Free for academic non-profit institutions. Other users need a Commercial license
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
TFF1 (Trefoil Factor 1) is a Protein Coding gene. Diseases associated with TFF1 include Bile Reflux and Gastric Ulcer. Among its related pathways are FOXA1 transcription factor network and Relaxin signaling pathway. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is TFF2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16189514 |
GO:0008083 | growth factor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IEA,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Adhesion |
-
|
|
2 | Relaxin signaling pathway | ||
3 | Development Ligand-independent activation of ESR1 and ESR2 |
Development Ligand-independent activation of ESR1 and ESR2
.35
|
|
4 | FOXA1 transcription factor network |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005975 | carbohydrate metabolic process | TAS | 2303034 |
GO:0007165 | signal transduction | IEA | -- |
GO:0008285 | negative regulation of cell proliferation | IEA | -- |
GO:0010039 | response to iron ion | IEA | -- |
GO:0030154 | cell differentiation | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TFF1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TFF1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tff1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tff1 30 |
|
||
Cow (Bos Taurus) |
Mammalia | TFF1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TFF1 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
716702 | Benign: not provided | 42,366,424(-) | G/A | SYNONYMOUS_VARIANT | |
779477 | Benign: not provided | 42,362,504(-) | G/A | INTRON_VARIANT | |
rs1203145163 | A gastric carcinoma sample | p.Gly55Val | |||
VAR_015281 | A gastric carcinoma sample | p.Thr32Ile | |||
VAR_015282 | A gastric carcinoma sample | p.Thr32Lys |
Disorder | Aliases | PubMed IDs |
---|---|---|
bile reflux |
|
|
gastric ulcer |
|
|
breast ductal carcinoma |
|
|
breast cancer |
|
|
breast disease |
|