Aliases for TFAP2C Gene
External Ids for TFAP2C Gene
Previous GeneCards Identifiers for TFAP2C Gene
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]
GeneCards Summary for TFAP2C Gene
TFAP2C (Transcription Factor AP-2 Gamma) is a Protein Coding gene. Diseases associated with TFAP2C include Breast Cancer and Exencephaly. Among its related pathways are Ectoderm Differentiation and SUMOylation. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is TFAP2A.
UniProtKB/Swiss-Prot for TFAP2C Gene
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5-GCCNNNGGC-3 and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.