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Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466])... See more...
Aliases for TFAP4 Gene
Aliases for TFAP4 Gene
External Ids for TFAP4 Gene
- HGNC: 11745
- Entrez Gene: 7023
- Ensembl: ENSG00000090447
- OMIM: 600743
- UniProtKB: Q01664
Previous GeneCards Identifiers for TFAP4 Gene
- GC16M004330
- GC16M004307
Summaries for TFAP4 Gene
-
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]
GeneCards Summary for TFAP4 Gene
TFAP4 (Transcription Factor AP-4) is a Protein Coding gene. Diseases associated with TFAP4 include Retinitis Pigmentosa 58. Among its related pathways are Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is MLXIPL.
UniProtKB/Swiss-Prot Summary for TFAP4 Gene
-
Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TFAP4 Gene
Genomics for TFAP4 Gene
GeneHancer (GH) Regulatory Elements for TFAP4 Gene
Promoters and enhancers for TFAP4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TFAP4 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TFAP4
- Top Transcription factor binding sites by QIAGEN in the TFAP4 gene promoter:
-
- C/EBPalpha
- CREB
- deltaCREB
- NF-1
- NF-1/L
- p53
- TBP
Genomic Locations for TFAP4 Gene
Genomic Locations for TFAP4 Gene
- chr16:4,257,186-4,273,075
- (GRCh38/hg38)
- Size:
- 15,890 bases
- Orientation:
- Minus strand
- chr16:4,307,187-4,323,076
- (GRCh37/hg19)
- Size:
- 15,890 bases
- Orientation:
- Minus strand
Genomic View for TFAP4 Gene
Genes around TFAP4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.3 by HGNC
- 16p13.3 by Entrez Gene
- 16p13.3 by Ensembl
TFAP4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TFAP4 Gene
Proteins for TFAP4 Gene
-
Protein details for TFAP4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01664-TFAP4_HUMAN
- Recommended name:
- Transcription factor AP-4
- Protein Accession:
- Q01664
- O60409
Protein attributes for TFAP4 Gene
- Size:
- 338 amino acids
- Molecular mass:
- 38726 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Homodimer.
Protein Expression for TFAP4 Gene
Post-translational modifications for TFAP4 Gene
Other Protein References for TFAP4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-TFAP4 monoclonal antibody, clone 072D6b
- Creative Biolabs Chicken Anti-TFAP4 Polyclonal IgY
- Novus Biologicals Antibodies for TFAP4
-
Abcam antibodies for TFAP4
- Invitrogen Antibodies for TFAP4 (AFLGC-TFAP4)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TFAP4
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for TFAP4
- Origene Custom Protein Services for TFAP4
-
Signalway Proteins for TFAP4
-
Abcam proteins for TFAP4
No data available for DME Specific Peptides for TFAP4 Gene
Domains & Families for TFAP4 Gene
Gene Families for TFAP4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for TFAP4 Gene
- Blocks:
-
- Basic helix-loop-helix dimerization domain bHLH
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TFAP4 Gene
- GenScript: Design optimal peptide antigens:
-
- TFAP4 protein (Q6FHM5_HUMAN)
- Class C basic helix-loop-helix protein 41 (TFAP4_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TFAP4 Gene
Function for TFAP4 Gene
Molecular function for TFAP4 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.
- GENATLAS Biochemistry:
- transcription factor AP-4,activating enhancer binding protein 4,involved in signal-mediated trafficking of integral membrane proteins
Phenotypes From GWAS Catalog for TFAP4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS,IDA | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA | -- |
| GO:0003677 | DNA binding | IDA,IEA | 9931457 |
| GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
Phenotypes for TFAP4 Gene
- MGI mutant phenotypes for TFAP4:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for TFAP4:
-
- Decreased HPV16-GFP infection
- G0/1 arrest
- Increased G2M DNA content, increased 8N DNA content
- Increased virus production
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased p24 protein expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
- Decreased IL-8 secretion
- Increased viability
Animal Models for TFAP4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TFAP4 - Select products 50% OFF >
- * TFAP4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for TFAP4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TFAP4
- genomics-online: gRNA clones - Search for available TFAP4 gRNA products
- Overview of 98 available TFAP4 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for TFAP4
miRNA for TFAP4 Gene
- miRTarBase miRNAs that target TFAP4
-
- hsa-mir-373-3p (MIRT002538)
- hsa-mir-335-5p (MIRT018094)
- hsa-mir-124-3p (MIRT022725)
- hsa-mir-101-3p (MIRT027354)
- hsa-mir-16-5p (MIRT031768)
- hsa-mir-4720-3p (MIRT553666)
- hsa-mir-4804-3p (MIRT553667)
- hsa-mir-519c-3p (MIRT553668)
- hsa-mir-519b-3p (MIRT553669)
- hsa-mir-519a-3p (MIRT553670)
- hsa-mir-4428 (MIRT553671)
- hsa-mir-548as-3p (MIRT553672)
- hsa-mir-302c-3p (MIRT553673)
- hsa-mir-302b-3p (MIRT553674)
- hsa-mir-302e (MIRT553675)
- hsa-mir-520a-3p (MIRT553676)
- hsa-mir-520b (MIRT553677)
- hsa-mir-520c-3p (MIRT553678)
- hsa-mir-520d-3p (MIRT553679)
- hsa-mir-520e (MIRT553680)
- hsa-mir-372-3p (MIRT553681)
- hsa-mir-302a-3p (MIRT553682)
- hsa-mir-302d-3p (MIRT553683)
- hsa-mir-520f-3p (MIRT553684)
- hsa-mir-582-5p (MIRT553685)
- hsa-mir-16-1-3p (MIRT553686)
- hsa-mir-583 (MIRT553687)
- hsa-mir-144-3p (MIRT553688)
- hsa-mir-1233-5p (MIRT736271)
- hsa-mir-1237-5p (MIRT736326)
- hsa-mir-1827 (MIRT738159)
- hsa-mir-185-3p (MIRT738225)
- hsa-mir-1910-3p (MIRT738447)
- hsa-mir-2467-3p (MIRT739311)
- hsa-mir-30c-1-3p (MIRT739844)
- hsa-mir-30c-2-3p (MIRT739887)
- hsa-mir-328-5p (MIRT741303)
- hsa-mir-3612 (MIRT741614)
- hsa-mir-4257 (MIRT743438)
- hsa-mir-4443 (MIRT744597)
- hsa-mir-4447 (MIRT744667)
- hsa-mir-4472 (MIRT744993)
- hsa-mir-4488 (MIRT745249)
- hsa-mir-4492 (MIRT745302)
- hsa-mir-4498 (MIRT745383)
- hsa-mir-4505 (MIRT745543)
- hsa-mir-4651 (MIRT746581)
- hsa-mir-4693-3p (MIRT747151)
- hsa-mir-4697-5p (MIRT747252)
- hsa-mir-4731-5p (MIRT747952)
- hsa-mir-5001-5p (MIRT749376)
- hsa-mir-5192 (MIRT749957)
- hsa-mir-5787 (MIRT751492)
- hsa-mir-608 (MIRT752018)
- hsa-mir-6134 (MIRT752471)
- hsa-mir-637 (MIRT752704)
- hsa-mir-650 (MIRT753062)
- hsa-mir-6511a-5p (MIRT753172)
- hsa-mir-6731-5p (MIRT754045)
- hsa-mir-6752-5p (MIRT754657)
- hsa-mir-6756-5p (MIRT754831)
- hsa-mir-6766-5p (MIRT755139)
- hsa-mir-6778-5p (MIRT755467)
- hsa-mir-6788-5p (MIRT755996)
- hsa-mir-6795-5p (MIRT756143)
- hsa-mir-6842-5p (MIRT757391)
- hsa-mir-6846-5p (MIRT757450)
- hsa-mir-6848-5p (MIRT757524)
- hsa-mir-6878-5p (MIRT758238)
- hsa-mir-6885-5p (MIRT758550)
- hsa-mir-6887-5p (MIRT758602)
- hsa-mir-7109-5p (MIRT758959)
- hsa-mir-7110-5p (MIRT759017)
- hsa-mir-762 (MIRT759518)
- hsa-mir-8085 (MIRT760249)
- hsa-mir-92a-2-5p (MIRT760600)
Transcription Factor Targets for TFAP4 Gene
Targeted motifs for TFAP4 Gene
HOMER Transcription Factor Regulatory Elements motif TFAP4
- Consensus sequence: NAHCAGCTGD Submotif: canonical Cell Type: AML GEO ID: GSE45738
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TFAP4
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TFAP4
- genomics-online: shRNA clones - Search for available TFAP4 shRNA products
- Overview of 98 available TFAP4 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for TFAP4 - Select products 50% OFF >
- * TFAP4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TFAP4
- Addgene plasmids for TFAP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TFAP4
- genomics-online: cdna clones - Search for available TFAP4 CDNA products
- Overview of 98 available TFAP4 gene related products
- orf clones - Search for available TFAP4 ORF products
- Overview of 98 available TFAP4 gene related products
Cell Line Products
-
Horizon Cell Lines for TFAP4
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for TFAP4 Gene
Localization for TFAP4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TFAP4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IDA,IBA | 7933101 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0017053 | transcriptional repressor complex | IEA,ISS | -- |
Pathways & Interactions for TFAP4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Proteoglycans in cancer | ||
Pathways by source for TFAP4 Gene
1 KEGG pathway for TFAP4 Gene
Interacting Proteins for TFAP4 Gene
Selected Interacting proteins:
Q01664-TFAP4_HUMAN
ENSP00000204517
for TFAP4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TFAP4
SIGNOR curated interactions for TFAP4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | IDA | 18818310 |
| GO:0008285 | negative regulation of cell proliferation | IMP | 18818310 |
| GO:0010629 | negative regulation of gene expression | IEA | -- |
| GO:0043065 | positive regulation of apoptotic process | IDA | 18818310 |
Transcripts for TFAP4 Gene
mRNA/cDNA for TFAP4 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000204517 2163 bps (ENST00000204517.11)
- ENST00000572393 507 bps (ENST00000572393.1)
- ENST00000573476 785 bps (ENST00000573476.1)
- ENST00000574639 595 bps (ENST00000574639.1)
- ENST00000575300 1326 bps (ENST00000575300.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TFAP4 - Select products 50% OFF >
- * TFAP4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TFAP4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TFAP4
- genomics-online: gRNA clones - Search for available TFAP4 gRNA products
- Overview of 98 available TFAP4 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for TFAP4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TFAP4
- Browse OriGene Inhibitory RNA Products For TFAP4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TFAP4
- genomics-online: shRNA clones - Search for available TFAP4 shRNA products
- Overview of 98 available TFAP4 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for TFAP4 - Select products 50% OFF >
- * TFAP4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TFAP4
- Addgene plasmids for TFAP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TFAP4
- genomics-online: cdna clones - Search for available TFAP4 CDNA products
- Overview of 98 available TFAP4 gene related products
- orf clones - Search for available TFAP4 ORF products
- Overview of 98 available TFAP4 gene related products
Relevant External Links for TFAP4 Gene
- GeneLoc Exon Structure for
- TFAP4
Expression for TFAP4 Gene
This gene is overexpressed in CD8 Tcells (24.8), Pancreas (20.7), Blymphocyte (11.4), and Ovary (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TFAP4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TFAP4
SOURCE GeneReport for Unigene cluster for TFAP4 Gene:
Hs.513305Evidence on tissue expression from TISSUES for TFAP4 Gene
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for TFAP4
-
OriGene qPCR primer pairs and template standards for TFAP4
- genomics-online: primer clones - Search for available TFAP4 Primer products
- Overview of 98 available TFAP4 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TFAP4 Gene
Orthologs for TFAP4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TFAP4 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TFAP4 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TFAP4 31 30 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TFAP4 31 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tfap4 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tfap4 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TFAP4 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TFAP4 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TFAP4 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tfap4 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tfap4 31 30 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | crp 31 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | hlh-11 31 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2164 31 |
|
OneToOne |
- Species where no ortholog for TFAP4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for TFAP4 Gene
- ENSEMBL:
- Gene Tree for TFAP4 (if available)
- TreeFam:
- Gene Tree for TFAP4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TFAP4: view image
Paralogs for TFAP4 Gene
Variants for TFAP4 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1290n106 | CNV | deletion | 24896259 |
| esv21490 | CNV | gain+loss | 19812545 |
| nsv1046986 | CNV | gain | 25217958 |
| nsv1070316 | CNV | deletion | 25765185 |
| nsv527866 | CNV | loss | 19592680 |
| nsv827529 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.89;
48.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TFAP4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TFAP4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFAP4 Gene
Disorders for TFAP4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 58 |
|
|
Search TFAP4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TFAP4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TFAP4 Gene
Publications for TFAP4 Gene
- Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. (PMID: 2123466) Hu YF … Tjian R (Genes & development 1990) 2 3 4 23 54
- Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. (PMID: 7933101) Ou SH … Gaynor RB (Journal of virology 1994) 3 4 23 54
- Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. (PMID: 19505873) Ku WC … Chen YJ (Molecular & cellular proteomics : MCP 2009) 3 23 54
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
ExternalLinks
Products for TFAP4 Gene
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- antibodies-online: Show 30 available TFAP4 Antibodies ranked by validation data
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- antibodies-online: Show 4 available TFAP4 Proteins ranked by validation data
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- Search Santa Cruz Biotechnology (SCBT) for TFAP4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TFAP4
- Horizon Cell Lines for TFAP4
- genomics-online: cdna clones - Search for available TFAP4 CDNA products
- Overview of 98 available TFAP4 gene related products
- orf clones - Search for available TFAP4 ORF products
- Overview of 98 available TFAP4 gene related products
- genomics-online: gRNA clones - Search for available TFAP4 gRNA products
- Overview of 98 available TFAP4 gene related products
- genomics-online: primer clones - Search for available TFAP4 Primer products
- Overview of 98 available TFAP4 gene related products
- genomics-online: shRNA clones - Search for available TFAP4 shRNA products
- Overview of 98 available TFAP4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TFAP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TFAP4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TFAP4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TFAP4
- Search for TFAP4 ELISA kits at Signalway
- Signalway Proteins for TFAP4
Sources for TFAP4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody