This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver... See more...

Aliases for TF Gene

Aliases for TF Gene

  • Transferrin 2 3 4 5
  • Serotransferrin 2 3 4
  • Beta-1 Metal-Binding Globulin 3 4
  • Siderophilin 3 4
  • PRO1557 2 3
  • PRO2086 2 3
  • Epididymis Secretory Sperm Binding Protein Li 71p 3
  • HEL-S-71p 3
  • EC 3.4.21 50
  • TFQTL1 3
  • TF 5

External Ids for TF Gene

Previous GeneCards Identifiers for TF Gene

  • GC03P130424
  • GC03P134209
  • GC03P134746
  • GC03P134786
  • GC03P134727
  • GC03P134947
  • GC03P133419
  • GC03P130844
  • GC03P133464
  • GC03P133745
  • GC03P133663

Summaries for TF Gene

Entrez Gene Summary for TF Gene

  • This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

GeneCards Summary for TF Gene

TF (Transferrin) is a Protein Coding gene. Diseases associated with TF include Atransferrinemia and Iron Deficiency Anemia. Among its related pathways are Insulin receptor recycling and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and ferric iron transmembrane transporter activity. An important paralog of this gene is LTF.

UniProtKB/Swiss-Prot Summary for TF Gene

  • Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
  • (Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use.

Gene Wiki entry for TF Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TF Gene

Genomics for TF Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J133660 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 255 -0.2 -197 3.6 MYC ATF2 POLR2A MXD4 CEBPB SMAD5 SIN3A ELK1 ETS1 FEZF1 INHCAP TOPBP1 TF lnc-TF-3 lnc-CDV3-2 CDV3
GH03J133746 Promoter/Enhancer 1.4 EPDnew Ensembl dbSUPER 281.3 +84.3 84254 1.1 SSRP1 CEBPA ATF3 BRCA1 YY1 MXD4 HOMEZ KMT2B THAP11 FOXA2 TF HSALNG0029072 piR-60885-083 SRPRB INHCAP TOPBP1
GH03J133663 Enhancer 0.8 ENCODE 250.7 +1.9 1894 0.5 ZNF654 YY1 CTCF REST TRIM22 THAP11 RXRA SAP130 RAD21 SMC3 TOPBP1 INHCAP TF RNU6-678P RF00026-707 lnc-TF-3 SRPRB
GH03J133784 Promoter 0.3 EPDnew 250.1 +122.8 122827 0.1 SRPRB lnc-TF-12 piR-31508-035 TF LOC105374116 RAB6B
GH03J133757 Enhancer 0.5 Ensembl 59.8 +96.3 96303 2.6 RBM22 NFE2 PAF1 POLR2A RBFOX2 ENSG00000244062 lnc-SRPRB-3 TF SRPRB TOPBP1 RNU6-678P HSALNG0029072
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TF on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TF

Top Transcription factor binding sites by QIAGEN in the TF gene promoter:
  • AREB6
  • FOXD3
  • HNF-3beta
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • NRSF form 1
  • NRSF form 2

Genomic Locations for TF Gene

Latest Assembly
chr3:133,661,998-133,796,641
(GRCh38/hg38)
Size:
134,644 bases
Orientation:
Plus strand

Previous Assembly
chr3:133,380,842-133,515,485
(GRCh37/hg19 by Entrez Gene)
Size:
134,644 bases
Orientation:
Plus strand

chr3:133,464,800-133,497,850
(GRCh37/hg19 by Ensembl)
Size:
33,051 bases
Orientation:
Plus strand

Genomic View for TF Gene

Genes around TF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TF Gene

Proteins for TF Gene

  • Protein details for TF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02787-TRFE_HUMAN
    Recommended name:
    Serotransferrin
    Protein Accession:
    P02787
    Secondary Accessions:
    • O43890
    • Q1HBA5
    • Q9NQB8
    • Q9UHV0

    Protein attributes for TF Gene

    Size:
    698 amino acids
    Molecular mass:
    77064 Da
    Quaternary structure:
    • Monomer.
    • (Microbial infection) Binds to Neisseria transferrin-binding protein A (tbpA or tbp1). Forms a large complex with TbpA and TbpB.
    • (Microbial infection) Binds to Neisseria transferrin-binding protein B (tbpb or tbp2).
    SequenceCaution:
    • Sequence=AAF22007.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TF Gene

neXtProt entry for TF Gene

Selected DME Specific Peptides for TF Gene

P02787:
  • GDVAFVK
  • KADRDQYELLC
  • YSGAFKCL
  • GKKSCHT

Post-translational modifications for TF Gene

  • Glycosylation at Ser51, Asn432, Asn491, Asn523, and Asn630
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TRFE_HUMAN (558)

Antibodies for research

  • Invitrogen Antibodies for TF (AFLGC-Tf)

Domains & Families for TF Gene

Gene Families for TF Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TF Gene

Suggested Antigen Peptide Sequences for TF Gene

GenScript: Design optimal peptide antigens:
  • TF protein (A0PJA6_HUMAN)
  • cDNA FLJ54029, highly similar to Serotransferrin (B4DHZ6_HUMAN)
  • Transferrin (Q06AH7_HUMAN)
  • Siderophilin (TRFE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P02787

UniProtKB/Swiss-Prot:

TRFE_HUMAN :
  • Has a bilobed structure, each lobe binds a single Fe(3+) ion. Does not always bind 2 Fe(3+) ions.
  • Belongs to the transferrin family.
Domain:
  • Has a bilobed structure, each lobe binds a single Fe(3+) ion. Does not always bind 2 Fe(3+) ions.
  • (Microbial infection) Binds to Neisseria transferrin-binding proteins A and B via its C-terminal lobe only. The L3 helix finger of TbpA inserts into the C-terminal lobe of TF, altering its conformation and probably disturbing the coordination of iron 2. Electron microscopy suggests that in the TbpA-TbpB-TF complex, TF is captured directly above the loop domain of TbpA in a chamber of about 1000 Angstroms(3) formed by the 3 proteins, where interactions between the proteins serve to abstract iron 2 from TF (PubMed:22343719, PubMed:22327295). Binding to TbpB does not alter the conformation of the C-terminal lobe (PubMed:22343719).
Family:
  • Belongs to the transferrin family.
genes like me logo Genes that share domains with TF: view

Function for TF Gene

Molecular function for TF Gene

UniProtKB/Swiss-Prot Function:
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use.
GENATLAS Biochemistry:
transferrin with three predominant variants Tfc1,Tfc2 (P570S),TFC3

Enzyme Numbers (IUBMB) for TF Gene

Phenotypes From GWAS Catalog for TF Gene

Gene Ontology (GO) - Molecular Function for TF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14691533
GO:0008198 ferrous iron binding IDA 18353247
GO:0008199 ferric iron binding IEA --
GO:0034986 iron chaperone activity IDA 18353247
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TF: view
genes like me logo Genes that share phenotypes with TF: view

Human Phenotype Ontology for TF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for TF Gene

miRTarBase miRNAs that target TF

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TF

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TF Gene

Localization for TF Gene

Subcellular locations from UniProtKB/Swiss-Prot for TF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TF gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
endoplasmic reticulum 4
cytoskeleton 2
mitochondrion 2
cytosol 2
nucleus 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA,IDA 15880641
GO:0005770 late endosome IDA 15880641
genes like me logo Genes that share ontologies with TF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TF Gene

Pathways & Interactions for TF Gene

genes like me logo Genes that share pathways with TF: view

SIGNOR curated interactions for TF Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis HEP 23580065
GO:0002576 platelet degranulation TAS --
GO:0006811 ion transport IEA --
GO:0006826 iron ion transport IBA 21873635
GO:0006879 cellular iron ion homeostasis TAS --
genes like me logo Genes that share ontologies with TF: view

Drugs & Compounds for TF Gene

(104) Drugs for TF Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aluminium Approved, Investigational Pharma Target 0
Copper Approved, Investigational Pharma Target 276
Iron Approved Pharma Target 1663
Iron Dextran Approved, Vet_approved Pharma Carrier, substrate 0
Aluminium phosphate Approved, Investigational Pharma Target 0

(57) Additional Compounds for TF Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen carbonate
  • [CO(OH)2]
  • Dihydrogen carbonate
  • H2CO3
  • Koehlensaeure
  • Dihydrogen carbonic acid
71-52-3

(1) ApexBio Compounds for TF Gene

Compound Action Cas Number
transferrin fragment Transferrin fragment
genes like me logo Genes that share compounds with TF: view

Drug products for research

Transcripts for TF Gene

mRNA/cDNA for TF Gene

3 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TF

Alternative Splicing Database (ASD) splice patterns (SP) for TF Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^
SP1: - - - - -
SP2: - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - -
SP4: -
SP5: - -
SP6:
SP7: - - -
SP8:

ExUns: 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TF Gene

GeneLoc Exon Structure for
TF

Expression for TF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TF Gene

This gene is overexpressed in Liver (x19.0), Brain - Spinal cord (cervical c-1) (x13.3), and Brain - Substantia nigra (x5.4).

Protein differential expression in normal tissues from HIPED for TF Gene

This gene is overexpressed in Vitreous humor (10.4), Plasma (7.7), and Cerebrospinal fluid (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TF Gene



Protein tissue co-expression partners for TF Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TF

SOURCE GeneReport for Unigene cluster for TF Gene:

Hs.518267

mRNA Expression by UniProt/SwissProt for TF Gene:

P02787-TRFE_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for TF Gene

  • Heart(5)
  • Nervous system(5)
  • Liver(5)
  • Eye(4.9)
  • Kidney(4.6)
  • Saliva(4.3)
  • Bone marrow(4.3)
  • Gall bladder(3.4)
  • Intestine(3.3)
  • Blood(3.1)
  • Pancreas(2.9)
  • Lung(2.8)
  • Adrenal gland(2.5)
  • Spleen(2.3)
  • Muscle(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TF Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • lymphatic
  • respiratory
Regions:
Head and neck:
  • ear
Thorax:
  • heart
  • lung
Abdomen:
  • liver
General:
  • blood
  • blood vessel
  • red blood cell
genes like me logo Genes that share expression patterns with TF: view

Primer products for research

Orthologs for TF Gene

This gene was present in the common ancestor of animals.

Orthologs for TF Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TF 29 30
  • 99.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TF 29 30
  • 80.32 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Trf 29 16 30
  • 78.15 (n)
OneToMany
Gm20425 30
  • 51 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia TF 29 30
  • 77.7 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tf 29
  • 77.28 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 59 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 58 (a)
OneToMany
Chicken
(Gallus gallus)
Aves TF 29 30
  • 60.26 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 51 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tf 29
  • 59.25 (n)
Zebrafish
(Danio rerio)
Actinopterygii tfa 29 30
  • 53.8 (n)
OneToMany
Dr.28538 29
Fruit Fly
(Drosophila melanogaster)
Insecta Tsf2 30
  • 28 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4617 30
  • 31 (a)
ManyToMany
Species where no ortholog for TF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TF Gene

ENSEMBL:
Gene Tree for TF (if available)
TreeFam:
Gene Tree for TF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TF: view image
Alliance of Genome Resources:
Additional Orthologs for TF

Paralogs for TF Gene

Paralogs for TF Gene

(2) SIMAP similar genes for TF Gene using alignment to 11 proteins:

  • TRFE_HUMAN
  • A0PJA6_HUMAN
  • B4DHZ6_HUMAN
  • C9JB55_HUMAN
  • C9JVG0_HUMAN
  • F8WC57_HUMAN
  • F8WCI6_HUMAN
  • F8WEK9_HUMAN
  • H7C5E8_HUMAN
  • J3KN47_HUMAN
  • Q06AH7_HUMAN

Pseudogenes.org Pseudogenes for TF Gene

genes like me logo Genes that share paralogs with TF: view

Variants for TF Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TF Gene

TRFE_HUMAN-P02787
Different polymorphic variants of transferrin are known. The sequence shown is the predominant electrophoretic variant (C1 or TF*C1).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TF Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
769614 Likely Benign: not provided 133,766,289(+) A/.
NM_001063.4(TF):c.1342= (p.Ile448=)
NO_SEQUENCE_ALTERATION
899433 Uncertain Significance: Atransferrinemia 133,756,326(+) C/T
NM_001063.4(TF):c.680C>T (p.Ser227Leu)
MISSENSE
899434 Uncertain Significance: Atransferrinemia 133,756,929(+) C/G
NM_001063.4(TF):c.790C>G (p.Gln264Glu)
MISSENSE
899492 Uncertain Significance: Atransferrinemia 133,778,981(+) T/C
NM_001063.4(TF):c.*361T>C
THREE_PRIME_UTR
900514 Uncertain Significance: Atransferrinemia 133,746,423(+) C/T
NM_001063.4(TF):c.-18C>T
FIVE_PRIME_UTR_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TF Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TF Gene

Variant ID Type Subtype PubMed ID
esv3380897 CNV duplication 20981092
nsv4018 CNV deletion 18451855
nsv829729 CNV loss 17160897

Variation tolerance for TF Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TF Gene

Human Gene Mutation Database (HGMD)
TF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TF
Leiden Open Variation Database (LOVD)
TF

SNP Genotyping and Copy Number Assays for research

Disorders for TF Gene

MalaCards: The human disease database

(50) MalaCards diseases for TF Gene - From: OMI, CVR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
atransferrinemia
  • hypotransferrinemia, familial
iron deficiency anemia
  • iron-deficiency anemia
nutritional deficiency disease
  • nutritional deficiency
iron metabolism disease
  • disorder of iron metabolism
iron overload in africa
  • african iron overload
- elite association - COSMIC cancer census association via MalaCards
Search TF in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TRFE_HUMAN
  • Atransferrinemia (ATRAF) [MIM:209300]: A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia. {ECO:0000269 PubMed:11110675, ECO:0000269 PubMed:15466165}. Note=The disease is caused by variants affecting the gene represented in this entry.

Genatlas disease for TF Gene

hypotransferrinemia,familial

Additional Disease Information for TF

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TF: view

Publications for TF Gene

  1. Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease. (PMID: 20029940) Kauwe JS … Alzheimer's Disease Neuroimaging Initiative (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 22 40 72
  2. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PMID: 19084217) Benyamin B … Visscher PM (American journal of human genetics 2009) 3 22 40
  3. Iron genes, iron load and risk of Alzheimer's disease. (PMID: 17047092) Lehmann DJ … Robson KJ (Journal of medical genetics 2006) 3 22 40
  4. Soluble transferrin receptor and mutations in hemochromatosis and transferrin genes in a general Catalan population. (PMID: 15698609) Bérez V … Joven J (Clinica chimica acta; international journal of clinical chemistry 2005) 3 22 40
  5. Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease. (PMID: 15060098) Robson KJ … Smith AD (Journal of medical genetics 2004) 3 40 72

Products for TF Gene

  • Addgene plasmids for TF

Sources for TF Gene