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This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/... See more...
Aliases for TGFA Gene
Aliases for TGFA Gene
External Ids for TGFA Gene
- HGNC: 11765
- Entrez Gene: 7039
- Ensembl: ENSG00000163235
- OMIM: 190170
- UniProtKB: P01135
Previous GeneCards Identifiers for TGFA Gene
- GC02M070683
- GC02M070885
- GC02M070648
- GC02M070586
- GC02M070410
- GC02M070674
Summaries for TGFA Gene
-
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for TGFA Gene
TGFA (Transforming Growth Factor Alpha) is a Protein Coding gene. Diseases associated with TGFA include Tooth Agenesis and Cholesteatoma Of Middle Ear. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and NF-KappaB Family Pathway. Gene Ontology (GO) annotations related to this gene include growth factor activity and epidermal growth factor receptor binding. An important paralog of this gene is BTC.
UniProtKB/Swiss-Prot Summary for TGFA Gene
-
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Additional gene information for TGFA Gene
- HGNC(11765)
- Entrez Gene(7039)
- Ensembl(ENSG00000163235)
- OMIM(190170)
- UniProtKB(P01135)
- Open Targets Platform(ENSG00000163235)
- Monarch Initiative
- Search for TGFA at DataMed
- Search for TGFA at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TGFA Gene
Genomics for TGFA Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TGFA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TGFA on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TGFA
- Top Transcription factor binding sites by QIAGEN in the TGFA gene promoter:
-
- c-Ets-1
- Evi-1
- FOXC1
- NF-AT
- NF-AT1
- NF-AT2
- NF-AT3
- NF-AT4
- p53
Genomic Locations for TGFA Gene
Genomic Locations for TGFA Gene
- chr2:70,447,284-70,554,193
- (GRCh38/hg38)
- Size:
- 106,910 bases
- Orientation:
- Minus strand
- chr2:70,674,412-70,781,325
- (GRCh37/hg19)
- Size:
- 106,914 bases
- Orientation:
- Minus strand
Genomic View for TGFA Gene
Genes around TGFA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p13.3 by HGNC
- 2p13.3 by Entrez Gene
- 2p13.3 by Ensembl
TGFA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TGFA Gene
Proteins for TGFA Gene
-
Protein details for TGFA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01135-TGFA_HUMAN
- Recommended name:
- Protransforming growth factor alpha
- Protein Accession:
- P01135
- A8K286
- Q15577
- Q53SK7
- Q9BS56
- Q9UEI3
- Q9UKM1
- Q9UKM2
- Q9UKM3
Protein attributes for TGFA Gene
- Size:
- 160 amino acids
- Molecular mass:
- 17006 Da
- Quaternary structure:
-
- Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2.
Three dimensional structures from OCA and Proteopedia for TGFA Gene
Protein Expression for TGFA Gene
Post-translational modifications for TGFA Gene
-
Glycosylation at Asn25
- NX_P01135 (NX_P01135-1)
Other Protein References for TGFA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ TGF alpha Antibody and Immunotag™ TGFA Antibody
- NSJ Bioreagents TGF alpha Antibody (Mouse Monoclonal)
-
Custom Antibody ServicesOriGene Antibodies for TGFA
- Novus Biologicals Antibodies for TGFA
-
Abcam antibodies for TGFA
- Invitrogen Antibodies for TGFA (AFLGC-TGFA)
- antibodies-online: Show 71 available TGFA Antibodies ranked by validation data
- Compare Top TGFA Antibodies
-
Recommended
- 147 WB Antibodies (anti-human)
- 129 IHC Antibodies (anti-human)
- 99 IHC (p) Antibodies (anti-human)
- 22 IP Antibodies (anti-human)
- 21 IHC (f) Antibodies (anti-human)
- 14 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 52 WB Antibodies (anti-mouse)
- 21 IHC (f) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 4 IF Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 IHC (fro) Antibodies (anti-mouse)
- 63 WB Antibodies (anti-rat)
- 21 IHC (f) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IF Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 3 FACS Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 2 IHC (fro) Antibodies (anti-rat)
- 1 EIA Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TGFA
- Sino Biological Antibodies for TGFA
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for TGFA
- Origene Custom Protein Services for TGFA
- Sino Biological Recombinant Proteins for TGFA
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for TGFA
-
Abcam proteins for TGFA
Assay Products
- RayBiotech Human TGF-alpha ELISA
- Novus Biologicals ELISA Kits for TGFA
- antibodies-online: Show 101 available TGFA Elisa Kits ranked by validation data
- Compare Top TGFA Elisa Kits
-
Quality Products:
- ABIN625093
- ABIN921075
- ABIN1117561
- ABIN414921
- ABIN3032990
- ABIN491822
- ABIN924864
- ABIN1888492
- ABIN5522431
- ABIN2708380
- ABIN1117393
- ABIN415582
- ABIN365477
- ABIN5522432
- ABIN5669997
- ABIN1572655
- ABIN5593165
- ABIN773869
- ABIN1381544
- ABIN5659418
- ABIN1117562
- ABIN365580
- ABIN1572657
- ABIN5522434
- ABIN416295
- ABIN5670659
- ABIN5593166
- ABIN772535
- ABIN5659419
No data available for DME Specific Peptides for TGFA Gene
Domains & Families for TGFA Gene
Gene Families for TGFA Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for TGFA Gene
- InterPro:
- Blocks:
-
- Type I EGF
- Type I EGF signature
- ProtoNet:
Suggested Antigen Peptide Sequences for TGFA Gene
- GenScript: Design optimal peptide antigens:
-
- Transforming growth factor, alpha, isoform CRA_d (Q15578_HUMAN)
- Transforming growth factor alpha (Q9UE87_HUMAN)
- Transforming growth factor-alpha variant I (Q9UKM3_HUMAN)
- Transforming growth factor alpha (Q9UQ91_HUMAN)
- Protransforming growth factor alpha (TGFA_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TGFA Gene
Function for TGFA Gene
Molecular function for TGFA Gene
- UniProtKB/Swiss-Prot Function:
- TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
- GENATLAS Biochemistry:
- transforming growth factor,alpha,17kDa,expressed in macrophages,brain cells,keratinocyte,also expressed at high levels in the epithelial tissue of the medial edge of the palatal shelves at the time of shelf fusion in mice,epidermal growth factor family,involved in mitogenesis and angiogenenesis,potentially mutated in cleft lip with or without cleft palate
Phenotypes From GWAS Catalog for TGFA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005154 | epidermal growth factor receptor binding | IEA,IDA | 11278323 |
| GO:0005515 | protein binding | IPI | 12297049 |
| GO:0008083 | growth factor activity | IDA | 11278323 |
Phenotypes for TGFA Gene
- MGI mutant phenotypes for TGFA:
-
inferred from 4 alleles
- immune system phenotype
- cardiovascular system phenotype
- muscle phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- skeleton phenotype
- integument phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for TGFA:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TGFA - Select products 50% OFF >
- * TGFA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TGFA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TGFA
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGFA
miRNA for TGFA Gene
- miRTarBase miRNAs that target TGFA
-
- mmu-miR-17-5p (MIRT009853)
- mmu-miR-297a-5p (MIRT012949)
- hsa-miR-152-3p (MIRT035552)
- hsa-miR-92a-3p (MIRT049451)
- hsa-miR-376c-3p (MIRT437890)
- hsa-miR-203b-3p (MIRT444594)
- hsa-miR-7158-3p (MIRT444595)
- hsa-miR-30e-5p (MIRT444596)
- hsa-miR-30d-5p (MIRT444597)
- hsa-miR-30c-5p (MIRT444598)
- hsa-miR-30a-5p (MIRT444599)
- hsa-miR-30b-5p (MIRT444600)
- hsa-miR-7155-3p (MIRT444601)
- hsa-miR-3136-3p (MIRT444602)
- hsa-miR-6814-5p (MIRT444603)
- hsa-miR-4495 (MIRT444604)
- hsa-miR-6757-5p (MIRT444605)
- hsa-miR-6818-5p (MIRT652743)
- hsa-miR-6873-3p (MIRT652744)
- hsa-miR-222-5p (MIRT652745)
- hsa-miR-6817-3p (MIRT652746)
- hsa-miR-7110-3p (MIRT652747)
- hsa-miR-6738-3p (MIRT712890)
- hsa-miR-5001-3p (MIRT712891)
- hsa-miR-4727-5p (MIRT712892)
- hsa-miR-744-5p (MIRT712893)
- hsa-miR-4749-5p (MIRT712894)
- hsa-miR-4706 (MIRT712895)
- hsa-miR-4641 (MIRT712896)
- hsa-miR-4734 (MIRT712897)
- hsa-miR-18a-3p (MIRT712898)
- hsa-miR-324-3p (MIRT712899)
- hsa-miR-1913 (MIRT712900)
- hsa-miR-6845-3p (MIRT712901)
- hsa-miR-1976 (MIRT712902)
- hsa-miR-3653-5p (MIRT712903)
- hsa-miR-3193 (MIRT712904)
- hsa-miR-1539 (MIRT712905)
- hsa-miR-505-3p (MIRT732578)
- hsa-miR-490-3p (MIRT732589)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TGFA
- Browse OriGene Inhibitory RNA Products For TGFA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGFA
Clone Products
- Applied Biological Materials (abm): Clones for TGFA - Select products 50% OFF >
- * TGFA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TGFA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TGFA
Cell Line Products
-
Horizon Cell Lines for TGFA
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TGFA Gene
Localization for TGFA Gene
Subcellular locations from UniProtKB/Swiss-Prot for TGFA Gene
- [Transforming growth factor alpha]: Secreted, extracellular space.
- [Protransforming growth factor alpha]: Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA,IDA | 12743035 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
Pathways & Interactions for TGFA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
| 3 | ErbB signaling pathway | ||
| 4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 5 | Transport to the Golgi and subsequent modification | ||
Pathways by source for TGFA Gene
9 BioSystems pathways for TGFA Gene
13 Reactome pathways for TGFA Gene
1 PharmGKB pathway for TGFA Gene
14 KEGG pathways for TGFA Gene
3 GeneGo (Thomson Reuters) pathways for TGFA Gene
- Development EGFR signaling pathway
- Development ERBB-family signaling
- Mucin expression in CF via TLRs, EGFR signaling pathways
55 Qiagen pathways for TGFA Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
2 Cell Signaling Technology pathways for TGFA Gene
Interacting Proteins for TGFA Gene
Selected Interacting proteins:
P01135-TGFA_HUMAN
ENSP00000295400
for TGFA Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TGFA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000187 | activation of MAPK activity | IDA | 11278323 |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | -- |
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
Transcripts for TGFA Gene
mRNA/cDNA for TGFA Gene
- 4 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000295400 4117 nts (view in UCSC)
- ENST00000394241 568 nts (view in UCSC)
- ENST00000418333 1225 nts (view in UCSC)
- ENST00000419940 681 nts (view in UCSC)
- ENST00000444975 985 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TGFA - Select products 50% OFF >
- * TGFA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TGFA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TGFA
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGFA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TGFA
- Browse OriGene Inhibitory RNA Products For TGFA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGFA
Clone Products
- Applied Biological Materials (abm): Clones for TGFA - Select products 50% OFF >
- * TGFA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TGFA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TGFA
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||
| SP8: |
Relevant External Links for TGFA Gene
- GeneLoc Exon Structure for
- TGFA
Expression for TGFA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- Neural Tube (Nervous System)
- Brain (Nervous System)
- Fibroblasts (Uncategorized)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Head Mesenchyme (Muscoskeletal System)
- Dermis (Integumentary System)
- Epidermis (Integumentary System)
- Hair
mRNA differential expression in normal tissues according to GTEx for TGFA Gene
This gene is overexpressed in Whole Blood (x4.9), Brain - Spinal cord (cervical c-1) (x4.9), and Esophagus - Mucosa (x4.0).
This gene is overexpressed in Frontal cortex (61.3) and Retina (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TGFA Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TGFA
SOURCE GeneReport for Unigene cluster for TGFA Gene:
Hs.170009mRNA Expression by UniProt/SwissProt for TGFA Gene:
P01135-TGFA_HUMAN
Tissue specificity:
Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.
Evidence on tissue expression from TISSUES for TGFA Gene
- Nervous system(4.7)
- Intestine(4.5)
- Kidney(4.5)
- Heart(2.7)
- Skin(2.6)
- Lung(2.6)
- Muscle(2.6)
- Liver(2.6)
- Stomach(2.5)
- Pancreas(2.5)
- Spleen(2.4)
- Blood(2.3)
- Thyroid gland(2.3)
- Lymph node(2.2)
- Adrenal gland(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TGFA Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- skeleton
Regions:
Head and neck:
- chin
- face
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- skull
- tooth
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for TGFA
-
OriGene qPCR primer pairs and template standards for TGFA
Gene Expression Assay Products
Orthologs for TGFA Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TGFA 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TGFA 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tgfa 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TGFA 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tgfa 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | TGFA 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TGFA 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TGFA 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485434 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tgfa 31 |
|
OneToOne |
- Species where no ortholog for TGFA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TGFA Gene
- ENSEMBL:
- Gene Tree for TGFA (if available)
- TreeFam:
- Gene Tree for TGFA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TGFA: view image
Paralogs for TGFA Gene
Variants for TGFA Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TGFA Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709603 | Benign: not provided | 70,456,379(-) | C/T | MISSENSE_VARIANT | |
| 714126 | Benign: not provided | 70,514,916(-) | T/C | INTRON_VARIANT | |
| 746325 | Benign: not provided | 70,456,428(-) | A/G | SYNONYMOUS_VARIANT | |
| 750438 | Likely Benign: not provided | 70,465,606(-) | G/A | INTRON_VARIANT | |
| 764953 | Likely Benign: not provided | 70,450,875(-) | A/G | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3892614 | CNV | gain | 25118596 |
| nsv1000118 | CNV | gain | 25217958 |
| nsv472110 | CNV | novel sequence insertion | 20440878 |
| nsv834255 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.46;
43.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TGFA Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TGFA
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGFA Gene
Disorders for TGFA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tooth agenesis |
|
|
| cholesteatoma of middle ear |
|
|
| cleft lip |
|
|
| gastritis, familial giant hypertrophic |
|
|
| cleft lip with or without cleft palate |
|
|
Search TGFA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TGFA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TGFA Gene
Publications for TGFA Gene
- Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft lip/palate and cleft palate only. (PMID: 10552925) Machida J … Murray JC (Genomics 1999) 2 3 4 23
- Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6. (PMID: 20047592) Han SW … Kim TY (Cancer science 2010) 3 23 41
- Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association. (PMID: 8910478) Shum L … Derynck R (The Journal of biological chemistry 1996) 3 4 23
- Transforming growth factor-alpha: characterization of the BamHI, RsaI, and TaqI polymorphic regions. (PMID: 8100397) Qian JF … May E (American journal of human genetics 1993) 3 4 23
- Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PMID: 21507922) Ramsuran V … Ndung'u T (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011) 3 41
ExternalLinks
Products for TGFA Gene
- View all 11 R&D Systems TGFA (TGF-alpha) Products
- View all R&D Systems TGFA (TGF-alpha) Proteins and Enzymes
- View all 3 R&D Systems TGFA (TGF-alpha) Primary Antibodies
- View all 3 R&D Systems TGFA (TGF-alpha) ELISAs
- View all 3 R&D Systems TGFA (TGF-alpha) Luminex Assays
- View all R&D Systems TGFA (TGF-alpha) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom TGFA antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for TGFA
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for TGFA
- Origene Custom Protein Services for TGFA
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TGFA
- Browse OriGene Inhibitory RNA Products For TGFA
- OriGene qPCR primer pairs for TGFA
- OriGene qPCR primer pairs and template standards for TGFA
- OriGene CRISPR knockouts for TGFA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TGFA
- Sino Biological Human cDNA Clone for TGFA
- Sino Biological Recombinant Proteins for TGFA
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for TGFA
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TGFA
- Novus Biologicals proteins and lysates for TGFA
- Novus Biologicals ELISA Kits for TGFA
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TGFA
- Abcam proteins for TGFA
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for TGFA (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TGFA (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TGFA (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TGFA CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TGFA
- antibodies-online: Show 71 available TGFA Antibodies ranked by validation data
- Compare Top TGFA Antibodies
- Recommended
- 147 WB Antibodies (anti-human)
- 129 IHC Antibodies (anti-human)
- 99 IHC (p) Antibodies (anti-human)
- 22 IP Antibodies (anti-human)
- 21 IHC (f) Antibodies (anti-human)
- 14 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 52 WB Antibodies (anti-mouse)
- 21 IHC (f) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 4 IF Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 IHC (fro) Antibodies (anti-mouse)
- 63 WB Antibodies (anti-rat)
- 21 IHC (f) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IF Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 3 FACS Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 2 IHC (fro) Antibodies (anti-rat)
- 1 EIA Antibody (anti-rat)
- antibodies-online: Show 101 available TGFA Elisa Kits ranked by validation data
- Compare Top TGFA Elisa Kits
- Quality Products:
- ABIN625093
- ABIN921075
- ABIN1117561
- ABIN414921
- ABIN3032990
- ABIN491822
- ABIN924864
- ABIN1888492
- ABIN5522431
- ABIN2708380
- ABIN1117393
- ABIN415582
- ABIN365477
- ABIN5522432
- ABIN5669997
- ABIN1572655
- ABIN5593165
- ABIN773869
- ABIN1381544
- ABIN5659418
- ABIN1117562
- ABIN365580
- ABIN1572657
- ABIN5522434
- ABIN416295
- ABIN5670659
- ABIN5593166
- ABIN772535
- ABIN5659419
- antibodies-online: Show 48 available TGFA Proteins ranked by validation data
- Compare Top TGFA Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TGFA
- Search Santa Cruz Biotechnology (SCBT) for TGFA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TGFA
- Horizon Cell Lines for TGFA
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TGFA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TGFA
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TGFA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TGFA
Sources for TGFA Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB