Aliases for TFDP2 Gene
External Ids for TFDP2 Gene
Previous GeneCards Identifiers for TFDP2 Gene
The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
GeneCards Summary for TFDP2 Gene
TFDP2 (Transcription Factor Dp-2) is a Protein Coding gene. Diseases associated with TFDP2 include Retinoblastoma. Among its related pathways are Pre-NOTCH Expression and Processing and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein domain specific binding. An important paralog of this gene is TFDP1.
UniProtKB/Swiss-Prot Summary for TFDP2 Gene
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).