Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follic... See more...

Aliases for TG Gene

Aliases for TG Gene

  • Thyroglobulin 2 3 4 5
  • AITD3 3
  • TGN 3
  • Tg 4

External Ids for TG Gene

Previous GeneCards Identifiers for TG Gene

  • GC08P132608
  • GC08P133966
  • GC08P133550
  • GC08P133835
  • GC08P133948
  • GC08P129197
  • GC08P133879

Summaries for TG Gene

Entrez Gene Summary for TG Gene

  • Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]

GeneCards Summary for TG Gene

TG (Thyroglobulin) is a Protein Coding gene. Diseases associated with TG include Thyroid Dyshormonogenesis 3 and Autoimmune Thyroid Disease 3. Among its related pathways are Aldosterone synthesis and secretion and Thyroxine (Thyroid Hormone) Production. Gene Ontology (GO) annotations related to this gene include hormone activity and carboxylic ester hydrolase activity. An important paralog of this gene is NLGN4Y.

UniProtKB/Swiss-Prot Summary for TG Gene

  • Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

Gene Wiki entry for TG Gene

Additional gene information for TG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TG Gene

Genomics for TG Gene

GeneHancer (GH) Regulatory Elements for TG Gene

Promoters and enhancers for TG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J132191 Promoter 0.5 EPDnew 500 -675.0 -675040 0.1 CTCF RBM39 TG lnc-HHLA1-2 lnc-HHLA1-3 KCNQ3
GH08J132866 Promoter 0.3 EPDnew 500.7 +0.0 4 0.1 TG piR-32286-014
GH08J133051 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.1 +197.8 197759 25.8 USF1 FOS RFX1 MEF2C CTCF MEF2B POLR2A SPI1 BATF MAFK SLA TG CCN4 TMEM71 PHF20L1 ENSG00000270137 5MWI_A-187 PTCSC1 lnc-NDRG1-4
GH08J133031 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 19.4 +168.1 168052 6.8 ZNF217 TCF12 JUND FOS EP300 CTBP1 NR2F2 ESRRA DEK SMARCC1 TG PHF20L1 CCN4 SLA ENSG00000223697 TMEM71 lnc-NDRG1-6 LOC105375768
GH08J133128 Promoter/Enhancer 1.5 EPDnew FANTOM5 ENCODE dbSUPER 12.8 +263.0 262974 3.4 TCF12 FOS ZBTB7A MXI1 CEBPB GATA3 SMARCC1 FOSL2 JUND SIN3A SLA CCN4 TG ST3GAL1 PHF20L1 NDRG1 HSALNG0068721 HSALNG0068723
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TG on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TG

Top Transcription factor binding sites by QIAGEN in the TG gene promoter:
  • AP-1
  • ATF-2
  • ATF6
  • c-Jun
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx2-5

Genomic Locations for TG Gene

Genomic Locations for TG Gene
chr8:132,866,935-133,134,903
(GRCh38/hg38)
Size:
267,969 bases
Orientation:
Plus strand
chr8:133,879,203-134,147,147
(GRCh37/hg19)
Size:
267,945 bases
Orientation:
Plus strand

Genomic View for TG Gene

Genes around TG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
  • 8q24.22 by