Aliases for TFCP2 Gene
External Ids for TFCP2 Gene
Previous GeneCards Identifiers for TFCP2 Gene
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]
GeneCards Summary for TFCP2 Gene
TFCP2 (Transcription Factor CP2) is a Protein Coding gene. Diseases associated with TFCP2 include Rapp-Hodgkin Syndrome and Spastic Hemiplegia. Among its related pathways are Signaling events mediated by HDAC Class I and Adhesion. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is UBP1.
UniProtKB/Swiss-Prot Summary for TFCP2 Gene
Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.