This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternati... See more...
Aliases for TGFBR3 Gene
Aliases for TGFBR3 Gene
External Ids for TGFBR3 Gene
- HGNC: 11774
- Entrez Gene: 7049
- Ensembl: ENSG00000069702
- OMIM: 600742
- UniProtKB: Q03167
Previous GeneCards Identifiers for TGFBR3 Gene
- GC01M092604
- GC01M091345
- GC01M091485
- GC01M091619
- GC01M091860
- GC01M092145
- GC01M090263
Summaries for TGFBR3 Gene
-
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
GeneCards Summary for TGFBR3 Gene
TGFBR3 (Transforming Growth Factor Beta Receptor 3) is a Protein Coding gene. Diseases associated with TGFBR3 include Familial Cerebral Saccular Aneurysm and Intermediate Uveitis. Among its related pathways are p70S6K Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include heparin binding and SMAD binding. An important paralog of this gene is ENG.
UniProtKB/Swiss-Prot Summary for TGFBR3 Gene
-
Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
Additional gene information for TGFBR3 Gene
- Monarch Initiative
- Search for TGFBR3 at DataMed
- Search for TGFBR3 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TGFBR3 Gene
Genomics for TGFBR3 Gene
GeneHancer (GH) Regulatory Elements for TGFBR3 Gene
Promoters and enhancers for TGFBR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TGFBR3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TGFBR3 gene promoter:
-
- c-Myc
- GCNF-2
- Max1
- MyoD
- Pax-2
- Pax-2a
- Pax-2b
- Sox9
- Sp1
Genomic Locations for TGFBR3 Gene
Genomic Locations for TGFBR3 Gene
- chr1:91,680,343-91,906,335
- (GRCh38/hg38)
- Size:
- 225,993 bases
- Orientation:
- Minus strand
- chr1:92,145,900-92,371,892
- (GRCh37/hg19)
- Size:
- 225,993 bases
- Orientation:
- Minus strand
Genomic View for TGFBR3 Gene
Genes around TGFBR3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.1 by HGNC
- 1p22.1 by Entrez Gene
- 1p22.1 by Ensembl
TGFBR3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TGFBR3 Gene
Proteins for TGFBR3 Gene
-
Protein details for TGFBR3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03167-TGBR3_HUMAN
- Recommended name:
- Transforming growth factor beta receptor type 3
- Protein Accession:
- Q03167
- A0AUW8
- A8K5N0
- B9EG88
- Q5T2T4
- Q5U731
- Q9UGI2
Protein attributes for TGFBR3 Gene
- Size:
- 851 amino acids
- Molecular mass:
- 93499 Da
- Quaternary structure:
-
- Interacts with TCTEX1D4.
- SequenceCaution:
-
- Sequence=AAA67061.1; Type=Frameshift; Positions=70, 73, 349, 350; Evidence={ECO:0000305};
Protein Expression for TGFBR3 Gene
Post-translational modifications for TGFBR3 Gene
- Extensively modified by glycosaminoglycan groups (GAG).
-
Glycosylation at Asn141, Thr369, Asn492, Ser534, Ser545, Asn571, Asn590, and Asn697
- NX_Q03167 (NX_Q03167-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TGFBR3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ TGF ß Receptor III Antibody
- Atlas Antibodies Anti-TGFBR3 Antibody
- Novus Biologicals Antibodies for TGFBR3
-
Abcam antibodies for TGFBR3
- Invitrogen Antibodies for TGFBR3 (AFLGC-TGFBR3)
-
Biorbyt antibodies for TGFBR3
-
Santa Cruz Biotechnology (SCBT) Antibodies for TGFBR3
- Sino Biological Antibodies for TGFBR3
Protein Products
- Atlas Antibodies PrEST Antigen TGFBR3
-
OriGene Purified Proteins for TGFBR3
- Search Origene for MassSpec and Protein Over-expression Lysates for TGFBR3
- Origene Custom Protein Services for TGFBR3
- Sino Biological Recombinant Proteins for TGFBR3
- Sino Biological Cell Lysates for TGFBR3
- antibodies-online: Show 10 available TGFBR3 Proteins ranked by validation data
- Compare Top TGFBR3 Proteins
-
Quality Products:
Assay Products
- RayBiotech Human TGF-beta RIII ELISA
- Aviva Systems Biology TGFBR3 ELISA Kit (Human) (OKEH07184)
- antibodies-online: Show 23 available TGFBR3 Elisa Kits ranked by validation data
- Compare Top TGFBR3 Elisa Kits
-
Quality Products:
-
Abcam assays for TGFBR3
No data available for DME Specific Peptides for TGFBR3 Gene
Domains & Families for TGFBR3 Gene
Gene Families for TGFBR3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for TGFBR3 Gene
- GenScript: Design optimal peptide antigens:
-
- Transforming growth factor beta receptor III (TGBR3_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TGFBR3 Gene
Function for TGFBR3 Gene
Molecular function for TGFBR3 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
- GENATLAS Biochemistry:
- transforming growth factor beta,receptor type III
Phenotypes From GWAS Catalog for TGFBR3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005024 | transforming growth factor beta-activated receptor activity | IDA | 12958365 |
| GO:0005114 | type II transforming growth factor beta receptor binding | IDA | 11157754 |
| GO:0005160 | transforming growth factor beta receptor binding | ISS,IEA | 1333192 |
| GO:0005515 | contributes_to protein binding | IPI | 10746731 |
| GO:0005539 | glycosaminoglycan binding | TAS | 1333192 |
Phenotypes for TGFBR3 Gene
- MGI mutant phenotypes for TGFBR3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for TGFBR3:
-
- Increased shRNA abundance (Z-score > 2)
- Increased number of mitotic cells
- Decreased cell number
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Decreased viability with carboplatin
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
Animal Models for TGFBR3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TGFBR3 - Select products 50% OFF >
- * TGFBR3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TGFBR3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for TGFBR3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TGFBR3
- genomics-online: gRNA clones - Search for available TGFBR3 gRNA products
- Overview of 124 available TGFBR3 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGFBR3
miRNA for TGFBR3 Gene
- miRTarBase miRNAs that target TGFBR3
-
- hsa-mir-21-5p (MIRT005330)
- hsa-mir-193b-3p (MIRT016418)
- hsa-mir-181a-5p (MIRT025118)
- hsa-mir-101-3p (MIRT027244)
- hsa-mir-6817-3p (MIRT292287)
- hsa-mir-6873-3p (MIRT292289)
- hsa-mir-7110-3p (MIRT292290)
- hsa-mir-541-5p (MIRT439463)
- hsa-mir-136-3p (MIRT439465)
- hsa-mir-382-3p (MIRT439466)
- hsa-mir-218-5p (MIRT439467)
- hsa-mir-513a-5p (MIRT466397)
- hsa-mir-369-5p (MIRT466398)
- hsa-mir-186-5p (MIRT466399)
- hsa-mir-3681-3p (MIRT466400)
- hsa-mir-27b-3p (MIRT466401)
- hsa-mir-216a-3p (MIRT466402)
- hsa-mir-27a-3p (MIRT466403)
- hsa-mir-128-3p (MIRT466404)
- hsa-mir-582-5p (MIRT546321)
- hsa-mir-202-3p (MIRT546322)
- hsa-mir-6715a-3p (MIRT546323)
- hsa-mir-144-3p (MIRT546324)
- hsa-let-7a-5p (MIRT546325)
- hsa-let-7c-5p (MIRT546326)
- hsa-mir-98-5p (MIRT546327)
- hsa-mir-4500 (MIRT546328)
- hsa-let-7d-5p (MIRT546329)
- hsa-let-7f-5p (MIRT546330)
- hsa-let-7g-5p (MIRT546331)
- hsa-let-7i-5p (MIRT546332)
- hsa-mir-4458 (MIRT546333)
- hsa-let-7e-5p (MIRT546334)
- hsa-let-7b-5p (MIRT546335)
- hsa-mir-196a-5p (MIRT546336)
- hsa-mir-196b-5p (MIRT546337)
- hsa-mir-4638-3p (MIRT565383)
- hsa-mir-3690 (MIRT565384)
- hsa-mir-7157-5p (MIRT565385)
- hsa-mir-4310 (MIRT565386)
- hsa-mir-548x-3p (MIRT565387)
- hsa-mir-548j-3p (MIRT565388)
- hsa-mir-548aq-3p (MIRT565389)
- hsa-mir-548aj-3p (MIRT565390)
- hsa-mir-548am-3p (MIRT565391)
- hsa-mir-548ah-3p (MIRT565392)
- hsa-mir-548ae-3p (MIRT565393)
- hsa-mir-330-3p (MIRT565394)
- hsa-mir-497-5p (MIRT565395)
- hsa-mir-195-5p (MIRT565396)
- hsa-mir-6838-5p (MIRT565397)
- hsa-mir-15b-5p (MIRT565398)
- hsa-mir-16-5p (MIRT565399)
- hsa-mir-15a-5p (MIRT565400)
- hsa-mir-424-5p (MIRT565401)
- hsa-mir-103a-3p (MIRT565402)
- hsa-mir-107 (MIRT565403)
- hsa-mir-1238-3p (MIRT621836)
- hsa-mir-670-3p (MIRT621837)
- hsa-mir-4753-3p (MIRT621838)
- hsa-mir-6881-3p (MIRT621839)
- hsa-mir-6780a-3p (MIRT621840)
- hsa-mir-7111-3p (MIRT621841)
- hsa-mir-130b-5p (MIRT621842)
- hsa-mir-6769b-3p (MIRT621843)
- hsa-mir-4723-3p (MIRT621844)
- hsa-mir-3183 (MIRT621845)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TGFBR3
- Browse OriGene Inhibitory RNA Products For TGFBR3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGFBR3
- genomics-online: shRNA clones - Search for available TGFBR3 shRNA products
- Overview of 124 available TGFBR3 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for TGFBR3 - Select products 50% OFF >
- * TGFBR3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TGFBR3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG210951
- MR210951
- MR210951L3
- MR210951L3V
- MR210951L4
- MR210951L4V
- RC216595
- RC216595L1
- RC216595L1V
- RC216595L2
- RC216595L2V
- RC216595L3
- RC216595L3V
- RC216595L4
- RC216595L4V
- RC230881
- RC230881L1
- RC230881L1V
- RC230881L2
- RC230881L2V
- RC230881L3
- RC230881L3V
- RC230881L4
- RC230881L4V
- RC234962
- RG216595
- RG230881
- RG234962
- RR204151
- RR204151L3
- RR204151L3V
- RR204151L4
- RR204151L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TGFBR3
- Addgene plasmids for TGFBR3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TGFBR3
Cell Line Products
-
Horizon Cell Lines for TGFBR3
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TGFBR3 Gene
Localization for TGFBR3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TGFBR3 Gene
- Secreted. Secreted, extracellular space. Cell membrane; Single-pass type I membrane protein. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| cytosol | 2 |
| nucleus | 1 |
| endoplasmic reticulum | 0 |
| lysosome | 0 |
| golgi apparatus | 0 |
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | TAS,IEA | 18184661 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | IEA,ISS | -- |
Pathways & Interactions for TGFBR3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
|
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | Apoptosis Pathway |
.39
|
|
| 3 | PAK Pathway |
Antioxidant Action of Vitamin-C
.56
PAK Pathway
.56
|
Epithelial Adherens Junctions
.36
|
| 4 | CREB Pathway |
CREB Pathway
.68
|
Activation of PKC through GPCR
.63
|
| 5 | Sertoli-Sertoli Cell Junction Dynamics |
Sertoli-Sertoli Cell Junction Dynamics
.38
|
Epithelial Tight Junctions
.36
|
Pathways by source for TGFBR3 Gene
5 BioSystems pathways for TGFBR3 Gene
2 GeneGo (Thomson Reuters) pathways for TGFBR3 Gene
1 R&D Systems pathway for TGFBR3 Gene
4 Tocris pathways for TGFBR3 Gene
29 Qiagen pathways for TGFBR3 Gene
- Actin-Based Motility by Rho Family GTPases
- Activation of PKC through GPCR
- Antioxidant Action of Vitamin-C
- Apoptotic Pathways in Synovial Fibroblasts
- Breast Cancer Regulation by Stathmin1
2 Cell Signaling Technology pathways for TGFBR3 Gene
Interacting Proteins for TGFBR3 Gene
Selected Interacting proteins:
Q03167-TGBR3_HUMAN
ENSP00000212355
for TGFBR3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TGFBR3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001837 | epithelial to mesenchymal transition | IDA | 18184661 |
| GO:0001889 | liver development | ISS | -- |
| GO:0003007 | heart morphogenesis | ISS | -- |
| GO:0003150 | muscular septum morphogenesis | ISS | -- |
Drugs & Compounds for TGFBR3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Atlas Antibodies PrEST Antigen TGFBR3
Transcripts for TGFBR3 Gene
mRNA/cDNA for TGFBR3 Gene
- (3) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (189) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000212355 6339 bps (ENST00000212355.8)
- ENST00000370399 4550 bps (ENST00000370399.6)
- ENST00000417833 551 bps (ENST00000417833.2)
- ENST00000465892 2908 bps (ENST00000465892.6)
- ENST00000468996 569 bps (ENST00000468996.2)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TGFBR3 - Select products 50% OFF >
- * TGFBR3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TGFBR3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for TGFBR3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TGFBR3
- genomics-online: gRNA clones - Search for available TGFBR3 gRNA products
- Overview of 124 available TGFBR3 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGFBR3
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TGFBR3
- Browse OriGene Inhibitory RNA Products For TGFBR3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGFBR3
- genomics-online: shRNA clones - Search for available TGFBR3 shRNA products
- Overview of 124 available TGFBR3 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for TGFBR3 - Select products 50% OFF >
- * TGFBR3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TGFBR3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG210951
- MR210951
- MR210951L3
- MR210951L3V
- MR210951L4
- MR210951L4V
- RC216595
- RC216595L1
- RC216595L1V
- RC216595L2
- RC216595L2V
- RC216595L3
- RC216595L3V
- RC216595L4
- RC216595L4V
- RC230881
- RC230881L1
- RC230881L1V
- RC230881L2
- RC230881L2V
- RC230881L3
- RC230881L3V
- RC230881L4
- RC230881L4V
- RC234962
- RG216595
- RG230881
- RG234962
- RR204151
- RR204151L3
- RR204151L3V
- RR204151L4
- RR204151L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TGFBR3
- Addgene plasmids for TGFBR3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TGFBR3
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for TGFBR3 Gene
This gene is overexpressed in Serum (22.4), Urine (9.3), Urinary Bladder (8.8), and Ovary (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TGFBR3 Gene
NURSA nuclear receptor signaling pathways regulating expression of TGFBR3 Gene:
TGFBR3SOURCE GeneReport for Unigene cluster for TGFBR3 Gene:
Hs.482390Evidence on tissue expression from TISSUES for TGFBR3 Gene
- Nervous system(4.4)
- Blood(4.3)
- Lung(2.3)
- Muscle(2.1)
- Heart(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TGFBR3 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- nervous
Regions:
Head and neck:
- brain
- head
General:
- blood vessel
Primer Products
-
OriGene qPCR primer pairs for TGFBR3
- genomics-online: primer clones - Search for available TGFBR3 Primer products
- Overview of 124 available TGFBR3 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TGFBR3 Gene
Orthologs for TGFBR3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TGFBR3 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TGFBR3 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TGFBR3 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tgfbr3 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tgfbr3 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TGFBR3 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | TGFBR3 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TGFBR3 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tgfbr3 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tgfbr3 33 32 |
|
OneToOne |
- Species where no ortholog for TGFBR3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for TGFBR3 Gene
- ENSEMBL:
- Gene Tree for TGFBR3 (if available)
- TreeFam:
- Gene Tree for TGFBR3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TGFBR3: view image
Paralogs for TGFBR3 Gene
(38) SIMAP similar genes for TGFBR3 Gene using alignment to 4 proteins:
- TGBR3_HUMAN
- E9PAW7_HUMAN
- E9PKY4_HUMAN
- E9PMG7_HUMAN
Variants for TGFBR3 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11466577 | likely-benign, Thoracic aortic aneurysm and aortic dissection | 91,734,979(-) | G/A/T | intron_variant | |
| rs147485470 | uncertain-significance, Connective tissue disorder | 91,712,382(-) | A/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs147586574 | likely-benign, Thoracic aortic aneurysm and aortic dissection | 91,861,477(-) | T/C/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs149079126 | likely-benign, Connective tissue disorder | 91,722,095(-) | A/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs17883665 | likely-benign, Thoracic aortic aneurysm and aortic dissection | 91,734,891(-) | C/T | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant |
Residual Variation Intolerance Score:
67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.24;
81.13% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TGFBR3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGFBR3 Gene
Disorders for TGFBR3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| familial cerebral saccular aneurysm |
|
|
| intermediate uveitis |
|
|
| priapism |
|
|
| benign perivascular tumor |
|
|
| vogt-koyanagi-harada disease |
|
|
Search TGFBR3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TGFBR3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TGFBR3 Gene
Publications for TGFBR3 Gene
- Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors. (PMID: 1333192) Morén A … Miyazono K (Biochemical and biophysical research communications 1992) 2 3 4 23 56
- Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema. (PMID: 19131638) Hersh CP … ICGN Investigators (American journal of respiratory cell and molecular biology 2009) 3 23 43 56
- Mutational analysis of the betaglycan gene-coding region in susceptibility for ovarian failure. (PMID: 16613887) Dixit H … Singh L (Human reproduction (Oxford, England) 2006) 3 23 43 56
- Eleven single nucleotide polymorphisms and one triple nucleotide insertion of the human TGF-beta III receptor gene. (PMID: 10944857) Zippert R … Schunkert H (Journal of human genetics 2000) 3 4 23 56
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
ExternalLinks
Products for TGFBR3 Gene
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- genomics-online: cdna clones - Search for available TGFBR3 CDNA products
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Sources for TGFBR3 Gene
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- (46) Atlas
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- (70) Reactome
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