Aliases for TEX45 Gene

Aliases for TEX45 Gene

  • Testis Expressed 45 2 3 5
  • Testis-Expressed Protein 45 3 4
  • C19orf45 3 4
  • Chromosome 19 Open Reading Frame 45 2
  • Uncharacterized Protein C19orf45 3

External Ids for TEX45 Gene

Previous HGNC Symbols for TEX45 Gene

  • C19orf45

Summaries for TEX45 Gene

GeneCards Summary for TEX45 Gene

TEX45 (Testis Expressed 45) is a Protein Coding gene. Diseases associated with TEX45 include Microcephalic Osteodysplastic Primordial Dwarfism, Type Ii.

Additional gene information for TEX45 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEX45 Gene

Genomics for TEX45 Gene

GeneHancer (GH) Regulatory Elements for TEX45 Gene

Promoters and enhancers for TEX45 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J007493 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 500.7 +1.6 1616 2.2 CTCF PHB2 ZBTB5 REST TOE1 SKI TRIM25 HINFP MXI1 ZSCAN9 RF00017-2785 TEX45 PEX11G TRIP10 ENSG00000269680 L13712-013
GH19J007491 Enhancer 0.7 ENCODE 500.7 -0.4 -440 1.4 ZNF623 EP300 CREB1 GABPA CEBPG CEBPB FOSL1 ZNF589 ZNF384 ATF4 TEX45 PEX11G piR-43939-015 L13712-013
GH19J007497 Promoter 0.6 EPDnew 500.7 +4.6 4564 0.1 CTCF NRF1 RAD21 ZNF143 PEX11G RF00017-2785 TEX45 piR-57460-337 L13712-013
GH19J007499 Enhancer 0.6 FANTOM5 Ensembl 79.7 +6.2 6225 2 ZFP36 ZNF121 ZSCAN4 PEX11G piR-57460-337 TEX45 PCP2 PNPLA6 EVI5L ENSG00000267952 L13712-013
GH19J007394 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.2 -97.4 -97375 3.2 HNRNPK ZBTB40 SIN3A MYC NRF1 POLR2G SP1 PHF8 ZIC2 ZBTB10 ENSG00000267852 ARHGEF18 INSR TEX45 PEX11G NDUFA7 ENSG00000268861 HSALNG0123637
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEX45 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEX45

Genomic Locations for TEX45 Gene

Genomic Locations for TEX45 Gene
chr19:7,492,976-7,515,233
(GRCh38/hg38)
Size:
22,258 bases
Orientation:
Plus strand
chr19:7,557,862-7,573,336
(GRCh37/hg19)
Size:
15,475 bases
Orientation:
Plus strand

Genomic View for TEX45 Gene

Genes around TEX45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX45 Gene

Proteins for TEX45 Gene

  • Protein details for TEX45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA69-TEX45_HUMAN
    Recommended name:
    Testis-expressed protein 45
    Protein Accession:
    Q8NA69
    Secondary Accessions:
    • Q8N115

    Protein attributes for TEX45 Gene

    Size:
    505 amino acids
    Molecular mass:
    57331 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29824.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH34779.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TEX45 Gene

Post-translational modifications for TEX45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEX45 Gene

No data available for DME Specific Peptides for TEX45 Gene

Domains & Families for TEX45 Gene

Gene Families for TEX45 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEX45 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TEX45: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TEX45 Gene

Function for TEX45 Gene

Phenotypes From GWAS Catalog for TEX45 Gene

genes like me logo Genes that share phenotypes with TEX45: view

Animal Models for TEX45 Gene

MGI Knock Outs for TEX45:
  • Tex45 Tex45<tm3b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TEX45 Gene

Localization for TEX45 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX45 gene
Compartment Confidence
mitochondrion 1
nucleus 1
cytosol 1
peroxisome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TEX45 Gene

Pathways & Interactions for TEX45 Gene

PathCards logo

SuperPathways for TEX45 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEX45 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TEX45 Gene

Drugs & Compounds for TEX45 Gene

No Compound Related Data Available

Transcripts for TEX45 Gene

mRNA/cDNA for TEX45 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX45 Gene

No ASD Table

Relevant External Links for TEX45 Gene

GeneLoc Exon Structure for
TEX45

Expression for TEX45 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEX45

mRNA Expression by UniProt/SwissProt for TEX45 Gene:

Q8NA69-TEX45_HUMAN
Tissue specificity: Highly expressed in testis.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX45 Gene

Orthologs for TEX45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf45 30
  • 99.21 (n)
C19orf45 31
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H19orf45 30
  • 79 (n)
C19orf45 31
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700019B03Rik 31 30
  • 69.38 (n)
OneToOne
Tex45 17
rat
(Rattus norvegicus)
Mammalia RGD1563425 30
  • 69.05 (n)
dog
(Canis familiaris)
Mammalia C19orf45 31
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C19orf45 31
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf45 31
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves C28H19orf45 30
  • 48.56 (n)
C19orf45 31
  • 30 (a)
OneToOne
Species where no ortholog for TEX45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEX45 Gene

ENSEMBL:
Gene Tree for TEX45 (if available)
TreeFam:
Gene Tree for TEX45 (if available)

Paralogs for TEX45 Gene

No data available for Paralogs for TEX45 Gene

Variants for TEX45 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEX45 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1133378 - p.Pro497Ser
rs3826736 - p.Tyr396Asn
rs475923 - p.Tyr434Asn
rs484870 - p.Asp256Gly
rs608144 - p.Leu500Pro

Additional dbSNP identifiers (rs#s) for TEX45 Gene

Structural Variations from Database of Genomic Variants (DGV) for TEX45 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
esv3367657 CNV insertion 20981092
esv3643587 CNV loss 21293372
nsv1060887 CNV gain 25217958
nsv2400 CNV insertion 18451855
nsv828416 CNV loss 20364138

Variation tolerance for TEX45 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.57; 98.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX45 Gene

Human Gene Mutation Database (HGMD)
TEX45
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX45 Gene

Disorders for TEX45 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TEX45 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search TEX45 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TEX45

genes like me logo Genes that share disorders with TEX45: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEX45 Gene

Publications for TEX45 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for TEX45 Gene

Sources for TEX45 Gene