Aliases for TFAP4 Gene
Aliases for TFAP4 Gene
External Ids for TFAP4 Gene
- HGNC: 11745
- Entrez Gene: 7023
- Ensembl: ENSG00000090447
- OMIM: 600743
- UniProtKB: Q01664
Previous GeneCards Identifiers for TFAP4 Gene
- GC16M004330
- GC16M004307
Summaries for TFAP4 Gene
-
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]
GeneCards Summary for TFAP4 Gene
TFAP4 (Transcription Factor AP-4) is a Protein Coding gene. Diseases associated with TFAP4 include Spinocerebellar Ataxia 12. Among its related pathways are Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.
UniProtKB/Swiss-Prot for TFAP4 Gene
-
Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5-CAGCTG-3.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFAP4 Gene
Genomics for TFAP4 Gene
GeneHancer (GH) Regulatory Elements for TFAP4 Gene
Promoters and enhancers for TFAP4 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH16I004270 | Promoter/Enhancer | 2.6 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 552.5 | +0.4 | 360 | 4.5 | HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 | TFAP4 GC16P004274 ZNF75A ZNF500 CREBBP ANKS3 ENSG00000261938 TIGD7 CLUAP1 ZNF597 | |
| GH16I003625 | Enhancer | 0.9 | Ensembl ENCODE | 10.5 | +646.7 | 646667 | 1.7 | CTCF CEBPG RBBP5 BATF RAD21 POLR2A RUNX3 SRF ZNF654 SOX6 | GC16M003627 NLRC3 ZNF263 TFAP4 DNASE1 GC16P003615 | |
| GH16I004263 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 0.4 | +8.8 | 8823 | 2.1 | HDGF KLF17 RAD21 GLIS2 KLF13 EGR2 SP3 SP5 ZNF398 SP1 | LINC01569 GC16M004260 TFAP4 | |
| GH16I004271 | Enhancer | 0.6 | ENCODE dbSUPER | 0.8 | +2.7 | 2747 | 0 | SCRT1 SCRT2 | TFAP4 GC16M004260 | |
| GH16I004261 | Enhancer | 0.7 | ENCODE | 0.4 | +11.3 | 11310 | 0.2 | MEIS2 CTCF ZBTB6 RB1 SAP130 SIN3A ZNF2 ZNF48 RAD21 CTBP1 | GC16M004260 TFAP4 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TFAP4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TFAP4 gene promoter:
Regulatory Element Products
Genomic Locations for TFAP4 Gene
Genomic Locations for TFAP4 Gene
- chr16:4,257,186-4,273,075
- (GRCh38/hg38)
- Size:
- 15,890 bases
- Orientation:
- Minus strand
- chr16:4,307,187-4,323,076
- (GRCh37/hg19)
Genomic View for TFAP4 Gene
Genes around TFAP4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.3 by Ensembl
- 16p13.3 by Entrez Gene
- 16p13.3 by HGNC
TFAP4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TFAP4 Gene
Proteins for TFAP4 Gene
-
Protein details for TFAP4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01664-TFAP4_HUMAN
- Recommended name:
- Transcription factor AP-4
- Protein Accession:
- Q01664
- O60409
Protein attributes for TFAP4 Gene
- Size:
- 338 amino acids
- Molecular mass:
- 38726 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Homodimer.
Protein Expression for TFAP4 Gene
Post-translational modifications for TFAP4 Gene
Other Protein References for TFAP4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TFAP4
-
Abcam antibodies for TFAP4
- Invitrogen Antibodies for TFAP4
- antibodies-online: Search results for 91 available TFAP4 Antibodies ranked by validation data
- Compare Top TFAP4 Antibodies
-
Recommended
- Search GeneTex for Antibodies for TFAP4
-
Santa Cruz Biotechnology (SCBT) Antibodies for TFAP4
Protein Products
-
OriGene Purified Proteins for TFAP4
- Search Origene for MassSpec and Protein Over-expression Lysates for TFAP4
- Origene Custom Protein Services for TFAP4
- Search GeneTex for Proteins for TFAP4
-
Abcam proteins for TFAP4
Assay Products
No data available for DME Specific Peptides for TFAP4 Gene
Domains & Families for TFAP4 Gene
Gene Families for TFAP4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for TFAP4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TFAP4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TFAP4 Gene
Function for TFAP4 Gene
Molecular function for TFAP4 Gene
- GENATLAS Biochemistry:
- transcription factor AP-4,activating enhancer binding protein 4,involved in signal-mediated trafficking of integral membrane proteins
- UniProtKB/Swiss-Prot Function:
- Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5-CAGCTG-3.
Phenotypes From GWAS Catalog for TFAP4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0003677 | DNA binding | IEA,IDA | 9931457 |
| GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | IDA | 2833704 |
| GO:0003713 | NOT transcription coactivator activity | IDA | 11171123 |
| GO:0005515 | protein binding | IPI | 16924111 |
Phenotypes for TFAP4 Gene
- MGI mutant phenotypes for TFAP4:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for TFAP4:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Decreased p24 protein expression
- Decreased NF-kappaB reporter expression
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- G0/1 arrest
- Decreased IL-8 secretion
- Increased HPV16-GFP infection
- Increased virus production
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TFAP4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TFAP4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TFAP4 gene
- Search ViGene Biosciences for TFAP4
CRISPR Products
-
OriGene CRISPR knockouts for TFAP4
- genomics-online: gRNA clones - Search results for 84 available TFAP4 gene related products
- Overview of 84 available TFAP4 gene related products
- Applied Biological Materials CRISPR for TFAP4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TFAP4
- GenScript: Design CRISPR guide RNA sequences for TFAP4
miRNA for TFAP4 Gene
- miRTarBase miRNAs that target TFAP4
-
- hsa-mir-373-3p (MIRT002538)
- hsa-mir-335-5p (MIRT018094)
- hsa-mir-124-3p (MIRT022725)
- hsa-mir-101-3p (MIRT027354)
- hsa-mir-16-5p (MIRT031768)
- hsa-mir-4720-3p (MIRT553666)
- hsa-mir-4804-3p (MIRT553667)
- hsa-mir-519c-3p (MIRT553668)
- hsa-mir-519b-3p (MIRT553669)
- hsa-mir-519a-3p (MIRT553670)
- hsa-mir-4428 (MIRT553671)
- hsa-mir-548as-3p (MIRT553672)
- hsa-mir-302c-3p (MIRT553673)
- hsa-mir-302b-3p (MIRT553674)
- hsa-mir-302e (MIRT553675)
- hsa-mir-520a-3p (MIRT553676)
- hsa-mir-520b (MIRT553677)
- hsa-mir-520c-3p (MIRT553678)
- hsa-mir-520d-3p (MIRT553679)
- hsa-mir-520e (MIRT553680)
- hsa-mir-372-3p (MIRT553681)
- hsa-mir-302a-3p (MIRT553682)
- hsa-mir-302d-3p (MIRT553683)
- hsa-mir-520f-3p (MIRT553684)
- hsa-mir-582-5p (MIRT553685)
- hsa-mir-16-1-3p (MIRT553686)
- hsa-mir-583 (MIRT553687)
- hsa-mir-144-3p (MIRT553688)
- hsa-mir-1233-5p (MIRT736271)
- hsa-mir-1237-5p (MIRT736326)
- hsa-mir-1827 (MIRT738159)
- hsa-mir-185-3p (MIRT738225)
- hsa-mir-1910-3p (MIRT738447)
- hsa-mir-2467-3p (MIRT739311)
- hsa-mir-30c-1-3p (MIRT739844)
- hsa-mir-30c-2-3p (MIRT739887)
- hsa-mir-328-5p (MIRT741303)
- hsa-mir-3612 (MIRT741614)
- hsa-mir-4257 (MIRT743438)
- hsa-mir-4443 (MIRT744597)
- hsa-mir-4447 (MIRT744667)
- hsa-mir-4472 (MIRT744993)
- hsa-mir-4488 (MIRT745249)
- hsa-mir-4492 (MIRT745302)
- hsa-mir-4498 (MIRT745383)
- hsa-mir-4505 (MIRT745543)
- hsa-mir-4651 (MIRT746581)
- hsa-mir-4693-3p (MIRT747151)
- hsa-mir-4697-5p (MIRT747252)
- hsa-mir-4731-5p (MIRT747952)
- hsa-mir-5001-5p (MIRT749376)
- hsa-mir-5192 (MIRT749957)
- hsa-mir-5787 (MIRT751492)
- hsa-mir-608 (MIRT752018)
- hsa-mir-6134 (MIRT752471)
- hsa-mir-637 (MIRT752704)
- hsa-mir-650 (MIRT753062)
- hsa-mir-6511a-5p (MIRT753172)
- hsa-mir-6731-5p (MIRT754045)
- hsa-mir-6752-5p (MIRT754657)
- hsa-mir-6756-5p (MIRT754831)
- hsa-mir-6766-5p (MIRT755139)
- hsa-mir-6778-5p (MIRT755467)
- hsa-mir-6788-5p (MIRT755996)
- hsa-mir-6795-5p (MIRT756143)
- hsa-mir-6842-5p (MIRT757391)
- hsa-mir-6846-5p (MIRT757450)
- hsa-mir-6848-5p (MIRT757524)
- hsa-mir-6878-5p (MIRT758238)
- hsa-mir-6885-5p (MIRT758550)
- hsa-mir-6887-5p (MIRT758602)
- hsa-mir-7109-5p (MIRT758959)
- hsa-mir-7110-5p (MIRT759017)
- hsa-mir-762 (MIRT759518)
- hsa-mir-8085 (MIRT760249)
- hsa-mir-92a-2-5p (MIRT760600)
Transcription Factor Targets for TFAP4 Gene
Targeted motifs for TFAP4 Gene
HOMER Transcription Factor Regulatory Elements motif TFAP4
- Consensus sequence: NAHCAGCTGD Submotif: canonical Cell Type: AML GEO ID: GSE45738
miRNA Products
- Search ViGene Biosciences for TFAP4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TFAP4
- Browse OriGene Inhibitory RNA Products For TFAP4
- genomics-online: shRNA clones - Search results for 84 available TFAP4 gene related products
- Overview of 84 available TFAP4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TFAP4 gene
Clone Products
- Sino Biological Human cDNA Clone for TFAP4
- VectorBuilder custom plasmid, inducible vectors for TFAP4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TFAP4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TFAP4
- Applied Biological Materials Clones for TFAP4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TFAP4
-
ViGene Biosciences adenoviral particle packaged cDNA for TFAP4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TFAP4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TFAP4 gene
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for TFAP4 Gene
Localization for TFAP4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TFAP4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 4 |
- Nucleoplasm (3)
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 7933101 |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0017053 | transcriptional repressor complex | ISS,IEA | -- |
Pathways & Interactions for TFAP4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Proteoglycans in cancer | ||
Pathways by source for TFAP4 Gene
1 KEGG pathway for TFAP4 Gene
Interacting Proteins for TFAP4 Gene
Selected Interacting proteins:
Q01664-TFAP4_HUMAN
ENSP00000204517
for TFAP4 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
| GO:0006461 | protein complex assembly | IDA,IEA | 19505873 |
| GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | IDA | 18818310 |
No data available for SIGNOR curated interactions for TFAP4 Gene
Transcripts for TFAP4 Gene
mRNA/cDNA for TFAP4 Gene
- (3) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (73) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TFAP4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TFAP4
- genomics-online: gRNA clones - Search results for 84 available TFAP4 gene related products
- Overview of 84 available TFAP4 gene related products
- Applied Biological Materials CRISPR for TFAP4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TFAP4
- GenScript: Design CRISPR guide RNA sequences for TFAP4
miRNA Products
- Search ViGene Biosciences for TFAP4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TFAP4
- Browse OriGene Inhibitory RNA Products For TFAP4
- genomics-online: shRNA clones - Search results for 84 available TFAP4 gene related products
- Overview of 84 available TFAP4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TFAP4 gene
Clone Products
- Sino Biological Human cDNA Clone for TFAP4
- VectorBuilder custom plasmid, inducible vectors for TFAP4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TFAP4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TFAP4
- Applied Biological Materials Clones for TFAP4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TFAP4 Gene
This gene is overexpressed in CD8 Tcells (24.8), Pancreas (20.7), Blymphocyte (11.4), and Ovary (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TFAP4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TFAP4 Gene:
TFAP4SOURCE GeneReport for Unigene cluster for TFAP4 Gene:
Hs.513305Evidence on tissue expression from TISSUES for TFAP4 Gene
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for TFAP4
-
OriGene qPCR primer pairs and template standards for TFAP4
- genomics-online: primer clones - Search results for 84 available TFAP4 gene related products
- Overview of 84 available TFAP4 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TFAP4 Gene
Orthologs for TFAP4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TFAP4 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TFAP4 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TFAP4 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TFAP4 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tfap4 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tfap4 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TFAP4 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TFAP4 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TFAP4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tfap4 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tfap4 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | crp 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | hlh-11 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2164 34 |
|
OneToOne |
- Species where no ortholog for TFAP4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TFAP4 Gene
(1) SIMAP similar genes for TFAP4 Gene using alignment to 5 proteins:
No data available for Paralogs for TFAP4 Gene
Variants for TFAP4 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000191770 | -- | 4,274,039(-) | G/C | upstream_transcript_variant | |
| rs1000363655 | -- | 4,263,705(-) | G/C | intron_variant | |
| rs1000416546 | -- | 4,269,310(-) | A/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000696021 | -- | 4,264,804(-) | C/G | intron_variant | |
| rs1000893653 | -- | 4,258,949(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1290n106 | CNV | deletion | 24896259 |
| esv21490 | CNV | gain+loss | 19812545 |
| nsv1046986 | CNV | gain | 25217958 |
| nsv1070316 | CNV | deletion | 25765185 |
| nsv527866 | CNV | loss | 19592680 |
| nsv827529 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.89;
48.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TFAP4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TFAP4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFAP4 Gene
Disorders for TFAP4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinocerebellar ataxia 12 |
|
|
Search TFAP4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TFAP4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TFAP4 Gene
Publications for TFAP4 Gene
- Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. (PMID: 2123466) Hu YF … Tjian R (Genes & development 1990) 2 3 4 22 58
- Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. (PMID: 7933101) Ou SH … Gaynor RB (Journal of virology 1994) 3 4 22 58
- Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. (PMID: 19505873) Ku WC … Chen YJ (Molecular & cellular proteomics : MCP 2009) 3 22 58
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for TFAP4 Gene
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TFAP4
- Sino Biological Human cDNA Clone for TFAP4
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TFAP4
- Novus Biologicals lysates and proteins for TFAP4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TFAP4
- Abcam proteins for TFAP4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for TFAP4
- VectorBuilder custom plasmid, inducible vectors for TFAP4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TFAP4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TFAP4
- antibodies-online: Search results for 91 available TFAP4 Antibodies ranked by validation data
- Compare Top TFAP4 Antibodies
- Recommended
- antibodies-online: Search results for available TFAP4 related products ranked by validation data
- antibodies-online: Search results for 4 available TFAP4 Proteins ranked by validation data
- Compare Top TFAP4 Proteins
- Search GeneTex for Antibodies for TFAP4
- Search GeneTex for Proteins for TFAP4
- ViGene Biosciences adenoviral particle packaged cDNA for TFAP4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TFAP4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TFAP4 gene
- Search ViGene Biosciences for TFAP4
- Santa Cruz Biotechnology (SCBT) Antibodies for TFAP4
- Search Santa Cruz Biotechnology (SCBT) for TFAP4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TFAP4
- Horizon Cell Lines for TFAP4
- genomics-online: cdna clones - Search results for 84 available TFAP4 gene related products
- Overview of 84 available TFAP4 gene related products
- orf clones - Search results for 84 available TFAP4 gene related products
- Overview of 84 available TFAP4 gene related products
- genomics-online: gRNA clones - Search results for 84 available TFAP4 gene related products
- Overview of 84 available TFAP4 gene related products
- genomics-online: primer clones - Search results for 84 available TFAP4 gene related products
- Overview of 84 available TFAP4 gene related products
- genomics-online: shRNA clones - Search results for 84 available TFAP4 gene related products
- Overview of 84 available TFAP4 gene related products
Sources for TFAP4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
