There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010] See more...

Aliases for TFG Gene

Aliases for TFG Gene

  • Trafficking From ER To Golgi Regulator 2 3 5
  • TRK-Fused Gene Protein 3 4
  • Protein TFG 3 4
  • TRKT3 Oncogene 3
  • TRK-Fused Gene 2
  • TRK-Fused 3
  • HMSNP 3
  • SPG57 3
  • TRKT3 3
  • TF6 3

External Ids for TFG Gene

Previous GeneCards Identifiers for TFG Gene

  • GC03P097099
  • GC03P099713
  • GC03P101709
  • GC03P101749
  • GC03P101910
  • GC03P100428
  • GC03P097796

Summaries for TFG Gene

Entrez Gene Summary for TFG Gene

  • There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for TFG Gene

TFG (Trafficking From ER To Golgi Regulator) is a Protein Coding gene. Diseases associated with TFG include Spastic Paraplegia 57, Autosomal Recessive and Neuropathy, Hereditary Motor And Sensory, Okinawa Type. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include identical protein binding and obsolete signal transducer activity.

UniProtKB/Swiss-Prot Summary for TFG Gene

  • Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858).

Gene Wiki entry for TFG Gene

Additional gene information for TFG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TFG Gene

Genomics for TFG Gene

GeneHancer (GH) Regulatory Elements for TFG Gene

Promoters and enhancers for TFG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J100707 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 510.2 +0.4 400 4.6 FOXK2 HNRNPK ZBTB40 ZNF217 CTCF TCF12 NRF1 POLR2G SP1 PHF8 TFG LNP1 NONHSAG035601.2
GH03J100713 Promoter 0.3 EPDnew 500.7 +4.4 4390 0.1 TFG ENSG00000252989 NONHSAG035601.2
GH03J101572 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 14.1 +865.4 865417 4.6 FOXK2 ZBTB40 ZNF217 EP300 CTCF SIN3A MYC TCF12 POLR2G NCOR1 PCNP piR-32331-004 lnc-SENP7-1 SENP7 ZBTB11-AS1 NXPE3 TFG ENSG00000242299 RPL24 NFKBIZ
GH03J099858 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 19.8 -845.7 -845683 10.8 ZSCAN5C ZNF300 POLR2G JUND FOS ZNF10 ZNF510 RELA ZNF662 OSR2 ENSG00000273374 FILIP1L DCBLD2 TBC1D23 TFG CMSS1 TMEM45A TOMM70 lnc-FILIP1L-2 piR-47830
GH03J100608 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 16.4 -96.8 -96832 7.2 NCOR1 KDM6A U2AF2 FOXA2 JUND ZFHX2 TAL1 ZNF511 NR2F1 ZGPAT ADGRG7 TFG ENSG00000252989 TOMM70 TMEM45A LNP1 HSALNG0027580
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TFG on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TFG

Top Transcription factor binding sites by QIAGEN in the TFG gene promoter:
  • AP-1
  • COUP
  • COUP-TF
  • HNF-1
  • HNF-1A
  • IRF-7A
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for TFG Gene

Genomic Locations for TFG Gene
chr3:100,709,284-100,748,967
(GRCh38/hg38)
Size:
39,684 bases
Orientation:
Plus strand
chr3:100,428,134-100,467,811
(GRCh37/hg19)
Size:
39,678 bases
Orientation:
Plus strand

Genomic View for TFG Gene

Genes around TFG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFG Gene

Proteins for TFG Gene

  • Protein details for TFG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92734-TFG_HUMAN
    Recommended name:
    Protein TFG
    Protein Accession:
    Q92734
    Secondary Accessions:
    • D3DN49
    • G5E9V1
    • K0J5S8
    • K0J6K2
    • Q15656
    • Q969I2

    Protein attributes for TFG Gene

    Size:
    400 amino acids
    Molecular mass:
    43448 Da
    Quaternary structure:
    • Self-associates to form an oligomeric complex (PubMed:23479643). Interacts with PDCD6; promoting localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Interacts with SEC16B (PubMed:21478858).

    Alternative splice isoforms for TFG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TFG Gene

Post-translational modifications for TFG Gene

  • Ubiquitination at Lys47 and Lys103
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TFG Gene

Domains & Families for TFG Gene

Gene Families for TFG Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TFG Gene

Blocks:
  • Octicosapeptide/Phox/Bem1p
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TFG Gene

GenScript: Design optimal peptide antigens:
  • TRK-fused gene protein (TFG_HUMAN)
genes like me logo Genes that share domains with TFG: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TFG Gene

Function for TFG Gene

Molecular function for TFG Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858).
GENATLAS Biochemistry:
TRK fused gene,involved in chromosomal rearrangement involving TRKA(NTRK1),in papillary thyroid carcinoma

Gene Ontology (GO) - Molecular Function for TFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI,IEA 16189514
GO:0042802 identical protein binding IPI,IEA 16169070
genes like me logo Genes that share ontologies with TFG: view
genes like me logo Genes that share phenotypes with TFG: view

Human Phenotype Ontology for TFG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for TFG

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TFG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for TFG Gene

Localization for TFG Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFG Gene

Endoplasmic reticulum. Note=Localizes to endoplasmic reticulum exit site (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:27813252, PubMed:21478858). {ECO:0000269 PubMed:21478858, ECO:0000269 PubMed:27813252}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TFG gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
nucleus 3
golgi apparatus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm NAS 7565764
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TFG: view

Pathways & Interactions for TFG Gene

genes like me logo Genes that share pathways with TFG: view

SIGNOR curated interactions for TFG Gene

Activates:

Gene Ontology (GO) - Biological Process for TFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IMP 21478858
GO:0016192 vesicle-mediated transport IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP 12761501
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with TFG: view

Drugs & Compounds for TFG Gene

(1) Drugs for TFG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TFG: view

Transcripts for TFG Gene

mRNA/cDNA for TFG Gene

4 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TFG

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TFG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5:
SP6: - - -
SP7: - - - -
SP8: - - -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - -

ExUns: 10b ^ 11 ^ 12
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TFG Gene

GeneLoc Exon Structure for
TFG

Expression for TFG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TFG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TFG Gene

This gene is overexpressed in Bone marrow stromal cell (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TFG Gene



Protein tissue co-expression partners for TFG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TFG

SOURCE GeneReport for Unigene cluster for TFG Gene:

Hs.518123

mRNA Expression by UniProt/SwissProt for TFG Gene:

Q92734-TFG_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TFG Gene

  • Nervous system(4.9)
  • Pancreas(4.5)
  • Liver(4.4)
  • Lung(3)
  • Kidney(2.8)
  • Muscle(2.5)
  • Skin(2.5)
  • Thyroid gland(2.5)
  • Heart(2.2)
  • Blood(2.1)
  • Intestine(2.1)
  • Adrenal gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TFG Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
  • thyroid
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • duodenum
  • intestine
  • kidney
  • liver
  • small intestine
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with TFG: view

No data available for mRNA differential expression in normal tissues for TFG Gene

Orthologs for TFG Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFG 31 30
  • 99.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TFG 31 30
  • 93.67 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 93 (a)
OneToMany
-- 31
  • 85 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TFG 31 30
  • 92.5 (n)
OneToMany
-- 31
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TFG 31
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102546978 30
  • 88.41 (n)
mouse
(Mus musculus)
Mammalia Tfg 17 31 30
  • 88.38 (n)
chicken
(Gallus gallus)
Aves TFG 31 30
  • 73.69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TFG 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tfg 30
  • 71.04 (n)
Str.2241 30
African clawed frog
(Xenopus laevis)
Amphibia tfg-prov 30
zebrafish
(Danio rerio)
Actinopterygii tfg 31 30
  • 62.14 (n)
OneToOne
wufb11c10 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToOne
Cin.3867 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3867 30
Species where no ortholog for TFG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TFG Gene

ENSEMBL:
Gene Tree for TFG (if available)
TreeFam:
Gene Tree for TFG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TFG: view image

Paralogs for TFG Gene

(2) SIMAP similar genes for TFG Gene using alignment to 7 proteins:

  • TFG_HUMAN
  • C9JJP5_HUMAN
  • C9JTY3_HUMAN
  • C9JUE0_HUMAN
  • K0J5S8_HUMAN
  • K0J6K2_HUMAN
  • Q05BK6_HUMAN

Pseudogenes.org Pseudogenes for TFG Gene

genes like me logo Genes that share paralogs with TFG: view

No data available for Paralogs for TFG Gene

Variants for TFG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TFG Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
640949 Uncertain Significance: Neuropathy, hereditary motor and sensory, Okinawa type; Spastic paraplegia 57, autosomal recessive 100,748,364(+) C/T NONSENSE
643529 Uncertain Significance: Neuropathy, hereditary motor and sensory, Okinawa type; Spastic paraplegia 57, autosomal recessive 100,748,226(+) C/T MISSENSE_VARIANT
645167 Uncertain Significance: Neuropathy, hereditary motor and sensory, Okinawa type; Spastic paraplegia 57, autosomal recessive 100,748,493(+) G/C MISSENSE_VARIANT
646590 Uncertain Significance: Neuropathy, hereditary motor and sensory, Okinawa type; Spastic paraplegia 57, autosomal recessive 100,732,550(+) C/T MISSENSE_VARIANT
647551 Uncertain Significance: Neuropathy, hereditary motor and sensory, Okinawa type; Spastic paraplegia 57, autosomal recessive 100,748,358(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TFG Gene

Structural Variations from Database of Genomic Variants (DGV) for TFG Gene

Variant ID Type Subtype PubMed ID
dgv1397e212 CNV gain 25503493
dgv182e55 CNV gain 17911159
dgv183e55 CNV gain 17911159
dgv4830n100 CNV gain 25217958
dgv613n27 CNV gain 19166990
dgv614n27 CNV gain 19166990
dgv8476n54 CNV gain 21841781
dgv8479n54 CNV gain 21841781
dgv917e214 CNV gain 21293372
esv2751970 CNV gain 17911159
esv2763708 CNV gain 21179565
nsv460787 CNV gain 19166990
nsv470794 CNV gain 18288195
nsv516418 CNV gain 19592680
nsv591164 CNV gain 21841781

Variation tolerance for TFG Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TFG Gene

Human Gene Mutation Database (HGMD)
TFG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TFG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFG Gene

Disorders for TFG Gene

MalaCards: The human disease database

(22) MalaCards diseases for TFG Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TFG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TFG_HUMAN
  • Note=A chromosomal aberration involving TFG is found in papillary thyroid carcinomas (PTCs). Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript. {ECO:0000269 PubMed:7565764}.
  • Neuropathy, hereditary motor and sensory, Okinawa type (HMSNO) [MIM:604484]: A neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles amyotrophic lateral sclerosis. {ECO:0000269 PubMed:22883144, ECO:0000269 PubMed:27813252}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Spastic paraplegia 57, autosomal recessive (SPG57) [MIM:615658]: A complicated form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations. {ECO:0000269 PubMed:23479643, ECO:0000269 PubMed:27492651, ECO:0000269 PubMed:27813252, ECO:0000269 PubMed:30237576}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TFG

genes like me logo Genes that share disorders with TFG: view

No data available for Genatlas for TFG Gene

Publications for TFG Gene

  1. Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma. (PMID: 9169129) Mencinger M … Aman P (Genomics 1997) 2 3 4 23 54
  2. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure. (PMID: 23479643) Beetz C … Audhya A (Proceedings of the National Academy of Sciences of the United States of America 2013) 2 3 4 54
  3. The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. (PMID: 7565764) Greco A … Pierotti MA (Molecular and cellular biology 1995) 3 4 23 54
  4. The calcium-binding protein ALG-2 promotes endoplasmic reticulum exit site localization and polymerization of Trk-fused gene (TFG) protein. (PMID: 27813252) Kanadome T … Maki M (The FEBS journal 2017) 3 4 54
  5. Novel Genetic, Clinical, and Pathomechanistic Insights into TFG-Associated Hereditary Spastic Paraplegia. (PMID: 27492651) Harlalka GV … Crosby AH (Human mutation 2016) 3 4 54

Products for TFG Gene

Sources for TFG Gene