Aliases for TGFBR3 Gene
External Ids for TGFBR3 Gene
Previous GeneCards Identifiers for TGFBR3 Gene
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
GeneCards Summary for TGFBR3 Gene
TGFBR3 (Transforming Growth Factor Beta Receptor 3) is a Protein Coding gene. Diseases associated with TGFBR3 include Familial Cerebral Saccular Aneurysm and Intermediate Uveitis. Among its related pathways are p70S6K Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include heparin binding and SMAD binding. An important paralog of this gene is ENG.
UniProtKB/Swiss-Prot Summary for TGFBR3 Gene
Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.