Aliases for TGFB1I1 Gene
External Ids for TGFB1I1 Gene
Previous GeneCards Identifiers for TGFB1I1 Gene
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for TGFB1I1 Gene
TGFB1I1 (Transforming Growth Factor Beta 1 Induced Transcript 1) is a Protein Coding gene. Diseases associated with TGFB1I1 include Mesangial Proliferative Glomerulonephritis and Proliferative Glomerulonephritis. Among its related pathways are Androgen receptor signaling pathway and Translation Non-genomic (rapid) action of Androgen Receptor. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and I-SMAD binding. An important paralog of this gene is PXN.
UniProtKB/Swiss-Prot Summary for TGFB1I1 Gene
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.