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Aliases for TFPT Gene

Aliases for TFPT Gene

  • TCF3 Fusion Partner 2 3 5
  • INO80 Complex Subunit F 2 3 4
  • TCF3 (E2A) Fusion Partner (In Childhood Leukemia) 2 3
  • Amida, Partner Of The E2A 2 3
  • INO80F 3 4
  • Protein FB1 4
  • Amida 3
  • FB1 3

External Ids for TFPT Gene

Previous GeneCards Identifiers for TFPT Gene

  • GC19M055256
  • GC19M055034
  • GC19M059286
  • GC19M059302
  • GC19M054610
  • GC19M050926

Summaries for TFPT Gene

GeneCards Summary for TFPT Gene

TFPT (TCF3 Fusion Partner) is a Protein Coding gene. Diseases associated with TFPT include Childhood Leukemia. Among its related pathways are Metabolism of proteins and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and protein kinase binding.

UniProtKB/Swiss-Prot for TFPT Gene

  • Appears to promote apoptosis in a p53/TP53-independent manner.

  • Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Gene Wiki entry for TFPT Gene

Additional gene information for TFPT Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFPT Gene

Genomics for TFPT Gene

GeneHancer (GH) Regulatory Elements for TFPT Gene

Promoters and enhancers for TFPT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I054114 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.5 464 2.4 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC PRPF31 GC19P054117 GC19P054118 PIR52942 TFPT LENG8-AS1 ZNF765 CNOT3 LENG8 ZNF845
GH19I053864 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.7 +246.8 246761 9.8 HDGF FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B SLC30A9 MYADM LOC105372457 ENSG00000269001 ZNF845 ZNF765 ZNF816 LENG8 ENSG00000235681 ZNF813 TPM3P6
GH19I053961 Enhancer 1.1 FANTOM5 ENCODE 3.4 +153.6 153560 0.3 PKNOX1 NFRKB GLI4 ZBTB40 ZNF335 GLIS2 ZNF366 EGR2 YY2 ZBTB11 CACNG8 ZNF347 ZNF702P ENSG00000267838 ZNF665 TFPT NDUFA3 CACNG7 MYADM PRPF31
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TFPT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TFPT gene promoter:

Genomic Locations for TFPT Gene

Genomic Locations for TFPT Gene
chr19:54,107,013-54,115,675
(GRCh38/hg38)
Size:
8,663 bases
Orientation:
Minus strand
chr19:54,610,320-54,619,055
(GRCh37/hg19)

Genomic View for TFPT Gene

Genes around TFPT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFPT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFPT Gene

Proteins for TFPT Gene

  • Protein details for TFPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C1Z6-TFPT_HUMAN
    Recommended name:
    TCF3 fusion partner
    Protein Accession:
    P0C1Z6
    Secondary Accessions:
    • G5E9B5

    Protein attributes for TFPT Gene

    Size:
    253 amino acids
    Molecular mass:
    28278 Da
    Quaternary structure:
    • Interacts with NOL3; translocates NOL3 into the nucleus and negatively regulated TFPT-induced cell death (By similarity). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.

    Alternative splice isoforms for TFPT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TFPT Gene

Post-translational modifications for TFPT Gene

No Post-translational modifications

Other Protein References for TFPT Gene

No data available for DME Specific Peptides for TFPT Gene

Domains & Families for TFPT Gene

Gene Families for TFPT Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TFPT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TFPT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TFPT: view

No data available for UniProtKB/Swiss-Prot for TFPT Gene

Function for TFPT Gene

Molecular function for TFPT Gene

UniProtKB/Swiss-Prot Function:
Appears to promote apoptosis in a p53/TP53-independent manner.
UniProtKB/Swiss-Prot Function:
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Phenotypes From GWAS Catalog for TFPT Gene

Gene Ontology (GO) - Molecular Function for TFPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0005515 protein binding IPI 17395368
genes like me logo Genes that share ontologies with TFPT: view
genes like me logo Genes that share phenotypes with TFPT: view

Animal Model Products

CRISPR Products

miRNA for TFPT Gene

miRTarBase miRNAs that target TFPT

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TFPT

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TFPT Gene

Localization for TFPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFPT Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TFPT gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TFPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0031011 Ino80 complex IDA 21303910
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with TFPT: view

Pathways & Interactions for TFPT Gene

genes like me logo Genes that share pathways with TFPT: view

Gene Ontology (GO) - Biological Process for TFPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with TFPT: view

No data available for SIGNOR curated interactions for TFPT Gene

Drugs & Compounds for TFPT Gene

(10) Drugs for TFPT Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(30) Additional Compounds for TFPT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TFPT: view

Transcripts for TFPT Gene

Unigene Clusters for TFPT Gene

TCF3 (E2A) fusion partner (in childhood Leukemia):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TFPT

Alternative Splicing Database (ASD) splice patterns (SP) for TFPT Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5:

Relevant External Links for TFPT Gene

GeneLoc Exon Structure for
TFPT
ECgene alternative splicing isoforms for
TFPT

Expression for TFPT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TFPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TFPT Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.5), Placenta (19.0), Blymphocyte (10.7), CD8 Tcells (8.2), and NK cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TFPT Gene



Protein tissue co-expression partners for TFPT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TFPT Gene:

TFPT

SOURCE GeneReport for Unigene cluster for TFPT Gene:

Hs.590939

Evidence on tissue expression from TISSUES for TFPT Gene

  • Liver(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with TFPT: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TFPT Gene

Orthologs for TFPT Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFPT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFPT 33 34
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia TFPT 33 34
  • 89.24 (n)
dog
(Canis familiaris)
Mammalia TFPT 33 34
  • 88.54 (n)
mouse
(Mus musculus)
Mammalia Tfpt 33 16 34
  • 87.28 (n)
rat
(Rattus norvegicus)
Mammalia Tfpt 33
  • 87.22 (n)
oppossum
(Monodelphis domestica)
Mammalia TFPT 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TFPT 34
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TFPT 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tfpt 33
  • 61.3 (n)
Str.20229 33
zebrafish
(Danio rerio)
Actinopterygii TFPT 34
  • 47 (a)
OneToOne
Species where no ortholog for TFPT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TFPT Gene

ENSEMBL:
Gene Tree for TFPT (if available)
TreeFam:
Gene Tree for TFPT (if available)

Paralogs for TFPT Gene

No data available for Paralogs for TFPT Gene

Variants for TFPT Gene

Sequence variations from dbSNP and Humsavar for TFPT Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs117225554 likely-benign, Retinitis Pigmentosa, Dominant 54,115,396(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs17526361 uncertain-significance, Retinitis Pigmentosa, Dominant 54,115,693(-) G/C upstream_transcript_variant
rs373430109 uncertain-significance, Retinitis Pigmentosa, Dominant 54,115,785(-) G/T upstream_transcript_variant
rs45619231 uncertain-significance, Retinitis Pigmentosa, Dominant 54,115,619(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs4806711 likely-benign, Retinitis Pigmentosa, Dominant 54,115,811(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TFPT Gene

Variant ID Type Subtype PubMed ID
nsv953613 CNV deletion 24416366
nsv833877 CNV loss 17160897
nsv515623 CNV loss 19592680
nsv510773 CNV deletion 20534489
nsv470157 CNV loss 18288195
nsv1056177 CNV gain 25217958
esv3893246 CNV gain 25118596
esv2718854 CNV deletion 23290073
esv2718853 CNV deletion 23290073
esv2718812 CNV deletion 23290073

Variation tolerance for TFPT Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TFPT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TFPT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFPT Gene

Disorders for TFPT Gene

MalaCards: The human disease database

(1) MalaCards diseases for TFPT Gene - From: GeneCards

Disorder Aliases PubMed IDs
childhood leukemia
- elite association - COSMIC cancer census association via MalaCards
Search TFPT in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TFPT_HUMAN
  • Note=A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Inversion inv(19)(p13;q13) with TCF3. {ECO:0000269 PubMed:10086727}.

Additional Disease Information for TFPT

genes like me logo Genes that share disorders with TFPT: view

No data available for Genatlas for TFPT Gene

Publications for TFPT Gene

  1. Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced. (PMID: 17041757) Franchini C … Privitera E (Apoptosis : an international journal on programmed cell death 2006) 3 4 22 58
  2. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J … Conaway JW (The Journal of biological chemistry 2005) 2 3 4 58
  3. Identification of a novel molecular partner of the E2A gene in childhood leukemia. (PMID: 10086727) Brambillasca F … Privitera E (Leukemia 1999) 3 4 22 58
  4. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L … Conaway RC (The Journal of biological chemistry 2011) 3 4 58
  5. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T … Conaway JW (Molecular cell 2008) 3 4 58

Products for TFPT Gene

Sources for TFPT Gene

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