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Aliases for TEX45 Gene

Aliases for TEX45 Gene

  • Testis Expressed 45 2 3 5
  • C19orf45 3 4
  • Chromosome 19 Open Reading Frame 45 2
  • Uncharacterized Protein C19orf45 3
  • Testis-Expressed Protein 45 3

External Ids for TEX45 Gene

Previous HGNC Symbols for TEX45 Gene

  • C19orf45

Summaries for TEX45 Gene

GeneCards Summary for TEX45 Gene

TEX45 (Testis Expressed 45) is a Protein Coding gene.

Additional gene information for TEX45 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX45 Gene

Genomics for TEX45 Gene

GeneHancer (GH) Regulatory Elements for TEX45 Gene

Promoters and enhancers for TEX45 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I007493 Enhancer 1.2 Ensembl ENCODE 550.8 +1.6 1616 2.2 HDGF PKNOX1 ATF1 ARID4B DMAP1 ZNF48 ZNF280A TCF12 ARID2 ATF7 TEX45 PEX11G TRIP10 ENSG00000269680 HNRNPM
GH19I007491 Enhancer 0.9 Ensembl ENCODE 550.8 -0.4 -375 1.6 ATF1 JUN CEBPG MCM2 FOSL1 POLR2A CREM SOX6 CEBPB ATF2 TEX45 PEX11G HNRNPM LOC100128573
GH19I007497 Promoter 0.8 EPDnew 550.8 +4.6 4564 0.1 CTCF NRF1 ZNF143 RAD21 TEX45 PEX11G ENSG00000267952
GH19I007498 Enhancer 0.3 FANTOM5 79.7 +5.8 5848 0.1 ZFP36 PEX11G TEX45 PCP2 PNPLA6 EVI5L ENSG00000267952
GH19I007394 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.2 -97.4 -97410 2.8 PKNOX1 ARID4B SIN3A ZNF48 ETS1 ZNF121 POLR2B GLIS2 E2F8 ELK1 ENSG00000267852 ARHGEF18 TEX45 PEX11G NDUFA7 ENSG00000268861 GC19P007434
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TEX45 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TEX45 Gene

Genomic Locations for TEX45 Gene
chr19:7,492,976-7,515,233
(GRCh38/hg38)
Size:
22,258 bases
Orientation:
Plus strand
chr19:7,557,862-7,573,336
(GRCh37/hg19)

Genomic View for TEX45 Gene

Genes around TEX45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX45 Gene

Proteins for TEX45 Gene

  • Protein details for TEX45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA69-TEX45_HUMAN
    Recommended name:
    Testis-expressed protein 45
    Protein Accession:
    Q8NA69
    Secondary Accessions:
    • Q8N115

    Protein attributes for TEX45 Gene

    Size:
    505 amino acids
    Molecular mass:
    57331 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29824.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH34779.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TEX45 Gene

Post-translational modifications for TEX45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TEX45 Gene

Domains & Families for TEX45 Gene

Gene Families for TEX45 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEX45 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TEX45: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TEX45 Gene

Function for TEX45 Gene

genes like me logo Genes that share phenotypes with TEX45: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEX45 Gene

Localization for TEX45 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX45 gene
Compartment Confidence
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TEX45 Gene

Pathways & Interactions for TEX45 Gene

SuperPathways for TEX45 Gene

No Data Available

Interacting Proteins for TEX45 Gene

Gene Ontology (GO) - Biological Process for TEX45 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TEX45 Gene

Drugs & Compounds for TEX45 Gene

No Compound Related Data Available

Transcripts for TEX45 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX45 Gene

No ASD Table

Relevant External Links for TEX45 Gene

GeneLoc Exon Structure for
TEX45
ECgene alternative splicing isoforms for
TEX45

Expression for TEX45 Gene

NURSA nuclear receptor signaling pathways regulating expression of TEX45 Gene:

TEX45

mRNA Expression by UniProt/SwissProt for TEX45 Gene:

Q8NA69-TEX45_HUMAN
Tissue specificity: Highly expressed in testis.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX45 Gene

Orthologs for TEX45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf45 33
  • 99.21 (n)
C19orf45 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H19orf45 33
  • 79 (n)
C19orf45 34
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700019B03Rik 33 34
  • 69.38 (n)
Tex45 16
rat
(Rattus norvegicus)
Mammalia RGD1563425 33
  • 69.05 (n)
dog
(Canis familiaris)
Mammalia C19orf45 34
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C19orf45 34
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf45 34
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves C28H19orf45 33
  • 48.56 (n)
C19orf45 34
  • 30 (a)
OneToOne
Species where no ortholog for TEX45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEX45 Gene

ENSEMBL:
Gene Tree for TEX45 (if available)
TreeFam:
Gene Tree for TEX45 (if available)

Paralogs for TEX45 Gene

No data available for Paralogs for TEX45 Gene

Variants for TEX45 Gene

Sequence variations from dbSNP and Humsavar for TEX45 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000103707 -- 7,499,189(+) G/A intron_variant
rs1000485092 -- 7,505,908(+) C/A/G intron_variant
rs1000545164 -- 7,499,960(+) G/A intron_variant
rs1000638630 -- 7,500,332(+) C/T intron_variant
rs1000836036 -- 7,505,553(+) C/G coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TEX45 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
esv3367657 CNV insertion 20981092
esv3643587 CNV loss 21293372
nsv1060887 CNV gain 25217958
nsv2400 CNV insertion 18451855
nsv828416 CNV loss 20364138

Variation tolerance for TEX45 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.57; 98.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX45 Gene

Human Gene Mutation Database (HGMD)
TEX45
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX45 Gene

Disorders for TEX45 Gene

No disorders were found for TEX45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX45 Gene

Publications for TEX45 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for TEX45 Gene

Sources for TEX45 Gene

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