Aliases for TGFBR3 Gene
Aliases for TGFBR3 Gene
External Ids for TGFBR3 Gene
- HGNC: 11774
- Entrez Gene: 7049
- Ensembl: ENSG00000069702
- OMIM: 600742
- UniProtKB: Q03167
Previous GeneCards Identifiers for TGFBR3 Gene
- GC01M092604
- GC01M091345
- GC01M091485
- GC01M091860
- GC01M092145
- GC01M090263
Summaries for TGFBR3 Gene
-
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
GeneCards Summary for TGFBR3 Gene
TGFBR3 (Transforming Growth Factor Beta Receptor 3) is a Protein Coding gene. Diseases associated with TGFBR3 include Familial Cerebral Saccular Aneurysm and Intermediate Uveitis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include heparin binding and SMAD binding. An important paralog of this gene is ENG.
UniProtKB/Swiss-Prot for TGFBR3 Gene
-
Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
Additional gene information for TGFBR3 Gene
- Monarch Initiative
- Search for TGFBR3 at DataMed
- Search for TGFBR3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGFBR3 Gene
Genomics for TGFBR3 Gene
GeneHancer (GH) Regulatory Elements for TGFBR3 Gene
Promoters and enhancers for TGFBR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TGFBR3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TGFBR3 Gene
Genomic Locations for TGFBR3 Gene
- chr1:91,680,343-91,906,335
- (GRCh38/hg38)
- Size:
- 225,993 bases
- Orientation:
- Minus strand
- chr1:92,145,900-92,371,892
- (GRCh37/hg19)
Genomic View for TGFBR3 Gene
Genes around TGFBR3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.1 by Ensembl
- 1p22.1 by Entrez Gene
- 1p22.1 by HGNC
TGFBR3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TGFBR3 Gene
Proteins for TGFBR3 Gene
-
Protein details for TGFBR3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03167-TGBR3_HUMAN
- Recommended name:
- Transforming growth factor beta receptor type 3
- Protein Accession:
- Q03167
- A0AUW8
- A8K5N0
- B9EG88
- Q5T2T4
- Q5U731
- Q9UGI2
Protein attributes for TGFBR3 Gene
- Size:
- 851 amino acids
- Molecular mass:
- 93499 Da
- Quaternary structure:
-
- Interacts with TCTEX1D4.
- SequenceCaution:
-
- Sequence=AAA67061.1; Type=Frameshift; Positions=70, 73, 349, 350; Evidence={ECO:0000305};
Protein Expression for TGFBR3 Gene
Post-translational modifications for TGFBR3 Gene
- Extensively modified by glycosaminoglycan groups (GAG).
- Glycosylation at posLast=141141, isoforms=369, isoforms=2492, posLast=534534, posLast=545545, posLast=571571, posLast=590590, and posLast=697697
Other Protein References for TGFBR3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TGFBR3 (TGF-beta RIII)
- Cell Signaling Technology (CST) Antibodies for TGFBR3 (TGFBR3)
-
Custom Antibody ServicesOriGene Antibodies for TGFBR3
- Novus Biologicals Antibodies for TGFBR3
-
Abcam antibodies for TGFBR3
- Invitrogen Antibodies for TGFBR3
- GeneTex TGFBR3 antibody for TGFBR3
-
Santa Cruz Biotechnology (SCBT) Antibodies for TGFBR3
- Sino Biological Antibodies for TGFBR3
Protein Products
- R&D Systems Proteins and Enzymes for TGFBR3 (TGF-beta RIII)
-
OriGene Purified Proteins for TGFBR3
- Search Origene for MassSpec and Protein Over-expression Lysates for TGFBR3
- Origene Custom Protein Services for TGFBR3
- Sino Biological Recombinant Proteins for TGFBR3
- Sino Biological Cell Lysates for TGFBR3
- Search GeneTex for Proteins for TGFBR3
Assay Products
- R&D Systems ELISAs and other biochemical assays for TGFBR3 (TGF-beta RIII)
- antibodies-online: Search results for 15 available TGFBR3 Elisa Kits ranked by validation data
- Compare Top TGFBR3 Elisa Kits
-
Quality Products:
-
Abcam assays for TGFBR3
No data available for DME Specific Peptides for TGFBR3 Gene
Domains & Families for TGFBR3 Gene
Gene Families for TGFBR3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for TGFBR3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TGFBR3 Gene
Function for TGFBR3 Gene
Molecular function for TGFBR3 Gene
- GENATLAS Biochemistry:
- transforming growth factor beta,receptor type III
- UniProtKB/Swiss-Prot Function:
- Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
Phenotypes From GWAS Catalog for TGFBR3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005024 | transforming growth factor beta-activated receptor activity | IDA | 12958365 |
| GO:0005114 | type II transforming growth factor beta receptor binding | IDA | 11157754 |
| GO:0005160 | transforming growth factor beta receptor binding | IEA,ISS | 1333192 |
| GO:0005515 | contributes_to protein binding | IPI | 10746731 |
| GO:0005539 | glycosaminoglycan binding | TAS | 1333192 |
Phenotypes for TGFBR3 Gene
- MGI mutant phenotypes for TGFBR3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for TGFBR3:
-
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
- Strongly decreased CFP-tsO45G cell surface transport
- Increased G1 DNA content
- Increased shRNA abundance (Z-score > 2)
- Increased number of mitotic cells
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability with carboplatin
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TGFBR3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TGFBR3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TGFBR3 gene
- Search ViGene Biosciences for TGFBR3
CRISPR Products
-
OriGene CRISPR knockouts for TGFBR3
- genomics-online: gRNA clones - Search results for 116 available TGFBR3 gene related products
- Overview of 116 available TGFBR3 gene related products
- Applied Biological Materials CRISPR for TGFBR3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGFBR3
- GenScript: Design CRISPR guide RNA sequences for TGFBR3
miRNA for TGFBR3 Gene
- miRTarBase miRNAs that target TGFBR3
-
- hsa-mir-21-5p (MIRT005330)
- hsa-mir-193b-3p (MIRT016418)
- hsa-mir-181a-5p (MIRT025118)
- hsa-mir-101-3p (MIRT027244)
- hsa-mir-6817-3p (MIRT292287)
- hsa-mir-6873-3p (MIRT292289)
- hsa-mir-7110-3p (MIRT292290)
- hsa-mir-541-5p (MIRT439463)
- hsa-mir-136-3p (MIRT439465)
- hsa-mir-382-3p (MIRT439466)
- hsa-mir-218-5p (MIRT439467)
- hsa-mir-513a-5p (MIRT466397)
- hsa-mir-369-5p (MIRT466398)
- hsa-mir-186-5p (MIRT466399)
- hsa-mir-3681-3p (MIRT466400)
- hsa-mir-27b-3p (MIRT466401)
- hsa-mir-216a-3p (MIRT466402)
- hsa-mir-27a-3p (MIRT466403)
- hsa-mir-128-3p (MIRT466404)
- hsa-mir-582-5p (MIRT546321)
- hsa-mir-202-3p (MIRT546322)
- hsa-mir-6715a-3p (MIRT546323)
- hsa-mir-144-3p (MIRT546324)
- hsa-let-7a-5p (MIRT546325)
- hsa-let-7c-5p (MIRT546326)
- hsa-mir-98-5p (MIRT546327)
- hsa-mir-4500 (MIRT546328)
- hsa-let-7d-5p (MIRT546329)
- hsa-let-7f-5p (MIRT546330)
- hsa-let-7g-5p (MIRT546331)
- hsa-let-7i-5p (MIRT546332)
- hsa-mir-4458 (MIRT546333)
- hsa-let-7e-5p (MIRT546334)
- hsa-let-7b-5p (MIRT546335)
- hsa-mir-196a-5p (MIRT546336)
- hsa-mir-196b-5p (MIRT546337)
- hsa-mir-4638-3p (MIRT565383)
- hsa-mir-3690 (MIRT565384)
- hsa-mir-7157-5p (MIRT565385)
- hsa-mir-4310 (MIRT565386)
- hsa-mir-548x-3p (MIRT565387)
- hsa-mir-548j-3p (MIRT565388)
- hsa-mir-548aq-3p (MIRT565389)
- hsa-mir-548aj-3p (MIRT565390)
- hsa-mir-548am-3p (MIRT565391)
- hsa-mir-548ah-3p (MIRT565392)
- hsa-mir-548ae-3p (MIRT565393)
- hsa-mir-330-3p (MIRT565394)
- hsa-mir-497-5p (MIRT565395)
- hsa-mir-195-5p (MIRT565396)
- hsa-mir-6838-5p (MIRT565397)
- hsa-mir-15b-5p (MIRT565398)
- hsa-mir-16-5p (MIRT565399)
- hsa-mir-15a-5p (MIRT565400)
- hsa-mir-424-5p (MIRT565401)
- hsa-mir-103a-3p (MIRT565402)
- hsa-mir-107 (MIRT565403)
- hsa-mir-1238-3p (MIRT621836)
- hsa-mir-670-3p (MIRT621837)
- hsa-mir-4753-3p (MIRT621838)
- hsa-mir-6881-3p (MIRT621839)
- hsa-mir-6780a-3p (MIRT621840)
- hsa-mir-7111-3p (MIRT621841)
- hsa-mir-130b-5p (MIRT621842)
- hsa-mir-6769b-3p (MIRT621843)
- hsa-mir-4723-3p (MIRT621844)
- hsa-mir-3183 (MIRT621845)
miRNA Products
- Search ViGene Biosciences for TGFBR3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TGFBR3
- Browse OriGene Inhibitory RNA Products For TGFBR3
- genomics-online: shRNA clones - Search results for 116 available TGFBR3 gene related products
- Overview of 116 available TGFBR3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TGFBR3 gene
Clone Products
- Sino Biological Human cDNA Clone for TGFBR3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TGFBR3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TGFBR3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TGFBR3
- Applied Biological Materials Clones for TGFBR3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TGFBR3 (TGF-beta RIII)
Cell Line Products
-
Horizon Cell Lines for TGFBR3
-
ViGene Biosciences adenoviral particle packaged cDNA for TGFBR3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TGFBR3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TGFBR3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TGFBR3 Gene
Localization for TGFBR3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TGFBR3 Gene
- Secreted. Secreted, extracellular space. Cell membrane; Single-pass type I membrane protein. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 2 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
| GO:0005615 | extracellular space | IEA,TAS | 18184661 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
Pathways & Interactions for TGFBR3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
|
.66
.65
.61
.60
|
| 2 | Apoptosis Pathway |
.39
|
|
| 3 | PAK Pathway |
.56
|
|
| 4 | CREB Pathway |
.68
|
|
| 5 | Sertoli-Sertoli Cell Junction Dynamics | ||
Pathways by source for TGFBR3 Gene
2 Cell Signaling Technology pathways for TGFBR3 Gene
5 BioSystems pathways for TGFBR3 Gene
2 GeneGo (Thomson Reuters) pathways for TGFBR3 Gene
1 R&D Systems pathway for TGFBR3 Gene
4 Tocris pathways for TGFBR3 Gene
Interacting Proteins for TGFBR3 Gene
Selected Interacting proteins:
ENSP00000212355
Q03167-TGBR3_HUMAN
for TGFBR3 Gene via
STRING
UniProtKB
IID
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001837 | epithelial to mesenchymal transition | IDA | 18184661 |
| GO:0001889 | liver development | ISS | -- |
| GO:0003007 | heart morphogenesis | ISS | -- |
| GO:0003150 | muscular septum morphogenesis | ISS | -- |
Transcripts for TGFBR3 Gene
mRNA/cDNA for TGFBR3 Gene
- (5) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (189) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TGFBR3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TGFBR3
- genomics-online: gRNA clones - Search results for 116 available TGFBR3 gene related products
- Overview of 116 available TGFBR3 gene related products
- Applied Biological Materials CRISPR for TGFBR3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGFBR3
- GenScript: Design CRISPR guide RNA sequences for TGFBR3
miRNA Products
- Search ViGene Biosciences for TGFBR3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TGFBR3
- Browse OriGene Inhibitory RNA Products For TGFBR3
- genomics-online: shRNA clones - Search results for 116 available TGFBR3 gene related products
- Overview of 116 available TGFBR3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TGFBR3 gene
Clone Products
- Sino Biological Human cDNA Clone for TGFBR3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TGFBR3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TGFBR3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TGFBR3
- Applied Biological Materials Clones for TGFBR3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TGFBR3 (TGF-beta RIII)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for TGFBR3 Gene
This gene is overexpressed in Serum (22.4), Urine (9.3), Urinary Bladder (8.8), and Ovary (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TGFBR3 Gene
NURSA nuclear receptor signaling pathways regulating expression of TGFBR3 Gene:
TGFBR3SOURCE GeneReport for Unigene cluster for TGFBR3 Gene:
Hs.482390Evidence on tissue expression from TISSUES for TGFBR3 Gene
- Nervous system(4.4)
- Blood(4.3)
- Lung(2.2)
- Muscle(2.1)
- Heart(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TGFBR3 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- nervous
Regions:
Head and neck:
- brain
- head
General:
- blood vessel
Primer Products
-
OriGene qPCR primer pairs for TGFBR3
- genomics-online: primer clones - Search results for 116 available TGFBR3 gene related products
- Overview of 116 available TGFBR3 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TGFBR3 Gene
Orthologs for TGFBR3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TGFBR3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TGFBR3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TGFBR3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tgfbr3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tgfbr3 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TGFBR3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | TGFBR3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TGFBR3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tgfbr3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tgfbr3 33 34 |
|
- Species where no ortholog for TGFBR3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TGFBR3 Gene
(38) SIMAP similar genes for TGFBR3 Gene using alignment to 4 proteins:
Variants for TGFBR3 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920827 | uncertain-significance, Malignant tumor of prostate | 91,683,776(-) | G/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000017637 | -- | 91,697,457(-) | G/A | intron_variant | |
| rs1000043196 | -- | 91,894,899(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000058247 | -- | 91,755,884(-) | A/G | intron_variant | |
| rs1000069414 | -- | 91,843,409(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.24;
81.13% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TGFBR3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGFBR3 Gene
Disorders for TGFBR3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| familial cerebral saccular aneurysm |
|
|
| intermediate uveitis |
|
|
| eisenmenger syndrome |
|
|
| priapism |
|
|
| vogt-koyanagi-harada disease |
|
|
Search TGFBR3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TGFBR3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TGFBR3 Gene
Publications for TGFBR3 Gene
- Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors. (PMID: 1333192) Morén A … Miyazono K (Biochemical and biophysical research communications 1992) 2 3 4 22 58
- Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema. (PMID: 19131638) Hersh CP … ICGN Investigators (American journal of respiratory cell and molecular biology 2009) 3 22 44 58
- Mutational analysis of the betaglycan gene-coding region in susceptibility for ovarian failure. (PMID: 16613887) Dixit H … Singh L (Human reproduction (Oxford, England) 2006) 3 22 44 58
- Eleven single nucleotide polymorphisms and one triple nucleotide insertion of the human TGF-beta III receptor gene. (PMID: 10944857) Zippert R … Schunkert H (Journal of human genetics 2000) 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
Products for TGFBR3 Gene
- R&D Systems Antibodies for TGFBR3 (TGF-beta RIII)
- R&D Systems Proteins and Enzymes for TGFBR3 (TGF-beta RIII)
- R&D Systems ELISAs and other biochemical assays for TGFBR3 (TGF-beta RIII)
- R&D Systems cDNA Clones for TGFBR3 (TGF-beta RIII)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for TGFBR3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TGFBR3
- Search Origene for MassSpec and Protein Over-expression Lysates for TGFBR3
- Origene Custom Protein Services for TGFBR3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TGFBR3
- Browse OriGene Inhibitory RNA Products For TGFBR3
- OriGene qPCR primer pairs for TGFBR3
- OriGene CRISPR knockouts for TGFBR3
- OriGene ORF clones in human for TGFBR3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TGFBR3
- GenScript: Next-day shipping of latest version cDNA ORF clones for TGFBR3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TGFBR3
- GenScript Custom Assay Services for TGFBR3
- GenScript Custom overexpressing Cell Line Services for TGFBR3
- GenScript: Design CRISPR guide RNA sequences for TGFBR3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TGFBR3
- Cell Signaling Technology (CST) Antibodies for TGFBR3 (TGFBR3)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for TGFBR3
- Sino Biological Cell Lysates for TGFBR3
- Sino Biological Recombinant Proteins for TGFBR3
- Sino Biological Antibodies for TGFBR3
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TGFBR3
- Novus Biologicals lysates and proteins for TGFBR3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TGFBR3
- Abcam assays for TGFBR3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for TGFBR3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for TGFBR3
- VectorBuilder custom plasmid, inducible vectors for TGFBR3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TGFBR3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TGFBR3
- antibodies-online: Search results for 103 available TGFBR3 Antibodies ranked by validation data
- Compare Top TGFBR3 Antibodies
- antibodies-online: Search results for 15 available TGFBR3 Elisa Kits ranked by validation data
- Compare Top TGFBR3 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 10 available TGFBR3 Proteins ranked by validation data
- Compare Top TGFBR3 Proteins
- Quality Products:
- GeneTex TGFBR3 antibody for TGFBR3
- Search GeneTex for Proteins for TGFBR3
- ViGene Biosciences adenoviral particle packaged cDNA for TGFBR3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TGFBR3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TGFBR3 gene
- Search ViGene Biosciences for TGFBR3
- Santa Cruz Biotechnology (SCBT) Antibodies for TGFBR3
- Search Santa Cruz Biotechnology (SCBT) for TGFBR3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TGFBR3
- Horizon Cell Lines for TGFBR3
- genomics-online: cdna clones - Search results for 116 available TGFBR3 gene related products
- Overview of 116 available TGFBR3 gene related products
- orf clones - Search results for 116 available TGFBR3 gene related products
- Overview of 116 available TGFBR3 gene related products
- genomics-online: gRNA clones - Search results for 116 available TGFBR3 gene related products
- Overview of 116 available TGFBR3 gene related products
- genomics-online: primer clones - Search results for 116 available TGFBR3 gene related products
- Overview of 116 available TGFBR3 gene related products
- genomics-online: shRNA clones - Search results for 116 available TGFBR3 gene related products
- Overview of 116 available TGFBR3 gene related products
Sources for TGFBR3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew