antibodies for TGIF1
- Invitrogen Antibodies for TGIF1 (AFLGC-TGIF1)
-
Boster Bio Antibodies for TGIF1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TGIF1
Protein Products
-
OriGene Purified Proteins for TGIF1
- NM_173208
- NM_173207
- NM_173208
- NM_173209
- NM_173210
- NM_173211
- NM_170695
- NM_003244
- NM_003244
- NM_173207
- NM_173209
- NM_173211
- NM_173207
- NM_173208
- NM_173209
- NM_173210
- NM_173211
- NM_170695
- NM_003244
- NM_003244
- NM_173207
- NM_173209
- NM_173211
- NM_173208
- NM_001164075
- NM_173208
- NM_174886
- NM_173210
- NM_003244
- NM_170695
- NM_173209
- Search Origene for MassSpec and Protein Over-expression Lysates for TGIF1
- Origene Custom Protein Services for TGIF1
No data available for DME Specific Peptides for TGIF1 Gene
Domains & Families for TGIF1 Gene
Gene Families for TGIF1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for TGIF1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TGIF1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ76181, highly similar to Homo sapiens TGFB-induced factor (TALE family homeobox) (TGIF), transcript variant 2, mRNA (F8VZB6_HUMAN)
- 5'-TG-3'-interacting factor 1 (TGIF1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15583- Family:
-
- Belongs to the TALE/TGIF homeobox family.
Function for TGIF1 Gene
Molecular function for TGIF1 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Phenotypes From GWAS Catalog for TGIF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 10764806 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IMP | 10764806 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | TAS | 8537382 |
Phenotypes for TGIF1 Gene
- MGI mutant phenotypes for TGIF1:
-
inferred from 6 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- embryo phenotype
- craniofacial phenotype
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for TGIF1:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased Salmonella proliferation
- Increased Nanog expression
- Decreased shRNA abundance (Z-score < -2)
- Elongated cells
- Increased shRNA abundance (Z-score > 2)
- Dynamic nuclei (hole, folded or small irregular), decreased viability (cell death)
Animal Models for TGIF1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TGIF1 - Select products 50% OFF >
- * TGIF1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TGIF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TGIF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGIF1
miRNA for TGIF1 Gene
- miRTarBase miRNAs that target TGIF1
-
- hsa-miR-21-5p (MIRT004287)
- mmu-miR-340-5p (MIRT010364)
- mmu-miR-19b-3p (MIRT012416)
- hsa-miR-597-3p (MIRT080057)
- hsa-miR-2117 (MIRT080059)
- hsa-miR-3692-3p (MIRT080069)
- hsa-miR-4717-3p (MIRT080071)
- hsa-miR-6716-5p (MIRT080073)
- hsa-miR-19a-3p (MIRT117352)
- hsa-miR-19b-3p (MIRT117353)
- hsa-miR-1277-5p (MIRT117356)
- hsa-miR-3163 (MIRT117357)
- hsa-miR-5011-5p (MIRT117359)
- hsa-miR-5692a (MIRT117361)
- hsa-miR-1253 (MIRT117362)
- hsa-miR-3148 (MIRT117365)
- hsa-miR-4668-5p (MIRT483875)
- hsa-miR-6825-5p (MIRT483876)
- hsa-miR-7106-5p (MIRT483877)
- hsa-miR-4747-5p (MIRT483878)
- hsa-miR-5196-5p (MIRT483879)
- hsa-miR-766-5p (MIRT483880)
- hsa-miR-3202 (MIRT483881)
- hsa-miR-3179 (MIRT483882)
- hsa-miR-3613-3p (MIRT483883)
- hsa-miR-9500 (MIRT483884)
- hsa-miR-7-2-3p (MIRT483885)
- hsa-miR-7-1-3p (MIRT483886)
- hsa-miR-5688 (MIRT483887)
- hsa-miR-495-3p (MIRT483888)
- hsa-miR-548c-3p (MIRT483889)
- hsa-miR-4684-5p (MIRT533827)
- hsa-miR-6770-5p (MIRT533828)
- hsa-miR-520f-5p (MIRT533829)
- hsa-miR-374b-3p (MIRT533830)
- hsa-miR-3908 (MIRT533831)
- hsa-miR-4703-5p (MIRT533832)
- hsa-miR-3942-5p (MIRT533833)
- hsa-miR-5700 (MIRT533834)
- hsa-miR-410-3p (MIRT553661)
- hsa-miR-372-5p (MIRT641075)
- hsa-miR-371a-5p (MIRT641076)
- hsa-miR-616-5p (MIRT641077)
- hsa-miR-373-5p (MIRT641078)
- hsa-miR-371b-5p (MIRT641079)
- hsa-miR-5003-3p (MIRT641080)
- hsa-miR-6507-5p (MIRT641081)
- hsa-miR-186-5p (MIRT641082)
- hsa-miR-144-5p (MIRT734437)
- mmu-miR-146a-3p (MIRT735234)
- mmu-miR-146a-5p (MIRT735237)
- hsa-miR-23b-3p (MIRT735550)
- hsa-miR-1273e (MIRT761874)
- hsa-miR-1273g-3p (MIRT761992)
- hsa-miR-3689d (MIRT767105)
- hsa-miR-377-5p (MIRT767487)
- hsa-miR-4252 (MIRT768056)
- hsa-miR-4459 (MIRT769359)
- hsa-miR-455-3p (MIRT770441)
- hsa-miR-6086 (MIRT775617)
- hsa-miR-6134 (MIRT775973)
- hsa-miR-6499-3p (MIRT776386)
- hsa-miR-6516-5p (MIRT777233)
- hsa-miR-665 (MIRT777631)
- hsa-miR-6807-5p (MIRT779619)
- hsa-miR-6840-3p (MIRT780189)
- hsa-miR-6851-5p (MIRT780440)
- hsa-miR-6880-5p (MIRT780865)
- hsa-miR-7847-3p (MIRT782179)
Transcription Factor Targets for TGIF1 Gene
Targeted motifs for TGIF1 Gene
HOMER Transcription Factor Regulatory Elements motif TGIF1
- Consensus sequence: YTGWCADY Submotif: canonical Cell Type: mES GEO ID: GSE55404
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TGIF1
- Browse OriGene Inhibitory RNA Products For TGIF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGIF1
Clone Products
- Applied Biological Materials (abm): Clones for TGIF1 - Select products 50% OFF >
- * TGIF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203642
- MG223245
- MG223789
- MG223793
- MG224610
- MR203642
- MR203642L3
- MR203642L4
- MR223245
- MR223245L3
- MR223245L4
- MR223789
- MR223789L3
- MR223789L4
- MR223793
- MR223793L3
- MR223793L4
- MR224610
- MR224610L3
- MR224610L4
- RC201549
- RC201549L3
- RC201549L4
- RC206945
- RC206945L1
- RC206945L2
- RC206945L3
- RC206945L4
- RC212969
- RC212969L1
- RC212969L2
- RC212969L3
- RC212969L4
- RC217799
- RC217799L3
- RC217799L4
- RC221666
- RC221666L3
- RC221666L4
- RC223096
- RC223096L3
- RC223096L4
- RC223200
- RC223200L3
- RC223200L4
- RC223830
- RC223830L1
- RC223830L2
- RC223830L3
- RC223830L4
- RC236943
- RC237074
- RC237091
- RG201549
- RG206945
- RG212969
- RG217799
- RG221666
- RG223096
- RG223200
- RG223830
- RR202719
- RR202719L3
- RR202719L4
- MR203642L3V
- MR203642L4V
- MR223245L3V
- MR223245L4V
- MR223789L3V
- MR223789L4V
- MR223793L3V
- MR223793L4V
- MR224610L3V
- MR224610L4V
- RC201549L3V
- RC201549L4V
- RC206945L1V
- RC206945L2V
- RC206945L3V
- RC206945L4V
- RC212969L1V
- RC212969L2V
- RC212969L3V
- RC212969L4V
- RC217799L3V
- RC217799L4V
- RC221666L3V
- RC221666L4V
- RC223096L3V
- RC223096L4V
- RC223200L3V
- RC223200L4V
- RC223830L1V
- RC223830L2V
- RC223830L3V
- RC223830L4V
- RR202719L3V
- RR202719L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TGIF1
- Addgene plasmids for TGIF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TGIF1
Cell Line Products
-
Horizon Cell Lines for TGIF1
No data available for Enzyme Numbers (IUBMB) for TGIF1 Gene
Localization for TGIF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TGIF1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for TGIF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
| 2 | Gene Expression |
.48
|
|
| 3 | TGF-beta signaling pathway (KEGG) | ||
| 4 | SMAD Signaling Network |
SMAD Signaling Network
-
|
|
| 5 | Signaling by GPCR | ||
Pathways by source for TGIF1 Gene
6 BioSystems pathways for TGIF1 Gene
1 KEGG pathway for TGIF1 Gene
1 Qiagen pathway for TGIF1 Gene
- SMAD Signaling Network
Interacting Proteins for TGIF1 Gene
Selected Interacting proteins:
Q15583-TGIF1_HUMAN
ENSP00000327959
for TGIF1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TGIF1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | TAS | 8537382 |
| GO:0010629 | negative regulation of gene expression | IEA | -- |
| GO:0042493 | response to drug | IEA | -- |
Transcripts for TGIF1 Gene
mRNA/cDNA for TGIF1 Gene
- 13 REFSEQ mRNAs :
- 25 NCBI additional mRNA sequence :
- 23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000330513 1980 nts (view in UCSC)
- ENST00000343820 3175 nts (view in UCSC)
- ENST00000345133 1088 nts (view in UCSC)
- ENST00000400167 1352 nts (view in UCSC)
- ENST00000401449 1670 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TGIF1 - Select products 50% OFF >
- * TGIF1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TGIF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TGIF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGIF1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TGIF1
- Browse OriGene Inhibitory RNA Products For TGIF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGIF1
Clone Products
- Applied Biological Materials (abm): Clones for TGIF1 - Select products 50% OFF >
- * TGIF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203642
- MG223245
- MG223789
- MG223793
- MG224610
- MR203642
- MR203642L3
- MR203642L4
- MR223245
- MR223245L3
- MR223245L4
- MR223789
- MR223789L3
- MR223789L4
- MR223793
- MR223793L3
- MR223793L4
- MR224610
- MR224610L3
- MR224610L4
- RC201549
- RC201549L3
- RC201549L4
- RC206945
- RC206945L1
- RC206945L2
- RC206945L3
- RC206945L4
- RC212969
- RC212969L1
- RC212969L2
- RC212969L3
- RC212969L4
- RC217799
- RC217799L3
- RC217799L4
- RC221666
- RC221666L3
- RC221666L4
- RC223096
- RC223096L3
- RC223096L4
- RC223200
- RC223200L3
- RC223200L4
- RC223830
- RC223830L1
- RC223830L2
- RC223830L3
- RC223830L4
- RC236943
- RC237074
- RC237091
- RG201549
- RG206945
- RG212969
- RG217799
- RG221666
- RG223096
- RG223200
- RG223830
- RR202719
- RR202719L3
- RR202719L4
- MR203642L3V
- MR203642L4V
- MR223245L3V
- MR223245L4V
- MR223789L3V
- MR223789L4V
- MR223793L3V
- MR223793L4V
- MR224610L3V
- MR224610L4V
- RC201549L3V
- RC201549L4V
- RC206945L1V
- RC206945L2V
- RC206945L3V
- RC206945L4V
- RC212969L1V
- RC212969L2V
- RC212969L3V
- RC212969L4V
- RC217799L3V
- RC217799L4V
- RC221666L3V
- RC221666L4V
- RC223096L3V
- RC223096L4V
- RC223200L3V
- RC223200L4V
- RC223830L1V
- RC223830L2V
- RC223830L3V
- RC223830L4V
- RR202719L3V
- RR202719L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TGIF1
- Addgene plasmids for TGIF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TGIF1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | · | 8g |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP10: | - | - |
Relevant External Links for TGIF1 Gene
- GeneLoc Exon Structure for
- TGIF1
Expression for TGIF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
- Neurons
-
Uterus (Reproductive System)
-
Spinal Cord (Nervous System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Ovary (Reproductive System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TGIF1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TGIF1
SOURCE GeneReport for Unigene cluster for TGIF1 Gene:
Hs.373550Evidence on tissue expression from TISSUES for TGIF1 Gene
- Liver(4.5)
- Nervous system(4.4)
- Skin(2.4)
- Intestine(2.4)
- Kidney(2.3)
- Lung(2.2)
- Thyroid gland(2)
- Spleen(2)
- Muscle(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TGIF1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- endocrine
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- eye
- eyelid
- face
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- nose
- pharynx
- pituitary gland
- skull
- tooth
General:
- skin
Primer Products
-
OriGene qPCR primer pairs for TGIF1
-
OriGene qPCR primer pairs and template standards for TGIF1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TGIF1 Gene
Orthologs for TGIF1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TGIF1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| TGIF1 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | TGIF1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tgif1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tgif1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TGIF1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TGIF1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TGIF1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TGIF1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tgif1 30 |
|
||
| MGC75852 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | tgif-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tgif1 30 31 |
|
OneToOne | |
| wufb33g11 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13280 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | achi 31 |
|
ManyToMany | |
| vis 31 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TOS8 31 |
|
ManyToMany | |
| CUP9 31 33 33 33 |
|
ManyToMany |
- Species where no ortholog for TGIF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TGIF1 Gene
- ENSEMBL:
- Gene Tree for TGIF1 (if available)
- TreeFam:
- Gene Tree for TGIF1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TGIF1: view image
Paralogs for TGIF1 Gene
Paralogs for TGIF1 Gene
(20) SIMAP similar genes for TGIF1 Gene using alignment to 11 proteins:
- TGIF1_HUMAN
- F8VUY0_HUMAN
- F8VVS9_HUMAN
- F8VW34_HUMAN
- F8VWK5_HUMAN
- F8VX54_HUMAN
- F8VXG3_HUMAN
- F8VYL4_HUMAN
- F8VZH2_HUMAN
- F8W1J9_HUMAN
- J3KS32_HUMAN
Pseudogenes.org Pseudogenes for TGIF1 Gene
Variants for TGIF1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TGIF1 Gene
| SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 672771 | Benign: not provided | 3,447,963(+) | A/G | INTRON_VARIANT | |
| 672772 | Benign: not provided | 3,457,187(+) | T/G | INTRON_VARIANT | |
| 674961 | Benign: not provided | 3,447,873(+) | T/C | INTRON_VARIANT | |
| 674962 | Benign: not provided | 3,451,541(+) | GA/G | INTRON_VARIANT | |
| 675019 | Benign: not provided | 3,447,727(+) | C/T | FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1720477 | CNV | insertion | 17803354 |
| esv3641584 | CNV | loss | 21293372 |
| esv3641585 | CNV | gain | 21293372 |
| esv3641597 | CNV | gain | 21293372 |
| nsv1110716 | CNV | insertion | 24896259 |
| nsv2190 | CNV | insertion | 18451855 |
| nsv516490 | CNV | loss | 19592680 |
| nsv527676 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.46;
91.01% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TGIF1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGIF1 Gene
Disorders for TGIF1 Gene
(30) MalaCards diseases for TGIF1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| holoprosencephaly 4 |
|
|
| semilobar holoprosencephaly |
|
|
| midline interhemispheric variant of holoprosencephaly |
|
|
| lobar holoprosencephaly |
|
|
| microform holoprosencephaly |
|
|
Search TGIF1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TGIF1_HUMAN- Holoprosencephaly 4 (HPE4) [MIM:142946]: A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. {ECO:0000269 PubMed:10835638, ECO:0000269 PubMed:15221788}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for TGIF1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for TGIF1 Gene
Publications for TGIF1 Gene
- Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination. (PMID: 10835638) Gripp KW … Elledge SJ (Nature genetics 2000) 2 3 4 23
- A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif. (PMID: 8537382) Bertolino E … Clerc RG (The Journal of biological chemistry 1995) 2 3 4 23
- Assessment of TGIF as a candidate gene for myopia. (PMID: 18172074) Pertile KK … Baird PN (Investigative ophthalmology & visual science 2008) 3 23 41
- TGFB-induced factor (TGIF): a candidate gene for psychosis on chromosome 18p. (PMID: 17440433) Chavarría-Siles I … Escamilla MA (Molecular psychiatry 2007) 3 23 41
- Analysis of single nucleotide polymorphisms at 13 loci within the transforming growth factor-induced factor gene shows no association with high myopia in Japanese subjects. (PMID: 17048038) Hasumi Y … Mizuki N (Immunogenetics 2006) 3 23 41
ExternalLinks
Products for TGIF1 Gene
- Custom Antibody ServicesOriGene Antibodies for TGIF1
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- OriGene Purified Proteins for TGIF1
- NM_173208
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- OriGene qPCR primer pairs for TGIF1
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- MG203642
- MG223245
- MG223789
- MG223793
- MG224610
- MR203642
- MR203642L3
- MR203642L4
- MR223245
- MR223245L3
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- MR223789
- MR223789L3
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- MR223793
- MR223793L3
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- MR224610
- MR224610L3
- MR224610L4
- RC201549
- RC201549L3
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- RC206945
- RC206945L1
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- RC212969
- RC212969L1
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- RC212969L3
- RC212969L4
- RC217799
- RC217799L3
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- RC221666
- RC221666L3
- RC221666L4
- RC223096
- RC223096L3
- RC223096L4
- RC223200
- RC223200L3
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- RC223830
- RC223830L1
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- RC236943
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- RG201549
- RG206945
- RG212969
- RG217799
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- RG223096
- RG223200
- RG223830
- RR202719
- RR202719L3
- RR202719L4
- MR203642L3V
- MR203642L4V
- MR223245L3V
- MR223245L4V
- MR223789L3V
- MR223789L4V
- MR223793L3V
- MR223793L4V
- MR224610L3V
- MR224610L4V
- RC201549L3V
- RC201549L4V
- RC206945L1V
- RC206945L2V
- RC206945L3V
- RC206945L4V
- RC212969L1V
- RC212969L2V
- RC212969L3V
- RC212969L4V
- RC217799L3V
- RC217799L4V
- RC221666L3V
- RC221666L4V
- RC223096L3V
- RC223096L4V
- RC223200L3V
- RC223200L4V
- RC223830L1V
- RC223830L2V
- RC223830L3V
- RC223830L4V
- RR202719L3V
- RR202719L4V
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