External Ids for TG Gene
Previous GeneCards Identifiers for TG Gene
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
GeneCards Summary for TG Gene
TG (Thyroglobulin) is a Protein Coding gene. Diseases associated with TG include Thyroid Dyshormonogenesis 3 and Autoimmune Thyroid Disease 3. Among its related pathways are Aldosterone synthesis and secretion and Thyroxine (Thyroid Hormone) Production. Gene Ontology (GO) annotations related to this gene include hormone activity and carboxylic ester hydrolase activity. An important paralog of this gene is NLGN4Y.
UniProtKB/Swiss-Prot Summary for TG Gene
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).