Aliases for TGFBI Gene
External Ids for TGFBI Gene
Previous HGNC Symbols for TGFBI Gene
Previous GeneCards Identifiers for TGFBI Gene
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
GeneCards Summary for TGFBI Gene
TGFBI (Transforming Growth Factor Beta Induced) is a Protein Coding gene. Diseases associated with TGFBI include Corneal Dystrophy, Thiel-Behnke Type and Corneal Dystrophy, Avellino Type. Among its related pathways are Adhesion and Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include integrin binding and extracellular matrix binding. An important paralog of this gene is POSTN.
UniProtKB/Swiss-Prot Summary for TGFBI Gene
Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity).