Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TEX44 Gene

Aliases for TEX44 Gene

  • Testis Expressed 44 2 3 5
  • C2orf57 3 4
  • Chromosome 2 Open Reading Frame 57 2
  • Uncharacterized Protein C2orf57 3
  • Testis-Expressed Protein 44 3

External Ids for TEX44 Gene

Previous HGNC Symbols for TEX44 Gene

  • C2orf57

Summaries for TEX44 Gene

GeneCards Summary for TEX44 Gene

TEX44 (Testis Expressed 44) is a Protein Coding gene.

Additional gene information for TEX44 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX44 Gene

Genomics for TEX44 Gene

GeneHancer (GH) Regulatory Elements for TEX44 Gene

Promoters and enhancers for TEX44 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J231611 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +20.7 20669 4.9 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 E2F8 LOC105373928 TEX44 NMUR1 LINC00471 PTMA DIS3L2 RN7SL499P
GH02J231619 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +28.4 28416 3.2 DDX20 SIN3A BMI1 ZNF664 E2F1 ZNF121 ZFHX2 VEZF1 FOS EGR2 TEX44 RPL28P2 DIS3L2 NMUR1 LOC105373928 RN7SL499P
GH02J231513 Promoter/Enhancer 1.5 Ensembl ENCODE 9.8 -78.4 -78363 2.6 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 ZNF207 LINC00471 NMUR1 TEX44 GC02P231518
GH02J231648 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.4 +55.9 55916 0.8 ELF3 ARID4B RAD21 SCRT2 SMARCA5 ZNF654 REST SREBF1 ZNF217 MTA1 TEX44 RN7SL499P GC02M231678
GH02J231627 Enhancer 0.8 Ensembl ENCODE dbSUPER 12.4 +35.2 35197 1.5 ZNF121 NR2F6 ZNF384 TEX44 LINC00471 LOC105373928 RN7SL499P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TEX44 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TEX44 Gene

Genomic Locations for TEX44 Gene
chr2:231,592,864-231,594,283
(GRCh38/hg38)
Size:
1,420 bases
Orientation:
Plus strand
chr2:232,457,575-232,458,994
(GRCh37/hg19)

Genomic View for TEX44 Gene

Genes around TEX44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX44 Gene

Proteins for TEX44 Gene

  • Protein details for TEX44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53QW1-TEX44_HUMAN
    Recommended name:
    Testis-expressed protein 44
    Protein Accession:
    Q53QW1
    Secondary Accessions:
    • Q8N4F2

    Protein attributes for TEX44 Gene

    Size:
    395 amino acids
    Molecular mass:
    41589 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEX44 Gene

Post-translational modifications for TEX44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEX44 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEX44 Gene

Domains & Families for TEX44 Gene

Gene Families for TEX44 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEX44 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TEX44: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TEX44 Gene

Function for TEX44 Gene

Phenotypes From GWAS Catalog for TEX44 Gene

Gene Ontology (GO) - Molecular Function for TEX44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TEX44: view
genes like me logo Genes that share phenotypes with TEX44: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEX44 Gene

Localization for TEX44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX44 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX44 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TEX44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 26168773
genes like me logo Genes that share ontologies with TEX44: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEX44 Gene

Pathways & Interactions for TEX44 Gene

SuperPathways for TEX44 Gene

No Data Available

Interacting Proteins for TEX44 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315557%0d%0a9606.ENSP00000312189%0d%0a
Selected Interacting proteins: ENSP00000315557 Q53QW1-TEX44_HUMAN for TEX44 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for TEX44 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TEX44 Gene

Drugs & Compounds for TEX44 Gene

No Compound Related Data Available

Transcripts for TEX44 Gene

mRNA/cDNA for TEX44 Gene

(23) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX44 Gene

No ASD Table

Relevant External Links for TEX44 Gene

GeneLoc Exon Structure for
TEX44
ECgene alternative splicing isoforms for
TEX44

Expression for TEX44 Gene

NURSA nuclear receptor signaling pathways regulating expression of TEX44 Gene:

TEX44

mRNA Expression by UniProt/SwissProt for TEX44 Gene:

Q53QW1-TEX44_HUMAN
Tissue specificity: Testis. Detected in germ cells at all stages of the seminiferous epithelium, strong expression in elongating spermatids (at protein level) (PubMed:26168773).

Evidence on tissue expression from TISSUES for TEX44 Gene

  • Nervous system(4)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX44 Gene

Orthologs for TEX44 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TEX44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2BH2orf57 33
  • 98.42 (n)
C2orf57 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C2H2orf57 33
  • 70.58 (n)
C2orf57 34
  • 51 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C25H2orf57 33
  • 69.31 (n)
C2orf57 34
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700019O17Rik 34 33
  • 64.26 (n)
OneToOne
Tex44 16
rat
(Rattus norvegicus)
Mammalia LOC501180 33
  • 61.75 (n)
oppossum
(Monodelphis domestica)
Mammalia C2orf57 34
  • 27 (a)
OneToOne
Species where no ortholog for TEX44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEX44 Gene

ENSEMBL:
Gene Tree for TEX44 (if available)
TreeFam:
Gene Tree for TEX44 (if available)

Paralogs for TEX44 Gene

No data available for Paralogs for TEX44 Gene

Variants for TEX44 Gene

Sequence variations from dbSNP and Humsavar for TEX44 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000791595 -- 231,591,061(+) C/A upstream_transcript_variant
rs1000938276 -- 231,591,211(+) G/C upstream_transcript_variant
rs1000977112 -- 231,591,736(+) T/C upstream_transcript_variant
rs1003037931 -- 231,592,677(+) A/G upstream_transcript_variant
rs1003862606 -- 231,591,439(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TEX44 Gene

Variant ID Type Subtype PubMed ID
esv3584963 CNV gain 24956385
nsv999161 CNV gain 25217958

Variation tolerance for TEX44 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX44 Gene

Disorders for TEX44 Gene

No disorders were found for TEX44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX44 Gene

Publications for TEX44 Gene

  1. Human Spermatozoa as a Model for Detecting Missing Proteins in the Context of the Chromosome-Centric Human Proteome Project. (PMID: 26168773) Jumeau F … Pineau C (Journal of proteome research 2015) 2 3 4 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58

Products for TEX44 Gene

Sources for TEX44 Gene

Content
Loading form....