Aliases for TFPI Gene
External Ids for TFPI Gene
Previous HGNC Symbols for TFPI Gene
Previous GeneCards Identifiers for TFPI Gene
This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]
GeneCards Summary for TFPI Gene
TFPI (Tissue Factor Pathway Inhibitor) is a Protein Coding gene. Diseases associated with TFPI include Thrombosis and Hemophilia. Among its related pathways are Syndecan-4-mediated signaling events and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity. An important paralog of this gene is TFPI2.
UniProtKB/Swiss-Prot Summary for TFPI Gene
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.