The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] See more...

Aliases for TFDP2 Gene

Aliases for TFDP2 Gene

  • Transcription Factor Dp-2 2 3 4 5
  • Transcription Factor Dp-2 (E2F Dimerization Partner 2) 2 3
  • E2F Dimerization Partner 2 2 4
  • DP2 3 4
  • TFDP2 5
  • Dp-2 2

External Ids for TFDP2 Gene

Previous GeneCards Identifiers for TFDP2 Gene

  • GC03M138604
  • GC03M142499
  • GC03M142951
  • GC03M142991
  • GC03M143153
  • GC03M141665
  • GC03M139036

Summaries for TFDP2 Gene

Entrez Gene Summary for TFDP2 Gene

  • The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for TFDP2 Gene

TFDP2 (Transcription Factor Dp-2) is a Protein Coding gene. Diseases associated with TFDP2 include Retinoblastoma. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein domain specific binding. An important paralog of this gene is TFDP1.

UniProtKB/Swiss-Prot Summary for TFDP2 Gene

  • Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Gene Wiki entry for TFDP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TFDP2 Gene

Genomics for TFDP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TFDP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J142026 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.1 +121.3 121304 3.9 PRDM10 ZNF512 LEF1 IKZF1 FOXA1 MTA2 RELA PKNOX1 POLR2A REST TFDP2 RNU6-425P GK5 ATP1B3 RPL19P6 piR-52951 lnc-TFDP2-1
GH03J142147 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.7 744 3.2 SP1 CREB1 PRDM10 RFX5 BACH1 TARDBP FOXA1 LARP7 PRDM1 ZIC2 TFDP2 lnc-TFDP2-1 RF00026-740 RNU6-425P ATP1B3
GH03J142000 Promoter/Enhancer 0.6 EPDnew Ensembl 600.1 +148.9 148943 0.8 GATA3 TFDP2 RNU6-425P ATP1B3 TRPC1 RPL19P6 piR-52951 lnc-ATP1B3-3 lnc-TFDP2-1
GH03J142044 Promoter 0.4 EPDnew 600.1 +105.3 105299 0.1 ZBTB33 RPL19P6 piR-56497-107 TFDP2 RNU6-425P lnc-TFDP2-1 ATP1B3
GH03J142997 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -851.2 -851211 6.9 CEBPG SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 TFE3 LEF1 U2SURP ENSG00000268129 LOC100289361 XRN1 ATR PBX2P1 ST13P15 PAQR9 PAQR9-AS1 TFDP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TFDP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TFDP2

Top Transcription factor binding sites by QIAGEN in the TFDP2 gene promoter:
  • AML1a
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • E4BP4
  • NF-Y
  • NF-YA
  • NF-YB
  • Nkx3-1 v4

Genomic Locations for TFDP2 Gene

Genomic Locations for TFDP2 Gene
chr3:141,944,428-142,149,544
(GRCh38/hg38)
Size:
205,117 bases
Orientation:
Minus strand
chr3:141,663,270-141,868,386
(GRCh37/hg19)
Size:
205,117 bases
Orientation:
Minus strand

Genomic View for TFDP2 Gene

Genes around TFDP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFDP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFDP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFDP2 Gene

Proteins for TFDP2 Gene

  • Protein details for TFDP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14188-TFDP2_HUMAN
    Recommended name:
    Transcription factor Dp-2
    Protein Accession:
    Q14188
    Secondary Accessions:
    • B7Z8C8
    • B7Z8L5
    • D3DNG1
    • E9PFC3
    • F8WAI2
    • Q13331
    • Q14187
    • Q6R754
    • Q8WU88
    • Q9UG28

    Protein attributes for TFDP2 Gene

    Size:
    446 amino acids
    Molecular mass:
    49236 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with E2F family members. The complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that inhibit the E2F transactivation domain. During the cell cycle, RB becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Interacts with GMCL (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. The complex TFDP2:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target genes promoters and represses its transcriptional activity (PubMed:20176812).
    SequenceCaution:
    • Sequence=AAR89905.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB45775.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TFDP2 Gene

    Alternative splice isoforms for TFDP2 Gene

neXtProt entry for TFDP2 Gene

Post-translational modifications for TFDP2 Gene

  • Ser-24 is probably phosphorylated by CDK2.
  • Ubiquitination at Lys120, Lys178, Lys205, Lys224, Lys249, and Lys328
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TFDP2 Gene

Domains & Families for TFDP2 Gene

Gene Families for TFDP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TFDP2 Gene

InterPro:
Blocks:
  • Transcription factor E2F/dimerisation partner (TDP)
ProtoNet:

Suggested Antigen Peptide Sequences for TFDP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52424, highly similar to Transcription factor Dp-2 (B7Z8L5_HUMAN)
  • E2F dimerization partner 2 (TFDP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14188

UniProtKB/Swiss-Prot:

TFDP2_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with TFDP2: view

Function for TFDP2 Gene

Molecular function for TFDP2 Gene

UniProtKB/Swiss-Prot Function:
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
GENATLAS Biochemistry:
transcription factor 2 heterodimerizing with E2F family members

Phenotypes From GWAS Catalog for TFDP2 Gene

Gene Ontology (GO) - Molecular Function for TFDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 contributes_to RNA polymerase II regulatory region sequence-specific DNA binding IDA 7739537
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IDA 7739537
GO:0003677 DNA binding TAS 7784053
GO:0003700 DNA-binding transcription factor activity NAS 7784053
genes like me logo Genes that share ontologies with TFDP2: view
genes like me logo Genes that share phenotypes with TFDP2: view

Animal Model Products

CRISPR Products

miRNA for TFDP2 Gene

miRTarBase miRNAs that target TFDP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TFDP2

Clone Products

  • Addgene plasmids for TFDP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TFDP2 Gene

Localization for TFDP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFDP2 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Mitotic spindle (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TFDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with TFDP2: view

No data available for Subcellular locations from COMPARTMENTS for TFDP2 Gene

Pathways & Interactions for TFDP2 Gene

genes like me logo Genes that share pathways with TFDP2: view

Gene Ontology (GO) - Biological Process for TFDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with TFDP2: view

No data available for SIGNOR curated interactions for TFDP2 Gene

Drugs & Compounds for TFDP2 Gene

No Compound Related Data Available

Transcripts for TFDP2 Gene

mRNA/cDNA for TFDP2 Gene

14 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TFDP2

Clone Products

  • Addgene plasmids for TFDP2

Alternative Splicing Database (ASD) splice patterns (SP) for TFDP2 Gene

No ASD Table

Relevant External Links for TFDP2 Gene

GeneLoc Exon Structure for
TFDP2

Expression for TFDP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TFDP2 Gene

mRNA differential expression in normal tissues according to GTEx for TFDP2 Gene

This gene is overexpressed in Testis (x4.7).

Protein differential expression in normal tissues from HIPED for TFDP2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TFDP2 Gene



Protein tissue co-expression partners for TFDP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TFDP2

SOURCE GeneReport for Unigene cluster for TFDP2 Gene:

Hs.379018

mRNA Expression by UniProt/SwissProt for TFDP2 Gene:

Q14188-TFDP2_HUMAN
Tissue specificity: High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines.
genes like me logo Genes that share expression patterns with TFDP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TFDP2 Gene

Orthologs for TFDP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TFDP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TFDP2 30 31
  • 99.93 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TFDP2 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TFDP2 30 31
  • 94.99 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tfdp2 30 17 31
  • 91.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tfdp2 30
  • 91.26 (n)
Oppossum
(Monodelphis domestica)
Mammalia TFDP2 31
  • 91 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TFDP2 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TFDP2 30 31
  • 80.26 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TFDP2 31
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tfdp2 30
  • 69.43 (n)
Str.21 30
Zebrafish
(Danio rerio)
Actinopterygii tfdp2 30 31
  • 65.13 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Dp 31 32
  • 35 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea dpl-1 31 32
  • 24 (a)
OneToMany
Soybean
(Glycine max)
eudicotyledons Gma.17914 30
Rice
(Oryza sativa)
Liliopsida Os.46788 30
Corn
(Zea mays)
Liliopsida Zm.2249 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4055 31
  • 38 (a)
OneToMany
Species where no ortholog for TFDP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TFDP2 Gene

ENSEMBL:
Gene Tree for TFDP2 (if available)
TreeFam:
Gene Tree for TFDP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TFDP2: view image

Paralogs for TFDP2 Gene

Paralogs for TFDP2 Gene

(2) SIMAP similar genes for TFDP2 Gene using alignment to 12 proteins:

  • TFDP2_HUMAN
  • C9J461_HUMAN
  • C9J5D5_HUMAN
  • C9J872_HUMAN
  • C9J977_HUMAN
  • C9JCY5_HUMAN
  • C9JNB6_HUMAN
  • C9JTZ9_HUMAN
  • F8W6Z7_HUMAN
  • F8WAY9_HUMAN
  • H7C5C2_HUMAN
  • R4GN09_HUMAN
genes like me logo Genes that share paralogs with TFDP2: view

Variants for TFDP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TFDP2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs11569200 - p.Pro81Ser
rs748095099 - p.Ile64Thr

Additional dbSNP identifiers (rs#s) for TFDP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TFDP2 Gene

Variant ID Type Subtype PubMed ID
dgv1412e212 CNV gain 25503493
dgv299n21 CNV gain 19592680
dgv4912n100 CNV gain 25217958
dgv619n27 CNV gain 19166990
dgv8625n54 CNV gain 21841781
dgv8626n54 CNV gain 21841781
esv24180 CNV loss 19812545
esv26432 CNV loss 19812545
esv2657934 CNV deletion 23128226
esv2669675 CNV deletion 23128226
esv2674102 CNV deletion 23128226
esv2751979 CNV gain 17911159
esv2759182 CNV gain 17122850
esv2763767 CNV gain 21179565
esv34483 CNV gain 17911159
esv3597992 CNV loss 21293372
esv3597995 CNV gain 21293372
esv3597996 CNV gain 21293372
esv3597997 CNV loss 21293372
esv3597998 CNV loss 21293372
nsv1008873 CNV gain 25217958
nsv1013352 CNV gain 25217958
nsv1117031 CNV deletion 24896259
nsv1120462 CNV tandem duplication 24896259
nsv474635 CNV novel sequence insertion 20440878
nsv507126 OTHER sequence alteration 20534489
nsv591915 CNV loss 21841781
nsv822270 CNV loss 20364138
nsv955361 CNV duplication 24416366
nsv963365 CNV duplication 23825009

Variation tolerance for TFDP2 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TFDP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TFDP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFDP2 Gene

Disorders for TFDP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TFDP2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • rb1
- elite association - COSMIC cancer census association via MalaCards
Search TFDP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TFDP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TFDP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TFDP2 Gene

Publications for TFDP2 Gene

  1. Cloning and characterization of human DP2, a novel dimerization partner of E2F. (PMID: 7784053) Zhang Y … Chellappan SP (Oncogene 1995) 2 3 4 23
  2. Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. (PMID: 9027491) Zhang Y … Chellappan SP (Genomics 1997) 2 3 23
  3. DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. (PMID: 8755520) Rogers KT … Horowitz JM (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 23
  4. Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. (PMID: 20176812) Zaragoza K … Leutz A (Molecular and cellular biology 2010) 3 4
  5. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) Köttgen A … Fox CS (Nature genetics 2010) 3 41

Products for TFDP2 Gene

  • Signalway Proteins for TFDP2

Sources for TFDP2 Gene