This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing res... See more...

Aliases for TFDP1 Gene

Aliases for TFDP1 Gene

  • Transcription Factor Dp-1 2 3 4 5
  • DRTF1 2 3 4
  • DP1 2 3 4
  • Down-Regulated In Liver Cancer Stem Cells 2 3
  • E2F Dimerization Partner 1 3 4
  • DRTF1-Polypeptide 1 3 4
  • DILC 2 3
  • Dp-1 2 3
  • E2F-Related Transcription Factor 3
  • TFDP1 5

External Ids for TFDP1 Gene

Previous GeneCards Identifiers for TFDP1 Gene

  • GC13P112848
  • GC13P108876
  • GC13P113325
  • GC13P112187
  • GC13P113287
  • GC13P114239
  • GC13P094679

Summaries for TFDP1 Gene

Entrez Gene Summary for TFDP1 Gene

  • This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]

GeneCards Summary for TFDP1 Gene

TFDP1 (Transcription Factor Dp-1) is a Protein Coding gene. Diseases associated with TFDP1 include Colorectal Cancer and Hepatocellular Carcinoma. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is TFDP3.

UniProtKB/Swiss-Prot Summary for TFDP1 Gene

  • Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Gene Wiki entry for TFDP1 Gene

Additional gene information for TFDP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TFDP1 Gene

Genomics for TFDP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TFDP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J113583 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.3 313 2.8 ZNF629 KDM1A ZNF692 POLR2A BACH1 LARP7 MTA2 ZNF143 ZIC2 ZSCAN4 5EW4_A-014 TFDP1 CDC16 GRK1 GAS6 TUBGCP3 TMCO3
GH13J113544 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE CraniofacialAtlas 600.3 -38.1 -38138 5.9 HNRNPL PRDM10 ZNF692 ZNF600 NR2F2 WT1 ZFHX2 ZNF792 SAP130 RCOR1 NONHSAG014278.2 TFDP1 TMCO3 DCUN1D2 ENSG00000267868 ADPRHL1 ENSG00000276248
GH13J113582 Promoter/Enhancer 0.9 Ensembl ENCODE 600.7 -1.6 -1614 0.3 HNRNPL GATAD2A RBFOX2 TFDP1 GABPB1 SMAD4 HNF4A ZFP64 IKZF5 DMAP1 TFDP1 TMCO3 HSALNG0099605 DCUN1D2
GH13J113584 Enhancer 0.5 ENCODE 600.7 -1.4 -1354 0.1 HNRNPL RBFOX2 GABPB1 ZFP64 IKZF5 DMAP1 ZKSCAN1 KDM1A KAT8 5EW4_A-014 TFDP1 HSALNG0099605 DCUN1D2
GH13J113489 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 0.2 -92.3 -92310 8.4 CEBPG SP1 CREB1 GATAD2A CTCF HNRNPL ATF7 PRDM10 ZNF629 TFE3 TMCO3 ADPRHL1 DCUN1D2 TUBGCP3 PCID2 GRTP1 CDC16 DCUN1D2-AS CHAMP1 GRTP1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TFDP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TFDP1

Top Transcription factor binding sites by QIAGEN in the TFDP1 gene promoter:
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for TFDP1 Gene

Genomic Locations for TFDP1 Gene
chr13:113,584,688-113,641,473
(GRCh38/hg38)
Size:
56,786 bases
Orientation:
Plus strand
chr13:114,239,003-114,295,788
(GRCh37/hg19)
Size:
56,786 bases
Orientation:
Plus strand

Genomic View for TFDP1 Gene

Genes around TFDP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFDP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFDP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFDP1 Gene

Proteins for TFDP1 Gene

  • Protein details for TFDP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14186-TFDP1_HUMAN
    Recommended name:
    Transcription factor Dp-1
    Protein Accession:
    Q14186
    Secondary Accessions:
    • B4DLQ9
    • Q5JSB4
    • Q8IZL5

    Protein attributes for TFDP1 Gene

    Size:
    410 amino acids
    Molecular mass:
    45070 Da
    Quaternary structure:
    • Component of the E2F:DP transcription factor complex. Forms heterodimers with E2F family members. The complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that inhibit the E2F transactivation domain. This repression involves recruitment of histone deacetylase (HDAC). During the cell cycle, from mid-to-late G1 phase, RB family members become phosphorylated, detach from the DRTF1/E2F complex to render E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Part of the E2F6.com-1 complex in G0 phase is composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 YAF2. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. The complex TFDP1:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (PubMed:20176812).
    Miscellaneous:
    • E2F/DP transactivation can be mediated by several cofactors including TBP, TFIIH, MDM2 and CBP.

    Three dimensional structures from OCA and Proteopedia for TFDP1 Gene

    Alternative splice isoforms for TFDP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TFDP1 Gene

Post-translational modifications for TFDP1 Gene

  • Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.
  • Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation.
  • Ubiquitination at Lys44, Lys190, Lys234, and Lys320
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TFDP1 Gene

Domains & Families for TFDP1 Gene

Gene Families for TFDP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TFDP1 Gene

InterPro:
Blocks:
  • Transcription factor E2F/dimerisation partner (TDP)
ProtoNet:

Suggested Antigen Peptide Sequences for TFDP1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50802, highly similar to Transcription factor Dp-1 (B4DLQ9_HUMAN)
  • E2F dimerization partner 1 (TFDP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14186

UniProtKB/Swiss-Prot:

TFDP1_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with TFDP1: view

Function for TFDP1 Gene

Molecular function for TFDP1 Gene

UniProtKB/Swiss-Prot Function:
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
UniProtKB/Swiss-Prot Induction:
Down-regulated during differentiation.
GENATLAS Biochemistry:
transcription factor 1,heterodimerizing with E2F family member,ubiquitously expressed,highly amplified in esophageal squamous cell carcinoma

Phenotypes From GWAS Catalog for TFDP1 Gene

Gene Ontology (GO) - Molecular Function for TFDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 contributes_to RNA polymerase II regulatory region sequence-specific DNA binding IDA 7739537
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0000987 proximal promoter sequence-specific DNA binding IEA --
GO:0001228 contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IDA 7739537
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TFDP1: view
genes like me logo Genes that share phenotypes with TFDP1: view

Animal Models for TFDP1 Gene

MGI Knock Outs for TFDP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TFDP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TFDP1 Gene

Localization for TFDP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFDP1 Gene

Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1. {ECO:0000250 UniProtKB:Q08639}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TFDP1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 3
extracellular 2
plasma membrane 1
cytoskeleton 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TFDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IEA,IDA 17062573
genes like me logo Genes that share ontologies with TFDP1: view

Pathways & Interactions for TFDP1 Gene

genes like me logo Genes that share pathways with TFDP1: view

Pathways by source for TFDP1 Gene

5 GeneGo (Thomson Reuters) pathways for TFDP1 Gene
  • Cell cycle Cell cycle (generic schema)
  • Cell cycle ESR1 regulation of G1/S transition
  • Cell cycle Regulation of G1/S transition (part 2)
  • Cell cycle Start of DNA replication in early S phase
  • Cell cycle Transition and termination of DNA replication
4 Qiagen pathways for TFDP1 Gene
  • Cyclins and Cell Cycle Regulation
  • Estrogen-mediated S-Phase Entry
  • G1-S Phase Transition
  • MNAR-PELP1 and Estrogen Receptor Interaction

SIGNOR curated interactions for TFDP1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TFDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS,IBA 21873635
GO:0006366 transcription by RNA polymerase II IMP 27825926
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with TFDP1: view

Drugs & Compounds for TFDP1 Gene

(1) Additional Compounds for TFDP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TFDP1: view

Transcripts for TFDP1 Gene

mRNA/cDNA for TFDP1 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TFDP1

Alternative Splicing Database (ASD) splice patterns (SP) for TFDP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ·
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - -
SP6: - -
SP7: - -
SP8: - - -
SP9: - - - -

ExUns: 16d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TFDP1 Gene

GeneLoc Exon Structure for
TFDP1

Expression for TFDP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TFDP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TFDP1 Gene

This gene is overexpressed in Testis (36.2), Fetal heart (13.5), and Fetal Liver (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TFDP1 Gene



Protein tissue co-expression partners for TFDP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TFDP1

SOURCE GeneReport for Unigene cluster for TFDP1 Gene:

Hs.79353

mRNA Expression by UniProt/SwissProt for TFDP1 Gene:

Q14186-TFDP1_HUMAN
Tissue specificity: Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.

Evidence on tissue expression from TISSUES for TFDP1 Gene

  • Muscle(4.4)
  • Nervous system(3.6)
  • Bone marrow(2.5)
  • Intestine(2.4)
  • Skin(2.4)
  • Lymph node(2.3)
  • Liver(2.2)
  • Kidney(2.1)
  • Lung(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with TFDP1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TFDP1 Gene

Orthologs for TFDP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TFDP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TFDP1 30 31
  • 99.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 93 (a)
OneToMany
TFDP1 30
  • 88.55 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 93 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 88 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Tfdp1 30 17 31
  • 87.48 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia MGC112830 30
  • 86.98 (n)
Cow
(Bos Taurus)
Mammalia TFDP1 30 31
  • 85.79 (n)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 90 (a)
OneToMany
TFDP1 30
  • 80.88 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 90 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tfdp1 30
  • 77.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33142 30
Zebrafish
(Danio rerio)
Actinopterygii tfdp1a 30 31
  • 72.79 (n)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10859 30
Fruit Fly
(Drosophila melanogaster)
Insecta Dp 31 32
  • 36 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea dpl-1 31 32
  • 23 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4055 31
  • 38 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4637 30
Species where no ortholog for TFDP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TFDP1 Gene

ENSEMBL:
Gene Tree for TFDP1 (if available)
TreeFam:
Gene Tree for TFDP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TFDP1: view image

Paralogs for TFDP1 Gene

Paralogs for TFDP1 Gene

(2) SIMAP similar genes for TFDP1 Gene using alignment to 5 proteins:

  • TFDP1_HUMAN
  • B4DLQ9_HUMAN
  • F5H452_HUMAN
  • Q5JSB5_HUMAN
  • Q5JSB6_HUMAN

Pseudogenes.org Pseudogenes for TFDP1 Gene

genes like me logo Genes that share paralogs with TFDP1: view

Variants for TFDP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TFDP1 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
716180 Benign: not provided 113,636,018(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
778731 Benign: not provided 113,611,016(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs4150823 - p.Asp401Asn

Additional dbSNP identifiers (rs#s) for TFDP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TFDP1 Gene

Variant ID Type Subtype PubMed ID
dgv1133e59 CNV duplication 20981092
esv23154 CNV loss 19812545
esv2664676 CNV deletion 23128226
esv2748339 CNV deletion 23290073
esv2748340 CNV deletion 23290073
esv2748342 CNV deletion 23290073
esv2748343 CNV deletion 23290073
esv2748344 CNV deletion 23290073
esv2748345 CNV deletion 23290073
esv2748346 CNV deletion 23290073
esv2748347 CNV deletion 23290073
esv2748348 CNV deletion 23290073
esv3390681 CNV duplication 20981092
esv3551159 CNV deletion 23714750
nsv1048814 CNV gain 25217958
nsv1071131 CNV deletion 25765185
nsv1121869 CNV deletion 24896259
nsv1143743 CNV deletion 24896259
nsv1145981 CNV duplication 26484159
nsv1151671 CNV deletion 26484159
nsv1152323 CNV deletion 26484159
nsv509523 CNV insertion 20534489
nsv563380 CNV loss 21841781
nsv820428 CNV duplication 20802225
nsv832726 CNV loss 17160897
nsv951929 CNV deletion 24416366
nsv983621 CNV duplication 23825009

Variation tolerance for TFDP1 Gene

Residual Variation Intolerance Score: 7.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TFDP1 Gene

Human Gene Mutation Database (HGMD)
TFDP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TFDP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFDP1 Gene

Disorders for TFDP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TFDP1 Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TFDP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TFDP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TFDP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TFDP1 Gene

Publications for TFDP1 Gene

  1. Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. (PMID: 9027491) Zhang Y … Chellappan SP (Genomics 1997) 2 3 23
  2. DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. (PMID: 8039504) Bandara LR … La Thangue NB (The EMBO journal 1994) 3 4 23
  3. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. (PMID: 8405995) Helin K … Harlow E (Genes & development 1993) 3 4 23
  4. Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. (PMID: 20176812) Zaragoza K … Leutz A (Molecular and cellular biology 2010) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41

Products for TFDP1 Gene

  • Boster Bio Antibodies for TFDP1
  • Boster Bio ELISA Kits for TFDP1
  • Signalway Proteins for TFDP1

Sources for TFDP1 Gene