Aliases for TFAP2E Gene
External Ids for TFAP2E Gene
Previous GeneCards Identifiers for TFAP2E Gene
GeneCards Summary for TFAP2E Gene
TFAP2E (Transcription Factor AP-2 Epsilon) is a Protein Coding gene. Among its related pathways are Gene Expression and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is TFAP2B.
UniProtKB/Swiss-Prot for TFAP2E Gene
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5-GCCNNNGGC-3 and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).