Aliases for TFF2 Gene
External Ids for TFF2 Gene
Previous HGNC Symbols for TFF2 Gene
Previous GeneCards Identifiers for TFF2 Gene
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
GeneCards Summary for TFF2 Gene
TFF2 (Trefoil Factor 2) is a Protein Coding gene. Diseases associated with TFF2 include Gastritis and Barrett Esophagus. Gene Ontology (GO) annotations related to this gene include CXCR4 chemokine receptor binding. An important paralog of this gene is TFF1.
UniProtKB/Swiss-Prot Summary for TFF2 Gene
Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).