Aliases for TF Gene
External Ids for TF Gene
Previous GeneCards Identifiers for TF Gene
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]
GeneCards Summary for TF Gene
TF (Transferrin) is a Protein Coding gene. Diseases associated with TF include Atransferrinemia and Iron Deficiency Anemia. Among its related pathways are Insulin receptor recycling and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and ferric iron transmembrane transporter activity. An important paralog of this gene is LTF.
UniProtKB/Swiss-Prot Summary for TF Gene
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
(Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use.