Free for academic non-profit institutions. Other users need a Commercial license
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]
TFAP4 (Transcription Factor AP-4) is a Protein Coding gene. Among its related pathways are Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is MLXIP.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 14645924 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IDA,ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA | -- |
GO:0003677 | DNA binding | IEA,IDA | 9931457 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA,IDA | 7933101 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005739 | mitochondrion | IDA | -- |
GO:0017053 | transcriptional repressor complex | IEA,ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Proteoglycans in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | IDA | 18818310 |
GO:0008285 | negative regulation of cell proliferation | IMP | 18818310 |
GO:0010629 | negative regulation of gene expression | IEA | -- |
GO:0043065 | positive regulation of apoptotic process | IDA | 18818310 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TFAP4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TFAP4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TFAP4 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TFAP4 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tfap4 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tfap4 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | TFAP4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TFAP4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TFAP4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tfap4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tfap4 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | crp 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | hlh-11 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2164 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1290n106 | CNV | deletion | 24896259 |
esv21490 | CNV | gain+loss | 19812545 |
nsv1046986 | CNV | gain | 25217958 |
nsv1070316 | CNV | deletion | 25765185 |
nsv527866 | CNV | loss | 19592680 |
nsv827529 | CNV | gain | 20364138 |
No disorders were found for TFAP4 Gene.