Aliases for TGFBI Gene
External Ids for TGFBI Gene
Previous HGNC Symbols for TGFBI Gene
Previous GeneCards Identifiers for TGFBI Gene
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
GeneCards Summary for TGFBI Gene
TGFBI (Transforming Growth Factor Beta Induced) is a Protein Coding gene. Diseases associated with TGFBI include Corneal Dystrophy, Avellino Type and Corneal Dystrophy, Reis-Bucklers Type. Among its related pathways are Metabolism of proteins and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include integrin binding and extracellular matrix binding. An important paralog of this gene is POSTN.
UniProtKB/Swiss-Prot Summary for TGFBI Gene
Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity).