Aliases for TFPI2 Gene
External Ids for TFPI2 Gene
Previous GeneCards Identifiers for TFPI2 Gene
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for TFPI2 Gene
TFPI2 (Tissue Factor Pathway Inhibitor 2) is a Protein Coding gene. Diseases associated with TFPI2 include Fibrosarcoma and Choriocarcinoma. Among its related pathways are Matrix Metalloproteinases and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity. An important paralog of this gene is TFPI.
UniProtKB/Swiss-Prot Summary for TFPI2 Gene
May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.